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Volatile Biomarkers

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Volatile Biomarkers

Volatile Biomarkers Book
Author : Anton Amann,David Smith
Publisher : Newnes
Release : 2013-03-27
ISBN : 0444626204
Language : En, Es, Fr & De

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Book Description :

Volatile organic compounds (VOCs) in exhaled breath, sweat or urine carry much information on the state of human health. The role of VOCs in clinical diagnosis and therapeutic monitoring is expected to become increasingly significant due to recent advances in the field. Volatile Biomarkers: Non-Invasive Diagnosis in Physiology and Medicine includes the latest discoveries and applications for VOCs from the world's foremost scientists and clinicians working in this emerging analytic area. Appeals to a multidisciplinary audience, including scientists, researchers, and clinicians with an interest in breath analysis Features the latest scientific research and technical breakthroughs in the diagnostic and therapeutic aspects of volatile organic compounds Includes case presentations documenting applications in multiple areas of human health and safety

Volatile Biomarkers for Human Health

Volatile Biomarkers for Human Health Book
Author : Hossam Haik
Publisher : Royal Society of Chemistry
Release : 2022-09-30
ISBN : 1839164301
Language : En, Es, Fr & De

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Book Description :

This book offers an outlook into the challenges in the continuing development of volatile biomarkers and their wider availability to healthcare research and industries.

Breathborne Biomarkers and the Human Volatilome

Breathborne Biomarkers and the Human Volatilome Book
Author : Cristina Davis,Joachim Pleil,Jonathan Beauchamp
Publisher : Elsevier
Release : 2020-06-06
ISBN : 0128223979
Language : En, Es, Fr & De

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Book Description :

Breathborne biomarkers carry information on the state of human health, and their role in aiding clinical diagnosis or in therapeutic monitoring has become increasingly important as advances in the field are made. Breathborne Biomarkers and the Human Volatilome, Second Edition, provides a comprehensive update and reworking of the 2013 book Volatile Biomarkers, by Anton Amann and David Smith. The new editing team has expanded this edition beyond volatile organic compounds to cover the broad field of breath analysis, including the many exciting developments that have occurred since the first edition was published. This thoroughly revised volume includes the latest discoveries and applications in breath research from the world's foremost scientists, and offers insights into related future developments. It is an ideal resource for researchers, scientists, and clinicians with an interest in breath analysis. Presents recent advances in the field of breath analysis Includes an extensive overview of established biomarkers, detection tools, disease targets, specific applications, data analytics, and study design Offers a broad treatise of each topic, from basic concepts to a comprehensive review of discoveries, current consensus of understanding, and prospective future developments Acts as both a primer for beginners and a reference for seasoned researchers

Biomarkers in Allergy and Asthma An Issue of Immunology and Allergy Clinics of North America E Book

Biomarkers in Allergy and Asthma  An Issue of Immunology and Allergy Clinics of North America E Book Book
Author : Flavia Hoyte,Rohit K. Katial
Publisher : Elsevier Health Sciences
Release : 2018-10-23
ISBN : 0323641407
Language : En, Es, Fr & De

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Book Description :

This issue of Immunology and Allergy Clinics, guest edited by Drs. Flavia Hoyte and Rohit Katial, is devoted to Biomarkers in Allergy and Asthma. Articles in this issue include: Exhaled Nitric Oxide; Biomarkers in Exhaled Breath Condensate (EBC); Role of Eosinophils in Asthma; Bronchoprovocation Testing in Asthma; Periostin and DPP4; Role of Neutrophils in Asthma; Urinary LTE4; Biomarkers in Nasal Polyps; IgE as a Biomarker in Asthma; Genetics of Asthma; and Biomarker-directed Therapies for Asthma.

Update on Biomarkers in Allergy and Asthma An Issue of Immunology and Allergy Clinics

Update on Biomarkers in Allergy and Asthma  An Issue of Immunology and Allergy Clinics Book
Author : Rohit Katial
Publisher : Elsevier Health Sciences
Release : 2012-10-22
ISBN : 1455750921
Language : En, Es, Fr & De

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Book Description :

This issue of Immunology and Allergy Clinics provides a comprehensive review of the current state of biomarkers and their role in the asthma diagnostic and therapeutic algorithm.Since the last issue on Biomarkers, which published in 2007, significant research directly targeted at biomarker development and clinical trials with new biologics, using biomarkers such as exhaled nitric oxide, sputum and tissue eosinophilia as endpoints, has occurred.

Recent Advancements in Biomarkers and Early Detection of Gastrointestinal Cancers

Recent Advancements in Biomarkers and Early Detection of Gastrointestinal Cancers Book
Author : Pallaval Veera Bramhachari,Nageswara Rao Reddy Neelapu
Publisher : Springer Nature
Release : 2020-07-21
ISBN : 981154431X
Language : En, Es, Fr & De

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Book Description :

This book describes various novel biomarkers for the early diagnosis of gastrointestinal (GI) cancers. It also highlights recent advances in understanding the role of molecular markers and biomarkers, such as volatile biomarkers, serum biomarkers, predictive and prognostic molecular markers for the early detection of GI cancers. Further, it discusses novel biomarkers, including circulating microRNAs, serum microRNA and plasma microRNA in GI cancer. The book presents breakthrough technologies like ultra-sensitive nano-chips, nanosensors, nanodevices, biosensors, electrochemical biosensors, optical biosensors, DNA biosensors, synthetic biology devices, and 'omics' technologies for the early diagnosis of gastrointestinal cancer. In addition it examines the potential of genome-wide association studies, big data analytics, computation biology, systems biology, and nanotechnology for early diagnostics and therapeutics for gastrointestinal cancer, with a focus on personalized cancer treatment. The book is a valuable source for researchers and clinicians engaged in detection and diagnosis of gastrointestinal cancers.

The Handbook of Biomarkers

The Handbook of Biomarkers Book
Author : Kewal K. Jain
Publisher : Humana Press
Release : 2017-09-16
ISBN : 1493974319
Language : En, Es, Fr & De

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Book Description :

Involved in nearly every therapeutic area, particularly cancer, biomarkers have experienced tremendous advances since the first edition of this book, both in the discovery of biomarkers and in their applications. To aid in this imperative research, Prof. Kewal K. Jain’s Handbook of Biomarkers, Second Edition features a full revision and additional chapters to thoroughly describe many different types of biomarkers and their discovery using various "-omics" technologies, along with the background information needed for the evaluation of biomarkers as well as the essential procedures for their validation and use in clinical trials. With biomarkers described first according to technologies and then according to various diseases, this detailed book features the key correlations between diseases and classifications of biomarkers, which provides the reader with a guide to sort out current and future biomarkers. Comprehensive and cutting-edge, The Handbook of Biomarkers, Second Edition serves as a vital guide to furthering our understanding of biomarkers, which, by facilitating the combination of therapeutics with diagnostics, promise to play an important role in the development of personalized medicine, one of the most important trends in healthcare today.

The Detection of Biomarkers

The Detection of Biomarkers Book
Author : Sibel A. Ozkan,Nurgul K. Bakirhan,Fariba Mollaraosouli
Publisher : Academic Press
Release : 2021-12-05
ISBN : 0128230754
Language : En, Es, Fr & De

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Book Description :

Reliable, precise and accurate detection and analysis of biomarkers remains a significant challenge for clinical researchers. Methods for the detection of biomarkers are rather complex, requiring pre-treatment steps before analysis can take place. Moreover, comparing various biomarker assays and tracing research progress in this area systematically is a challenge for researchers. The Detection of Biomarkers presents developments in biomarker detection, including methods tools and strategies, biosensor design, materials, and applications. The book presents methods, materials and procedures that are simple, precise, sensitive, selective, fast and economical, and therefore highly practical for use in clinical research scenarios. This volume situates biomarker detection in its research context and sets out future prospects for the area. Its 20 chapters offer a comprehensive coverage of biomarkers, including progress on nanotechnology, biosensor types, synthesis, immobilization, and applications in various fields. The book also demonstrates, for students, how to synthesize and immobilize biosensors for biomarker assay. It offers researchers real alternative and innovative ways to think about the field of biomarker detection, increasing the reliability, precision and accuracy of biomarker detection. Locates biomarker detection in its research context, setting out present and future prospects Allows clinical researchers to compare various biomarker assays systematically Presents new methods, materials and procedures that are simple, precise, sensitive, selective, fast and economical Gives innovative biomarker assays that are viable alternatives to current complex methods Helps clinical researchers who need reliable, precise and accurate biomarker detection methods

The Biomarker Guide Volume 1 Biomarkers and Isotopes in the Environment and Human History

The Biomarker Guide  Volume 1  Biomarkers and Isotopes in the Environment and Human History Book
Author : K. E. Peters,C. C. Walters,J. M. Moldowan
Publisher : Cambridge University Press
Release : 2007-08-16
ISBN : 1107079373
Language : En, Es, Fr & De

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Book Description :

The second edition of The Biomarker Guide is a fully updated and expanded version of this essential reference. Now in two volumes, it provides a comprehensive account of the role that biomarker technology plays both in petroleum exploration and in understanding Earth history and processes. Biomarkers and Isotopes in the Environment and Human History details the origins of biomarkers and introduces basic chemical principles relevant to their study. It discusses analytical techniques, and applications of biomarkers to environmental and archaeological problems. The Biomarker Guide is an invaluable resource for geologists, petroleum geochemists, biogeochemists, environmental scientists and archaeologists.

Volatile Organic Compound Analysis in Biomedical Diagnosis Applications

Volatile Organic Compound Analysis in Biomedical Diagnosis Applications Book
Author : Raquel Cumeras,Xavier Correig
Publisher : CRC Press
Release : 2018-11-09
ISBN : 042978242X
Language : En, Es, Fr & De

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Book Description :

This volume presents a thought-provoking state-of-the-art picture of how volatile compounds are used in metabolomics, currently a hot topic in the metabolomics field. It provides a thorough description of what volatile organic compounds (VOCs) are, why they are important in biomedicine, and what the analytical platforms are used. It also looks at multivariate analysis and databases needs. Because VOCs are end-up compounds of metabolic processes, volatiles can be linked to different diseases or pathologies for both diagnosis and prognosis. The authors provide authoritative information and guidance on the analytical and statistical techniques used and how to identify, and they review the main current areas of application, which include breath metabolomics, cancer diagnosis, and microbial volatiles. Key Features: Presents a thorough overview of volatile research in biomedical applications Examines both gold standard techniques (metabolomics based) and artificial olfactory systems Reviews all aspects of volatile metabolites in biomedicine research, from origin to detection platforms Describes relevant diseases diagnosis and prognosis achievements, including cancer

Volatile Biomarkers for Human Health

Volatile Biomarkers for Human Health Book
Author : Hossam Haick
Publisher : Royal Society of Chemistry
Release : 2022-09-30
ISBN : 1839167009
Language : En, Es, Fr & De

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Book Description :

Volatile biomarkers play a significant signalling role in communication between biological cells living as individual entities or as mini-societies that sense, respond and adapt to changes in their environment. In this process, volatile biomarkers can leak into the blood, from which they can be secreted into most body fluids (blood, breath, skin, urine, saliva, feces, etc.), from which sensing devices can capture and interpret their chemical fingerprint to reflect any association with health disorders in a fast, easy, and minimally non-invasive manner. This book introduces the concept of biomarkers within the body in terms of basic and translational sciences. It starts with a comprehensive review of the expression and mechanistic pathways involving volatile biomarkers at single cell and (micro)organism levels, cell-to-cell and cell-to-organism communications, and their secretion into body fluids. It discusses several ways for discovering and detecting the secreted biomarkers using mass spectrometry and other spectroscopic techniques. This is followed by an appraisal and translation of the accumulating knowledge from the laboratory to the Point-of-Care phase, using selective sensors as well as desktop and wearable artificial sensing devices, e.g., electronic noses and electronic skins, in conjugation with AI-assisted data processing and healthcare decision-making in diagnostics. The book offers an outlook into the challenges in the continuing development of volatile biomarkers and their wider availability to healthcare, which can be substantially improved. It should appeal to research groups in universities, start-up and large-scale industries associated in all aspects of biomedicine.

The Biomarker Guide

The Biomarker Guide Book
Author : Kenneth Eric Peters,K. E. Peters,C. C. Walters,J. M. Moldowan
Publisher : Cambridge University Press
Release : 2005
ISBN : 0521781582
Language : En, Es, Fr & De

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Book Description :

The first part of an all-inclusive two volume reference on biological markers in petroleum geochemistry, environmental science and archaeology.

Bioelectronics

Bioelectronics Book
Author : Anuj Kumar,Ram K. Gupta
Publisher : CRC Press
Release : 2022-12-08
ISBN : 1000789470
Language : En, Es, Fr & De

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Book Description :

Bioelectronics is emerging as a new area of research where electronics can selectively detect, record, and monitor physiological signals. This is a rapidly expanding area of medical research, that relies heavily on multidisciplinary technology development and cutting-edge research in chemical, biological, engineering, and physical science. This book provides extensive information on the (i) fundamental concepts of bioelectronics, (ii) materials for the developments of bioelectronics such as implantable electronics, self-powered devices, bioelectronic sensors, flexible bioelectronics, etc, and (iii) an overview of the trends and gathering of the latest bioelectronic progress. This book will broaden our knowledge about newer technologies and processes used in bioelectronics.

Targeted Biomarker Quantitation by LC MS

Targeted Biomarker Quantitation by LC MS Book
Author : Naidong Weng,Wenying Jian
Publisher : John Wiley & Sons
Release : 2017-07-05
ISBN : 1119413060
Language : En, Es, Fr & De

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Book Description :

The first book to offer a blueprint for overcoming the challenges to successfully quantifying biomarkers in living organisms The demand among scientists and clinicians for targeted quantitation experiments has experienced explosive growth in recent years. While there are a few books dedicated to bioanalysis and biomarkers in general, until now there were none devoted exclusively to addressing critical issues surrounding this area of intense research. Target Biomarker Quantitation by LC-MS provides a detailed blueprint for quantifying biomarkers in biological systems. It uses numerous real-world cases to exemplify key concepts, all of which were carefully selected and presented so as to allow the concepts they embody to be easily expanded to future applications, including new biomarker development. Target Biomarker Quantitation by LC-MS primarily focuses on the assay establishment for biomarker quantitation—a critical issue rarely treated in depth. It offers comprehensive coverage of three core areas of biomarker assay establishment: the relationship between the measured biomarkers and their intended usage; contemporary regulatory requirements for biomarker assays (a thorough understanding of which is essential to producing a successful and defendable submission); and the technical challenges of analyzing biomarkers produced inside a living organism or cell. Covers the theory of and applications for state-of-the-art mass spectrometry and chromatography and their applications in biomarker analysis Features real-life examples illustrating the challenges involved in target biomarker quantitation and the innovative approaches which have been used to overcome those challenges Addresses potential obstacles to obtain effective biomarker level and data interpretation, such as specificity establishment and sample collection Outlines a tiered approach and fit-for-purpose assay protocol for target biomarker quantitation Highlights the current state of the biomarker regulatory environment and protocol standards Target Biomarker Quantitation by LC-MS is a valuable resource for bioanalytical scientists, drug metabolism and pharmacokinetics scientists, clinical scientists, analytical chemists, and others for whom biomarker quantitation is an important tool of the trade. It also functions as an excellent text for graduate courses in pharmaceutical, biochemistry and chemistry.

Cancer Metabolomics 2018

Cancer Metabolomics 2018 Book
Author : Paula Guedes De Pinho,Márcia Carvalho,Joana Pinto
Publisher : MDPI
Release : 2019-09-03
ISBN : 3039213458
Language : En, Es, Fr & De

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Book Description :

The metabolomics approach, defined as the study of all endogenously-produced low-molecular-weight compounds, appeared as a promising strategy to define new cancer biomarkers. Information obtained from metabolomic data can help to highlight disrupted cellular pathways and, consequently, contribute to the development of new-targeted therapies and the optimization of therapeutics. Therefore, metabolomic research may be more clinically translatable than other omics approaches, since metabolites are closely related to the phenotype and the metabolome is sensitive to many factors. Metabolomics seems promising to identify key metabolic pathways characterizing features of pathological and physiological states. Thus, knowing that tumor metabolism markedly differs from the metabolism of normal cells, the use of metabolomics is ideally suited for biomarker research. Some works have already focused on the application of metabolomic approaches to different cancers, namely lung, breast and liver, using urine, exhaled breath and blood. In this Special Issue we contribute to a more complete understanding of cancer disease using metabolomics approaches.

Breath Analysis

Breath Analysis Book
Author : Giorgio Pennazza,Marco Santonico
Publisher : Academic Press
Release : 2018-11-29
ISBN : 0128145633
Language : En, Es, Fr & De

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Book Description :

Breath Analysis presents state-of-the-art research in this specialized field, also offering guidance on how best to design the technology and conduct analysis. The book primarily focuses on the diagnosis of lung cancer, asthma and Chronic Obstructive Pulmonary Diseases. The reliability, consistency and utility of the results from breath analysis depends on exhaled breath sampling procedures and tools, gas sensor array technology (sensing material and transducer), and finally, medical pertinence and interpretation. The book gives step-by-step procedures and discusses best practice solutions for problems in sample collection, sensor technology, clinical assessment, medical interpretation and data analysis. The book's primary audience would include biomedical engineers and medical doctors, but it is also useful for hospital technicians, hospital and biomedical SME leading figures, and those in PhD level Engineering and Medicine. Presents an overview of existing breath analysis technology, along with their pros and cons Provides a tool for mapping, bridging and translating different approaches and available devices Covers best practices and procedures for exhaled breath collection

Biosensing Technologies for the Detection of Pathogens

Biosensing Technologies for the Detection of Pathogens Book
Author : Toonika Rinken,Kairi Kivirand
Publisher : BoD – Books on Demand
Release : 2018-03-21
ISBN : 9535139150
Language : En, Es, Fr & De

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Book Description :

Rapid multiplex detection of pathogens in the environment and in our food is a key factor for the prevention and effective treatment of infectious diseases. Biosensing technologies combining the high selectivity of biomolecular recognition and the sensitivity of modern signal detection platforms are a prospective option for automated analyses. They allow rapid detection of single molecules as well as cellular substances. This book, including 12 chapters from 50 authors, introduces the principles of identification of specific pathogen biomarkers along with different biosensor-based technologies applied for pathogen detection.

Volatile Biomarkers

Volatile Biomarkers Book
Author : Anton Amann,David Smith
Publisher : Elsevier Science Limited
Release : 2013
ISBN : 9780444626134
Language : En, Es, Fr & De

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Book Description :

Volatile organic compounds (VOCs) in exhaled breath, sweat or urine carry much information on the state of human health. The role of VOCs in clinical diagnosis and therapeutic monitoring is expected to become increasingly significant due to recent advances in the field. Volatile Biomarkers: Non-Invasive Diagnosis in Physiology and Medicine includes the latest discoveries and applications for VOCs from the world's foremost scientists and clinicians working in this emerging analytic area. - Appeals to a multidisciplinary audience, including scientists, researchers, and clinicians with an interest in breath analysis - Features the latest scientific research and technical breakthroughs in the diagnostic and therapeutic aspects of volatile organic compounds - Includes case presentations documenting applications in multiple areas of human health and safety

Studies on Respiratory Disorders

Studies on Respiratory Disorders Book
Author : Nirmal K. Ganguly,Surinder K. Jindal,Shyam Biswal,Peter J. Barnes,Ruby Pawankar
Publisher : Springer Science & Business Media
Release : 2014-03-31
ISBN : 1493904973
Language : En, Es, Fr & De

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Book Description :

This volume covers data describing the role of free radicals and antioxidants in respiratory disorders, including the data that deal with clinical and pre-clinical trials. Chapters describe the relationship of oxidative stress to a number of respiratory and pulmonary conditions from a basic science and clinical perspective, including chronic obstructive pulmonary disease, asthma, acute lung injury, pulmonary hypertension, toxicity and fibrosis, cancer and asbestosis. The book also discusses the use of conventional biomarkers of oxidative stress and breath condensates as adjuncts to classical laboratory testing, the effect of antioxidants on cellular protection, as well as the development of novel antioxidant modalities.

Advanced Techniques in Diagnostic Microbiology

Advanced Techniques in Diagnostic Microbiology Book
Author : Yi-Wei Tang,Charles W. Stratton
Publisher : Springer
Release : 2018-11-09
ISBN : 3319339001
Language : En, Es, Fr & De

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Book Description :

In recent years, advanced molecular techniques in diagnostic microbiology have been revolutionizing the practice of clinical microbiology in the hospital setting. Molecular diagnostic testing in general and nucleic acid-based amplification methods in particular have been heralded as diagnostic tools for the new millennium. This third edition covers not only the most recent updates and advances, but details newly invented omic techniques, such as next generation sequencing. It is divided into two distinct volumes, with Volume 1 describing the techniques, and Volume 2 addressing their applications in the field. In addition, both volumes focus more so on the clinical relevance of the test results generated by these techniques than previous editions.