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Understanding Cancer From A Systems Biology Point Of View

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Understanding Cancer from a Systems Biology Point of View

Understanding Cancer from a Systems Biology Point of View Book
Author : Irina Kareva
Publisher : Academic Press
Release : 2018-02-07
ISBN : 012813674X
Language : En, Es, Fr & De

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Book Description :

Understanding Cancer from a Systems Biology Point of View: From Observation to Theory and Back starts with a basic question, why do we sometimes observe accelerated metastatic growth after resection of primary tumors? Next, it helps readers understand the systemic nature of cancer and how it affects treatment approaches and decisions. The book puts together aspects of cancer that many readers have most likely never combined, using unfamiliar, novel methods. It is a valuable resource for cancer researchers, cancer biologists, mathematicians and members of the biomedical field who are interested in applying systems biology methodologies for understanding and treating cancer. Explains the systemic nature of cancer and how it affects decisions on treatment Brings a variety of methods together, showing, in detail, the logical approach to finding answers to complex questions Discusses the theoretical underpinnings of cancer as a systemic disease, providing the reader with valuable information on applicable cases

Computational Systems Biology of Cancer

Computational Systems Biology of Cancer Book
Author : Emmanuel Barillot,Laurence Calzone,Philippe Hupe,Jean-Philippe Vert,Andrei Zinovyev
Publisher : CRC Press
Release : 2012-08-25
ISBN : 1439831440
Language : En, Es, Fr & De

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Book Description :

The future of cancer research and the development of new therapeutic strategies rely on our ability to convert biological and clinical questions into mathematical models—integrating our knowledge of tumour progression mechanisms with the tsunami of information brought by high-throughput technologies such as microarrays and next-generation sequencing. Offering promising insights on how to defeat cancer, the emerging field of systems biology captures the complexity of biological phenomena using mathematical and computational tools. Novel Approaches to Fighting Cancer Drawn from the authors’ decade-long work in the cancer computational systems biology laboratory at Institut Curie (Paris, France), Computational Systems Biology of Cancer explains how to apply computational systems biology approaches to cancer research. The authors provide proven techniques and tools for cancer bioinformatics and systems biology research. Effectively Use Algorithmic Methods and Bioinformatics Tools in Real Biological Applications Suitable for readers in both the computational and life sciences, this self-contained guide assumes very limited background in biology, mathematics, and computer science. It explores how computational systems biology can help fight cancer in three essential aspects: Categorising tumours Finding new targets Designing improved and tailored therapeutic strategies Each chapter introduces a problem, presents applicable concepts and state-of-the-art methods, describes existing tools, illustrates applications using real cases, lists publically available data and software, and includes references to further reading. Some chapters also contain exercises. Figures from the text and scripts/data for reproducing a breast cancer data analysis are available at www.cancer-systems-biology.net.

Cancer Systems Biology

Cancer Systems Biology Book
Author : Edwin Wang
Publisher : CRC Press
Release : 2010-05-04
ISBN : 9781439811863
Language : En, Es, Fr & De

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Book Description :

The unprecedented amount of data produced with high-throughput experimentation forces biologists to employ mathematical representation and computation methods to glean meaningful information in systems-level biology. Applying this approach to the underlying molecular mechanisms of tumorigenesis, cancer researchers can uncover a series of new discov

Recent Developments in Cancer Systems Biology

Recent Developments in Cancer Systems Biology Book
Author : Raghu Sinha,Kazim Yalcin Arga
Publisher : MDPI
Release : 2021-08-18
ISBN : 3036514724
Language : En, Es, Fr & De

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Book Description :

This book includes original research articles and reviews to update readers on the state of the art systems approach to not only discover novel diagnostic and prognostic biomarkers for several cancer types, but also evaluate methodologies to map out important genomic signatures. In addition, therapeutic targets and drug repurposing have been emphasized for a variety of cancer types. In particular, new and established researchers who desire to learn about cancer systems biology and why it is possibly the leading front to a personalized medicine approach will enjoy reading this book.

Understanding Cancer

Understanding Cancer Book
Author : Richard Mcintosh/Mcd Biology
Publisher : Garland Science
Release : 2019-05-02
ISBN : 0429576269
Language : En, Es, Fr & De

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Book Description :

Understanding Cancer is a brand-new undergraduate textbook that uses simple language and well-chosen examples to explain the biological processes that underlie cancer and inform our methods for the diagnosis and treatment of this disease. The book has been carefully designed to provide key information relevant for students seeking a broad and accessible introduction to the cancer problem, even if they have no prior training in biology or chemistry.

Systems Biology of Cancer

Systems Biology of Cancer Book
Author : Sam Thiagalingam
Publisher : Cambridge University Press
Release : 2015-04-09
ISBN : 0521493390
Language : En, Es, Fr & De

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Book Description :

An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Molecular Biology of the Cell

Molecular Biology of the Cell Book
Author : Bruce Alberts
Publisher : Unknown
Release : 2004
ISBN : 9780815332183
Language : En, Es, Fr & De

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Book Description :

Download Molecular Biology of the Cell book written by Bruce Alberts, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Systems Biology in Cancer Research and Drug Discovery

Systems Biology in Cancer Research and Drug Discovery Book
Author : Asfar S Azmi
Publisher : Springer Science & Business Media
Release : 2012-09-29
ISBN : 9400748183
Language : En, Es, Fr & De

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Book Description :

Systems Biology in Cancer Research and Drug Discovery provides a unique collection of chapters, by world-class researchers, describing the use of integrated systems biology and network modeling in the cancer field where traditional tools have failed to deliver expected promise. This book touches four applications/aspects of systems biology (i) in understanding aberrant signaling in cancer (ii) in identifying biomarkers and prognostic markers especially focused on angiogenesis pathways (iii) in unwinding microRNAs complexity and (iv) in anticancer drug discovery and in clinical trial design. This book reviews the state-of-the-art knowledge and touches upon cutting edge newer and improved applications especially in the area of network modeling. It is aimed at an audience ranging from students, academics, basic researcher and clinicians in cancer research. This book is expected to benefit the field of translational cancer medicine by bridging the gap between basic researchers, computational biologists and clinicians who have one ultimate goal and that is to defeat cancer.

Molecular Diagnostics and Treatment of Pancreatic Cancer

Molecular Diagnostics and Treatment of Pancreatic Cancer Book
Author : Asfar Azmi
Publisher : Elsevier
Release : 2014-04-14
ISBN : 0124079466
Language : En, Es, Fr & De

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Book Description :

Molecular Diagnostics and Treatment of Pancreatic Cancer describes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expression profiling, proteomics, metabolomics and systems level analyses of pancreatic cancer datasets. First of a kind and novel network strategies to understand oncogenic Kras signaling in pancreatic tumors are presented. The attempts to computationally model and prioritize microRNAs that cause pancreatic cancer resistance are also highlighted. Addressing this important area, Molecular Diagnostics and Treatment of Pancreatic Cancer provides insights into important network evaluation methodologies related to pancreatic cancer related microRNAs targetome. There are dedicated chapters on critical aspects of the evolving yet controversial field of pancreatic cancer stems cells. The work concludes by discussing the applications of network sciences in pancreatic cancer drug discovery and clinical trial design. Encompasses discussion of innovative tools including expression signatures in cell lines, 3D models, animal xenograft models, primary models and patient derived samples, aiding subversion of traditional biology paradigms, and enhancing comprehension across conventional length and temporal scales Coverage includes novel applications in targeted drugs, polypharmacology, network pharmacology and other related drug development arenas – helping researchers in pancreatic cancer drug discovery Summarizes many relevant computational and clinical references from fast-evolving literature Comprehensive glossary helps newer readers understand technical terms and specialized nomenclature

Modeling Evolution of Heterogeneous Populations

Modeling Evolution of Heterogeneous Populations Book
Author : Irina Kareva,Georgy Karev
Publisher : Academic Press
Release : 2019-10-16
ISBN : 0128144327
Language : En, Es, Fr & De

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Book Description :

Modeling Evolution of Heterogeneous Populations: Theory and Applications describes, develops and provides applications of a method that allows incorporating population heterogeneity into systems of ordinary and discrete differential equations without significantly increasing system dimensionality. The method additionally allows making use of results of bifurcation analysis performed on simplified homogeneous systems, thereby building on the existing body of tools and knowledge and expanding applicability and predictive power of many mathematical models. Introduces Hidden Keystone Variable (HKV) method, which allows modeling evolution of heterogenous populations, while reducing multi-dimensional selection systems to low-dimensional systems of differential equations Demonstrates that replicator dynamics is governed by the principle of maximal relative entropy that can be derived from the dynamics of selection systems instead of being postulated Discusses mechanisms behind models of both Darwinian and non-Darwinian selection Provides examples of applications to various fields, including cancer growth, global demography, population extinction, tragedy of the commons and resource sustainability, among others Helps inform differences in underlying mechanisms of population growth from experimental observations, taking one from experiment to theory and back

The Molecular Basis of Cancer

The Molecular Basis of Cancer Book
Author : John Mendelsohn,Peter M. Howley,Mark A. Israel,Joe W. Gray,Craig B. Thompson
Publisher : Elsevier Health Sciences
Release : 2008-04-01
ISBN : 1437710999
Language : En, Es, Fr & De

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Book Description :

Successfully fighting cancer starts with understanding how it begins. This thoroughly revised 3rd Edition explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of cancer. A team of leading experts thoroughly explain the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Incorporating cutting-edge advances and the newest research, the book provides thorough descriptions of everything from molecular abnormalities in common cancers to new approaches for cancer therapy. Features sweeping updates throughout, including molecular targets for the development of anti-cancer drugs, gene therapy, and vaccines...keeping you on the cutting edge of your specialty. Offers a new, more user-friendly full-color format so the information that you need is easier to find. Presents abundant figures-all redrawn in full color-illustrating major concepts for easier comprehension. Features numerous descriptions of the latest clinical strategies-helping you to understand and take advantage of today’s state-of-the-art biotechnology advances.

Systems Biology

Systems Biology Book
Author : Hsueh-Fen Juan,Hsuan-Cheng Huang
Publisher : World Scientific
Release : 2012
ISBN : 9814324450
Language : En, Es, Fr & De

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Book Description :

This volume presents an overview of recent developments in systems biology and their applications in cancer-related research. The ongoing advances in our understanding of genomics and proteomics, coupled with the development of new and more robust tools, have led to an emphasis on analyzing biological systems at multiple levels. Thus, there is a need to integrate different types of data into a comprehensive "systems" view. Written by active researchers in the emerging areas, this book gives senior undergraduate students, graduate students and new researchers an idea of where the frontiers of systems biology are and an opportunity to learn high-throughput techniques in use. One of the particular emphases of the book is to elucidate the molecular mechanisms in cancer. The discovery of biomarkers and anti-cancer drugs using systems biology approach is also extensively discussed.

Ecology and Evolution of Cancer

Ecology and Evolution of Cancer Book
Author : Beata Ujvari,Benjamin Roche,Frederic Thomas
Publisher : Academic Press
Release : 2017-02-08
ISBN : 0128043806
Language : En, Es, Fr & De

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Book Description :

Ecology and Evolution of Cancer is a timely work outlining ideas that not only represent a substantial and original contribution to the fields of evolution, ecology, and cancer, but also goes beyond by connecting the interfaces of these disciplines. This work engages the expertise of a multidisciplinary research team to collate and review the latest knowledge and developments in this exciting research field. The evolutionary perspective of cancer has gained significant international recognition and interest, which is fully understandable given that somatic cellular selection and evolution are elegant explanations for carcinogenesis. Cancer is now generally accepted to be an evolutionary and ecological process with complex interactions between tumor cells and their environment sharing many similarities with organismal evolution. As a critical contribution to this field of research the book is important and relevant for the applications of evolutionary biology to understand the origin of cancers, to control neoplastic progression, and to prevent therapeutic failures. Covers all aspects of the evolution of cancer, appealing to researchers seeking to understand its origins and effects of treatments on its progression, as well as to lecturers in evolutionary medicine Functions as both an introduction to cancer and evolution and a review of the current research on this burgeoning, exciting field, presented by an international group of leading editors and contributors Improves understanding of the origin and the evolution of cancer, aiding efforts to determine how this disease interferes with biotic interactions that govern ecosystems Highlights research that intends to apply evolutionary principles to help predict emergence and metastatic progression with the aim of improving therapies

Computational Biology of Cancer

Computational Biology of Cancer Book
Author : Dominik Wodarz,Natalia Komarova
Publisher : World Scientific
Release : 2005-01-24
ISBN : 9814481874
Language : En, Es, Fr & De

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Book Description :

' The book shows how mathematical and computational models can be used to study cancer biology. It introduces the concept of mathematical modeling and then applies it to a variety of topics in cancer biology. These include aspects of cancer initiation and progression, such as the somatic evolution of cells, genetic instability, and angiogenesis. The book also discusses the use of mathematical models for the analysis of therapeutic approaches such as chemotherapy, immunotherapy, and the use of oncolytic viruses. Contents:Cancer and Somatic EvolutionMathematical Modeling of TumorigenesisCancer Initiation: One-Hit and Two-Hit Stochastic ModelsMicrosatellite and Chromosomal Istability in Sporadic and Familial CancersCellular Origins of CancerCosts and Benefits of Chromosomal InstabilityDNA Damage and Genetic InstabilityTissue Aging and the Development of CancerBasic Models of Tumor Inhibition and PromotionMechanisms of Tumor NeovascularizationCancer and Immune ResponsesTherapeutic Approaches: Viruses as Anti-Tumor Weapons Readership: Researchers and academics in bioinformatics, biocomputing, biomathematics, cell/molecular biology and cancer biology, as well as clinicians. Keywords:Mathematics Models;Computational Biology;Cancer Initiation;Cancer Progression;Somatic Evolution;Genetic Instability;Therapy;Oncolytic VirusesKey Features:Provides an introduction to computational methods in cancer biologyFollows a multi-disciplinary approachReviews:“This book adds aspects not covered by other books and, therefore, represents a valuable addition to the literature about mathematical models in cancer biology.”Zentralblatt MATH '

Handbook of Systems Biology

Handbook of Systems Biology Book
Author : Marian Walhout,Marc Vidal,Job Dekker
Publisher : Academic Press
Release : 2012-12-31
ISBN : 012385945X
Language : En, Es, Fr & De

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Book Description :

This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as the importance of systems biology in human biological research. Technology, being an extremely important aspect of scientific progress overall, and in the creation of new fields in particular, is discussed in 'boxes' within each chapter to relate to appropriate topics. 2013 Honorable Mention for Single Volume Reference in Science from the Association of American Publishers' PROSE Awards Emphasizes the interdisciplinary nature of systems biology with contributions from leaders in a variety of disciplines Includes the latest research developments in human and animal models to assist with translational research Presents biological and computational aspects of the science side-by-side to facilitate collaboration between computational and biological researchers

Oxford Textbook of Cancer Biology

Oxford Textbook of Cancer Biology Book
Author : Francesco Pezzella,Mahvash Tavassoli,David Kerr
Publisher : Oxford University Press
Release : 2019-05-02
ISBN : 0198779453
Language : En, Es, Fr & De

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Book Description :

The study of the biology of tumours has grown to become markedly interdisciplinary, involving chemists, statisticians, epidemiologists, mathematicians, bioinformaticians, and computer scientists alongside biologists, geneticists, and clinicians. The Oxford Textbook of Cancer Biology brings together the most up-to-date developments from different branches of research into one coherent volume, providing a comprehensive and current account of this rapidly evolving field. Structured in eight sections, the book starts with a review of the development and biology of multi-cellular organisms, how they maintain a healthy homeostasis in an individual, and a description of the molecular basis of cancer development. The book then illustrates, as once cells become neoplastic, their signalling network is altered and pathological behaviour follows. It explores the changes that cancer cells can induce in nearby normal tissue, the new relationship established between them and the stroma, and the interaction between the immune system and tumour growth. The authors illustrate the contribution provided by high throughput techniques to map cancer at different levels, from genomic sequencing to cellular metabolic functions, and how information technology, with its vast amounts of data, is integrated with traditional cell biology to provide a global view of the disease. The effect of the different types of treatments on the biology of the neoplastic cells are explored to understand on the one side, why some treatments succeed, and on the other, how they can affect the biology of resistant and recurrent disease. The book concludes by summarizing what we know to date about cancer, and in what direction our understanding of cancer is moving. Edited by leading authorities in the field with an international team of contributors, this book is an essential resource for scholars and professionals working in the wide variety of sub-disciplines that make up today's cancer research and treatment community. It is written not only for consultation, but also for easy cover-to-cover reading.

Computational Systems Biology Approaches in Cancer Research

Computational Systems Biology Approaches in Cancer Research Book
Author : Inna Kuperstein,Emmanuel Barillot
Publisher : CRC Press
Release : 2019-09-09
ISBN : 1000682927
Language : En, Es, Fr & De

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Book Description :

Praise for Computational Systems BiologyApproaches in Cancer Research: "Complex concepts are written clearly and with informative illustrations and useful links. The book is enjoyable to read yet provides sufficient depth to serve as a valuable resource for both students and faculty." — Trey Ideker, Professor of Medicine, UC Xan Diego, School of Medicine "This volume is attractive because it addresses important and timely topics for research and teaching on computational methods in cancer research. It covers a broad variety of approaches, exposes recent innovations in computational methods, and provides acces to source code and to dedicated interactive web sites." — Yves Moreau, Department of Electrical Engineering, SysBioSys Centre for Computational Systems Biology, University of Leuven With the availability of massive amounts of data in biology, the need for advanced computational tools and techniques is becoming increasingly important and key in understanding biology in disease and healthy states. This book focuses on computational systems biology approaches, with a particular lens on tackling one of the most challenging diseases - cancer. The book provides an important reference and teaching material in the field of computational biology in general and cancer systems biology in particular. The book presents a list of modern approaches in systems biology with application to cancer research and beyond. It is structured in a didactic form such that the idea of each approach can easily be grasped from the short text and self-explanatory figures. The coverage of topics is diverse: from pathway resources, through methods for data analysis and single data analysis to drug response predictors, classifiers and image analysis using machine learning and artificial intelligence approaches. Features Up to date using a wide range of approaches Applicationexample in each chapter Online resources with useful applications’

Modeling Methods for Medical Systems Biology

Modeling Methods for Medical Systems Biology Book
Author : María Elena Álvarez-Buylla Roces,Juan Carlos Martínez-García,José Dávila-Velderrain,Elisa Domínguez-Hüttinger,Mariana Esther Martínez-Sánchez
Publisher : Springer
Release : 2018-08-03
ISBN : 3319893548
Language : En, Es, Fr & De

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Book Description :

This book contributes to better understand how lifestyle modulations can effectively halt the emergence and progression of human diseases. The book will allow the reader to gain a better understanding of the mechanisms by which the environment interferes with the bio-molecular regulatory processes underlying the emergence and progression of complex diseases, such as cancer. Focusing on key and early cellular bio-molecular events giving rise to the emergence of degenerative chronic disease, it builds on previous experience on the development of multi-cellular organisms, to propose a mathematical and computer based framework that allows the reader to analyze the complex interplay between bio-molecular processes and the (micro)-environment from an integrative, mechanistic, quantitative and dynamical perspective. Taking the wealth of empirical evidence that exists it will show how to build and analyze models of core regulatory networks involved in the emergence and progression of chronic degenerative diseases, using a bottom-up approach.

Systems Biology and Omics Approaches to Understand Complex Diseases Biology

Systems Biology and Omics Approaches to Understand Complex Diseases Biology Book
Author : Amit Kumar Yadav,Sanjay Kumar Banerjee,Kumardeep Chaudhary,Bhabatosh Das
Publisher : Frontiers Media SA
Release : 2022-05-03
ISBN : 2889760782
Language : En, Es, Fr & De

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Book Description :

Download Systems Biology and Omics Approaches to Understand Complex Diseases Biology book written by Amit Kumar Yadav,Sanjay Kumar Banerjee,Kumardeep Chaudhary,Bhabatosh Das, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Molecular and Cell Biology of Cancer

Molecular and Cell Biology of Cancer Book
Author : Rita Fior,Rita Zilhão
Publisher : Springer
Release : 2019-06-27
ISBN : 3030118126
Language : En, Es, Fr & De

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Book Description :

This textbook takes you on a journey to the basic concepts of cancer biology. It combines developmental, evolutionary and cell biology perspectives, to then wrap-up with an integrated clinical approach. The book starts with an introductory chapter, looking at cancer in a nut shell. The subsequent chapters are detailed and the idea of cancer as a mass of somatic cells undergoing a micro-evolutionary Darwinian process is explored. Further, the main Hanahan and Weinberg “Hallmarks of Cancer” are revisited. In most chapters, the fundamental experiments that led to key concepts, connecting basic biology and biomedicine are highlighted. In the book’s closing section all of these concepts are integrated in clinical studies, where molecular diagnosis as well as the various classical and modern therapeutic strategies are addressed. The book is written in an easy-to-read language, like a one-on-one conversation between the writer and the reader, without compromising the scientific accuracy. Therefore, this book is suited not only for advanced undergraduates and master students but also for patients or curious lay people looking for a further understanding of this shattering disease