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Understanding Cancer From A Systems Biology Point Of View

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Understanding Cancer from a Systems Biology Point of View

Understanding Cancer from a Systems Biology Point of View Book
Author : Irina Kareva
Publisher : Academic Press
Release : 2018-02-07
ISBN : 012813674X
Language : En, Es, Fr & De

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Book Description :

Understanding Cancer from a Systems Biology Point of View: From Observation to Theory and Back starts with a basic question, why do we sometimes observe accelerated metastatic growth after resection of primary tumors? Next, it helps readers understand the systemic nature of cancer and how it affects treatment approaches and decisions. The book puts together aspects of cancer that many readers have most likely never combined, using unfamiliar, novel methods. It is a valuable resource for cancer researchers, cancer biologists, mathematicians and members of the biomedical field who are interested in applying systems biology methodologies for understanding and treating cancer. Explains the systemic nature of cancer and how it affects decisions on treatment Brings a variety of methods together, showing, in detail, the logical approach to finding answers to complex questions Discusses the theoretical underpinnings of cancer as a systemic disease, providing the reader with valuable information on applicable cases

Journal of the National Cancer Institute

Journal of the National Cancer Institute Book
Author : Anonim
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Journal of the National Cancer Institute book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Modeling Evolution of Heterogeneous Populations

Modeling Evolution of Heterogeneous Populations Book
Author : Irina Kareva,Georgy Karev
Publisher : Academic Press
Release : 2019-10-16
ISBN : 0128144327
Language : En, Es, Fr & De

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Book Description :

Modeling Evolution of Heterogeneous Populations: Theory and Applications describes, develops and provides applications of a method that allows incorporating population heterogeneity into systems of ordinary and discrete differential equations without significantly increasing system dimensionality. The method additionally allows making use of results of bifurcation analysis performed on simplified homogeneous systems, thereby building on the existing body of tools and knowledge and expanding applicability and predictive power of many mathematical models. Introduces Hidden Keystone Variable (HKV) method, which allows modeling evolution of heterogenous populations, while reducing multi-dimensional selection systems to low-dimensional systems of differential equations Demonstrates that replicator dynamics is governed by the principle of maximal relative entropy that can be derived from the dynamics of selection systems instead of being postulated Discusses mechanisms behind models of both Darwinian and non-Darwinian selection Provides examples of applications to various fields, including cancer growth, global demography, population extinction, tragedy of the commons and resource sustainability, among others Helps inform differences in underlying mechanisms of population growth from experimental observations, taking one from experiment to theory and back

Computational Systems Biology of Cancer

Computational Systems Biology of Cancer Book
Author : Emmanuel Barillot,Laurence Calzone,Philippe Hupe,Jean-Philippe Vert,Andrei Zinovyev
Publisher : CRC Press
Release : 2012-08-25
ISBN : 1439831440
Language : En, Es, Fr & De

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Book Description :

The future of cancer research and the development of new therapeutic strategies rely on our ability to convert biological and clinical questions into mathematical models—integrating our knowledge of tumour progression mechanisms with the tsunami of information brought by high-throughput technologies such as microarrays and next-generation sequencing. Offering promising insights on how to defeat cancer, the emerging field of systems biology captures the complexity of biological phenomena using mathematical and computational tools. Novel Approaches to Fighting Cancer Drawn from the authors’ decade-long work in the cancer computational systems biology laboratory at Institut Curie (Paris, France), Computational Systems Biology of Cancer explains how to apply computational systems biology approaches to cancer research. The authors provide proven techniques and tools for cancer bioinformatics and systems biology research. Effectively Use Algorithmic Methods and Bioinformatics Tools in Real Biological Applications Suitable for readers in both the computational and life sciences, this self-contained guide assumes very limited background in biology, mathematics, and computer science. It explores how computational systems biology can help fight cancer in three essential aspects: Categorising tumours Finding new targets Designing improved and tailored therapeutic strategies Each chapter introduces a problem, presents applicable concepts and state-of-the-art methods, describes existing tools, illustrates applications using real cases, lists publically available data and software, and includes references to further reading. Some chapters also contain exercises. Figures from the text and scripts/data for reproducing a breast cancer data analysis are available at www.cancer-systems-biology.net.

Systems Biology

Systems Biology Book
Author : P. Bringmann,E. Butcher,G. Parry,B. Weiss
Publisher : Springer Science & Business Media
Release : 2007-05-26
ISBN : 3540313397
Language : En, Es, Fr & De

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Book Description :

This volume features contributions from participants of an ESRF Workshop on "Systems Biology" held in Berkeley, USA, in November 2005. Significant progress has been made in developing technologies that enable systems interrogations at a molecular level. Recent successes and challenges of applying systems level measurements to the different steps of drug discovery and development in the pharmaceutical industry are summarized.

Computational Systems Biology Approaches in Cancer Research

Computational Systems Biology Approaches in Cancer Research Book
Author : Inna Kuperstein,Emmanuel Barillot
Publisher : CRC Press
Release : 2019-09-09
ISBN : 1000682927
Language : En, Es, Fr & De

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Book Description :

Praise for Computational Systems BiologyApproaches in Cancer Research: "Complex concepts are written clearly and with informative illustrations and useful links. The book is enjoyable to read yet provides sufficient depth to serve as a valuable resource for both students and faculty." — Trey Ideker, Professor of Medicine, UC Xan Diego, School of Medicine "This volume is attractive because it addresses important and timely topics for research and teaching on computational methods in cancer research. It covers a broad variety of approaches, exposes recent innovations in computational methods, and provides acces to source code and to dedicated interactive web sites." — Yves Moreau, Department of Electrical Engineering, SysBioSys Centre for Computational Systems Biology, University of Leuven With the availability of massive amounts of data in biology, the need for advanced computational tools and techniques is becoming increasingly important and key in understanding biology in disease and healthy states. This book focuses on computational systems biology approaches, with a particular lens on tackling one of the most challenging diseases - cancer. The book provides an important reference and teaching material in the field of computational biology in general and cancer systems biology in particular. The book presents a list of modern approaches in systems biology with application to cancer research and beyond. It is structured in a didactic form such that the idea of each approach can easily be grasped from the short text and self-explanatory figures. The coverage of topics is diverse: from pathway resources, through methods for data analysis and single data analysis to drug response predictors, classifiers and image analysis using machine learning and artificial intelligence approaches. Features Up to date using a wide range of approaches Applicationexample in each chapter Online resources with useful applications’

Automated Reasoning for Systems Biology and Medicine

Automated Reasoning for Systems Biology and Medicine Book
Author : Pietro Liò,Paolo Zuliani
Publisher : Springer
Release : 2019-06-11
ISBN : 303017297X
Language : En, Es, Fr & De

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Book Description :

This book presents outstanding contributions in an exciting, new and multidisciplinary research area: the application of formal, automated reasoning techniques to analyse complex models in systems biology and systems medicine. Automated reasoning is a field of computer science devoted to the development of algorithms that yield trustworthy answers, providing a basis of sound logical reasoning. For example, in the semiconductor industry formal verification is instrumental to ensuring that chip designs are free of defects (or “bugs”). Over the past 15 years, systems biology and systems medicine have been introduced in an attempt to understand the enormous complexity of life from a computational point of view. This has generated a wealth of new knowledge in the form of computational models, whose staggering complexity makes manual analysis methods infeasible. Sound, trusted, and automated means of analysing the models are thus required in order to be able to trust their conclusions. Above all, this is crucial to engineering safe biomedical devices and to reducing our reliance on wet-lab experiments and clinical trials, which will in turn produce lower economic and societal costs. Some examples of the questions addressed here include: Can we automatically adjust medications for patients with multiple chronic conditions? Can we verify that an artificial pancreas system delivers insulin in a way that ensures Type 1 diabetic patients never suffer from hyperglycaemia or hypoglycaemia? And lastly, can we predict what kind of mutations a cancer cell is likely to undergo? This book brings together leading researchers from a number of highly interdisciplinary areas, including: · Parameter inference from time series · Model selection · Network structure identification · Machine learning · Systems medicine · Hypothesis generation from experimental data · Systems biology, systems medicine, and digital pathology · Verification of biomedical devices “This book presents a comprehensive spectrum of model-focused analysis techniques for biological systems ...an essential resource for tracking the developments of a fast moving field that promises to revolutionize biology and medicine by the automated analysis of models and data.”Prof Luca Cardelli FRS, University of Oxford

Systems Biology of Cancer

Systems Biology of Cancer Book
Author : Sam Thiagalingam
Publisher : Cambridge University Press
Release : 2015-04-09
ISBN : 0521493390
Language : En, Es, Fr & De

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Book Description :

An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Systems Biology

Systems Biology Book
Author : Anonim
Publisher : Unknown
Release : 2021-04-10
ISBN : 981446290X
Language : En, Es, Fr & De

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Book Description :

Download Systems Biology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cancer Systems Biology Bioinformatics and Medicine

Cancer Systems Biology  Bioinformatics and Medicine Book
Author : Alfredo Cesario,Frederick Marcus
Publisher : Springer Science & Business Media
Release : 2011-08-21
ISBN : 9789400715677
Language : En, Es, Fr & De

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Book Description :

This teaching monograph on systems approaches to cancer research and clinical applications provides a unique synthesis, by world-class scientists and doctors, of laboratory, computational, and clinical methods, thereby establishing the foundations for major advances not possible with current methods. Specifically, the book: 1) Sets the stage by describing the basis of systems biology and bioinformatics approaches, and the clinical background of cancer in a systems context; 2) Summarizes the laboratory, clinical, data systems analysis and bioinformatics tools, along with infrastructure and resources required; 3) Demonstrates the application of these tools to cancer research; 4) Extends these tools and methods to clinical diagnosis, drug development and treatment applications; and 5) Finishes by exploring longer term perspectives and providing conclusions. This book reviews the state-of-the-art, and goes beyond into new applications. It is written and highly referenced as a textbook and practical guide aimed at students, academics, doctors, clinicians, industrialists and managers in cancer research and therapeutic applications. Ideally, it will set the stage for integration of available knowledge to optimize communication between basic and clinical researchers involved in the ultimate fight against cancer, whatever the field of specific interest, whatever the area of activity within translational research.

Systems Biology of Tumor Physiology

Systems Biology of Tumor Physiology Book
Author : David H. Nguyen
Publisher : Springer
Release : 2015-12-11
ISBN : 3319256017
Language : En, Es, Fr & De

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Book Description :

This exciting SpringerBrief presents evidence for new ideas that will challenge several theories of how cancer biology is understood. Cancer biology has undergone several intellectual revolutions in the past 50 years. A mutation-centric view of cancer has given way to the tumor microenvironment view. Reductionistic studies of one gene at a time have given way to systems biology approaches that analyze the whole genome (omics) at the same time. However, this text combines the complex levels studying cancer at the molecular biology level, endocrinology level, and transcriptomics level. What researchers are now realizing is that there is a need to combine omics with physiology concepts in order to better understand cancer and this book will give insight to the merging of these two fields in order to define how cancer is studied in the future.​

Handbook of Research on Systems Biology Applications in Medicine

Handbook of Research on Systems Biology Applications in Medicine Book
Author : Daskalaki, Andriani
Publisher : IGI Global
Release : 2008-11-30
ISBN : 1605660779
Language : En, Es, Fr & De

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Book Description :

"This book highlights the use of systems approaches including genomic, cellular, proteomic, metabolomic, bioinformatics, molecular, and biochemical, to address fundamental questions in complex diseases like cancer diabetes but also in ageing"--Provided by publisher.

Genomics Proteomics

Genomics   Proteomics Book
Author : Arthur L. Shaffer
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Genomics Proteomics book written by Arthur L. Shaffer, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Computational Systems Biology

Computational Systems Biology Book
Author : Andres Kriete,Roland Eils
Publisher : Academic Press
Release : 2013-11-26
ISBN : 0124059384
Language : En, Es, Fr & De

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Book Description :

This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling. Logical information flow aids understanding of basic building blocks of life through disease phenotypes Evolved principles gives insight into underlying organizational principles of biological organizations, and systems processes, governing functions such as adaptation or response patterns Coverage of technical tools and systems helps researchers to understand and resolve specific systems biology problems using advanced computation Multi-scale modeling on disparate scales aids researchers understanding of dependencies and constraints of spatio-temporal relationships fundamental to biological organization and function.

Systems Biology for Signaling Networks

Systems Biology for Signaling Networks Book
Author : Sangdun Choi
Publisher : Springer Science & Business Media
Release : 2010-08-09
ISBN : 9781441957979
Language : En, Es, Fr & De

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Book Description :

System Biology encompasses the knowledge from diverse fields such as Molecular Biology, Immunology, Genetics, Computational Biology, Mathematical Biology, etc. not only to address key questions that are not answerable by individual fields alone, but also to help in our understanding of the complexities of biological systems. Whole genome expression studies have provided us the means of studying the expression of thousands of genes under a particular condition and this technique had been widely used to find out the role of key macromolecules that are involved in biological signaling pathways. However, making sense of the underlying complexity is only possible if we interconnect various signaling pathways into human and computer readable network maps. These maps can then be used to classify and study individual components involved in a particular phenomenon. Apart from transcriptomics, several individual gene studies have resulted in adding to our knowledge of key components that are involved in a signaling pathway. It therefore becomes imperative to take into account of these studies also, while constructing our network maps to highlight the interconnectedness of the entire signaling pathways and the role of that particular individual protein in the pathway. This collection of articles will contain a collection of pioneering work done by scientists working in regulatory signaling networks and the use of large scale gene expression and omics data. The distinctive features of this book would be: Act a single source of information to understand the various components of different signaling network (roadmap of biochemical pathways, the nature of a molecule of interest in a particular pathway, etc.), Serve as a platform to highlight the key findings in this highly volatile and evolving field, and Provide answers to various techniques both related to microarray and cell signaling to the readers.

Bioinformatics Methods in Clinical Research

Bioinformatics Methods in Clinical Research Book
Author : Rune Matthiesen
Publisher : Humana
Release : 2010
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Integrated bioinformatics solutions have become increasingly valuable in past years, as technological advances have allowed researchers to consider the potential of omics for clinical diagnosis, prognosis, and therapeutic purposes, and as the costs of such techniques have begun to lessen. In Bioinformatics Methods in Clinical Research, experts examine the latest developments impacting clinical omics, and describe in great detail the algorithms that are currently used in publicly available software tools. Chapters discuss statistics, algorithms, automated methods of data retrieval, and experimental consideration in genomics, transcriptomics, proteomics, and metabolomics. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, provides practical examples illustrating methods, results, and conclusions from data mining strategies wherever possible, and includes a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Informative and ground-breaking, Bioinformatics Methods in Clinical Research establishes a much-needed bridge between theory and practice, making it an indispensable resource for bioinformatics researchers.

The Molecular Biology of Cancer

The Molecular Biology of Cancer Book
Author : Stella Pelengaris,Michael Khan
Publisher : John Wiley & Sons
Release : 2009-03-12
ISBN : 1444309080
Language : En, Es, Fr & De

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Book Description :

This comprehensive text provides a detailed overview of the molecular mechanisms underpinning the development of cancer and its treatment. Written by an international panel of researchers, specialists and practitioners in the field, the text discusses all aspects of cancer biology from the causes, development and diagnosis through to the treatment of cancer. Written by an international panel of researchers, specialists and practitioners in the field Covers both traditional areas of study and areas of controversy and emerging importance, highlighting future directions for research Features up-to-date coverage of recent studies and discoveries, as well as a solid grounding in the key concepts in the field Each chapter includes key points, chapter summaries, text boxes, and topical references for added comprehension and review Supported by a dedicated website at www.blackwellpublishing.com/pelengaris An excellent text for upper-level courses in the biology of cancer, for medical students and qualified practitioners preparing for higher exams, and for researchers and teachers in the field

Systems Biology of Apoptosis

Systems Biology of Apoptosis Book
Author : Inna N. Lavrik
Publisher : Springer Science & Business Media
Release : 2012-09-13
ISBN : 1461440092
Language : En, Es, Fr & De

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Book Description :

Systems Biology of Apoptosis summarizes all current achievements in this emerging field. Apoptosis is a process common to all multicellular organisms. Apoptosis leads to the elimination of cells via a complex but highly defined cellular programme. Defects in the regulation of apoptosis result in serious diseases such as cancer, autoimmunity, AIDS and neurodegeneration. Recently, a substantial step forward in understanding the complex apoptotic pathways has been made by utilising systems biology approaches. Systems biology combines rigorous mathematical modelling with experimental approaches in a closed loop cycle for advancing our knowledge about complex biological processes. In this book, the editor describes the contemporary systems biology studies devoted to apoptotic signaling and focuses on the question how systems biology helps to understand life/death decisions made in the cell and to develop new approaches to rational treatment strategies.

Genetics Meets Metabolomics

Genetics Meets Metabolomics Book
Author : Karsten Suhre
Publisher : Springer Science & Business Media
Release : 2012-06-15
ISBN : 1461416892
Language : En, Es, Fr & De

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Book Description :

This book is written by leading researchers in the fields about the intersection of genetics and metabolomics which can lead to more comprehensive studies of inborn variation of metabolism.

Systems Biology and Synthetic Biology

Systems Biology and Synthetic Biology Book
Author : Pengcheng Fu,Sven Panke
Publisher : John Wiley & Sons
Release : 2009-08-13
ISBN : 9780470437971
Language : En, Es, Fr & De

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Book Description :

The genomic revolution has opened up systematic investigations and engineering designs for various life forms. Systems biology and synthetic biology are emerging as two complementary approaches, which embody the breakthrough in biology and invite application of engineering principles. Systems Biology and Synthetic Biology emphasizes the similarity between biology and engineering at the system level, which is important for applying systems and engineering theories to biology problems. This book demonstrates to students, researchers, and industry that systems biology relies on synthetic biology technologies to study biological systems, while synthetic biology depends on knowledge obtained from systems biology approaches.