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Turmeric And Curcumin For Neurodegenerative Disease

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Turmeric and Curcumin for Neurodegenerative Diseases

Turmeric and Curcumin for Neurodegenerative Diseases Book
Author : Magisetty Obulesu
Publisher : Academic Press
Release : 2021-02-12
ISBN : 0128224487
Language : En, Es, Fr & De

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Book Description :

Turmeric and Curcumin for Neurodegenerative Diseases examines protective mechanisms of turmeric products and novel nanotechnological therapeutics and biomaterial design strategies to circumvent Alzheimer's Disease, Parkinson's, and liver diseases. With neurodegenerative and liver diseases posing a serious threat to health care systems worldwide, this book addresses how existing nanotechnology and therapeutic strategies have not been as successful in their treatment. In addition to discussing drawbacks, possible future perspectives to overcome these challenges are also examined. Chapters also focus on therapeutic efficacy and drug delivery systems, providing readers with a full summary of research in this field in one handy reference. Summarizes the therapeutic efficacy of turmeric and curcumin for neurodegenerative diseases Includes effects on Alzheimer's, Parkinson's and liver diseases Focuses on different types of drug delivery systems and their challenges Examines novel nanotechnological therapeutics and biomaterial design strategies

Turmeric and Curcumin for Neurodegenerative Diseases

Turmeric and Curcumin for Neurodegenerative Diseases Book
Author : Magisetty Obulesu
Publisher : Academic Press
Release : 2021-02-10
ISBN : 0128224495
Language : En, Es, Fr & De

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Book Description :

Turmeric and Curcumin for Neurodegenerative Diseases examines protective mechanisms of turmeric products and novel nanotechnological therapeutics and biomaterial design strategies to circumvent Alzheimer’s Disease, Parkinson’s, and liver diseases. With neurodegenerative and liver diseases posing a serious threat to health care systems worldwide, this book addresses how existing nanotechnology and therapeutic strategies have not been as successful in their treatment. In addition to discussing drawbacks, possible future perspectives to overcome these challenges are also examined. Chapters also focus on therapeutic efficacy and drug delivery systems, providing readers with a full summary of research in this field in one handy reference. Summarizes the therapeutic efficacy of turmeric and curcumin for neurodegenerative diseases Includes effects on Alzheimer’s, Parkinson’s and liver diseases Focuses on different types of drug delivery systems and their challenges Examines novel nanotechnological therapeutics and biomaterial design strategies

Curcumin for Neurological and Psychiatric Disorders

Curcumin for Neurological and Psychiatric Disorders Book
Author : Tahira Farooqui,Akhlaq A. Farooqui
Publisher : Academic Press
Release : 2019-03-16
ISBN : 0128154624
Language : En, Es, Fr & De

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Book Description :

Curcumin for Neurological and Psychiatric Disorders: Neurochemical and Pharmacological Properties focuses on the different molecular mechanisms underlying curcumin-mediated beneficial effects in neurological diseases. The book's editors discuss the neurochemical and pharmacological properties of curcumin, followed by the effect of curcumin in neurotraumatic diseases, neurodegenerative diseases, and neuropsychiatric diseases. The book also offers a perspective on future studies on the treatment of neurological disorders. The beneficial effects of curcumin have been observed both in cultured cells and in animal models, thus paving the way for ongoing present and future human clinical trials. Curcumin produces antioxidant and anti-inflammatory effects not only by blocking oxidative stress and neuroinflammation in neurotraumatic and neurodegenerative diseases, but also by restoring cellular homeostasis and rebalancing redox equilibrium. Identifies molecular mechanisms of curcumin effects in neurological diseases Includes effects on neurotraumatic, neurodegenerative and psychiatric diseases Covers the antioxidant, anti-inflammatory and immunomodulatory effects of curcumin Examines curcumin’s potential in developing new therapeutic drugs

The Chemistry and Bioactive Components of Turmeric

The Chemistry and Bioactive Components of Turmeric Book
Author : Sreeraj Gopi,Sabu Thomas,Ajaikumar B Kunnumakkara,Bharat B Aggarwal,Augustine Amalraj
Publisher : Royal Society of Chemistry
Release : 2020-10-15
ISBN : 1839160594
Language : En, Es, Fr & De

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Book Description :

Turmeric belongs to the family Zingiberaceae and is a yellow spice of high economic importance due to its medicinal value. Cultivated in tropical and sub-tropical regions around the world, it is used extensively as a colouring, flavouring and preserving agent. In recent years, several drugs derived from natural products have been developed and current drug research is actively investigating the possible therapeutic roles of many Ayurvedic medicines, most notable among those being examined is turmeric. The wide range of pharmacological activities attributed to turmeric come mainly from curcuminoids and two related compounds, demethoxycurcumin and bisdemethoxycurcumin. This comprehensive book brings together the research carried out on constituents obtained from turmeric and highlights their chemical and biological activities. Comprising 17 chapters, each written by experts in their respective field and curated by authorities, it will be invaluable to all those who are involved in the production, processing, marketing, and the use of turmeric. Appealing to researchers and professionals in natural products, nutraceuticals and food chemists, this book is exposing some of the myths and showing areas for possible future use.

Turmeric

Turmeric Book
Author : P. N. Ravindran,K. Nirmal Babu,Kandaswamy Sivaraman
Publisher : CRC Press
Release : 2007-03-01
ISBN : 9781420006322
Language : En, Es, Fr & De

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Book Description :

For the last 6000 years turmeric has been used in Ayurvedic medicine to alleviate pain, balance digestion, purify body and mind, clear skin diseases, expel phlegm, and invigorate the blood. Nowadays, this plant has acquired great importance with its anti-aging, anti-cancer, anti-Altzheimer, antioxidant, and a variety of other medicinal properties. The need of the hour is to verify and validate the traditional uses by subjecting them to proper experimental studies. To do this effectively there needs to be a single comprehensive source of the knowledge to date. Turmeric: the genus Curcuma is the first comprehensive monographic treatment on turmeric. It covers all aspects of turmeric including botany, genetic resources, crop improvement, processing, biotechnology, pharmacology, medicinal and traditional uses, and its use as a spice and flavoring. Bringing together the premier experts in the field from India, Japan, UK, and USA, this book offers the most thorough examination of the cultivation, market trends, processing, and products as well as pharmacokinetic and medicinal properties of this highly regarded spice. While Ayurveda has known for millennia that turmeric cleanses the body, modern science has now discovered that it produces glutathione-s-transferase that detoxifies the body and therefore strengthens the liver, heart, and immune system. By comparing traditional uses with modern scientific discoveries, the text provides a complete view of the medicinal value and health benefits of turmeric. Heavily referenced with an exhaustive bibliography at the end of each chapter, the book collects and collates the currently available data on turmeric. Covering everything from cultivation to medicine, Turmeric: the Genus Curcuma serves as an invaluable reference for those involved with agriculture, marketing, processing or product development, and may function as a catalyst for future research into the health benefits and applications of turmeric.

Nanobiotechnology in Neurodegenerative Diseases

Nanobiotechnology in Neurodegenerative Diseases Book
Author : Mahendra Rai,Alka Yadav
Publisher : Springer Nature
Release : 2019-12-02
ISBN : 3030309304
Language : En, Es, Fr & De

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Book Description :

This book focuses on neurodegenerative diseases which have become a major threat to human health. Neurodegenerative diseases are age related disorders and have become increasingly prevalent in the elderly population in recent years. Hence, there is an urgent need to study and develop new strategies and alternative methods for the treatment of neurodegenerative diseases. This book showcases the promises that nanobiotechnology brings in research, diagnosis, and treatment of neurodegenerative diseases. It is very beneficial for varied group of readers including nanotechnologists, biotechnologists, pharmacists, medical professionals, bioengineers, biochemists and researchers working in this field. Nanobiotechnology in Neurodegenerative Diseases include various chapters including neurodegeneration and neurodegenerative diseases, nanotechnology for the rescue of neurodegenerative diseases, promising potential of nanomaterials for diagnosis and therapy of neurodegenerative diseases, nanotechnology mediated nose-to-brain drug delivery, and formulation and characterization of intranasal nanoparticles of antiretroviral drugs.

Levodopa Induced Dyskinesia in Parkinson s Disease

Levodopa Induced Dyskinesia in Parkinson s Disease Book
Author : Susan H. Fox,Jonathan M. Brotchie
Publisher : Springer
Release : 2014-10-08
ISBN : 1447165039
Language : En, Es, Fr & De

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Book Description :

This book aims to provide a single reference source on levodopa-induced dyskinesias (LID) from ‘bench to bedside’. Initial chapters review the clinical features and phenomenology of LID with video examples; epidemiology and genetic risk factors for LID are covered as a background to understanding risk factors for developing LID. The following chapters cover the latest preclinical studies aiming to understand the pathophysiology of LID at the cellular, neurochemical, neurophysiological and circuitry level with detailed discussion of mechanisms and future directions to take the field forward; clinical studies from phase II to phase IV; on going RCTs in LID and evidence-based medicine reviews of treatment options. Levodopa-Induced Dyskinesia in Parkinson’s Disease is aimed at an international audience of movement disorder neurologists; neuroscientists; trainees and graduate and post-graduate students.

Curcumin in Health and Disease

Curcumin in Health and Disease Book
Author : Beatrice E. Bachmeier
Publisher : MDPI
Release : 2019-10-11
ISBN : 3039214497
Language : En, Es, Fr & De

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Book Description :

The plant-derived polyphenol curcumin has been used in promoting health and combating disease for thousands of years. Its therapeutic effects have been successfully utilized in Ayurvedic and Traditional Chinese Medicine in order to treat inflammatory diseases. Current results from modern biomolecular research reveal the modulatory effects of curcumin on a variety of signal transduction pathways associated with inflammation and cancer. In this context, curcumin’s antioxidant, anti-inflammatory, anti-tumorigenic, and even anti-metastatic activities are discussed. On the cellular level, the reduced activity of several transcription factors (such as NFkB or AP-1) and the suppression of inflammatory cytokines, matrix degrading enzymes, metastasis related genes and even microRNAs are reported. On functional levels, these molecular effects translate into reduced proliferative, invasive, and metastatic capacity, as well as induced tumor cell apoptosis. All these effects have been observed not only in vitro but also in animal models. In combination with anti-neoplastic drugs like Taxol, kinase inhibitors, and radiation therapy, curcumin potentiates the drugs’ therapeutic power and can protect against undesired side effects. Natural plant-derived compounds like curcumin have one significant advantage: They do not usually cause side effects. This feature qualifies curcumin for primary prevention in healthy persons with a predisposition to cancer, arteriosclerosis, or chronic inflammatory diseases. Nonetheless, curcumin is considered safe, although potential toxic effects stemming from high dosages, long-term intake, and pharmacological interactions with other compounds have yet to be assessed. This Special Issue examines in detail and updates current research on the molecular targets, protective effects, and modes of action of natural plant-derived compounds and their roles in the prevention and treatment of human diseases.

The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease

The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease Book
Author : Bharat B. Aggarwal,Young-Joon Surh,S. Shishodia
Publisher : Springer Science & Business Media
Release : 2007-08-06
ISBN : 0387464018
Language : En, Es, Fr & De

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Book Description :

The medicinal uses of Curcumin (also called turmeric) have been known and described for more than 5000 years. A large body of recent research suggests that curcumin is potentially useful in the treatment of inflammatory diseases, through modulation of numerous molecular targets. This is the first monograph to focus on the potential use of curcumin in the treatment of cancer, diabetes, cardiovascular diseases, arthritis, Alzheimer’s, psoriasis and more.

Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases

Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases Book
Author : Tahira Farooqui,Akhlaq A. Farooqui
Publisher : Academic Press
Release : 2017-10-24
ISBN : 0128119608
Language : En, Es, Fr & De

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Book Description :

Role of the Mediterranean Diet in the Brain and Neurodegenerative Disease provides a comprehensive overview of the effects of all components of the Mediterranean diet on the brain, along with its beneficial effects in neurodegenerative diseases. It covers topics on neurodegenerative diseases (Alzheimer disease (AD), Parkinson disease, (PD) Huntington disease (HD) and Amyotrophic Lateral Sclerosis (ALS), also providing information on how cardiovascular disease, Type 2 Diabetes, and Metabolic Syndrome become risk factors for neurodegenerative diseases. This book focuses on how the Mediterranean diet suppresses oxidative stress and neuroinflammation in neurodegenerative diseases as well as signal transduction. The Mediterranean diet is characterized by the abundant consumption of olive oil, high consumption of plant foods (fruits, vegetables, pulses, cereals, nuts and seeds); frequent and moderate intake of wine (mainly with meals); moderate consumption of fish, seafood, yogurt, cheese, poultry and eggs; and low consumption of red meat and processed meat products. High consumption of dietary fiber, low glycemic index and glycemic load, anti-inflammatory effects, and antioxidant compounds may act together to produce favorable effects on health status. Collective evidence suggests that Mediterranean diet not only increases longevity by lowering cardiovascular disease, inhibiting cancer growth, but also by protecting the body from age-dependent cognitive decline. Comprehensively provides an overview of the effects of the Mediterranean diet on the brain and its beneficial effects in neurodegenerative diseases Discusses the relationship among Type 2 Diabetes, Metabolic Syndrome and Alzheimer's Disease, and the effect of the Mediterranean diet on normal aging, longevity, and other neurodegenerative diseases Focuses on how the Mediterranean diet suppresses oxidative stress and neuroinflammation in neurodegenerative disease

Neuroprotection in Alzheimer s Disease

Neuroprotection in Alzheimer s Disease Book
Author : Illana Gozes
Publisher : Academic Press
Release : 2016-12-30
ISBN : 0128037121
Language : En, Es, Fr & De

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Book Description :

Neuroprotection in Alzheimer’s Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management. This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Alzheimer's disease is the most common form of dementia, accounting for 60 to 80 percent of dementia cases. It is a progressive brain disease that slowly destroys memory, thinking skills, and eventually, even the ability to carry out the simplest tasks. It is characterized by death of synapses coupled to death nerve cells and brain degeneration which is manifested by loss of cognitive abilities. Understanding neuroprotection in Alzheimer’s disease will pave the path to better disease management and novel therapeutics. Comprehensive reference detailing neuroprotection in Alzheimer’s Disease, with details on nerve cell protection and new advances in disease management Combines the knowledge and points-of-view of both medical doctors and basic scientists, putting the subject at the forefront for further clinical development Edited by one of the leading researchers in Alzheimer’s Disease

Nutrition and Traumatic Brain Injury

Nutrition and Traumatic Brain Injury Book
Author : Institute of Medicine,Food and Nutrition Board,Committee on Nutrition, Trauma, and the Brain
Publisher : National Academies Press
Release : 2011-07-01
ISBN : 0309210089
Language : En, Es, Fr & De

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Book Description :

Traumatic brain injury (TBI) accounts for up to one-third of combat-related injuries in Iraq and Afghanistan, according to some estimates. TBI is also a major problem among civilians, especially those who engage in certain sports. At the request of the Department of Defense, the IOM examined the potential role of nutrition in the treatment of and resilience against TBI.

Paleo Principles

Paleo Principles Book
Author : Sarah Ballantyne
Publisher : Simon and Schuster
Release : 2017-11-07
ISBN : 1628609001
Language : En, Es, Fr & De

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Book Description :

From the New York Times bestselling author of The Paleo Approach and The Healing Kitchen comes the most comprehensive resource to date for those seeking a scientifically founded nutritional approach to optimal health. In her signature approachable yet comprehensive style, Sarah Ballantyne, PhD, has laid a complete foundation for understanding the principles of the Paleo template in order to inform and empower people’s day-to-day choices. Combined with an unprecedented collection of practical strategies, tips, and visual guides, plus more than 200 delicious recipes and twenty meal plans for a variety of health goals, this book is a one-stop-shop for nutrition nerds, health nuts, and gourmands alike. The Paleo diet is a nutrient-dense, anti-inflammatory whole-foods diet based on eating a variety of quality vegetables, meats, seafood, fruits, eggs, nuts, seeds, healthy fats, herbs, and spices. It is clinically proven to improve health by providing complete and balanced nutrition while omitting most processed and refined foods and empty calories. Far from being a historical re-enactment, the Paleo framework is derived from thousands of scientific studies that illuminate our understanding of which foods support health and which foods undermine it. Combined with attention to essential lifestyle factors like physical activity, sleep, and stress, the Paleo template is quite simply the most robust approach out there for optimal health, performance, and longevity! With the perfect balance of detailed explanations, accessible summaries of actionable information, and visual guides, Paleo Principles provides everything readers need to achieve their best health. Beyond a set of rules, this book teaches precisely why some foods are better choices than others while providing indispensable resources like food lists, shopping guides, and cooking how-tos. Health comes from more than just the foods on our plates, however, which is why Dr. Ballantyne also incorporates a focus on lifestyle factors known to improve health, including being active, getting enough sleep, managing stress, and connecting with community. People needn’t worry that following a Paleo-style diet will leave them feeling hungry or deprived. Healthy re-creations of family-friendly favorites, from pizza to pancakes, prove that you can regain your health and love every bite! Paleo Principles contains more than 200 nutritious Paleo recipes that are free of gluten, grain, dairy, legumes, and refined sugar—including kitchen basics, breakfasts, soups and salads, main dishes, side dishes, baked goods, and desserts—all labeled for the top eight allergen ingredients as well as other common food sensitivities, like FODMAPs and nightshades, and the Autoimmune Protocol. Adapt the Paleo template to serve your specific needs and health goals by using Paleo Principles’ guides on customizing macronutrient ratios, navigating gray-area foods, troubleshooting chronic illnesses and food sensitivities, transitioning to a Paleo-style diet, understanding your body’s individual response to different foods, and balancing Paleo priorities with competing interests for lifelong success. Combine these resources with twenty meal plans reflecting the most common health objectives, and you have the know-how to personalize your plan to fit your life. Join the millions of people taking back their health by following a Paleo lifestyle. Whether your goal is to lose weight, increase performance, reduce cardiovascular disease risk factors, prevent cancer, mitigate autoimmune disease, reverse diabetes, or simply achieve your best health, Paleo Principles gives you answers and a veritable toolkit to make lasting, positive change toward better health.

Neurotrophic Factors

Neurotrophic Factors Book
Author : Gary R. Lewin,Bruce D. Carter
Publisher : Springer Science & Business Media
Release : 2014-03-25
ISBN : 3642451063
Language : En, Es, Fr & De

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Book Description :

This book provides critical reviews of the role of neurotrophins and their receptors in a wide variety of diseases including neurodegenerative diseases like Huntington’s syndrome, cognitive function, psychiatric disorders such as clinical depression, Rett syndrome, motoneurone disease, spinal cord injury, pain, metabolic disease and cardiovascular disease. It also contains contributions from leaders in the field dealing with the basic biology, transcriptional and post-translational regulation of the neurotrophins and their receptors. The present book will review all recent areas of progress in the study of neurotrophins and their biological roles.

Oxidative Stress and Neurodegenerative Disorders

Oxidative Stress and Neurodegenerative Disorders Book
Author : G. Ali Qureshi,S. Hasan Parvez
Publisher : Elsevier
Release : 2007-03-22
ISBN : 9780080489490
Language : En, Es, Fr & De

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Book Description :

Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders. * Contains the latest information on the subject of neurodegenerative disorders * Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems

Preventing Alzheimer s

Preventing Alzheimer s Book
Author : William Rodman Shankle,Daniel G. Amen, M.D.
Publisher : Penguin
Release : 2005-06-07
ISBN : 9780399531606
Language : En, Es, Fr & De

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Book Description :

Drs. William Rodman Shankle and Daniel G. Amen reveal the latest research and treatment methods for preventing, delaying, and treating the devastation of Alzheimer's disease.

Advanced Plasma Technology

Advanced Plasma Technology Book
Author : Riccardo d'Agostino,Pietro Favia,Yoshinobu Kawai,Hideo Ikegami,Noriyoshi Sato,Farzaneh Arefi-Khonsari
Publisher : John Wiley & Sons
Release : 2008-09-08
ISBN : 3527622195
Language : En, Es, Fr & De

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Book Description :

A panel of internationally renowned scientists discuss the latest results in plasma technology. This volume has been compiled with both a didactic approach and an overview of the newest achievements for industrial applications. It is divided into two main sections. One is focused on fundamental technology, including plasma production and control, high-pressure discharges, modeling and simulation, diagnostics, dust control, and etching. The section on application technology covers polymer treatments, silicon solar cell, coating and spray, biomaterials, sterilization and waste treatment, plasma propulsion, plasma display panels, and anti-corrosion coatings. The result is an indispensable work for physicists, chemists and engineers involved in the field of plasma technology.

Stop Alzheimer s Now

Stop Alzheimer s Now  Book
Author : Bruce Fife
Publisher : Piccadilly Books, Ltd.
Release : 2016-04-11
ISBN : 0941599981
Language : En, Es, Fr & De

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Book Description :

Over 35 million people have dementia today. Each year 4.6 million new cases occur world-wide -- one new case every 7 seconds. Alzheimer's disease is the most common form of dementia. Parkinson's disease, another progressive brain disorder, affects about 4 million people world-wide. Millions more suffer with other neurodegenerative disorders. The number of people affected by these destructive diseases continues to increase every year. Dementia and other forms of neurodegeneration are not a part of the normal ageing process. The brain is fully capable of functioning normally for a lifetime, regardless of how long a person lives. While ageing is a risk factor for neurodegeneration, it is not the cause! Dementia and other neurodegenerative disorders are disease processes that can be prevented and successfully treated. This book outlines a program using ketone therapy and diet that is backed by decades of medical and clinical research and has proven successful in restoring mental function and improving both brain and overall health. You will learn how to prevent and even reverse symptoms associated with Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), Huntington's disease, epilepsy, diabetes, stroke, and various forms of dementia. The information in this book is useful not only for those who are suffering from neurodegenerative disease but for anyone who wants to be spared from ever encountering one or more of these devastating afflictions. These diseases don't just happen overnight. They take years, often decades, to develop. In the case of Alzheimer's disease, approximately 70 percent the brain cells responsible for memory are destroyed before symptoms become noticeable. You can stop Alzheimer's and other neurodegenerative diseases before they take over your life. The best time to start is now.

Dementia in Australia

Dementia in Australia Book
Author : Anonim
Publisher : AIHW
Release : 2012
ISBN : 9781742493497
Language : En, Es, Fr & De

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Book Description :

This report provides a comprehensive picture of dementia in Australia, illustrated by the latest available data and information on trends over time.

A Paradigm Shift to Prevent and Treat Alzheimer s Disease

A Paradigm Shift to Prevent and Treat Alzheimer s Disease Book
Author : Howard Friel,Sally A. Frautschy
Publisher : Academic Press
Release : 2017-07-18
ISBN : 012812279X
Language : En, Es, Fr & De

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Book Description :

A Paradigm Shift to Prevent and Treat Alzheimer’s Disease: From Monotargeting Pharmaceuticals to Pleiotropic Plant Polyphenols is the first book to systematically exhibit the powerful pleiotropic pharmacological effects on Alzheimer’s disease of plant-based compounds from ancient foods that humans have been consuming safely with substantial health benefits for thousands of years. These plant-based compounds include curcuminoids from turmeric, resveratrol from red wine and grape seed extract from other grape products, epigallocatechin-gallate (EGCG) from green tea, and oleocanthal and oleuropein from olive oil, in addition to a special extract, EGb 761, from the leaves of Ginkgo biloba, the oldest living species of tree on earth. This book also presents a new analytical framework that convincingly favors a multi-targeting ("pleiotropic") approach to the prevention and treatment of complex chronic diseases, in contrast to the mono-targeting of the pharmaceutical model. A Paradigm Shift to Prevent and Treat Alzheimer’s Disease is a unique and exciting resource for pharmaceutical scientists, pharmacologists, neurologists, general practitioners, research scientists in various medical and life sciences, healthcare professionals in clinical and executive positions, conventional medical schools, schools of naturopathic medicine, healthcare and medical journalists, executives in both national public healthcare systems and private insurers, and informed general readers. Presents carefully compiled evidence supporting the need to shift from pharmaceutical-based mono-targeting to plant polyphenol-based pleiotropic targeting for the prevention and treatment of Alzheimer’s disease Includes valuable tables that aggregate pleiotropic pharmacological effects of the plant polyphenols on Alzheimer’s disease-related pathogenic hallmarks Highlights regulatory aspects and discusses the challenges and potential solutions with respect to bioavailability of certain plant polyphenols