Skip to main content

Vagus Nerve Stimulation

In Order to Read Online or Download Vagus Nerve Stimulation Full eBooks in PDF, EPUB, Tuebl and Mobi you need to create a Free account. Get any books you like and read everywhere you want. Fast Download Speed ~ Commercial & Ad Free. We cannot guarantee that every book is in the library!

Vagus Nerve Stimulation

Vagus Nerve Stimulation Book
Author : James Robertson,Claude Roux,Kenneth G. Wiggins
Publisher : CRC Press
Release : 2002-12-19
ISBN : 1135412804
Language : En, Es, Fr & De

GET BOOK

Book Description :

This second edition presents a timely and practical discussion of vagal nerve stimulation in a clear and well-illustrated format. It provides a clinical approach to the treatment of patients with medically-intractable seizures, as well as for those with depression (a new indication since the publication of first edition). The book's focus has made

Out of the Black Hole

Out of the Black Hole Book
Author : Charles E. Donovan
Publisher : Wellness Publishers,L.L.C
Release : 2006
ISBN : 9780974848433
Language : En, Es, Fr & De

GET BOOK

Book Description :

This is the first book to be published by a patient about the journey out of the black hole of depression thanks to the remarkable medical breakthrough procedure of vagus nerve stimulation. Out of the Black Hole is written by a patient for patients with easy-to-understand explanations which demystify this simple, safe procedure and helps patients make an informed decision about the surgery. Vagus Nerve Stimulation is not related to brain surgery or ECT. There are no cognitive impairments (i.e. memory loss) or drug interactions. Included is information about the potential side effects, benefits, insurance reimbursement codes and reimbursement process.Vagus nerve stimulation has been FDA approved for epilepsy since 1997 and in July of 2005 the FDA approved vagus nerve stimulation for chronic or treatment-resistant depression. Over 30,000 patients have safely been implanted with the device for epilepsy. The procedure is generally done on an out-patient basis. This is considered one of the major breakthroughs in medical device history which could potentially help the 4.5 million Americans who suffer from the debilitating illness of chronic depression.

Vagus Nerve Stimulation Therapy in a Developing Country A Long Term Follow Up Study and Cost Utility Analysis

Vagus Nerve Stimulation Therapy in a Developing Country  A Long Term Follow Up Study and Cost Utility Analysis Book
Author : N.A
Publisher :
Release : 2015
ISBN :
Language : En, Es, Fr & De

GET BOOK

Book Description :

Highlights: VNS therapy is feasible and effective for children with refractory epilepsy in developing countries. Cost effectiveness analyses from developed countries cannot be applied to developing countries. Successful VNS therapy does reduce the financial burden of the device, however direct cost savings are difficult to achieve. There is acceptable QALY gain with VNS therapy in developing countries, with encouraging cost per QALY. Appropriate instruments for deducing utility values for children with epilepsy are needed. Abstract: Purpose: To evaluate clinical outcomes, quality-adjusted life years (QALY), cost effectiveness and cost utility associated with VNS therapy in children with refractory epilepsy in a developing country. Methods: Retrospective review of all children who underwent VNS implantation at King Abdullah University Hospital and Jordan University Hospital in Jordan. Results: Twenty eight patients (16 males) had implantation of the VNS therapy system between the years 2007 and 2011. Mean age at implantation was 9.4 years. Mean duration of epilepsy prior to implantation was 6.5 years. The most common seizure type was generalized tonic clonic seizures. Fifteen patients showed a 50% or more reduction in seizure frequency. There was a significant reduction in total number of seizures ( p = 0.002) and emergency room (ER) visits ( p = 0.042) after VNS therapy. Atonic seizures were more likely to respond than generalized tonic clonic seizures, p = 0.034. Direct hospital costs prior to VNS implantation were analyzed in relation to ER visits and intensive care unit (ICU) admissions. Cost savings per patient did reduce the financial burden of the device by about 30%. There was a QALY gain per lifetime of 3.78 years for children and 1 year for adolescents. Conclusion: Response to VNS implantation in Jordan was favorable and similar to what has been previously reported. QALY gain and cost per QALY analysis were encouraging. Cost savings were related to reduction in seizure severity. In circumstances of limited resources as in developing countries, targeting patients with frequent utilization of health services would improve cost effectiveness.

Vagus Nerve Stimulation

Vagus Nerve Stimulation Book
Author : Martin Norris
Publisher :
Release : 2020-08-24
ISBN : 9781952597275
Language : En, Es, Fr & De

GET BOOK

Book Description :

Do you feel anxious, stressed, depressed, or suffer from other conditions such as chronic inflammation? Do you know there is an essential nerve in your body called the vagus nerve that can significantly alter these conditions for the better? Do you want to know how to activate your vagus nerve to live a healthier life? If so, then read on

Vagus Nerve Stimulation

Vagus Nerve Stimulation Book
Author : Abraham Knox
Publisher :
Release : 2020-08-20
ISBN : 9781913868161
Language : En, Es, Fr & De

GET BOOK

Book Description :

Does Your Physical Or Mental Health Need A Serious Boost? Chronic health conditions are more common than ever, and they have the potential to seriously impair your life and your overall well-being. Maybe you can't play with your kids as much as you want to because you're feeling so broken and achy. Or you can't eat your favorite foods because your body won't digest them properly. Or you miss important deadlines at work because migraine attacks leave you bedridden for days. But have you ever wondered if all of your aches and pains - including mental health imbalances - share a common cause? In fact, science has come to support this point of view. You see, all of your vital organs are essentially connected to the brain via a single nerve, and this nerve tends to get blocked or damaged easily.

Cardiac based Vagus Nerve Stimulation Reduced Seizure Duration in a Patient with Refractory Epilepsy

Cardiac based Vagus Nerve Stimulation Reduced Seizure Duration in a Patient with Refractory Epilepsy Book
Author : N.A
Publisher :
Release : 2015
ISBN :
Language : En, Es, Fr & De

GET BOOK

Book Description :

Highlights: The Aspire VNS-device was implanted in a patient with refractory epilepsy. The effects of heart rate-triggered VNS-pulses on seizure duration were evaluated. The novel VNS-device detected seizures with high sensitivity but low specificity. Responsive VNS-stimulation significantly reduced seizure duration. Abstract: Purpose: A novel vagus nerve stimulation (VNS) device was recently approved in Europe which rapidly detects increases in heart rates (HR) and applies an additional stimulus if HR-increases exceed a given threshold. The effects of HR-triggered VNS-pulses on seizures were not reported yet under controlled conditions. Here, we quantified the effects of HR-triggered VNS-pulses on the seizure duration in one patient. Methods: The novel VNS device was implanted in a 29-year old man with refractory epilepsy. After implantation, the patient underwent video-EEG telemetry for 68 h with no changes in anticonvulsant drugs. On the first day the patient only received sham-stimulation. During the following 46 h HR-related VNS-stimulation was set to 2 mA. Seizure duration was determined based on clinical signs. Results: Twelve stereotypical seizures were recorded (six during sham- and six during the active stimulation). The VNS device recognised a total of 139 events as a seizure and correctly identified 11 seizures. The HR-triggered VNS-stimulation significantly reduced the total seizure duration from 33.2 ± 4.8 s to 26.5 ± 5 s and the remaining seizure duration after the onset of the extra-stimulation from 27.8 ± 4.3 s to 16.2 ± 3.2 s. With the given configuration in this patient, sensitivity and specificity of HR-based seizure-detection amounted to 92% and 13.5%, respectively. Conclusions: This case illustrates that VNS-stimulation in response to seizure-related HR-increases is able to significantly reduce seizure duration. Despite the limitations of our case, its promising results should prompt larger studies to confirm the clinical benefit of this novel device.

Vagus Nerve Stimulation

Vagus Nerve Stimulation Book
Author : Mi$ter X
Publisher :
Release : 2020-10-22
ISBN :
Language : En, Es, Fr & De

GET BOOK

Book Description :

Do you want to extirpate anxiety and develop an unshakable confidence?Do you want to learn how to master your emotions being full of energy vagus nerve stimulation? Do you want to know the never-spoken techniques used everyday by MI$TER X for raise the innate healing power of the human body?⚠ In life, it's difficult to avoid the impulsive convenient urge to put off stuff and to miss out on important commitments. It's equally difficult to avoid negative thoughts and feelings, and overthinking at this day and age. But if that has been causing by a constant overwhelming feeling, you are about to learn how to put an end to all that to turn your life around, for good!This smart book has a clear goal, which is to teach you the right mindset and habits you need to adopt in very simple steps to weed insecurity out, have positive thoughts, boost your mental toughness, and achieve anything you desire in life...In this book you will find: ① How to activate your dormant vagus nerve② How to reprogram and manipulate your subconscious mind through vagus nerve stimulation ③ Tips and tricks for self-healingLearn now ho to be always confident and full of energy and push your life to the next level by following a step-by-step program that boasts 1.947 case studies. Are you ready? Scroll up the page and Buy Now your copy of this Masterpiece of MI$TER X !

Vagus Nerve Stimulation

Vagus Nerve Stimulation Book
Author : Roy K McLean
Publisher :
Release : 2020-03
ISBN :
Language : En, Es, Fr & De

GET BOOK

Book Description :

Vagus Nerve Activation: Are you doing it right? This Will Help You Decide! Discover the Little-Known Facts About the Vagus Nerve Stimulation - And Why They Matter Learn how to get rid of modern maladies you don't know about and could have. Thanks to this new guide, you can learn how to stimulate vagal tone the right way, so you can reduce depression and anxiety and a multitude of health problems of modern living and how to prevent them. Inside this amazing book, you'll: Find out the Easy Self-Help Guide to Stimulate Vagal Tone. Discover How the Vagus Nerve Stimulation can Help you Overcome Inflammation, Trauma, Phobia, Sleep Disorder and Chronic Illness Dr. Roy K. McLean offers easy to follow tips that get you started right away. Vagus Nerve Stimulation it's a great gift for yourself or any person dealing with these modern health problems. Here's what's packed inside this new guide: Find out the "Whys" and "Hows" of Vagus Nerve Stimulation, so you can start the right way. Discover why your Vagus nerve is so important. Find out what happens to your digestive track when you don't take care of the vagus nerve Learn all about inflammation, and what a stimulated Vagus nerve can do about it. Discover the simple step-by-step action guide you can do each day to stimulate your Vagus nerve. Find out how breathing can help stimulate your Vagus nerve. Learn practical exercises to stimulate the Vagus nerve, and how it can improve your health dramatically. And so much more! It is truly the must-have guide! Don't miss your chance. Learn how to activate the Vagus nerve naturally and keep it healthy. Get now your copy of Vagus Nerve Stimulation. Go for it now and start as soon as today. Would You Like to Know More? Scroll up, click buy, and get started now!

Vagus Nerve Stimulation Inhibits Cortical Spreading Depression

Vagus Nerve Stimulation Inhibits Cortical Spreading Depression Book
Author : N.A
Publisher :
Release : 2016
ISBN :
Language : En, Es, Fr & De

GET BOOK

Book Description :

Abstract : Abstract: Vagus nerve stimulation has recently been reported to improve symptoms of migraine. Cortical spreading depression is the electrophysiological event underlying migraine aura and is a trigger for headache. We tested whether vagus nerve stimulation inhibits cortical spreading depression to explain its antimigraine effect. Unilateral vagus nerve stimulation was delivered either noninvasively through the skin or directly by electrodes placed around the nerve. Systemic physiology was monitored throughout the study. Both noninvasive transcutaneous and invasive direct vagus nerve stimulations significantly suppressed spreading depression susceptibility in the occipital cortex in rats. The electrical stimulation threshold to evoke a spreading depression was elevated by more than 2-fold, the frequency of spreading depressions during continuous topical 1 M KCl was reduced by ∼40%, and propagation speed of spreading depression was reduced by ∼15%. This effect developed within 30 minutes after vagus nerve stimulation and persisted for more than 3 hours. Noninvasive transcutaneous vagus nerve stimulation was as efficacious as direct invasive vagus nerve stimulation, and the efficacy did not differ between the ipsilateral and contralateral hemispheres. Our findings provide a potential mechanism by which vagus nerve stimulation may be efficacious in migraine and suggest that susceptibility to spreading depression is a suitable platform to optimize its efficacy. Abstract : Supplemental Digital Content is Available in the Text.Vagus nerve stimulation is a novel nonpharmacologic treatment in migraine, the mechanism of which might be mediated by suppressing the susceptibility to cortical spreading depression.

Quick Vagus Nerve Guide for Novices

Quick Vagus Nerve Guide for Novices Book
Author : Dr Fiomina J Avdeeva
Publisher :
Release : 2020-10-21
ISBN :
Language : En, Es, Fr & De

GET BOOK

Book Description :

Quick Vagus Nerve Guide for Novices: Full Guide on the Precise Stimulation of Vagus Nerve & How to Positively Use Its Influences for Anxiety, Depression Immunity Boost, Brain Diseases, Trauma& Inflammation, etc.Vagus nerve as it is uncommonly alluded to, is that the longest of the cranial nerves found in the human body. In addition, the exceptional nerve is obligated for the transmission of information to and from the human mind surface rapidly to significant tissues and valuable organs found inside the human body. Inquisitively, the uncommon nerve meanders about; it meanders directly from the human cerebrum to significant organs in your very mid-region, neck and furthermore on the chest. What's more, it's commonly known as nervus X or 10th nervus. This exceptional nerve is one in all the valuable and realized nerves that is subject for the relationship of the human cerebrum to various districts of the body. Furthermore, the significant nerve comprises of 2 arrangements of significant nerve cells, and its capacity to make affiliation the mind stem of our body. All the more thus, the vagal jobs or capacities to the different components or areas of the human body can't be overemphasized, since it plays a good commitment to the human automatic sensory system; and this incorporates thoughtful space in addition to the parasympathetic space. And if you want to know the basics of VAGUS NERVE from a to z, then this unique guide will show and explain to you everything regarding the VAGUS NERVE stimulation! It also includes the activities/how to appropriately do the stimulation of this special nerve! And many more! Just scroll up and click the BUY BUTTON NOW to download your copy today!You will be happy you did!

Modulation of Heart Rate by Temporally Patterned Vagus Nerve Stimulation in the Anesthetized Dog

Modulation of Heart Rate by Temporally Patterned Vagus Nerve Stimulation in the Anesthetized Dog Book
Author : N.A
Publisher :
Release : 2016
ISBN :
Language : En, Es, Fr & De

GET BOOK

Book Description :

Abstract: Despite current knowledge of the myriad physiological effects of vagus nerve stimulation (VNS) in various mammalian species (including humans), the impact of varying stimulation parameters on nerve recruitment and physiological responses is not well understood. We investigated nerve recruitment, cardiovascular responses, and skeletal muscle responses to different temporal patterns of VNS across 39 combinations of stimulation amplitude, frequency, and number of pulses per burst. Anesthetized dogs were implanted with stimulating and recording cuff electrodes around the cervical vagus nerve, whereas laryngeal electromyogram (EMG) and heart rate were recorded. In seven of eight dogs, VNS‐evoked bradycardia (defined as ≥10% decrease in heart rate) was achieved by applying stimuli at amplitudes equal to or greater than the threshold for activating slow B‐fibers. Temporally patterned VNS (minimum 5 pulses per burst) was sufficient to elicit bradycardia while reducing the concomitant activation of laryngeal muscles by more than 50%. Temporal patterns of VNS can be used to modulate heart rate while minimizing laryngeal motor fiber activation, and this is a novel approach to reduce the side effects produced by VNS. Abstract : Vagus nerve stimulation‐evoked bradycardia has been identified as an important biomarker for effective treatment of heart failure. We have shown in this preclinical study that very brief bursts of electrical pulses applied at the threshold for recruiting slow B‐fibers can effectively reduce heart rate while minimizing the activation of laryngeal muscles. We predict this novel pattern of nerve stimulation will improve the therapeutic efficacy of vagus nerve stimulation in heart failure patients.

Vagus Nerve Stimulation

Vagus Nerve Stimulation Book
Author : Marcus Porges
Publisher :
Release : 2020-02-19
ISBN :
Language : En, Es, Fr & De

GET BOOK

Book Description :

The vagus nerve is the most important nerve you probably didn't know you had. Indeed, most people don't know about the existence of the vagus nerve and how important it is for our body. The Vagus Nerve, is not just a nerve; Vagus Nerve influences several organs in our body and, if stimulated correctly, it yields several important benefits. So, if you want to improve your memories your breath and your heart, "Vagus Nerve Stimulation " - gives you the answers to most important questions and challenges every person with chronic pain. So here's what you'll find in this book and how it will help you to delve into this topic: What is the vagus nerve and how it works Why is the vagus nerve so important Which organs are influenced by the vagus nerve Ways To Unlock The Powers Of The Vagus Nerve Activities to Trigger your Vagus Nerve Vagus Nerve Stimulation Methods How to stimulate your vagus nerve How to create a Vagal Tone Routine A set of exercises and methodologies to activate your vagus nerve If you're serious about decreasing your anxiety and cure chronic illness, PTSD, anxiety and depression and you really want to know how to improve your memories your breath and your heart, then you need to grab a copy of "Vagus Nerve Stimulation " right now. If you're ready to access your vagus and switch it on, click add to cart now!

Vagus Nerve Stimulation

Vagus Nerve Stimulation Book
Author : Peter Staats,Cenk Ayata,Imanuel Lerman
Publisher : Academic Press
Release : 2021-06-15
ISBN : 9780128169964
Language : En, Es, Fr & De

GET BOOK

Book Description :

Vagus nerve stimulation is rapidly being considered one of the most exciting areas of clinical advancement, with broad areas of interest that cross multiple disciplines. There is a tremendous amount of animal research being done. With the ability to stimulate the vagus nerve non-invasively, scientists now have the ability to translate the basic science work into clinical practice without the need for surgical intervention. Vagus Nerve Stimulation serves as a compendium of what is known about stimulating the vagus nerve in many different disease states. Chapters include applications to neurologic conditions, psychiatric conditions, inflammatory conditions, metabolic disease, reperfusion injuries, and cardiac disease. Translates the science of Vagus Nerve Stimulation to Clinical Applications Includes understanding of VNS anatomy and signaling through Central Nervous System Reviews VNS treatment of neurological, psychiatric, and inflammatory disorders Extends clinical utility to cardiac, renal, and metabolic disorders Covers VNS treatment for headaches, TBI, stroke, seizures, and pain

VAGUS NERVE

VAGUS NERVE Book
Author : Brandon Morrison
Publisher : Ihekaire George
Release : 2020-03-09
ISBN :
Language : En, Es, Fr & De

GET BOOK

Book Description :

Self-Help Exercises to Stimulate Vagal Tone. Prevent Inflammation, Reduce Chronic Illness, Relieve Anxiety, Depression, Anxiety, Trauma, vagal tone PTSD and Lots More Do you experience the ill effects of daily, little or chronic torments? Have you attempted to heal with the exemplary cures however have not discovered any advantages? At that point... this fundamental guide is for you. Stimulating this one nerve through simple exercises can heal your anxiety and depression! According to a study published in the Journal of Inflammation Research, the FDA has already approved vagus nerve stimulation (VNS) as a cure for depression. Furthermore, research shows that VNS bears the promise of being applied to a broader range of therapeutic applications. Right now, will learn: - How to Strength Vagus Nerve Function and Restoring Your Body to Good Health - How to Save Time By Going Directly to the Source of The Problem and Fixing It from the Inside Out Without Any Concerning Side Effects - How to improve Social Behavior. It Is Possible to Alleviate Some of the Symptoms At The Core of Many Cases of Autism Spectrum Disorders - How to Stimulate Vagus Nerve So It Can Drastically Change Your Life and Become Healthy, Free of Stress and Anxiety This book will direct you to investigate how to stimulate your vagus nerve with straightforward exercises and exercises, just as normal medicines like: • Breathing Techniques • Meditation • Thermal Exposure • Diet Tips • Mood Boosting • Targeted Exercises • and substantially more Just scroll up, click on “Add to Cart” and get started.

Effects of Sub perceptual Vagus Nerve Stimulation on Brain Activity Measured Intra cranially in Humans

Effects of Sub perceptual Vagus Nerve Stimulation on Brain Activity Measured Intra cranially in Humans Book
Author : Yihan Zi
Publisher :
Release : 2020
ISBN :
Language : En, Es, Fr & De

GET BOOK

Book Description :

The general state of the human organism is modulated by the Autonomic Nervous System (ANS) comprised of two balancing influences: sympathetic and parasympathetic. The basal forebrain (BF) cholinergic and the locus coeruleus (LC) noradrenergic system within the brain innervates the cerebral cortex and regulates cognitive functions such as arousal, attention, learning, and sleep. The peripheral autonomic nervous system is linked with the cortical projection systems and modulates cortical activity levels in the human brain, which has been shown in various studies of vagus nerve stimulation (VNS) effect on cognitive functions, but its mechanism still remains unclear. The purpose of this study is to determine if sub-perception stimulation on the auricular branch of the vagus nerve will produce mild event-related cortical modulation. Our study provided a detailed view of local neuron population activity through depth electrodes implanted in 5 epileptic subjects, and analyzed the acute effect of VNS on intracranial EEG in post-stimulation period versus baseline in the time and frequency domains. We have found rare but significant (p

Vagus Nerve Stimulation and CBT Made Simple

Vagus Nerve Stimulation and CBT Made Simple Book
Author : Lee Henton,Charles P. Carlton
Publisher :
Release : 2020-07-13
ISBN : 9781952597206
Language : En, Es, Fr & De

GET BOOK

Book Description :

Are you looking for proven science-backed techniques to activate your vagus nerve to overcome depression, relieve chronic stress, and end anxiety? Or Do you want the most effective, tested, and trusted strategies to manage frequent explosive anger, and stop panic attacks? If so, then read on... We have all been consumed by negative emotions that felt would never go away. The impacts of these emotions, unfortunately, affects our lifestyle habit, our relationship with those we care about, and even our health is not spared. However starting today, you can take back charge of your mental health and overall wellbeing. The vagus nerve has been scientifically proven to help contain depression, stress, and anxiety levels successfully. And cognitive behavioral therapy (CBT) has been demonstrated to be a very effective tool in managing frequent explosive anger, and stopping panic attacks. This book is written with detailed techniques, case studies, and practice tests to guide you along the process to break the hold of negativity holding you back from a happy life. This book is made up of two parts: In Part I of this book, The Secrets of Vagus Nerve Stimulation, you will; Understand the important functions performed by your vagus nerve Be enlightened on the health conditions linked to a damaged vagus nerve Uncover substances and lifestyle habits that can damage your vagus nerve Discover science-backed natural exercises, and practices to stimulate your vagus nerve to overcome depression, anxiety, chronic stress, PTSD, etc. Know why your gut health is vital to your vagus nerve and how to live a gut-healthy lifestyle. In Part II of this book, Cognitive Behavioral Therapy Made Simple, you will; Understand how your thoughts determine your feelings and behaviors Discover science-backed research why CBT is a very effective therapeutic option for depression, anxiety, anger, and panic attacks Be enlightened on how your negative thoughts develop, and what to do to identify them Uncover life hacks to challenge and replace your negative thoughts with more rational thoughts Discover proven techniques for overcoming depression, ending anxiety, managing anger, and stopping panic attacks. ...and much more! Listen to that part of yourself that led you to this book instead of the thoughts of "what-ifs" or "should I's" holding you back. To begin, get a copy of this book right now

NON INVASIVE VAGUS NERVE STIMULATION NVNS REDUCES PERI INFARCT DEPOLARIZATIONS AND IMPROVES STROKE OUTCOME IN RATS

NON INVASIVE VAGUS NERVE STIMULATION  NVNS  REDUCES PERI INFARCT DEPOLARIZATIONS AND IMPROVES STROKE OUTCOME IN RATS Book
Author : Gabor C. Petzold
Publisher :
Release : 2017
ISBN :
Language : En, Es, Fr & De

GET BOOK

Book Description :

Vagus nerve stimulation (VNS) has been shown to reduce cortical spreading depression (CSD) (Chen et al., 2016) and improve stroke outcome (Ay et al., 2009). Peri-infarct depolarizations (PIDs), i.e. the pathophysiological equivalent to CSD in acute stroke, strongly contribute to infarct growth in the penumbra by exacerbating local blood flow reduction, inducing metabolic stress, and by triggering excitotoxicity and neuroinflammation (Rakers and Petzold, 2016). In anesthetized Wistar rats (9-11w, males), we here aimed to investigate the therapeutic potential of non-invasive (n)VNS on PIDs during middle cerebral artery occlusion (MCAO). Controlling regional cerebral blood flow (rCBF) by laser speckle contrast imaging, we induced permanent MCAO and analyzed PIDs after transcutaneous nVNS, as well as after invasive VNS (iVNS), by electrophysiology for 4 hours after filament occlusion. Concomitantly, we investigated the effect of nVNS during transient MCAO on motor function and infarct volume.Both VNS approaches (nVNS and iVNS) showed a significant decrease of PID frequency during permanent MCAO. During transient MCAO, nVNS significantly reduced the cortical infarct volume after 72 hours compared to control animals. Accordingly, behavioral data appeared to indicate an improvement of motor function by nVNS. In conclusion, VNS in acute ischemia improves stroke outcome by reducing the frequency of PIDs, implicating nVNS as a potent non-invasive method to mitigate neurological damage after stroke.

Effect of Transcutaneous Vagus Nerve Stimulation on Plasma Cytokine Profile

Effect of Transcutaneous Vagus Nerve Stimulation on Plasma Cytokine Profile Book
Author : Andy Huang
Publisher :
Release : 2016
ISBN :
Language : En, Es, Fr & De

GET BOOK

Book Description :

A number of brain imaging studies have shown the efficacy of surgically implanted vagus nerve stimulation (VNS) for the treatment of depression and epilepsy refractory to medical therapy. Direct vagus nerve stimulation effect on brain neurocircuitry has been cited as one of the mechanisms of action for this therapy. Recent studies have also shown that the normalization of plasma cytokine profile may be an additional therapeutic effects of VNS. VNS has been shown to decrease the amount of inflammatory cytokines (TNF-alpha, IL-6, IL-8 and IFN-gamma) and subsequently reduce the production of C-Reactive Protein. Furthermore, VNS also leads to decreased pain perception. There has been growing interest in the application of vagus nerve stimulation in the treatment of a constellation of medical issues that involve a perturbation of normal plasma cytokine profile. More recently, a phase II clinical trial for subjects with rheumatoid arthritis has shown that there was a significant reduction in pain and a decrease in C-Reactive Protein (CRP) in patients who received a surgically implanted VNS device that provides a maximum of 5 minutes of stimulation daily. Disruptions in the innate immune system have been shown to be one of the mechanisms that put patients at risk for developing Post-Traumatic Stress Disorder. Normalization of plasma cytokine profile may be beneficial for patients with PTSD thus VNS can potentially be utilized as a treatment modality for PTSD. For this study, we are particularly interested in determining the effect of transcutaneous vagus nerve stimulation of plasma cytokine profile as compared to effects from a sham device that only activates skin nociceptors.