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Twin And Family Studies Of Epigenetics

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Twin and Family Studies of Epigenetics

Twin and Family Studies of Epigenetics Book
Author : Shuai Li,John Hopper
Publisher : Academic Press
Release : 2021-10-15
ISBN : 9780128209516
Language : En, Es, Fr & De

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Book Description :

In recent years, epigenetic modifications have been shown to play an important role in human development and disease progression, and results from ongoing epidemiological studies are already driving advances in medicine and public health. Twin and family studies in epigenetics, by design, offer a unique ability to assess disease risk factors and evaluate interventions across the human lifespan. With Twin and Family Studies of Epigenetics, a new volume in the Translational Epigenetics series, Editors John Hopper and Shuai Li gather expert opinion on epigenetic twin and family study research methods, recent findings across various across disease areas, and future directions for research and clinical application. Here more than 15 leaders in the field provide in-depth coverage of epigenetics fundamentals, twin and family epigenetic study design, and the broader role of epigenetics in answering our questions on the developmental origins of health and disease. Throughout the volume, twin and family studies are employed to examine causes of epigenetic variation, the relationship between epigenetic modifications and mental illness, cancers, cardiovascular disease, diabetes, obesity, and high blood pressure, among other diseases and disorders. Emerging research methods applied in twin and family studies discussed include imaging epigenetics, exposure-specific DNA methylation changes, and unravelling time trends in epigenetic effects. Offers a practical, interdisciplinary approach across epigenetics, epidemiology, and various disease specialties Applies epigenetics twin and family studies to determine relationship between epigenetics and mental illness, cancers, cardiovascular disease, diabetes, obesity, and high blood pressure, among other diseases and disorders Features chapter contributions from a wide range of international researchers in the field

Behavior Genetics of Psychopathology

Behavior Genetics of Psychopathology Book
Author : Soo Hyun Rhee,Angelica Ronald
Publisher : Springer Science & Business Media
Release : 2014-02-03
ISBN : 1461495091
Language : En, Es, Fr & De

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Book Description :

As a dynamic, interdisciplinary field, behavior genetics and its evolution are being followed closely by scientists across the psychological and medical domains. The discoveries surrounding the human genome and the advancement in molecular genetic technologies have led to studies becoming increasingly sophisticated and yielding yet more conclusive and useful results. This is certainly the case in the area of child and adult psychopathology. Behavior Genetics of Psychopathology summarizes the state of the field, examining the role of genes and environment as they affect common neurodevelopmental and psychiatric conditions. Emphasizing key research areas (comorbidities, twin studies, the integration of methods), the book assesses the current literature, offers up-to-date findings, sorts through lingering controversies, and identifies a clear future agenda for the field. Expertly-written chapters focus on issues of both general salience that shape behavior genetics of psychopathology, to specific disorders of major clinical importance, among them: ADHD: the view from quantitative genetic research. Autism spectrum disorders and their complex heterogeneity Genetic influences on anxiety and depression in childhood and adolescence. Evidence for etiologically-defined subgroups within the construct of antisocial behavior. Sleep and psychopathology: the reasons for their co-occurrence. Behavioral genetic approaches to the etiology of comorbidity. Epigenetics of psychopathology. This combination of timeliness and depth of coverage make Behavior Genetics of Psychopathology a frontline resource for behavior geneticists, psychologists, psychiatrists, and neuroscientists, and is perfectly suited to graduate students looking to join these fields.

Developmental Human Behavioral Epigenetics

Developmental Human Behavioral Epigenetics Book
Author : Livio Provenzi,Rosario Montirosso
Publisher : Academic Press
Release : 2020-11-20
ISBN : 0128192631
Language : En, Es, Fr & De

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Book Description :

Developmental Human Behavioral Epigenetics: Principles, Methods, Evidence, and Future Directions, Volume 23, a new volume in the Translational Epigenetics series, offers the first systematic account of theoretical G79 frameworks, methodological approaches, findings, and future directions in the field of human behavioral epigenetics. Featuring contributions from leading scientists and international researchers, this book provides a comprehensive overview of human behavioral epigenetics, with a close examination of evidence gathered to-date from animal models, challenges of human-based research and clinical translation, pathways towards drug discovery, and next steps in research. Areas of focus include prenatal stress exposures, preterm behavioral epigenetics, intergenerational exposures, trauma and neglect, socio-economic conditions, maternal caregiving and attachment, study design, and epigenetics and psychotherapy. Enables more effective study design and methods application in behavioral epigenetics research across human and animal models Examines findings in human behavioral epigenetics to-date Features contributions from leading international researchers in behavioral epigenetics

Assessment of Genome wide Genetic and Epigenetic de Novo Variation in Families with Monozygotic Twins Discordant for Schizophrenia

Assessment of Genome wide Genetic and Epigenetic de Novo Variation in Families with Monozygotic Twins Discordant for Schizophrenia Book
Author : Christina Angela Castellani
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Schizophrenia (OMIM: 181500) is a common, debilitating and life-altering disorder. It affects 1% of the population worldwide and most often presents in early adulthood leading to devastating effects for patients, their families and society. Despite thousands of studies performed on the underlying mechanisms of schizophrenia, the causes of the disease remain unknown. However, what is known is that environmental, genetic and epigenetic factors contribute to the development of this complex disorder. Although a genetic role in schizophrenia is well established, the search for schizophrenia genes using traditional approaches has remained challenging. Interestingly, monozygotic twins show concordance for schizophrenia only 50% of the time and therefore provide a unique scenario for genomic analysis. This Doctoral thesis examines the genetic and epigenetic contributions to schizophrenia discordance in monozygotic twins. In this thesis, I have identified and characterized genome-wide changes through the use of the Affymetrix SNP 6.0 Microarray, Complete Genomics whole genome sequencing and the Nimblegen Methylation 720k Microarray. Specifically, I have identified genetic and epigenetic differences between monozygotic twins discordant for schizophrenia. The results show multiple genetic and epigenetic changes between monozygotic twins with discordance for schizophrenia. Some of these differences are patient-specific and others are shared between affected twins in the study. In addition, some of these differences affected genes and others did not. Many of the genes and genomic regions have been previously implicated in schizophrenia and neurodevelopmental disorders. The findings reinforce the concept that individual genomes harbor extensive variability, some inherited and some acquired. Even monozygotic twins are not identical and each individual may be a mosaic; carrying different sequence variations in different cells. The results also suggest that discordance for schizophrenia in monozygotic twins may result from the accumulation of genetic and epigenetic mutations that lead to the disease threshold being met in one twin only. The results argue for the involvement of de novo mutations in genetic individuality and complex disease. Improved understanding of the genomic contributions to schizophrenia is critical for movement towards earlier and more accurate diagnosis, better treatment and further understanding of this complex mental health disorder.

Psychology

Psychology Book
Author : Douglas A. Bernstein,Julie Ann Pooley,Lynne Cohen,Bethanie Gouldthorp,Stephen C. Provost,Jacquelyn Cranney,Louis A. Penner,Alison Clarke-Stewart,Edward J. Roy
Publisher : Cengage AU
Release : 2017-09-18
ISBN : 0170386309
Language : En, Es, Fr & De

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Book Description :

Make introductory psychology modern and accessible! Strike a balance between classic and contemporary topics and theory. The new edition of this text engages students with local ideas and examples, within the context of psychology as an international discipline. Rich cultural and indigenous coverage is integrated throughout the text, as well as new chapters, 'Indigenous psychology', and 'Culture and psychology'. There is also the continued, and unique focus throughout the text on graduate attributes for accreditation, careers in psychology and the professional discipline of psychology. Linkages features in the text knit together student understanding of psychology's sub-disciplines, and the research sections show the how and why of research. World class learning technology available with Bernstein includes CourseMate Express, and a new MindTap.

Brain Behavior and Epigenetics

Brain  Behavior and Epigenetics Book
Author : Arturas Petronis,Jonathan Mill
Publisher : Springer Science & Business Media
Release : 2011-05-19
ISBN : 9783642174261
Language : En, Es, Fr & De

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Book Description :

Biomedical research in the first decade of the 21st century has been marked by a rapidly growing interest in epigenetics. The reasons for this are numerous, but primarily it stems from the mounting realization that research programs focused solely on DNA sequence variation, despite their breadth and depth, are unlikely to address all fundamental aspects of human biology. Some questions are evident even to non-biologists. How does a single zygote develop into a complex multicellular organism composed of dozens of different tissues and hundreds of cell types, all genetically identical but performing very different functions? Why do monozygotic twins, despite their stunning external similarities, often exhibit significant differences in personality and predisposition to disease? If environmental factors are solely the cause of such variation, why are similar differences also observed between genetically identical animals housed in a uniform environment? Over the last couple of decades, epigenetics has undergone a significant metamorphosis from an abstract developmental theory to a very dynamic and rapidly developing branch of molecular biology. This volume represents a compilation of our current understanding about the key aspects of epigenetic processes in the brain and their role in behavior. The chapters in this book bring together some of the leading researchers in the field of behavioral epigenetics. They explore many of the epigenetic processes which operate or may be operating to mediate neurobiological functions in the brain and describe how perturbations to these systems may play a key role in mediating behavior and the origin of brain diseases.

The Encyclopaedia of Sports Medicine An IOC Medical Commission Publication The Olympic Textbook of Science in Sport

The Encyclopaedia of Sports Medicine  An IOC Medical Commission Publication  The Olympic Textbook of Science in Sport Book
Author : Ronald J. Maughan
Publisher : John Wiley & Sons
Release : 2009-01-26
ISBN : 9781444303322
Language : En, Es, Fr & De

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Book Description :

This new volume in the Encyclopaedia of Sports Medicine series, published under the auspices of the International Olympic Committee, delivers an up-to-date, state of the art presentation of the scientific aspects of conditioning, injury prevention, and competition. The book covers the key areas of scientific knowledge in sport and is divided into: physiology and biochemistry; nutrition; anthropometry; immunology; cell biology; biomechanics, engineering and ergonomics; psychology; pharmacology; limitations to performance; special populations; and exercise and health. Presented in a clear style and format, The Olympic Textbook of Science in Sport, draws on the expertise of an international collection of contributors who are recognized as leaders in their respective fields. It will be indispensable for all sport scientists and medical doctors who serve athletes and sports teams and is an invaluable reference for students of sport and exercise science.

Addictive Substances and Neurological Disease

Addictive Substances and Neurological Disease Book
Author : Ronald Ross Watson,Sherma Zibadi
Publisher : Academic Press
Release : 2017-02-18
ISBN : 0128092963
Language : En, Es, Fr & De

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Book Description :

Addictive Substances and Neurological Disease: Alcohol, Tobacco, Caffeine, and Drugs of Abuse in Everyday Lifestyles is a complete guide to the manifold effects of addictive substances on the brain, providing readers with the latest developing research on how these substances are implicated in neurological development and dysfunction. Cannabis, cocaine, and other illicit drugs can have substantial negative effects on the structure and functioning of the brain. However, other common habituating and addictive substances often used as part of an individual’s lifestyle, i.e., alcohol, tobacco, caffeine, painkillers can also compromise brain health and effect or accentuate neurological disease. This book provides broad coverage of the effects of addictive substances on the brain, beginning with an overview of how the substances lead to dysfunction before examining each substance in depth. It discusses the pathology of addiction, the structural damage resulting from abuse of various substances, and covers the neurobiological, neurodegenerative, behavioral, and cognitive implications of use across the lifespan, from prenatal exposure, to adolescence and old age. This book aids researchers seeking an understanding of the neurological changes that these substances induce, and is also extremely useful for those seeking potential treatments and therapies for individuals suffering from chronic abuse of these substances. Integrates current research on the actions of addictive substances in neurological disease Includes functional foods, such as caffeine beverages, that have habituating effects on the brain Provides a synopsis of key ideas associated with the consequences of addictive and habituating lifestyle substances

Neuroscience Year

Neuroscience Year Book
Author : Smith,Adelman
Publisher : Birkhäuser
Release : 1993-09-21
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The third and final supplement to the 1987 edition of the Encyclopedia of Neuroscience . As with the earlier two supplements, the categories of entries include (1) developing topics in neuroscience that were not covered as separate entries in the Encyclopedia or were only briefly covered in other re

Schizophrenia Bulletin

Schizophrenia Bulletin Book
Author : Anonim
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Schizophrenia Bulletin book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Acta Geneticae Medicae Et Gemellologiae Twin Research

Acta Geneticae Medicae Et Gemellologiae  Twin Research Book
Author : Anonim
Publisher : Unknown
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Acta Geneticae Medicae Et Gemellologiae Twin Research book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Handbook of Studies on Schizophrenia Epidemiology aetiology and clinical features

Handbook of Studies on Schizophrenia  Epidemiology  aetiology  and clinical features Book
Author : Graham D. Burrows,Trevor R. Norman,Gertrude Rubinstein
Publisher : Elsevier Publishing Company
Release : 1986
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Handbook of Studies on Schizophrenia Epidemiology aetiology and clinical features book written by Graham D. Burrows,Trevor R. Norman,Gertrude Rubinstein, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Proceedings of the National Academy of Sciences of the United States of America

Proceedings of the National Academy of Sciences of the United States of America Book
Author : National Academy of Sciences (U.S.)
Publisher : Unknown
Release : 1986
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The Proceedings of the National Academy of Sciences (PNAS) publishes research reports, commentaries, reviews, colloquium papers, and actions of the Academy. PNAS is a multidisciplinary journal that covers the biological, physical, and social sciences.

Gene Environment Transactions in Developmental Psychopathology

Gene Environment Transactions in Developmental Psychopathology Book
Author : Patrick H. Tolan,Bennett L. Leventhal
Publisher : Springer
Release : 2017-04-29
ISBN : 3319492276
Language : En, Es, Fr & De

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Book Description :

This book examines the current research in gene-environment transactions (GEX) and its potential use in developing interventions and applications tailored to individual genetic makeups. Key concepts underlying GEX studies in this area are defined, identifying fundamental challenges in devising informed research questions and conducting valid and useful experiments. Chapters analyze GEX models inspired by the present day genome-based frameworks, particularly in terms of advances in identifying and understanding complex environmental factors, using examples from common psychological conditions, such as antisocial behavior, chronic physical aggression, and chronic internalizing disorder. In addition, the book presents new and potential applications of the framework in the contexts of prevention science and intervention research. Topics featured in this book include: Epigenetics and the biology of gene x environment interactions. Gene by environment interactions and its potential use for intervention strategies in anxiety disorders. The challenges and potential for research on gene-environment interactions within autism spectrum disorder. Using genetically informed prevention trials to test gene x environment hypothese. Challenges for intervention research within the GEX framework. Gene-Environment Transactions in Developmental Psychopathology is a must-have resource for researchers/professors, clinicians, and related professionals as well as graduate students in developmental psychology, psychiatry, human genetics, and related disciplines.

Alcoholism

Alcoholism Book
Author : American Psychopathological Association. Meeting
Publisher : Lippincott Williams & Wilkins
Release : 1988
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Alcoholism book written by American Psychopathological Association. Meeting, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Handbook of Psychology Clinical Psychology

Handbook of Psychology  Clinical Psychology Book
Author : George Stricker,Thomas A. Widiger
Publisher : Wiley
Release : 2004-04-19
ISBN : 9780471666714
Language : En, Es, Fr & De

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Book Description :

Includes established theories and cutting-edge developments. Presents the work of an international group of experts. Presents the nature, origin, implications, an future course of major unresolved issues in the area.

Psychosocial Interventions for Genetically Influenced Problems in Childhood and Adolescence

Psychosocial Interventions for Genetically Influenced Problems in Childhood and Adolescence Book
Author : Richard Rende
Publisher : John Wiley & Sons
Release : 2014-08-18
ISBN : 111823569X
Language : En, Es, Fr & De

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Book Description :

How to weigh genetic factors while choosing the bestpsychosocial interventions Psychosocial Interventions for Genetically InfluencedProblems in Childhood and Adolescence explores empiricallysupported psychosocial interventions in light of our currentunderstanding of the genome. It considers how interventions may bemodified and enhanced as the products of genomic research continueto expand – and why they offer the most promise for makingsubstantial gains in treatment and prevention. Providing a clear, accessible assessment of our currentknowledge, both of the genome and evidence based treatments,Psychosocial Interventions for Genetically Influenced Problemsin Childhood and Adolescence provides practical advice toclinicians,policy makers, and others invested in treating youngpeople who present with a variety of conditions including anxiety,depression, ADHD, autism, substance abuse, and dyslexia. Rendediscusses the current understanding of genetic etiology ofpsychopathology, and explores the support, or lack thereof, forvarious modes of treatment in light of new genomic knowledge. Theoverall premise is that our advances in genetics will be put tobest therapeutic use by fueling translational psychosocialinterventions. Key points raised include: The need for treating children suffering today, rather thanwaiting for a biological "magic bullet" Discussion of how empirically-supported interventions mesh withgenetic vulnerabilities Ways in which interventions may change as genetic researchcontinues

American Psychiatric Press Textbook of Psychiatry

American Psychiatric Press Textbook of Psychiatry Book
Author : American Psychiatric Press
Publisher : Amer Psychiatric Pub Incorporated
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A clinically oriented, comprehensive textbook of psychiatry, for use principally by psychiatric residents and practicing psychiatrists, but also suitable as a reference for physicians in other specialties, and as an introduction to psychiatry for medical students. This edition is 20% larger than the first edition (1988), reflecting the substantial increase in the knowledge base of psychiatry. The multi-authored volume contains 45 chapters grouped into five sections: theoretical foundations; assessment; psychiatric disorders; psychiatric treatments; and special topics. As in the first edition, two appendices are included: the diagnostic criteria from DSM-IV and excerpts from the American Psychiatric Glossary, 7th edition. Annotation copyright by Book News, Inc., Portland, OR

Nebraska Symposium on Motivation

Nebraska Symposium on Motivation Book
Author : William D. Spaulding,James K. Cole
Publisher : Unknown
Release : 1984
ISBN : 9780803241480
Language : En, Es, Fr & De

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Book Description :

Download Nebraska Symposium on Motivation book written by William D. Spaulding,James K. Cole, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Nebraska Symposium on Motivation

Nebraska Symposium on Motivation Book
Author : William D. Spaulding,James K. Cole
Publisher : Unknown
Release : 1984
ISBN : 9780803241480
Language : En, Es, Fr & De

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Book Description :

Download Nebraska Symposium on Motivation book written by William D. Spaulding,James K. Cole, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.