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Viral Proteases And Their Inhibitors

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Viral Proteases and Their Inhibitors

Viral Proteases and Their Inhibitors Book
Author : Satya Prakash Gupta
Publisher : Academic Press
Release : 2017-07-03
ISBN : 0128096829
Language : En, Es, Fr & De

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Book Description :

Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents. Provides comprehensive, state-of-the-art coverage of virus infections, the virus lifecycle, and mechanisms of protease inhibition Analyzes structure-activity relationships of inhibitors of each viral protease Presents an in-depth view of the structure and function of viral proteases

Antiviral Strategies

Antiviral Strategies Book
Author : Hans-Georg Kräusslich,Ralf Bartenschlager
Publisher : Springer Science & Business Media
Release : 2008-12-02
ISBN : 3540790861
Language : En, Es, Fr & De

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Book Description :

A crucial issue for antiviral therapy is the fact that all antiviral substances rapidly select for resistance; thus, monitoring and overcoming resistance has become a most important clinical paradigm of antiviral therapy. This calls for cautious use of antiviral drugs and implementation of combination therapies. In parallel, efforts in drug discovery have to be continued to develop compounds with novel mode-of-action and activity against resistant strains. This book reviews the current status of antiviral therapy, from the roads to development of new compounds to their clinical use and cost effectiveness. Individual chapters address in more detail all available drug classes and outline new approaches currently under development.

Retroviral Proteases

Retroviral Proteases Book
Author : Lawrence C. Kuo,Jules A. Shafer
Publisher : Gulf Professional Publishing
Release : 1994-09-22
ISBN : 9780121821425
Language : En, Es, Fr & De

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Book Description :

Methods included in this volume apply to the expression and characterization of retroviral proteases and their inhibitor/substrate design.

Activation of Viruses by Host Proteases

Activation of Viruses by Host Proteases Book
Author : Eva Böttcher-Friebertshäuser,Wolfgang Garten,Hans Dieter Klenk
Publisher : Springer
Release : 2018-05-22
ISBN : 3319754742
Language : En, Es, Fr & De

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Book Description :

This book will give an overview on viruses undergoing proteolytic activation through host proteases. The chapters will be organized in three themed parts, the first part describing respective viruses and their characteristics in detail. In the second part the molecular and cellular biology of the proteases involved as well as their physiological functions will be further explored. The third part will contain a chapter on protease inhibitors that are promising tools for antiviral therapy. This book will engage scholars in virology and medical microbiology as well as researchers with an interest in enzymology and protein structure and function relationship.

Viral Proteases and Antiviral Protease Inhibitor Therapy

Viral Proteases and Antiviral Protease Inhibitor Therapy Book
Author : Uwe Lendeckel,Nigel M. Hooper
Publisher : Springer Science & Business Media
Release : 2009-06-19
ISBN : 9048123488
Language : En, Es, Fr & De

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Book Description :

The 8th volume in the Proteases in Biology and Disease series focuses on the role of proteases in virus function and their potential as anti-viral targets. Viral infections are still difficult to threat and some remained life-threatening diseases in spite of antiviral drug research over decades. Proteases are still regarded as an Achilles’ heel of the pathogens and, thus, protease inhibitors may help to handle the known and the emerging viral threads. The book discusses viral proteases of the most important pathogenic viruses, responsible for severe diseases: AIDS, SARS, Hepatitis, Cytomegalovirus, T-cell lymphotropic virus, Picornavirus. This book focuses specifically on the viral proteases, crucial prerequisites for viral entry into cells and viral replication. Viral proteases represent an important pharmaceutical target. The current stage of protease inhibitor development and therapy are summarised and discussed by experts in the field. This volume represents a timely and valuable continuation of the Proteases in Biology and Disease series. The reader will learn the potential for proteases as targets for effective anti-virals. This book will be a valuable source of information on viral proteases and provoke further research in this important field.

Cancer Leading Proteases

Cancer Leading Proteases Book
Author : Satya Prakash Gupta
Publisher : Academic Press
Release : 2020-02-03
ISBN : 0128181680
Language : En, Es, Fr & De

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Book Description :

Cancer-Leading Proteases: Structures, Functions, and Inhibition presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical industry as potential drug targets or as diagnostic and prognostic biomarkers. This book covers the structure and functions of proteases and the chemical and biological rationale of drug design relating to how these proteases can be exploited to find useful chemotherapeutics to fight cancers. In addition, the book encompasses the experimental and theoretical aspects of anticancer drug design based on proteases. It is a useful resource for pharmaceutical scientists, medicinal chemists, biochemists, microbiologists, and cancer researchers working on proteases. Explains the role of proteases in the biology of cancer Discusses how proteases can be used as potential drug targets or as diagnostic and prognostic biomarkers Covers a wide range of cancers and provides detailed discussions on protease examples

Viral Replication Enzymes and their Inhibitors Part A

Viral Replication Enzymes and their Inhibitors Part A Book
Author : Anonim
Publisher : Academic Press
Release : 2021-10-23
ISBN : 0128234695
Language : En, Es, Fr & De

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Book Description :

Viral Replication Enzymes and their Inhibitors Part A, Volume 49, the latest release in the Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of related topics. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in The Enzymes series

Encyclopedia of Molecular Pharmacology

Encyclopedia of Molecular Pharmacology Book
Author : Stefan Offermanns,W. Rosenthal
Publisher : Springer Science & Business Media
Release : 2008-08-14
ISBN : 3540389164
Language : En, Es, Fr & De

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Book Description :

An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.

Antiretroviral Resistance in Clinical Practice

Antiretroviral Resistance in Clinical Practice Book
Author : Anonim
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Antiretroviral Resistance in Clinical Practice book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Viral Proteases and Their Inhibitors

Viral Proteases and Their Inhibitors Book
Author : Satya P. Gupta
Publisher : Academic Press
Release : 2017-07-06
ISBN : 9780128097120
Language : En, Es, Fr & De

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Book Description :

7.1.17 - Cinanserin Analogs as Promising SARS-CoV 3CLpro Inhibitors

Dengue and Zika Control and Antiviral Treatment Strategies

Dengue and Zika  Control and Antiviral Treatment Strategies Book
Author : Rolf Hilgenfeld,Subhash G. Vasudevan
Publisher : Springer
Release : 2018-05-29
ISBN : 981108727X
Language : En, Es, Fr & De

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Book Description :

This contributed volume contains 25 chapters from leading international scientists working on dengue and Zika viruses, who came together in Praia do Tofo in Mozambique to discuss the latest developments in the fields of epidemiology, pathogenesis, structural virology, immunology, antiviral drug discovery and development, vaccine efficacy, and mosquito control programs. The meeting venue offered an opportunity to discuss current research on these flaviviruses in an idyllic setting, and also to develop first-hand appreciation of the issues in infectious diseases facing developing countries and of the research gaps in Africa. For readers, who should include basic and clinical researchers in the field and public health professionals, the chapters are organized to provide a comprehensive overview of the various topics in current dengue and Zika virus research. A unique feature of the proceedings of this meeting is the inclusion of the discussions that took place following presentations. These have been transcribed and appended to the end of the relevant chapters, and they form the “salt in the soup” of this book.

Aspartic Acid Proteases as Therapeutic Targets

Aspartic Acid Proteases as Therapeutic Targets Book
Author : Arun K. Ghosh
Publisher : John Wiley & Sons
Release : 2011-08-04
ISBN : 3527641629
Language : En, Es, Fr & De

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Book Description :

In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of aspartic acid proteases, their physiological functions, molecular structure and inhibition. Parts two to five present various case studies of successful protease inhibitor drug design and development, as well as current and potential uses of such inhibitors in pharmaceutical medicine, covering the major therapeutic targets HIV-1 protease, renin, beta-secretase, gamma-secretase,plasmepsins and fungal proteases. A ready reference aimed primarily at professionals in the pharmaceutical industry, as well as for anyone studying proteases and their function.

Proteolytic Enzymes

Proteolytic Enzymes Book
Author : Erwin E. Sterchi,Walter Stöcker
Publisher : Springer Science & Business Media
Release : 2013-11-11
ISBN : 3642598161
Language : En, Es, Fr & De

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Book Description :

Following an overview on proteolytic enzyme assays, this text covers procedures on how to investigate and study proteases. It describes the use of specific restriction proteases as well as inhibitors of proteases to prevent unwanted proteolysis.

Mechanisms of Catalysis

Mechanisms of Catalysis Book
Author : Anonim
Publisher : Academic Press
Release : 1991-01-28
ISBN : 9780080865966
Language : En, Es, Fr & De

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Book Description :

The remarkable expansion of information leading to a deeper understanding of enzymes on the molecular level necessitated the development of this volume which not only introduces new topics to The Enzymes series but presents new information on some covered in Volume I and II of this edition.

Handbook of Antimicrobial Resistance

Handbook of Antimicrobial Resistance Book
Author : Matthias Gotte,Albert Berghuis,Greg Matlashewski,Mark Wainberg,Donald Sheppard
Publisher : Springer
Release : 2018-02-12
ISBN : 9781493906932
Language : En, Es, Fr & De

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Book Description :

While many volumes have been written about various aspects of antimicrobial resistance, this book is a comprehensive reference work. All manifestations of resistance are addressed: viral; bacterial, parasitical and fungal are given dedicated sections. The underlining molecular mechanisms, which depend not only on the microbe but on the specific drug (target), are highly diverse. This work discusses and compares the biological, biochemical and structural aspects of resistance and its evolution.

Structural Biology in Drug Discovery

Structural Biology in Drug Discovery Book
Author : Jean-Paul Renaud
Publisher : John Wiley & Sons
Release : 2020-01-09
ISBN : 1118900502
Language : En, Es, Fr & De

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Book Description :

With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

Proteases as Targets for Therapy

Proteases as Targets for Therapy Book
Author : Klaus, von der Helm,BRUCE KORANT,John C. Cheronis
Publisher : Springer
Release : 2012-10-10
ISBN : 9783642630231
Language : En, Es, Fr & De

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Book Description :

With contributions by numerous experts

Plant Proteases

Plant Proteases Book
Author : Mercedes Diaz-Mendoza,Juan Guiamet,Frank Van Breusegem
Publisher : Frontiers Media SA
Release : 2020-01-24
ISBN : 2889633993
Language : En, Es, Fr & De

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Book Description :

Plant proteases are involved in most aspects of plant physiology and development, playing key roles in the generation of signaling molecules and as regulators of essential cellular processes such as cell division and metabolism. They take part in important pathways like protein turnover by the degradation of misfolded proteins and the ubiquitin-proteasome pathway, and they are responsible for post-translational modifications of proteins by proteolysis at highly specific sites. Proteases are also implicated in a great variety of environmentally controlled processes, including mobilization of storage proteins during seed germination, development of seedlings, senescence, programmed cell death and defense mechanisms against pests and pathogens. However, in spite of their importance, little is known about the functions and mode of actions of specific plant proteases. This Research Topic collects contributions covering diverse aspects of plant proteases research.

Antiviral Drug Discovery and Development

Antiviral Drug Discovery and Development Book
Author : Xinyong Liu,Peng Zhan,Luis Menéndez-Arias,Vasanthanathan Poongavanam
Publisher : Springer Nature
Release : 2021-07-13
ISBN : 9811602670
Language : En, Es, Fr & De

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Book Description :

This book summarizes state-of-the-art antiviral drug design and discovery approaches starting from natural products to de novo design, and provides a timely update on recently approved antiviral drugs and compounds in advanced clinical development. Special attention is paid to viral infections with a high impact on the world population or highly relevant from the public health perspective (HIV, hepatitis C, influenza virus, etc.). In these chapters, limitations associated with adverse effects and emergence of drug resistance are discussed in detail. In addition to classical antiviral strategies, chapters will be dedicated to discuss the non-classical drug development strategies to block viral infection, for instance, allosteric inhibitors, covalent antiviral agents, or antiviral compounds targeting protein–protein interactions. Finally, current prospects for producing broad-spectrum antiviral inhibitors will be also addressed. The book is distinctive in providing the most recent update in the rapidly evolving field of antiviral therapeutics. Authoritative reviews are written by international scientists well known for their contributions in their topics of research, which makes this book suitable for researchers not only within the antiviral research community but also attractive to a broad audience in the drug discovery field. This book covers molecular structures and biochemical mechanisms mediating the antiviral effects, while discussing various ligand design strategies, which include traditional medicinal chemistry, computational chemistry, and chemical biology approaches. The book provides a comprehensive review of antiviral drug discovery and development approaches, particularly focusing on current innovations and future trends.

Proteases in Human Diseases

Proteases in Human Diseases Book
Author : Sajal Chakraborti,Tapati Chakraborti,Naranjan S. Dhalla
Publisher : Springer
Release : 2017-07-13
ISBN : 9811031622
Language : En, Es, Fr & De

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Book Description :

This book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases. It represents a comprehensive overview of the multifaceted field of proteases in cellular environment and highlights the recently elucidated functions of complex proteolytic systems in different diseases. Several established investigators have elucidated the crucial role of proteases in biological processes, including how proteolytic function and regulation can be combined to develop new strategies of therapeutic interventions. Proteases form one of the largest and most diverse families of enzymes known. It is now clear that proteases are involved in every aspect of life functions of an organism. Under physiological conditions, proteases are regulated by their endogenous inhibitors; however, when the activity of proteases is not regulated appropriately, disease processes can result in. So, there is absolute need for a stringent control of proteolytic activities in cells and tissues. Dysregulation of proteases may cause derangement of cellular signalling network resulting in different pathophysiological conditions such as vascular remodelling, atherosclerotic plaque progression, ulcer and rheumatoid arthritis, Alzheimer disease, cancer metastasis, tumor progression and inflammation. Additionally, many infective microorganisms require proteases for replication or use proteases as virulence factors, which have facilitated the development of protease-targeted therapies for a variety of parasitic diseases.