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Unraveling The Complexities Of Metastasis

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Unraveling the Complexities of Metastasis

Unraveling the Complexities of Metastasis Book
Author : Ammad Ahmad Farooqi,Muhammad Zahid Qureshi,Uteuliyev Yerzhan Sabitaliyevi
Publisher : Academic Press
Release : 2020-09-15
ISBN : 9780128217894
Language : En, Es, Fr & De

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Book Description :

Unraveling the Complexities of Metastasis: Transition from a Segmented View to a Conceptual Continuum provides a critical overview of the recent developments of metastasis research and how progress can be further enhanced in the field. Metastasis is a highly complicated mechanism and prognostic analysis of different metastatic patterns in advanced cancer patients is becoming increasingly problematic. It is therefore essential to take a step back and focus on the underlying mechanisms of metastasis before moving ahead for effective translation of laboratory findings to clinically effective therapeutics. This book is surely helpful in putting together missing pieces of an incomplete jig-saw puzzle of molecular cancer. The book discusses topics such as the role of TRAIL-mediated signaling, late metastasis and mechanisms underlying tumor cell dormancy, CTCs and exomes, non-coding way of metastasis, and stem cells. Additionally, it brings relevant and updated information on nanotechnology-based docetaxel and the peculiarities of cancer cell metabolism. This book is a valuable source for cancer researchers, medical doctors and several members of biomedical field who need to understand better the complex mechanism of metastasis. Explains the mechanism of metastasis from basic to advanced level through easy and comprehensive chapters written by internationally distinguished researchers Provides simplified version of important process of metastasis for the readers to comprehend the latest advancements made in the field Presents colorful diagrams to make different aspects of scientifically difficult topics easier for young researchers and new-comers in the field of cancer metastasis

Molecular and Cellular Basis of Metastasis Road to Therapy

Molecular and Cellular Basis of Metastasis  Road to Therapy Book
Author : N.A
Publisher : Academic Press
Release : 2016-09-03
ISBN : 0128041587
Language : En, Es, Fr & De

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Book Description :

Molecular and Cellular Basis of Metastasis: Road to Therapy, the latest in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, with this volume covering the molecular and cellular basis of metastasis. Presents groundbreaking information on the molecular and cellular basis of metastasis Provides information on cancer research Outstanding and original reviews Suitable for both researchers and students

Genomic Instability and Cancer Metastasis

Genomic Instability and Cancer Metastasis Book
Author : Chris Maxwell,Cal Roskelley
Publisher : Springer
Release : 2014-12-04
ISBN : 3319121367
Language : En, Es, Fr & De

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Book Description :

Metastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse. This book connects cancer metastasis with genomic instability in a comprehensive manner. Section 1 outlines the fundamental mechanisms responsible for these cellular and tissue phenotypes. Section 2 discusses in silico, in vitro, and in vivo models used for the experimental study of these processes. Section 3 reviews emerging themes (ex., microenvironment, mechanotransduction, and immunomodulation), and Section 4 highlights new therapeutic approaches to overcome the unique challenges presented by the heterogeneous and metastatic tumor. This book is intended for undergraduates and postgraduates with an interest in the areas of medicine, oncology, and cancer biology as well as for the content expert searching for thorough reviews of current knowledge in these areas.

Metastasis Research Protocols

Metastasis Research Protocols Book
Author : Susan A. Brooks,Udo Schumacher
Publisher : Springer Science & Business Media
Release : 2001
ISBN : 1592591361
Language : En, Es, Fr & De

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Book Description :

Although ninety percent of fatal cancer cases involve the spread of a primary tumor, the formation of metastases is still a poorly understood, complex process and a significant problem in the treatment of cancer patients. In Metastasis Research Protocols, leading international investigators describe the key methods needed to investigate why and how metastasis occurs. Volume I of this two-volume set, Analysis of Cells and Tissues, presents a comprehensive collection of established and leading-edge techniques for analyzing the expression of key molecules and for examining their production at the genetic level. The work focuses on the analysis and mapping of molecules produced by cells and tissues, and on the molecular biology underlying their expression. The traditional methods range from the histopathological and the immunocytochemical to SDS-PAGE, Western blotting, and enzyme zymography. Newer and more specialized techniques for analyzing the genetic aspects of metastasis include in situ hybridization to localize mRNAs, FISH, CGH, methylation analysis of CpG islands, RT-PCR, and differential display. The second volume of this set, Analysis of Cell Behavior In Vitro and In Vivo, moves to the level of living cells and tissues to present methodologies applicable to examining metastatic behavior in vitro and in the whole animal. Comprehensive and authoritative, the two volumes of Metastasis Research Protocols constitute a gold-standard collection of readily reproducible methods for understanding the metastatic cascade-first at the cellular and molecular levels, then at the level of the whole organism-responsible for the spread of cancer and for developing novel strategies to combat its spread.

Metastasis

Metastasis Book
Author : Lalage Wakefield,Kent W. Hunter
Publisher : IOS Press
Release : 2007
ISBN : 9781586037536
Language : En, Es, Fr & De

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Book Description :

"Metastasis is the most dreaded aspect of the carcinogenic process. More than ninety percent of all cancer deaths are attributable to the consequences of the primary tumor successfully colonizing distant organs. Unlike the situation with colon cancer, a patient with breast cancer can never be considered cured, since as many as a third of breast cancer patients who have apparently curative surgery for their primary tumors ultimately relapse with metastatic disease, sometimes decades later. Much effort is now devoted to understanding this process of metastasis, and finding ways to predict and prevent its occurrence. This publication covers recent advances in the field, specifically as they relate to breast cancer. The availability of new tools and technological approaches has prompted a reconsideration of the very definition of a metastasis. Furthermore, a number of commonly held myths are being explored and a new definition of a metastasis, with important implications for clinical staging, is being proposed. Also, a novel conceptual framework for cancer progression based on the system-level dynamics of regulatory networks is presented and the role of chemokines in mediating some of the evolving transactional processes between tumor and stroma is being reviewed."

Cancer Research

Cancer Research Book
Author : N.A
Publisher :
Release : 2009-08
ISBN :
Language : En, Es, Fr & De

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Book Description :

Pain

Pain Book
Author : Nursing Now
Publisher :
Release : 1985
ISBN :
Language : En, Es, Fr & De

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Book Description :

Scientific Report

Scientific Report Book
Author : Scripps Research Institute
Publisher :
Release : 2000
ISBN :
Language : En, Es, Fr & De

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Book Description :

Stem Cells and Cancer

Stem Cells and Cancer Book
Author : Sudhir Srivastava,Lopa Mishra
Publisher : IOS Press
Release : 2007
ISBN : 9781586038021
Language : En, Es, Fr & De

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Book Description :

Describes the role of cancer stem cells and progenitor cells in the progression to cancer. This volume refers to the role of stem cells in well-characterized diseases such as prostate and hepatocellular cancer, melanoma, chronic myeloid leukaemia and stem cell/cancer stem cell properties.

Pediatric Radiation Oncology

Pediatric Radiation Oncology Book
Author : Edward C. Halperin
Publisher : Raven Press (ID)
Release : 1994
ISBN :
Language : En, Es, Fr & De

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Book Description :

The definitive text and reference on pediatric radiation oncology is now in its thoroughly revised and updated Fourth Edition. This edition features a brand-new section on intensity modulated radiation therapy (IMRT), detailed information on three-dimensional treatment planning, and diagrams showing three-dimensional treatment plans for brain tumors, retinoblastoma, sarcomas, and neuroblastoma. The authors review the most recent clinical trials on management of leukemia, supratentorial and infratentorial brain tumors, retinoblastoma, neuroblastoma, Hodgkin's disease, non-Hodgkin's lymphoma, Ewing's sarcoma, osteosarcoma, rhabdomyosarcoma, and Wilms' tumor. This edition also includes new information on the late effects of cancer treatment and the risk of treatment-induced secondary malignant neoplasms.

Internal Medicine for Dentistry

Internal Medicine for Dentistry Book
Author : Donald Kaye
Publisher : Mosby Incorporated
Release : 1990
ISBN :
Language : En, Es, Fr & De

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Book Description :

Ultrasound in Liquid and Solid Metals focuses on the effect of intensive ultrasound on metals, including the analysis of the development of cavitation and acoustic flows in melts, mechanism of metals' spraying and crystallization, the formation of dislocation structure in crystals, diffusion, phase transformation, and plastic deformation. Physical fundamentals of intensive ultrasound effects are covered, and detailed discussions are presented on the engineering principles of equipment and material design for the practical use of ultrasound in the refining of melts, crystallization of ingots and molds, pulverization, plating, pressure working of metals, surface strengthening, and other processes.