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Translational Neuroimaging

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Translational Neuroimaging

Translational Neuroimaging Book
Author : Robert A. McArthur
Publisher : Academic Press
Release : 2012-10-26
ISBN : 0123869455
Language : En, Es, Fr & De

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Book Description :

With a unique collaborative approach of author teams from industry and academia, Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment provides an integrated perspective of small animal and human brain imaging in the development of translational models and biomarkers to understand human neuropsychiatric disorders and to accelerate the development of novel drugs for their treatment. The book provides chapters on methodical issues in human and animal neuroimaging translational research, allowing a beginning researcher or researcher outside of his/her expertise the opportunity to understand the background of translational research and the use of imaging in studies. Additional chapters cover selected neuropsychiatric disorders, examining the role of neuroimaging in translational model development from the preclinical, animal model perspective as well as from the human experimental medicine perspective. Offering an accompanying website with illustrations and text available for further knowledge and presentations, Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment appeals to researchers working in and studying CNS drug treatment research across industry and academia. Provides a background of translational research and the use of imaging in studies Dicusses the application of imaging in specific disease states Features an accompanying website with additional images and text

Progress in Translational Neuroimaging Integrating Pathways Systems and Phenomenology in Neurology and Psychiatry

Progress in Translational Neuroimaging  Integrating Pathways  Systems and Phenomenology in Neurology and Psychiatry Book
Author : Drozdstoy Stoyanov,Paolo Brambilla
Publisher : Frontiers Media SA
Release : 2020-08-21
ISBN : 2889639541
Language : En, Es, Fr & De

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Book Description :

Download Progress in Translational Neuroimaging Integrating Pathways Systems and Phenomenology in Neurology and Psychiatry book written by Drozdstoy Stoyanov,Paolo Brambilla, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Translational Neuroimaging

Translational Neuroimaging Book
Author : Robert A. McArthur
Publisher : Academic Press
Release : 2012-10-05
ISBN : 0123869978
Language : En, Es, Fr & De

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Book Description :

Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment combines the experience of academic, clinical and industrial neuroimagers in a unique collaborative approach to provide an integrated perspective of the use of small animal and human brain imaging in developing and validating translational models and biomarkers for the study and treatment of neuropsychiatric disorders. Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment examines the translational role of neuroimaging in model development from preclinical animal models, to human experimental medicine, and finally to clinical studies. The focus of this book is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This book covers methodical issues in human and animal neuroimaging translational research as well as detailed applied examples of the use of neuroimaging in neuropsychiatric disorders and the development of drugs for their treatment. Offering an accompanying website with illustrations and text available for further knowledge and presentations, Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment appeals to non-clinical and clinical neuroscientists working in and studying neuropsychiatric disorders and their treatment as well as providing the novice researcher or researcher outside of his/her expertise the opportunity to understand the background of translational research and the use of imaging in this field. Provides a background to translational research and the use of brain imaging in neuropsychiatric disorders Critical discussion of the potential and limitations of neuroimaging as a translational tool for identifying and validating biomarkers Identifies cross species neurosystems and common endpoints necessary to help accelerate CNS drug discovery and development for the treatment of neuropsychiatric disorders Features an accompanying website with additional images and text

Translational Neuropsychopharmacology

Translational Neuropsychopharmacology Book
Author : Trevor W. Robbins,Barbara J. Sahakian
Publisher : Springer
Release : 2016-09-22
ISBN : 3319339133
Language : En, Es, Fr & De

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Book Description :

This book covers wide areas of animal and human psychopharmacology with clinical utility in the treatment of psychiatric and neurological (e.g Alzheimer's disease) disorders. The main theme is to develop a new paradigm for drug discovery that questions the claim that animal models or assays fail adequately to predict Phase 3 clinical trials. A new paradigm is advocated that stresses the importance of intermediate staging points between these extremes that depend on suitable translation of findings from animal studies to Phase 1 or Phase 2 studies utilising experimental medicine.

Translational Medicine in CNS Drug Development

Translational Medicine in CNS Drug Development Book
Author : George G. Nomikos,Douglas E. Feltner
Publisher : Academic Press
Release : 2019-06-18
ISBN : 0128031646
Language : En, Es, Fr & De

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Book Description :

Translational Medicine in CNS Drug Development, Volume 29, is the first book of its kind to offer a comprehensive overview of the latest developments in translational medicine and biomarker techniques. With extensive coverage on all aspects of biomarkers and personalized medicine, and numerous chapters devoted to the best strategies for developing drugs that target specific disorders, this book presents an essential reference for researchers in neuroscience and pharmacology who need the most up-to-date techniques for the successful development of drugs to treat central nervous system disorders. Despite increases in the number of individuals suffering from CNS-related disorders, the development and approval of drugs for their treatment have been hampered by inefficiencies in advancing compounds from preclinical discovery to the clinic. However, in the past decades, game-changing strides have been made in our understanding of the pathophysiology of CNS disorders and the relationship of drug exposure in plasma and CNS to pharmacodynamic measures in both animals and humans. Includes comprehensive coverage of biomarker tools and the role of personalized medicine in CNS drug development Discusses strategies for drug development for a full range of CNS indications, with particular attention to neuropsychiatric and neurocognitive disorders Includes chapters written by international experts from industry and academia

The Neuroimaging of Brain Diseases

The Neuroimaging of Brain Diseases Book
Author : Christophe Habas
Publisher : Springer
Release : 2018-06-15
ISBN : 3319789260
Language : En, Es, Fr & De

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Book Description :

Notable experts in the field of neuroimaging provide comprehensive overviews of advances in functional and structural aspects of both common and uncommon brain disorders. Functional imaging is evolving quickly but researchers and clinicians do not always have a strong understanding of the fundamental basis of the imaging techniques that they use. By focusing on both structure and function this book will provide a strong foundation for emerging developments in the field.

The Charnoly Body

The Charnoly Body Book
Author : Sushil Sharma
Publisher : CRC Press
Release : 2019-01-30
ISBN : 1351366718
Language : En, Es, Fr & De

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Book Description :

Diversified physicochemical injuries trigger Charnoly body (CB) formation as pleomorphic, electron-dense, multi-lamellar stacks of nonfunctional mitochondrial membranes in the most vulnerable cell. Free radicals induce downregulation of mitochondrial DNA, microRNA, AgNOR, and epigenetics to trigger CB molecular pathogenesis. CB is eliminated by energy (ATP)-driven lysosome-dependent charnolophagy as a basic molecular mechanism of intracellular detoxification to prevent acute and chronic diseases. Accumulation of CB at the junction of axon hillock and charnolosome (CS) at the synapses causes cognitive impairments; whereas, nonspecific induction of CB causes GIT stress, myelosuppression, alopecia, neurotoxicity, cardiotoxicity, and infertility in multidrug-resistant malignancies. Hence, stem cell-specific CB, charnolophagy, and CS agonists/antagonists are introduced as novel charnolopharmacotherapeutics for the successful treatment of cardiovascular diseases, neurodegenerative diseases, infectious diseases, drug addiction, and cancer. Nanoparticles to improve drug delivery, CS exocytosis, and disease-specific spatiotemporal charnolosomics employing correlative and combinatorial bioinformatics boost mitochondrial bioenergetics through balanced diet, exercise, and antioxidants. The book will be of interest to medical scientists and practitioners.

Anxiety Disorders Advances in Research and Treatment 2011 Edition

Anxiety Disorders  Advances in Research and Treatment  2011 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-01-09
ISBN : 146493763X
Language : En, Es, Fr & De

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Book Description :

Anxiety Disorders: Advances in Research and Treatment: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Anxiety Disorders in a concise format. The editors have built Anxiety Disorders: Advances in Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Anxiety Disorders in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Anxiety Disorders: Advances in Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Brain States and Neural Mechanisms of Consciousness

Brain States and Neural Mechanisms of Consciousness Book
Author : Olivia Gosseries
Publisher : Frontiers Media SA
Release : 2022-09-30
ISBN : 2832501230
Language : En, Es, Fr & De

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Book Description :

Download Brain States and Neural Mechanisms of Consciousness book written by Olivia Gosseries, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Nervous System Diseases Advances in Research and Treatment 2012 Edition

Nervous System Diseases   Advances in Research and Treatment  2012 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-12-26
ISBN : 1464993319
Language : En, Es, Fr & De

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Book Description :

Nervous System Diseases—Advances in Research and Treatment: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Nervous System Diseases. The editors have built Nervous System Diseases—Advances in Research and Treatment: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Nervous System Diseases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Nervous System Diseases—Advances in Research and Treatment: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Targets Tracers and Translation Novel Radiopharmaceuticals Boost Nuclear Medicine

Targets  Tracers and Translation     Novel Radiopharmaceuticals Boost Nuclear Medicine Book
Author : Gerald Reischl
Publisher : MDPI
Release : 2019-09-20
ISBN : 303921313X
Language : En, Es, Fr & De

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Book Description :

This is the fourth Special Issue in Pharmaceuticals within the last six years dealing with aspects of radiopharmaceutical sciences. It demonstrates the significant interest and increasing relevance to ameliorate nuclear medicine imaging with PET or SPECT, and also radiotherapeutical procedures.Numerous targets and mechanisms have been identified and have been under investigation over the previous years, covering many fields of medical and clinical research. This development is well illustrated by the articles in the present issue, including 13 original research papers and one review, covering a broad range of actual research topics in the field of radiopharmaceutical sciences.

Imaging in CNS Drug Discovery and Development

Imaging in CNS Drug Discovery and Development Book
Author : David Borsook,Lino R. Beccera,Edward Bullmore,Richard J. Hargreaves
Publisher : Springer Science & Business Media
Release : 2010-03-10
ISBN : 1441901345
Language : En, Es, Fr & De

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Book Description :

Drug development today needs to balance agility, speed, and risk in defining probability of success for molecules, mechanisms, and therapeutic concepts. New techniques such as fMRI promise to be part of a sequence that could transform drug development. Although numerous review articles exist that discuss the use of imaging in drug development, no one source is available that combines the various techniques and includes a discussion of disease mapping. Imaging in CNS Drug Discovery and Development, Implications for Disease and Therapy will serve to distill the most salient developments in the use of imaging in drug development and disease mapping. It will launch evolving concepts that integrate new imaging technologies and paradigms with molecular medicine and molecular profiling ("monics") as well as consider the ethical issues that arise as a result of disease or state diagnosis and the use of imaging in the public eye.

Brain Imaging Methods Editor s Pick 2021

Brain Imaging Methods Editor   s Pick 2021 Book
Author : Vince D. Calhoun
Publisher : Frontiers Media SA
Release : 2021-07-01
ISBN : 2889669653
Language : En, Es, Fr & De

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Book Description :

Download Brain Imaging Methods Editor s Pick 2021 book written by Vince D. Calhoun, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Translational Research in Traumatic Brain Injury

Translational Research in Traumatic Brain Injury Book
Author : Daniel Laskowitz,Gerald Grant
Publisher : CRC Press
Release : 2015-12-01
ISBN : 1498766579
Language : En, Es, Fr & De

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Book Description :

Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.

Pain Models

Pain Models Book
Author : Hermann O. Handwerker,Lars Arendt-Nielson
Publisher : Lippincott Williams & Wilkins
Release : 2015-06-01
ISBN : 1496331931
Language : En, Es, Fr & De

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Book Description :

The neurobiology and mechanisms discovered in animals often do not translate to patients with a chronic pain condition. To help researchers and clinicians develop and use models that can help translate data from animals into humans, this book presents experimental animal models, with a focus on how they may translate into humans human experimental pain models, including details about pain induction and assessment human surrogate pain models clinical applications of pain models models that may link mechanisms of pain and pruritus Pain Models contains 29 chapters by internationally recognized experts. It is a comprehensive survey of pain models at different levels, and commentaries by clinicians directly address clinical perspectives. This unique book is unprecedented in its content. It's a quick reminder of the hard work needed to investigate the complex issue of pain perception. With the advent of increasingly sensitive noninvasive investigational tools, the authors want readers to know that basic research is still needed to help develop new drugs. This book will enrich anyone who wishes to know all that goes into conducting pain research with a lab-based pain model.

MRI in Psychiatry

MRI in Psychiatry Book
Author : Christoph Mulert,Martha E. Shenton
Publisher : Springer
Release : 2014-06-27
ISBN : 3642545424
Language : En, Es, Fr & De

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Book Description :

This is the first comprehensive textbook on the use of MRI in psychiatry covering imaging techniques, brain systems and a review of findings in different psychiatric disorders. The book is divided into three sections, the first of which covers in detail all the major MRI-based methodological approaches available today, including fMRI, EEG-fMRI, DTI and MR spectroscopy. In addition, the role of MRI in imaging genetics and combined brain stimulation and imaging is carefully explained. The second section provides an overview of the different brain systems that are relevant for psychiatric disorders, including the systems for perception, emotion, cognition and reward. The final part of the book presents the MRI findings that are obtained in all the major psychiatric disorders using the previously discussed techniques. Numerous carefully chosen images support the informative text, making this an ideal reference work for all practitioners and trainees with an interest in this flourishing field.

Psychiatry in Practice

Psychiatry in Practice Book
Author : Andrea Fiorillo,Umberto Volpe,Dinesh Bhugra
Publisher : Oxford University Press
Release : 2016-03-03
ISBN : 0191035599
Language : En, Es, Fr & De

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Book Description :

Psychiatry in Practice: Education, Experience, and Expertise provides detailed advice and useful tips for early career psychiatrists, and all others who wish to enhance their practical psychiatry skills. Each chapter is written by prominent early career psychiatrists from around the world, offering relevant and timely advice to those who are newly qualified, as well as a global perspective on the practical issues faced today. Covering a variety of topics from 'Psychiatric Emergencies' to 'Ethics and clinical practice in psychiatry', chapters include vignettes of scenarios that may be encountered, making this book pertinent and easily applicable to many early career situations. Skills related to personal management and managing resources are often not taught during training but are key to establishing a career in psychiatry - this book will help the new clinician to develop professionally. The emphasis on practicality ensures psychiatrists are prepared for the needs of the modern health service and society at large, and ensures patients across the world experience the best treatment available.

Next Generation Antidepressants

Next Generation Antidepressants Book
Author : Chad E. Beyer,Stephen M. Stahl
Publisher : Cambridge University Press
Release : 2010-05-20
ISBN : 0521760585
Language : En, Es, Fr & De

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Book Description :

The future of mood-disorder research: covering identification of new therapeutic targets, preclinical models, and medicinal chemistry opportunities.

International Review of Neurobiology

International Review of Neurobiology Book
Author : Ronald J. Bradley,R. Adron Harris,Peter Jenner
Publisher : Elsevier
Release : 2006-06-07
ISBN : 0080463525
Language : En, Es, Fr & De

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Book Description :

Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume is a collection of articles covering recent advances in the field of neurobiology. Topics covered include chromosome 22 deletion syndrome and schizophrenia; characterization of proteome of human cerebrospinal fluid; hormonal pathways regulating intermale and interfemale aggression; neuronal gap junctions; effects of genes and stress on the neurobiology of depression; quantitative imaging with teh MicroPET small-animal PET tomograph; understanding myelination through studying its evolution.