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Vicinal Diaryl Substituted Heterocycles

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Vicinal Diaryl Substituted Heterocycles

Vicinal Diaryl Substituted Heterocycles Book
Author : M. R. Yadav,P. R. Murumkar,R. B. Ghuge
Publisher : Elsevier
Release : 2018-03-14
ISBN : 0081022492
Language : En, Es, Fr & De

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Book Description :

Vicinal Diaryl-Substituted Heterocycles: A Gold Mine for the Discovery of Novel Therapeutic Agents draws together all of the key information about these compounds in one place for the first time. Following an informative overview of the importance of these structures to the discovery of potential therapeutic agents, the text goes on to outline the main compound types, with each chapter focusing on the activities of a different structure. Designed to support researchers by consolidating this important information in a single, practical guide, the authors hope to encourage further advancement and development in the discovery of novel therapeutic agents. As flexible building blocks for the production of novel compounds, vicinal diaryl-substituted heterocycles are a rich source of leads for the development of new drugs. Their adaptability means that they can be used to produce structures with a broad range of attractive characteristics, and a large number of vicinal diaryl-substituted heterocyclic compounds have already been synthesized and investigated by medicinal chemists as promising lead molecules. Collects together details of the key vicinal diaryl-substituted heterocyclic compounds in one place for the first time Highlights biological activities and SAR of derivatives Structured practically for ease of navigation between different derivatives

Advances in Heterocyclic Chemistry

Advances in Heterocyclic Chemistry Book
Author : Eric Scriven,Christopher A. Ramsden
Publisher : Academic Press
Release : 2020-05
ISBN : 0128211687
Language : En, Es, Fr & De

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Book Description :

Advances in Heterocyclic Chemistry is the definitive series in the field - one of great importance to organic chemists, polymer chemists, and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature also is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds.

Modern Strategies for Heterocycle Synthesis

Modern Strategies for Heterocycle Synthesis Book
Author : Gianfranco Favi
Publisher : MDPI
Release : 2021-03-17
ISBN : 3036503404
Language : En, Es, Fr & De

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Book Description :

Heterocycles feature widely in natural products, agrochemicals, pharmaceuticals and dyes, and their synthesis is of great interest to synthetic chemists in both academia and industry. The contributions of recent applications of new methodologies in C–H activation, photoredox chemistry, cross-coupling strategies, borrowing hydrogen catalysis, multicomponent and solvent-free reactions, regio- and stereoselective syntheses, as well as other new, attractive approaches for the construction of heterocyclic scaffolds are of great interest. This Special Issue is dedicated to featuring the latest research that is ongoing in the field of heterocyclic synthesis. It is expected that most submissions will focus on five- and six-membered oxygen and nitrogen-containing heterocycles, but structures incorporating other rings/heteroatoms will also be considered. Original research (communications, full papers and reviews) that discusses innovative methodologies for assembling heterocycles with potential application in materials, catalysis and medicine are therefore welcome.

Bioactive Heterocycles VI

Bioactive Heterocycles VI Book
Author : Noboru Motohashi
Publisher : Springer
Release : 2008-07-02
ISBN : 354079218X
Language : En, Es, Fr & De

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Book Description :

Heterocyclic chemistry is the biggest branch of chemistry covering two-thirds of the chemical literature and this book covers the hot topics of frontier research summarized by reputed scientists in the field.

Advances in Heterocyclic Chemistry

Advances in Heterocyclic Chemistry Book
Author : Alan R. Katritzky
Publisher : Academic Press
Release : 2011-02-17
ISBN : 0123854652
Language : En, Es, Fr & De

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Book Description :

Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area—one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties. Provides up-to-date material on a fast-growing and highly topical subject area Contains the latest research covering a wide variety of heterocyclic topics Written by leading authorities and designed as a handbook for students and industry and academic researchers

Heterocyclic Chemistry

Heterocyclic Chemistry Book
Author : John A. Joule,Keith Mills
Publisher : John Wiley & Sons
Release : 2010-06-15
ISBN : 1405193654
Language : En, Es, Fr & De

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Book Description :

This book has so closely matched the requirements of its readership over the years that it has become the first choice for chemists worldwide. Heterocyclic chemistry comprises at least half of all organic chemistry research worldwide. In particular, the vast majority of organic work done in the pharmaceutical and agrochemical industries is heterocyclic chemistry. The fifth edition of Heterocyclic Chemistry maintains the principal objective of earlier editions – to teach the fundamentals of heterocyclic reactivity and synthesis in a way that is understandable to second- and third-year undergraduate chemistry students. The inclusion of more advanced and current material also makes the book a valuable reference text for postgraduate taught courses, postgraduate researchers, and chemists at all levels working with heterocyclic compounds in industry. Fully updated and expanded to reflect important 21st century advances, the fifth edition of this classic text includes the following innovations: Extensive use of colour to highlight changes in structure and bonding during reactions Entirely new chapters on organometallic heterocyclic chemistry, heterocyclic natural products, especially in biochemical processes, and heterocycles in medicine New sections focusing on heterocyclic fluorine compounds, isotopically labeled heterocycles, and solid-phase chemistry, microwave heating and flow reactors in the heterocyclic context Essential teaching material in the early chapters is followed by short chapters throughout the text which capture the essence of heterocyclic reactivity in concise resumés suitable as introductions or summaries, for example for examination preparation. Detailed, systematic discussions cover the reactivity and synthesis of all the important heterocyclic systems. Original references and references to reviews are given throughout the text, vital for postgraduate teaching and for research scientists. Problems, divided into straightforward revision exercises, and more challenging questions (with solutions available online), help the reader to understand and apply the principles of heterocyclic reactivity and synthesis.

N Sulfonated N Heterocycles

N Sulfonated N Heterocycles Book
Author : Galal H. Elgemeie,Rasha A. Azzam,Wafaa A. Zaghary,Ashraf A. Aly,Nadia H Metwally,Mona O. Sarhan,Elshimaa M. Abdelhafez,Rasha E. Elsayed
Publisher : Elsevier
Release : 2022-08-26
ISBN : 0128221828
Language : En, Es, Fr & De

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Book Description :

N-Sulfonated-N-Heterocycles covers the synthesis, chemistry and biological applications of these compounds, focusing on pioneering synthetic approaches, mechanistic insights and their limitations, as well as recent advances in this field. The synthesis of some of N-sulfonated N-heterocycles and their transformation to other useful cyclic and acyclic compounds are discussed, as well as their uses as useful intermediates in the preparation of polymeric and medicinal materials. This book includes detailed methods and protocols, and the focus on applications makes this resource an essential guide for all researchers in the area of organic, medicinal and polymeric synthetic study. Reviews the use of N-sulfonated N-heterocycles as important precursors for the synthesis of biologically active compounds Includes information on synthetically useful transformations of N-sulfonated N-heterocycles Covers a wide synthetic methods used for an important branch of heterocycles and their biological evaluation in detail Features over 500 schemes to illustrate different synthetic pathways and reactions of N-sulfonated N-heterocycles

Green Synthetic Approaches for Biologically Relevant Heterocycles

Green Synthetic Approaches for Biologically Relevant Heterocycles Book
Author : Goutam Brahmachari
Publisher : Elsevier
Release : 2021-02-26
ISBN : 0323851339
Language : En, Es, Fr & De

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Book Description :

Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, Volume Two: Green Catalytic Systems and Solvents reviews this significant group of organic compounds within the context of sustainable methods and processes, expanding on the first edition with fully updated coverage and a whole range of new chapters. Volume Two explores green catalytic systems and solvents and the techniques surrounding this approach, including metal and magnetic catalysis to organocatalysis and solid acid catalysis, cycloaddition reactions, and varied approaches using ionic liquids. This updated edition is an essential resource on sustainable approaches for academic researchers, R&D professionals, and students working across medicinal, organic, natural product and green chemistry. Provides fully updated coverage of the field with an emphasis on sustainability Highlights a range of different eco-friendly solvents and environmentally-friendly catalysts Collates the experience of a global team of expert contributors

Green Sustainable Process for Chemical and Environmental Engineering and Science

Green Sustainable Process for Chemical and Environmental Engineering and Science Book
Author : Dr. Inamuddin,Rajender Boddula,Abdullah M. Asiri
Publisher : Elsevier
Release : 2020-06-23
ISBN : 0128198494
Language : En, Es, Fr & De

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Book Description :

Green Sustainable Process for Chemical and Environmental Engineering and Science: Organic Synthesis in Water and Supercritical Water provides an in-depth review of purification and extraction methods for medicinal, analytical, engineering and bioactive compounds utilizing green chemistry protocols. It focuses on the synthesis of natural products and drugs, using industrial green solvents, water, supercritical water, and more. The book explores applications in organic synthesis and processing, including aqueous and non-aqueous promoted reactions. Aqueous media and supercritical water involved in organic synthesis are discussed for industrial use. Final sections cover green solvent assisted organic synthesis, such as addition, rearrangement, condensation, and more. Provides a broad overview of green solvents for sustainable organic synthesis Compares water and supercritical water as green solvents vs. conventional solvents Outlines eco-friendly organic synthesis and chemical processes using water/supercritical water Includes industrial/pharmaceutical production development using water and supercritical water as solvents Outlines synthetic methods for polymers, drugs etc., using water and supercritical water as solvents

Cu Fe catalyzed Cross coupling Reactions Enroute to Heterocycles

Cu Fe catalyzed Cross coupling Reactions  Enroute to Heterocycles Book
Author : Ashis Kumar Jena
Publisher : LAP Lambert Academic Publishing
Release : 2014-09-23
ISBN : 9783659610172
Language : En, Es, Fr & De

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Book Description :

This book described the Cu/Fe catalyzed Carbon-Carbon and Carbon-Heteroatom Cross-Coupling reactions. The catalytic applications of the synthesized CuFe2O4 nanoparticles were explored for various cross-coupling reactions. Terminal alkynes underwent cross-coupling reactions with aryl iodides in presence of base and CuFe2O4 nanoparticles under ligand free conditions. N-arylation of various NH-heterocycles with differently substituted aryl halides (X = I, Br, Cl) were investigated. Catalytic efficiency of CuFe2O4 nanoparticles was further exploited for the C-S cross-coupling of aryl and alkyl thiols with aryl halides. The superparamagnetic nature of CuFe2O4 nanoparticles was found to be advantageous for their easy, quick and quantitative separation from the reaction mixture. Negligible leaching of Cu and Fe in consecutive cycles makes the catalyst economically and environmentally benign. Scope of this catalytic protocol further extended to one-pot synthesis of tricyclic dibenzothiazepines. Furthermore, an expedite Fe-catalyzed, regioselective synthesis of 1,3- and 1,3,5-substituted pyrazoles from diaryl hydrazones and vicinal diols have been described.

Indian Journal of Chemistry

Indian Journal of Chemistry Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Indian Journal of Chemistry book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Synthesis of 4 to 7 membered Heterocycles by Ring Expansion

Synthesis of 4  to 7 membered Heterocycles by Ring Expansion Book
Author : Matthias D’hooghe,Hyun-Joon Ha
Publisher : Springer
Release : 2015-12-14
ISBN : 3319249606
Language : En, Es, Fr & De

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Book Description :

The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field. All chapters from Topics in Heterocyclic Chemistry are published Online First with an individual DOI. In references, Topics in Heterocyclic Chemistry is abbreviated as Top Heterocycl Chem and cited as a journal.

Organophosphorus Chemistry

Organophosphorus Chemistry Book
Author : John C. Tebby,David Loakes,David W. Allen
Publisher : Royal Society of Chemistry
Release : 2018-04-13
ISBN : 1788011678
Language : En, Es, Fr & De

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Book Description :

Coverage in this annual review of the literature presents a comprehensive and critical survey of the vast field of study involving organophosphorus compounds. From phosphines and related P-C bonded compounds through tervalent phosphorus acid derivatives, phosphine chalcogenides, and recent developments in green synthetic approaches in organophosphorus chemistry, the volume reflects established and current interests in the area. With an emphasis on interdisciplinary content, this book is aimed at the worldwide organic chemistry and engineering research communities.

Heterocyclic Chemistry 3rd Edition

Heterocyclic Chemistry  3rd Edition Book
Author : John A. Joule
Publisher : CRC Press
Release : 2020-11-26
ISBN : 1000154408
Language : En, Es, Fr & De

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Book Description :

Covering the fundamentals of heterocyclic reactivity and synthesis, this book teaches the subject in a way that is understandable to graduate students. Recognizing the level at which heterocyclic chemistry is often taught, the authors have included advanced material that make it appropriate for postgraduate courses. The text discusses the chemical reactivity and synthesis of particular heterocyclic systems. Exercises and solutions help students understand and apply the principles. Original references are included throughout, as well as many review references.

Heterocycles via Cross Dehydrogenative Coupling

Heterocycles via Cross Dehydrogenative Coupling Book
Author : Ananya Srivastava,Chandan K. Jana
Publisher : Springer Nature
Release : 2019-08-23
ISBN : 9811391440
Language : En, Es, Fr & De

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Book Description :

This book discusses the developments in the synthesis and functionalization of different heterocycles based on the formation of carbon-carbon (C-C) and carbon-heteroatom (C-X) bonds using cross-dehydrogenative coupling (CDC). Consisting of 13 chapters, the book systematically describes the advances in the synthesis and functionalization of nitrogen, oxygen, and sulfur-containing heterocycles. It also discusses the various mechanistic pathways to help readers gain an in-depth understanding of the CDC reactions of heterocycles. Lastly, in order to promote green chemistry, it addresses a range of metal-free CDC reactions of heterocycles – an area that has attracted significant attention in both academic and industrial research.

Heterocyclic Chemistry in Drug Discovery

Heterocyclic Chemistry in Drug Discovery Book
Author : Jie Jack Li
Publisher : John Wiley & Sons
Release : 2013-04-26
ISBN : 1118354435
Language : En, Es, Fr & De

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Book Description :

Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls. Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discovery Step-by-step descriptions of synthetic methods and practical techniques Examination of the physical properties for each heterocycle, including NMR data and quantum calculations Detailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles Heterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.

Nitro Compounds and Their Derivatives in Organic Synthesis

Nitro Compounds and Their Derivatives in Organic Synthesis Book
Author : Nagatoshi Nishiwaki
Publisher : Unknown
Release : 2020-09-16
ISBN : 9783039431489
Language : En, Es, Fr & De

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Book Description :

Nitro chemistry plays an important role in organic synthesis to construct new frameworks. This is due to the diverse properties of the nitro group. The strong electron-withdrawing ability of the nitro group reduces the electron density of the scaffold, facilitating reactions with nucleophiles or electron transfer. In addition, the -hydrogen of the nitro group is highly acidic, giving a stable anion, which facilitates reactions with both electrophilic and nucleophilic reagents. In addition, the nitro group also serves as a good leaving group, which facilitates transformation to a wide variety of functional groups. Despite the substantial contributions of many researchers, nitro chemistry is still an exciting and challenging research area. This book brings together recent original research and review articles contributed by an international team of leading experts and pioneers in organic synthesis using nitro groups. It is sure to provide useful information and promising insights for researchers.

Tables of Spectral Data for Structure Determination of Organic Compounds

Tables of Spectral Data for Structure Determination of Organic Compounds Book
Author : Ernö Pretsch,T. Clerc,J. Seibl,W. Simon
Publisher : Springer Science & Business Media
Release : 2013-06-29
ISBN : 3662224550
Language : En, Es, Fr & De

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Book Description :

Although numerical data are, in principle, universal, the compilations presented in this book are extensively annotated and interleaved with text. This translation of the second German edition has been prepared to facilitate the use of this work, with all its valuable detail, by the large community of English-speaking scientists. Translation has also provided an opportunity to correct and revise the text, and to update the nomenclature. Fortunately, spectroscopic data and their relationship with structure do not change much with time so one can predict that this book will, for a long period of time, continue to be very useful to organic chemists involved in the identification of organic compounds or the elucidation of their structure. Klaus Biemann Cambridge, MA, April 1983 Preface to the First German Edition Making use of the information provided by various spectroscopic tech niques has become a matter of routine for the analytically oriented organic chemist. Those who have graduated recently received extensive training in these techniques as part of the curriculum while their older colleagues learned to use these methods by necessity. One can, therefore, assume that chemists are well versed in the proper choice of the methods suitable for the solution of a particular problem and to translate the experimental data into structural information.

Comprehensive Organic Synthesis

Comprehensive Organic Synthesis Book
Author : Anonim
Publisher : Newnes
Release : 2014-02-14
ISBN : 008097743X
Language : En, Es, Fr & De

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Book Description :

The second edition of Comprehensive Organic Synthesis—winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers—builds upon the highly respected first edition in drawing together the new common themes that underlie the many disparate areas of organic chemistry. These themes support effective and efficient synthetic strategies, thus providing a comprehensive overview of this important discipline. Fully revised and updated, this new set forms an essential reference work for all those seeking information on the solution of synthetic problems, whether they are experienced practitioners or chemists whose major interests lie outside organic synthesis. In addition, synthetic chemists requiring the essential facts in new areas, as well as students completely new to the field, will find Comprehensive Organic Synthesis, Second Edition an invaluable source, providing an authoritative overview of core concepts. Winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers Contains more than170 articles across nine volumes, including detailed analysis of core topics such as bonds, oxidation, and reduction Includes more than10,000 schemes and images Fully revised and updated; important growth areas—including combinatorial chemistry, new technological, industrial, and green chemistry developments—are covered extensively

Strategic Applications of Named Reactions in Organic Synthesis

Strategic Applications of Named Reactions in Organic Synthesis Book
Author : Laszlo Kurti,Barbara Czako
Publisher : Elsevier
Release : 2005-04-29
ISBN : 0080575412
Language : En, Es, Fr & De

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Book Description :

Kurti and Czako have produced an indispensable tool for specialists and non-specialists in organic chemistry. This innovative reference work includes 250 organic reactions and their strategic use in the synthesis of complex natural and unnatural products. Reactions are thoroughly discussed in a convenient, two-page layout--using full color. Its comprehensive coverage, superb organization, quality of presentation, and wealth of references, make this a necessity for every organic chemist. * The first reference work on named reactions to present colored schemes for easier understanding * 250 frequently used named reactions are presented in a convenient two-page layout with numerous examples * An opening list of abbreviations includes both structures and chemical names * Contains more than 10,000 references grouped by seminal papers, reviews, modifications, and theoretical works * Appendices list reactions in order of discovery, group by contemporary usage, and provide additional study tools * Extensive index quickly locates information using words found in text and drawings