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Vaccinology

Vaccinology Book
Author : Alan D. T. Barrett
Publisher : John Wiley & Sons
Release : 2015-02-16
ISBN : 0470656166
Language : En, Es, Fr & De

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Book Description :

Vaccinology: An Essential Guide outlines in a clear, practical format the entire vaccine development process, from conceptualization and basic immunological principles through to clinical testing and licensing of vaccines. With an outstanding introduction to the history and practice of vaccinology, it also guides the reader through the basic science relating to host immune responses to pathogens. Covering the safety, regulatory, ethical, and economic and geographical issues that drive vaccine development and trials, it also presents vaccine delivery strategies, novel vaccine platforms (including experimental vaccines and pathogens), antigen development and selection, vaccine modelling, and the development of vaccines against emerging pathogens and agents of bioterror. There are also sections devoted to veterinary vaccines and associated regulatory processes. Vaccinology: An Essential Guide is a perfect tool for designed for undergraduate and graduate microbiologists and immunologists, as well as residents, fellows and trainees of infectious disease and vaccinology. It is also suitable for all those involved in designing and conducting clinical vaccine trials, and is the ideal companion to the larger reference book Vaccinology: Principles and Practice.

Vaccinology

Vaccinology Book
Author : W. John W. Morrow,Nadeem A. Sheikh,Clint S. Schmidt,D. Huw Davies
Publisher : John Wiley & Sons
Release : 2012-06-12
ISBN : 1118345347
Language : En, Es, Fr & De

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Book Description :

Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe. Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human application Includes evaluation of vaccine efficacy and safety Details clinical trial design, including regulatory requirements Discusses the emerging field of active cellular immunotherapy Vaccinology: Principles and Practice provides an invaluable resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.

Reverse Vaccinology

Reverse Vaccinology Book
Author : Pedro A Reche,Richard Moxon,Rino Rappuoli
Publisher : Frontiers Media SA
Release : 2020-01-15
ISBN : 2889633853
Language : En, Es, Fr & De

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Book Description :

Download Reverse Vaccinology book written by Pedro A Reche,Richard Moxon,Rino Rappuoli, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Modern Vaccinology

Modern Vaccinology Book
Author : Edouard Kurstak
Publisher : Springer Science & Business Media
Release : 2013-11-11
ISBN : 1489914501
Language : En, Es, Fr & De

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Book Description :

The recent developments in modern vaccinology are mainly based on: (i) cloning of microbial genes into recombinant vectors containing genetic information for expression of desired neutralizing immunogens; (ii) alternatives of attenuated vectors with deleted genes permitting the insertion of several foreign genes expressing antigens exposed to the host immune system during the abortive replication of such vectors; (iii) combined vaccines with the aim to protect against many diseases with a limited number of administrations; (iv) evidence demonstrating the ability of animals to respond serologically to DNA injections considered as a potential method of vaccination; (v) the possibility to manipulate the immune system with new and improved immunomodulators enhancing the immune response; and (vi) new microcarrier systems for particular immunogens or immunomodulators delivery, either in a single dose or sustained release, and presentation to the immune system for a relevant response. New vaccines being developed are mainly based on viral, bacterial or other vectors modified with genetic engineering technology, to possess and express desired antigens for vaccination against single or multiple infections. Existing combined vaccines like diphtheria, tetanus, pertussis (DTP) are also experimented with new additional components like recombinant hepatitis B virus surface antigen, inactivated poliovirus, and Haemophilus inJluenzae type b immunogens, in order to produce multivalent vaccines. Such types of vaccines permitting the reduction of multiple medical visits is of particular interest to pediatric immuni zation programs, and would benefit especially the developing countries assuring better vaccine compliance with immunization schedules.

Bioinformatics for Vaccinology

Bioinformatics for Vaccinology Book
Author : Darren R. Flower
Publisher : John Wiley & Sons
Release : 2008-10-13
ISBN : 0470699825
Language : En, Es, Fr & De

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Book Description :

“... this book was written from start to finish by one extremely dedicated and erudite individual. The author has done an excellent job of covering the many topics that fall under the umbrella of computational biology for vaccine design, demonstrating an admirable command of subject matter in fields as disparate as object-oriented databases and regulation of T cell response. Simply put, it has just the right breadth and depth, and it reads well. In fact, readability is one of its virtues—making the book enticing and useful, all at once...” Human Vaccines, 2010 "... This book has several strong points. Although there are many textbooks that deal with vaccinology, few attempts have been made to bring together descriptions of vaccines in history, basic bioinformatics, various computational solutions and challenges in vaccinology, detailed experimental methodologies, and cutting-edge technologies... This book may well serve as a first line of reference for all biologists and computer scientists..." –Virology Journal, 2009 Vaccines have probably saved more lives and reduced suffering in a greater number of people than any other medical intervention in human history, succeeding in eradicating smallpox and significantly reducing the mortality and incidence of other diseases. However, with the emergence of diseases such as SARS and the threat of biological warfare, vaccination has once again become a topic of major interest in public health. Vaccinology now has at its disposal an array of post-genomic approaches of great power. None has a more persuasive potential impact than the application of computational informatics to vaccine discovery; the recent expansion in genome data and the parallel increase in cheap computing power have placed the bioinformatics exploration of pathogen genomes centre stage for vaccine researchers. This is the first book to address the area of bioinformatics as applied to rational vaccine design, discussing the ways in which bioinformatics can contribute to improved vaccine development by introducing the subject of harnessing the mathematical and computing power inherent in bioinformatics to the study of vaccinology putting it into a historical and societal context, and exploring the scope of its methods and applications. Bioinformatics for Vaccinology is a one-stop introduction to computational vaccinology. It will be of particular interest to bioinformaticians with an interest in immunology, as well as to immunologists, and other biologists who need to understand how advances in theoretical and computational immunobiology can transform their working practices.

Current Challenges in Vaccinology

Current Challenges in Vaccinology Book
Author : Ursula Wiedermann,Rita Carsetti,Ed C. Lavelle,Winfried F. Pickl
Publisher : Frontiers Media SA
Release : 2021-02-22
ISBN : 2889664538
Language : En, Es, Fr & De

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Book Description :

We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS).

Innovation in Vaccinology

Innovation in Vaccinology Book
Author : Selene Baschieri
Publisher : Springer Science & Business Media
Release : 2012-07-20
ISBN : 9400745435
Language : En, Es, Fr & De

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Book Description :

Prevention of infectious diseases by vaccination is one of the most significant achievements of modern medicine. During the 20th century, the average human life span in the developed world was about 70 years and it is expected to increase, with a significant portion of this increase directly attributed to vaccination. Since the first empiric vaccination trials, knowledge and technology have enormously evolved and new vaccination strategies are emerging on the market. Indeed, in spite of the great success, conventional vaccination strategies sometimes may result ineffective and, above all, may raise safety concerns. The aim of this book is to provide an overview of some of the technology platforms that have been realized or are currently under development to try to address unsolved and new issues in the field of vaccine development. Common denominator of all thematic areas described herein is the multidisciplinary teamwork. Most of the enabling technologies have been established by putting in the “melting pot” expertise in fields that, at first glance, may appear very far apart. I hope that this collection of articles will make the readers aware that vaccinology is rapidly taking a new direction, ceasing to be an empirical science.

Progress in Fish Vaccinology

Progress in Fish Vaccinology Book
Author : Paul J. Midtlyng
Publisher : S Karger Ag
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This volume gives a comprehensive update on recent developments in fish vaccinology and the potential and current use of vaccines in modern fish farming. Among the topics presented in 25 overview articles and original contributions are: new findings on immune mechanisms in fish and crustaceans update on bacterial and viral vaccines for farmed fish overview of adjuvant technology and mechanisms causing adverse effects bath immunisation using ultrasound, and oral vaccination methods development of recombinant, live and DNA vaccines for fish critical assessment of regulatory standards and tests immunological control of reproduction The book will be an indispensable aid and source of up-to-date information for fish health professionals, managers in the aquaculture industry, and industrial researchers working in the field of fish immunology, vaccine development and disease control worldwide.

Understanding Modern Vaccines

Understanding Modern Vaccines Book
Author : Lawrence R. Stanberry
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Understanding Modern Vaccines book written by Lawrence R. Stanberry, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Veterinary Vaccinology

Veterinary Vaccinology Book
Author : Paul-Pierre Pastoret
Publisher : Elsevier Science Limited
Release : 1997
ISBN : 9780444819680
Language : En, Es, Fr & De

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Book Description :

Hardbound. Vaccination is widely recognised as one of the most efficient tools in public health, showing obvious cost-benefit advantages for all target populations involved.Vaccines in the veterinary field can contribute greatly to the welfare of domestic and wild animals and, indirectly, to environmental protection. The aim of animal vaccination will increasingly be to prevent dissemination of zoonoses (such as rabies, taeniosis, salmonellosis, etc.) rather than to protect the animal itself, especially when infection or infestation is not harmful to the reservoir (cysticercosis)At present there is insufficient overall understanding of some important aspects of veterinary vaccines. Literature on the subject exists, but often consists of either research communications or 'catalogue-type' descriptive works. This unique book fills a gap within the already available literature. The scope is broad and covers all aspects of vaccines and vaccination in the

DNA Vaccines

DNA Vaccines Book
Author : Margaret A. Liu,Maurice R. Hilleman,Reinhard Kurth
Publisher : Unknown
Release : 1995
ISBN : 9780897669979
Language : En, Es, Fr & De

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Book Description :

This conference provides an evaluation of current research on the powerful new technology of DNA vaccines. DNA vaccines hold great promise for prevention and immunotherapy of viral and parasitic infections and cancer, particularly those diseases for which development of traditional vaccines has proved difficult. Preclinical studies recently demonstrated the potential for polynucleotides encoding proteins from pathogens to be a novel and effective means of vaccination, generating cellular and antibody responses while avoiding the potential risks of approaches utilising live viruses.

Introduction to Molecular Vaccinology

Introduction to Molecular Vaccinology Book
Author : Matthias Giese
Publisher : Springer
Release : 2016-03-11
ISBN : 331925832X
Language : En, Es, Fr & De

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Book Description :

This textbook provides an easy-to-understand introduction to the complex topic of vaccine research and development. It gives a comprehensive though clearly arranged insight to the most important aspects of molecular vaccinology, leading from the basics in immunology, to design of vaccines and mode of action of vaccines to the actual formulation, manufacturing and registration of vaccines. The volume is therefore a valuable text about modern vaccinology for graduate students and a basic introduction for newcomers in vaccine design and development.

Societal Vaccinology

Societal Vaccinology Book
Author : Johannes Theodorus Hendriks
Publisher : Unknown
Release : 2017
ISBN : 9789462335745
Language : En, Es, Fr & De

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Book Description :

"Global health has improved remarkably through the introduction of a multitude of vaccines in childhood vaccination programmes since the 1950s. New vaccines that are now increasingly becoming available result from the science and technology field commonly called vaccinology which has become the domain of multinational pharmaceutical companies. The "privatisation" of vaccinology has been accompanied with the gradual erosion of public sector vaccine development and production. This thesis analyses the global impact of public sector vaccine manufacturing in the Netherlands before it was partially taken over in 2012 by the Serum Institute of India Ltd., one of the world's largest private vaccine manufacturers that plays a key role in the supply of affordable vaccines for developing countries. The main finding of this study is that national public sector vaccinology institutions, in particular the Netherlands public health institute, have over the past decennia had a hitherto hardly acknowledged but profoundly positive impact on the global vaccine system that aims to increase access to vaccines in developing countries. This impact is the result not of supply of vaccines, but through enabling vaccine manufacturing entities (public or private) in developing countries to set up or improve their capacity. From a societal and horizontal angle this study illustrates that a divergence between policies and practices between different ministries within the same government may lead to missed opportunities for global health."--Samenvatting auteur.

Developments in Biological Standardization

Developments in Biological Standardization Book
Author : Anonim
Publisher : Unknown
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Developments in Biological Standardization book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Vaccinia Vaccination Vaccinology

Vaccinia  Vaccination  Vaccinology Book
Author : Stanley A. Plotkin,Bernardino Fantini
Publisher : Elsevier Science Limited
Release : 1996
ISBN : 9782906077836
Language : En, Es, Fr & De

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Book Description :

Download Vaccinia Vaccination Vaccinology book written by Stanley A. Plotkin,Bernardino Fantini, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Essays In Vaccinology

Essays In Vaccinology Book
Author : Ibrahim Mohamad Saeed Shnawa Ph D,Ibrahim Shnawa
Publisher : Createspace Independent Publishing Platform
Release : 2018-03-09
ISBN : 9781986375818
Language : En, Es, Fr & De

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Book Description :

The book in section one spans around immunity to vaccine with details on cryoglobulin response post to bruccilla and Salmonilla. Human herd immunity with an array of immune herd plots to human infectious disease. while section two was devoted for dentiritic cell based for human tuberclosis vaccine as a compromise to BCG vaccine.Section three covers the vaccine alied biologics with an emphasis on probiotics and their possible action as vaccine and vaccine adjuvant.

Pharmaceutical Biotechnology

Pharmaceutical Biotechnology Book
Author : Carlos A. Guzmán,Giora Z. Feuerstein
Publisher : Springer Science & Business Media
Release : 2010-01-01
ISBN : 9781441911322
Language : En, Es, Fr & De

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Book Description :

Pharmaceutical Biotechnology is a unique compilation of reviews addressing frontiers in biologicals as a rich source for innovative medicines. This book fulfills the needs of a broad community of scientists interested in biologicals from diverse perspectives—basic research, biotechnology, protein engineering, protein delivery, medicines, pharmaceuticals and vaccinology. The diverse topics range from advanced biotechnologies aimed to introduce novel, potent engineered vaccines of unprecedented efficacy and safety for a wide scope of human diseases to natural products, small peptides and polypeptides engineered for discrete prophylaxis and therapeutic purposes. Modern biologicals promise to dramatically expand the scope of preventive medicine beyond the infectious disease arena into broad applications in immune and cancer treatment, as exemplified by anti-EGFR receptors antibodies for the treatment of breast cancer. The exponential growth in biologicals such as engineered proteins and vaccines has been boosted by unprecedented scientific breakthroughs made in the past decades culminating in an in-depth fundamental understanding of the scientific underpinnings of immune mechanisms together with knowledge of protein and peptide scaffolds that can be deliberately manipulated. This has in turn led to new strategies and processes. Deciphering the human, mammalian and numerous pathogens’ genomes provides opportunities that never before have been available—identification of discrete antigens (genomes and antigenomes) that lend themselves to considerably improved antigens and monoclonal antibodies, which with more sophisticated engineered adjuvants and agonists of pattern recognition receptors present in immune cells, deliver unprecedented safety and efficacy. Technological development such a nanobiotechnologies (dendrimers, nanobodies and fullerenes), biological particles (viral-like particles and bacterial ghosts) and innovative vectors (replication-competent attenuated, replication-incompetent recombinant and defective helper-dependent vectors) fulfill a broad range of cutting-edge research, drug discovery and delivery applications. Most recent examples of breakthrough biologicals include the human papilloma virus vaccine (HPV, prevention of women genital cancer) and the multivalent Pneumoccocal vaccines, which has virtually eradicated in some populations a most prevalent bacterial ear infection (i.e., otitis media). It is expected that in the years to come similar success will be obtained in the development of vaccines for diseases which still represent major threats for human health, such as AIDS, as well as for the generation of improved vaccines against diseases like pandemic flu for which vaccines are currently available. Furthermore, advances in comparative immunology and innate immunity revealed opportunities for innovative strategies for ever smaller biologicals and vaccines derived from species such as llama and sharks, which carry tremendous potential for innovative biologicals already in development stages in many pharmaceutical companies. Such recent discoveries and knowledge exploitations hold the promise for breakthrough biologicals, with the coming decade. Finally, this book caters to individuals not directly engaged in the pharmaceutical drug discovery process via a chapter outlining discovery, preclinical development, clinical development and translational medicine issues that are critical the drug development process. The authors and editors hope that this compilation of reviews will help readers rapidly and completely update knowledge and understanding of the frontiers in pharmaceutical biotechnologies.

Progress in Vaccinology

Progress in Vaccinology Book
Author : G. P. Talwar
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1461235081
Language : En, Es, Fr & De

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Book Description :

Vaccines have historically been considered to be the most cost-effective method for preventing communicable diseases. It was a vaccine that en abled global eradication of the dreaded disease smallpo. .

Vaccines for Humans

Vaccines for Humans Book
Author : European Commission. Directorate-General for Health and Consumer Protection
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Recoge : Basic vaccinology - Diseases specific vaccine research - Clinical research and capacity building.

4th European Conference on Vaccinology

4th European Conference on Vaccinology Book
Author : Anonim
Publisher : Unknown
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download 4th European Conference on Vaccinology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.