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Translational Medicine

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Translational Medicine

Translational Medicine Book
Author : Robert A. Meyers
Publisher : John Wiley & Sons
Release : 2018-07-16
ISBN : 3527336591
Language : En, Es, Fr & De

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Book Description :

This reference work gives a compete overview of the different stages of drug development using a translational approach. The book is structured in different parts, following the different stages in drug development. Almost half of the work is dedicated to core of drug discovery using a translational approach, the identification of appropriate targets and screening methods for the identification of compounds interacting with these targets. The rest of book covers the whole downstream pipeline after the identification of lead compounds, such as bioavailability issues, identification of appropriate drug delivery venues, production and scaling issues and preclinical trials. As has been the case with other works in the encyclopedia, the book is made up of long, comprehensive and authoritative chapters, written by outstanding researchers in the field.

Translational Medicine

Translational Medicine Book
Author : James Mittra,Christopher-Paul Milne
Publisher : CRC Press
Release : 2016-04-19
ISBN : 9814364843
Language : En, Es, Fr & De

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Book Description :

This book brings together a range of academic, industry and practitioner perspectives on translational medicine (TM). It enhances conceptual and practical understanding of the emergence and progress of the field and its potential impact on basic research, therapeutic development, and institutional infrastructure. In recognition of the various implications TM has for public health policy and commercial innovation, the book addresses the major systemic aspects of the field. The contributors explore the dynamic interactions and key challenges in translating new science into viable therapies for the clinic, which includes recognizing the importance of social, commercial, and regulatory environments in addition to good science.

Translational Medicine What Why and How An International Perspective

Translational Medicine   What  Why and How  An International Perspective Book
Author : B. Alving,K. Dai,S.H.H. Chan
Publisher : Karger Medical and Scientific Publishers
Release : 2012-12-21
ISBN : 3318022853
Language : En, Es, Fr & De

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Book Description :

This book is the first to provide an aerial view, as well as detailed information, on ‘how’ activities in translational medicine are under development in countries such as the USA, China, the UK, and Taiwan. Institutions in each country are training investigators to work as sophisticated interdisciplinary teams. Investigators from 11 US academic health centers explain how they are incentivizing collaborations through pilot project programs, forming partnerships with business schools to promote efficient management of basic and clinical research, creating ethical, high-value public-private (industry) partnerships, improving efficiency with utilization of informatics, and engaging the community in research. The essential role of evaluation is explained in a clear and concise manner. The readers will also learn about the role of private funding in Taiwan and the vision of the government in China in developing multiple translational research centers. The UK is developing methodical approaches to patient needs across their lifespans; ongoing innovation is encouraged through incubator programs. With the emphasis on open innovation and sharing, the concepts and practice of translational medicine are spreading rapidly on an international scale.

Translational Medicine

Translational Medicine Book
Author : Dennis Cosmatos,Shein-Chung Chow
Publisher : CRC Press
Release : 2008-12-17
ISBN : 9781584888734
Language : En, Es, Fr & De

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Book Description :

Examines Critical Decisions for Transitioning Lab Science to a Clinical Setting The development of therapeutic pharmaceutical compounds is becoming more expensive, and the success rates for getting such treatments approved for marketing and to the patients is decreasing. As a result, translational medicine (TM) is becoming increasingly important in the healthcare industry – a means of maximizing the consideration and use of information collected as compounds transition from initial lab discovery, through pre-clinical testing, early clinical trials, and late confirmatory studies that lead to regulatory approval of drug release to patients. Translational Medicine: Strategies and Statistical Methods suggests a process for transitioning from the initial lab discovery to the patient’s bedside with minimal disconnect and offers a comprehensive review of statistical design and methodology commonly employed in this bench-to-bedside research. Documents Alternative Research Approaches for Faster and More Accurate Data Judgment Calls Elaborating on how to introduce TM into clinical studies, this authoritative work presents a keen approach to building, executing, and validating statistical models that consider data from various phases of development. It also delineates a truly translational example to help bolster understanding of discussed concepts. This comprehensive guide effectively demonstrates how to overcome obstacles related to successful TM practice. It contains invaluable information for pharmaceutical scientists, research executives, clinicians, and biostatisticians looking to expedite successful implementation of this important process.

Translational Medicine and Drug Discovery

Translational Medicine and Drug Discovery Book
Author : Bruce H. Littman,Rajesh Krishna
Publisher : Cambridge University Press
Release : 2011-01-31
ISBN : 113949872X
Language : En, Es, Fr & De

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Book Description :

This book, edited by two innovative leaders in the field, focuses on the new discipline of translational medicine as it pertains to drug development within the pharmaceutical and biotechnology industry. Translational medicine seeks to translate biological and molecular knowledge of disease and how drugs work into innovative development strategies that reduce the cost and increase the speed of delivering new medicines for patients. This book outlines general strategies, biomarker development, imaging tools, translational human models and examples of their application to real drug development. The latest thinking is presented by researchers from many of the world's leading drug development companies, including Pfizer, Merck, Eli Lilly, Abbott and Novartis, as well as academic institutions and public-private partnerships that support translational research. This book is essential for anyone interested in translational medicine from a variety of backgrounds: university institutes, medical schools, pharmaceutical companies and drug development researchers and decision-makers.

Handbook of translational medicine

Handbook of translational medicine Book
Author : Josep M. Llovet
Publisher : Edicions Universitat Barcelona
Release : 2016-10-05
ISBN : 8447540308
Language : En, Es, Fr & De

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Book Description :

This handbook aims to capture the basic concepts of translational medicine, understood as a branch of the biomedical field that translates discoveries into the clinical setting. This discipline is currently closing the gap between basic science and clinical research. The book is intended to be straightforward, easy-to-read, intelligible and practical. It describes the basic principles of translational medicine, including major advances in genomics, new technologies, the processing of big data and biobanks. Regarding the biological foundations of translational medicine, we address concepts related to the molecular basis of cancer, inflammation, angiogenesis, stem cells and experimental models. More specifically on translational medicine, we present discoveries and breakthroughs in oncology, neuroscience, metabolic and systemic diseases, and public health. Finally, we have specific sections focused on clinical trials and biomarkers in the genomic era, advances in imaging techniques and entrepreneurship and innovation. Our purpose is to offer a manageable text to guide graduate and post-graduate students, professionals and researchers in biomedicine through the major technologies and advances that have occurred in the translational field. It is also intended to aid residents, fellows and physician-scientists working in hospitals and academic institutions.

Biomaterials in Translational Medicine

Biomaterials in Translational Medicine Book
Author : Lei Yang,Sarit Bhaduri,Thomas J. Webster
Publisher : Academic Press
Release : 2018-11-30
ISBN : 012813478X
Language : En, Es, Fr & De

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Book Description :

Biomaterials in Translational Medicine delivers timely and detailed information on the latest advances in biomaterials and their role and impact in translational medicine. Key topics addressed include the properties and functions of these materials and how they might be applied for clinical diagnosis and treatment. Particular emphasis is placed on basic fundamentals, biomaterial formulations, design principles, fabrication techniques and transitioning bench-to-bed clinical applications. The book is an essential reference resource for researchers, clinicians, materials scientists, engineers and anyone involved in the future development of innovative biomaterials that drive advancement in translational medicine. Systematically introduces the fundamental principles, rationales and methodologies of creating or improving biomaterials in the context of translational medicine Includes the translational or commercialization status of these new biomaterials Provides the reader with enough background knowledge for a fundamental grip of the difficulties and technicalities of using biomaterial translational medicine Directs the reader on how to find other up-to-date sources (i.e. peer reviewed journals) in the field of translational medicine and biomaterials

Dictionary of Stem Cells Regenerative Medicine and Translational Medicine

Dictionary of Stem Cells  Regenerative Medicine  and Translational Medicine Book
Author : Frank J. Dye
Publisher : John Wiley & Sons
Release : 2017-02-15
ISBN : 1118867750
Language : En, Es, Fr & De

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Book Description :

Stem cells, regenerative medicine, and translational medicine, are all areas of burgeoning basic research and clinical application. This dictionary includes the fundamental terminology of each of these areas, the major discoveries and significant scientists that comprise the history and current development of the field, as well as a number of concepts. The vocabulary is presented within the broader lexicon of developmental biology and embryology, which provides context for these three fields. Topics covered range from stem cells (embryonic, adult, and iPSCs) to teratology. The inclusion of extensive cross-referencing of the terms will enable readers to broaden their understanding of them. The Dictionary of Stem Cells, Regenerative Medicine, and Translational Medicine will provide both the basic background terminology needed by pre-health professions/biology major undergraduate students and early-stage graduate students, as well as being a valuable reference for university professors, researchers and peers in related disciplines.

Cell Biology and Translational Medicine Volume 1

Cell Biology and Translational Medicine  Volume 1 Book
Author : Kursad Turksen
Publisher : Springer
Release : 2018-08-21
ISBN : 3319938673
Language : En, Es, Fr & De

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Book Description :

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. With a goal to accelerate advances by timely information exchange, this new book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series is launched. Emerging areas of regenerative medicine and translational aspects of stem cells will be covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the first volume of a continuing series.

Cell Biology and Translational Medicine Volume 5

Cell Biology and Translational Medicine  Volume 5 Book
Author : Kursad Turksen
Publisher : Springer
Release : 2019-05-31
ISBN : 9783030175887
Language : En, Es, Fr & De

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Book Description :

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the fifth volume of a continuing series.

Carotenoids and Vitamin A in Translational Medicine

Carotenoids and Vitamin A in Translational Medicine Book
Author : Olaf Sommerburg,Werner Siems,Klaus Kraemer
Publisher : CRC Press
Release : 2013-04-24
ISBN : 1439855277
Language : En, Es, Fr & De

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Book Description :

Vitamin A (retinol) is an essential dietary compound with myriad metabolic and regulatory functions. Deficiency can result in vision problems, compromised immune responses, and a host of other medical issues. More than 600 carotenoids have been identified in plants, algae, fungi, and bacteria, and around 50 carotenoids—including β-carotene—can be converted into vitamin A. Carotenoids and Vitamin A in Translational Medicine reviews the medical use of carotenoids and vitamin A in cancer; diseases of the skin, eye, ear, and lung; and inflammatory bowel and metabolic diseases. It also discusses the analytics of carotenoids and the supply of carotenoids and vitamin A in developing countries. Serving a broad community of researchers and practitioners conducting basic and clinical analysis on carotenoids and vitamin A for medical purposes, the book evaluates basic research, epidemiological studies, and clinical trials in the field. It updates information on the worldwide problem of vitamin A deficiency and discusses extensively the pros and cons of carotenoid supplementation in cancer. The authors provide a comprehensive overview of the efforts made in the field of carotenoid research with respect to translational medicine and present the future outlook on carotenoids as new therapeutic agents. It is the editors’ intent through the contributions in this volume to expand this important discussion on therapeutic approaches using carotenoids and retinoids. In doing so, they hope to enhance the quality of research which brings safe, effective, and clinically proven medicines to patients.

Cell Biology and Translational Medicine Volume 9

Cell Biology and Translational Medicine  Volume 9 Book
Author : Kursad Turksen
Publisher : Springer Nature
Release : 2020-08-27
ISBN : 3030549178
Language : En, Es, Fr & De

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Book Description :

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the ninth volume of a continuing series.

Clinical and Translational Medicine

Clinical and Translational Medicine Book
Author : Anna Garner
Publisher : Unknown
Release : 2019-06-12
ISBN : 9781632428400
Language : En, Es, Fr & De

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Book Description :

Clinical and translational medicine refers to the therapeutic clinical potential and application of translational research that seeks to develop the understanding of mechanisms and treatments of human diseases. The clinical variation between diseases, biomarkers, pathogenesis and therapies are also highlighted through studies of clinical and translational medicine. This is a critical and core component of the full-spectrum of biomedical research. Translational medicine refers to an area of research that seeks to determine the relevance of novel discoveries in the biological science to human disease. It also integrates new knowledge in clinical practice and clinical observations into scientific knowledge. Hence, translational research, facilitates the generation of novel hypotheses and disease characterization based on direct human observation. Translational medicine can work to expedite the incorporation of novel endpoints into clinical testing, thus shortening the duration of clinical trials. This book brings forth some of the most innovative concepts and elucidates the unexplored aspects of clinical and translational medicine. The ever growing need of advanced technology is the reason that has fueled the research in this field in recent times. A number of latest researches have been included to keep the readers up-to-date with the global concepts in this area of study.

Translational Medicine in CNS Drug Development

Translational Medicine in CNS Drug Development Book
Author : George G. Nomikos,Douglas E. Feltner
Publisher : Academic Press
Release : 2019-06-18
ISBN : 0128031646
Language : En, Es, Fr & De

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Book Description :

Translational Medicine in CNS Drug Development, Volume 29, is the first book of its kind to offer a comprehensive overview of the latest developments in translational medicine and biomarker techniques. With extensive coverage on all aspects of biomarkers and personalized medicine, and numerous chapters devoted to the best strategies for developing drugs that target specific disorders, this book presents an essential reference for researchers in neuroscience and pharmacology who need the most up-to-date techniques for the successful development of drugs to treat central nervous system disorders. Despite increases in the number of individuals suffering from CNS-related disorders, the development and approval of drugs for their treatment have been hampered by inefficiencies in advancing compounds from preclinical discovery to the clinic. However, in the past decades, game-changing strides have been made in our understanding of the pathophysiology of CNS disorders and the relationship of drug exposure in plasma and CNS to pharmacodynamic measures in both animals and humans. Includes comprehensive coverage of biomarker tools and the role of personalized medicine in CNS drug development Discusses strategies for drug development for a full range of CNS indications, with particular attention to neuropsychiatric and neurocognitive disorders Includes chapters written by international experts from industry and academia

Cell Biology and Translational Medicine Volume 8

Cell Biology and Translational Medicine  Volume 8 Book
Author : Kursad Turksen
Publisher : Springer Nature
Release : 2020-06-09
ISBN : 3030458938
Language : En, Es, Fr & De

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Book Description :

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the eight volume of a continuing series.

Cell Biology and Translational Medicine Volume 7

Cell Biology and Translational Medicine  Volume 7 Book
Author : Kursad Turksen
Publisher : Springer Nature
Release : 2020-02-03
ISBN : 3030378454
Language : En, Es, Fr & De

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Book Description :

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the seventh volume of a continuing series.

Cell Biology and Translational Medicine Volume 6

Cell Biology and Translational Medicine  Volume 6 Book
Author : Kursad Turksen
Publisher : Springer Nature
Release : 2020-01-09
ISBN : 3030328236
Language : En, Es, Fr & De

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Book Description :

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the sixth volume of a continuing series.

The Silent Cry How to Turn Translational Medicine Towards Patients and Unmet Medical Needs

The Silent Cry  How to Turn Translational Medicine Towards Patients and Unmet Medical Needs Book
Author : Manuela Battaglia,Berent Prakken,Norman D. Rosenblum,Salvatore Albani
Publisher : Frontiers Media SA
Release : 2020-05-12
ISBN : 2889636798
Language : En, Es, Fr & De

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Book Description :

Download The Silent Cry How to Turn Translational Medicine Towards Patients and Unmet Medical Needs book written by Manuela Battaglia,Berent Prakken,Norman D. Rosenblum,Salvatore Albani, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Neurotherapeutics in the Era of Translational Medicine

Neurotherapeutics in the Era of Translational Medicine Book
Author : Richard A. Smith,Brian K. Kaspar,Clive N. Svendsen
Publisher : Academic Press
Release : 2020-11-28
ISBN : 0128172746
Language : En, Es, Fr & De

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Book Description :

For the first time in history, there is now hope for treating neurological disorders that had previously been considered untreatable. The remarkable confluence of events that has heralded this is the focus of Neurotherapeutics in the Era of Translational Medicine. This anthology, written by many of the prominent scientists and researchers in the field of biotechnology, recounts the breathtaking advances that are revolutionizing treatment for disorders such as amyotrophic lateral sclerosis‎, spinal muscular atrophy, multiple sclerosis, Parkinson’s disease, myasthenia gravis, migraine, and glioblastoma. The "story behind the story" of these translational efforts is told, with authors depicting the ups and downs encountered on the path of their drug discovery and development effort. In parallel with this path, advances in identifying novel biomarkers and disease models are summarized, as are contemporary issues focusing on clinical trial design, bioethics, innovative funding strategies, and collaborations between government and academia in an effort to facilitate breakthrough treatments. The book is written by members of the biotech and pharmaceutical ecosystem for those who belong to it and aspire to become part of it. Comprehensive review on the progress of translational research in neurotherapeutics for neurologic disorders Discusses important issues in clinical trials such as design and ethical issues Written for neuroscientists, neurologists and pharmacologists

Nasopharyngeal Carcinoma

Nasopharyngeal Carcinoma Book
Author : Pierre Busson
Publisher : Springer Science & Business Media
Release : 2013-03-12
ISBN : 1461459478
Language : En, Es, Fr & De

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Book Description :

This volume intends to contribute to “translational medicine and biology”. By this, we mean a bi-directional process whose aim is to develop knowledge from basic science towards diagnostic and therapeutic applications and reciprocally to raise new questions for basic scientists. One general requirement for translational research is to establish a multidisciplinary knowledge base shared by the actors of various specialties. This is precisely the aim of the 12 chapters of this book. It will be useful for scientists, including PhD students, who want to become more familiar with the main concepts of NPC pathology, medical imaging and current therapeutics. Conversely, medical doctors who want to update their knowledge of NPC biology will benefit from chapters on viral and cellular oncogenesis and various aspects of host-tumor interactions.