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Translational Medicine In Cns Drug Development

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Translational Medicine in CNS Drug Development

Translational Medicine in CNS Drug Development Book
Author : George G. Nomikos,Douglas E. Feltner
Publisher : Academic Press
Release : 2019-06-18
ISBN : 0128031646
Language : En, Es, Fr & De

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Book Description :

Translational Medicine in CNS Drug Development, Volume 29, is the first book of its kind to offer a comprehensive overview of the latest developments in translational medicine and biomarker techniques. With extensive coverage on all aspects of biomarkers and personalized medicine, and numerous chapters devoted to the best strategies for developing drugs that target specific disorders, this book presents an essential reference for researchers in neuroscience and pharmacology who need the most up-to-date techniques for the successful development of drugs to treat central nervous system disorders. Despite increases in the number of individuals suffering from CNS-related disorders, the development and approval of drugs for their treatment have been hampered by inefficiencies in advancing compounds from preclinical discovery to the clinic. However, in the past decades, game-changing strides have been made in our understanding of the pathophysiology of CNS disorders and the relationship of drug exposure in plasma and CNS to pharmacodynamic measures in both animals and humans. Includes comprehensive coverage of biomarker tools and the role of personalized medicine in CNS drug development Discusses strategies for drug development for a full range of CNS indications, with particular attention to neuropsychiatric and neurocognitive disorders Includes chapters written by international experts from industry and academia

Animal and Translational Models for CNS Drug Discovery Psychiatric Disorders

Animal and Translational Models for CNS Drug Discovery  Psychiatric Disorders Book
Author : Robert A. McArthur,Franco Borsini
Publisher : Academic Press
Release : 2008-11-17
ISBN : 008092039X
Language : En, Es, Fr & De

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Book Description :

Psychiatric Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for psychiatric disorders such as anxiety, obsessive-compulsive disorder, depression, schizophrenia, bipolar disorder, ADHD, and autistic spectrum disorder. Psychiatric Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the first volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, and is also available for purchase individually. Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process Critical evaluation of animal and translational models improving transition from drug discovery and clinical development Emphasizes what results mean to the overall drug discovery process Explores issues in clinical trial design and conductance in each therapeutic area Psychiatric Disorders is available for purchase individually.

Translational Medicine and Drug Discovery

Translational Medicine and Drug Discovery Book
Author : Bruce H. Littman,Rajesh Krishna
Publisher : Cambridge University Press
Release : 2011-01-31
ISBN : 113949872X
Language : En, Es, Fr & De

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Book Description :

This book, edited by two innovative leaders in the field, focuses on the new discipline of translational medicine as it pertains to drug development within the pharmaceutical and biotechnology industry. Translational medicine seeks to translate biological and molecular knowledge of disease and how drugs work into innovative development strategies that reduce the cost and increase the speed of delivering new medicines for patients. This book outlines general strategies, biomarker development, imaging tools, translational human models and examples of their application to real drug development. The latest thinking is presented by researchers from many of the world's leading drug development companies, including Pfizer, Merck, Eli Lilly, Abbott and Novartis, as well as academic institutions and public-private partnerships that support translational research. This book is essential for anyone interested in translational medicine from a variety of backgrounds: university institutes, medical schools, pharmaceutical companies and drug development researchers and decision-makers.

Imaging in CNS Drug Discovery and Development

Imaging in CNS Drug Discovery and Development Book
Author : David Borsook,Lino R. Beccera,Edward Bullmore,Richard J. Hargreaves
Publisher : Springer Science & Business Media
Release : 2010-03-10
ISBN : 1441901345
Language : En, Es, Fr & De

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Book Description :

Drug development today needs to balance agility, speed, and risk in defining probability of success for molecules, mechanisms, and therapeutic concepts. New techniques such as fMRI promise to be part of a sequence that could transform drug development. Although numerous review articles exist that discuss the use of imaging in drug development, no one source is available that combines the various techniques and includes a discussion of disease mapping. Imaging in CNS Drug Discovery and Development, Implications for Disease and Therapy will serve to distill the most salient developments in the use of imaging in drug development and disease mapping. It will launch evolving concepts that integrate new imaging technologies and paradigms with molecular medicine and molecular profiling ("monics") as well as consider the ethical issues that arise as a result of disease or state diagnosis and the use of imaging in the public eye.

Modern CNS Drug Discovery

Modern CNS Drug Discovery Book
Author : Rudy Schreiber
Publisher : Springer Nature
Release : 2021-06-17
ISBN : 3030623513
Language : En, Es, Fr & De

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Book Description :

This textbook provides a comprehensive overview of the currently used concepts, approaches and technologies in the discovery and development of new treatments for the full spectrum of disorders of the central nervous system. It guides the reader through all essential steps, from finding an innovative idea, to the registration of a new drug. Divided into four sections, the book starts by presenting a broad perspective on current approaches in central nervous system (CNS) drug discovery. The second section addresses the generation of ideas for the identification of targets and novel treatment strategies; covers core functions in early discovery, and provides an example of a novel treatment paradigm: brain stimulation. The third section highlights strategies and technologies in translational CNS drug discovery. In an effort to bridge the gap between discovery and clinical development, it also covers brain imaging, EEG and cognitive testing approaches. The fourth section extensively discusses the clinical phase of drug development, covering the basics of early clinical testing for psychopharmacological drugs. The book’s final chapter addresses the registration for newly developed drugs. Written by experts from academia and industry, the book covers important basics and best practices, as well as recent developments in drug discovery. Offering in-depth insights into the world of drug development, it represents essential reading for early researchers who want to prepare for a career in drug discovery in academia or industry.

Animal and Translational Models for CNS Drug Discovery Neurological disorders

Animal and Translational Models for CNS Drug Discovery  Neurological disorders Book
Author : Robert A. McArthur,Franco Borsini
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Animal and Translational Models for CNS Drug Discovery Neurological disorders book written by Robert A. McArthur,Franco Borsini, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Animal and Translational Models for CNS Drug Discovery 3 Vols Set

Animal and Translational Models for CNS Drug Discovery  3 Vols  Set Book
Author : Robert A. McArthur,Franco Borsini
Publisher : Unknown
Release : 2008-12
ISBN : 9780123738615
Language : En, Es, Fr & De

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Book Description :

Download Animal and Translational Models for CNS Drug Discovery 3 Vols Set book written by Robert A. McArthur,Franco Borsini, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Translating Molecules into Medicines

Translating Molecules into Medicines Book
Author : Shobha N. Bhattachar,John S. Morrison,Daniel R. Mudra,David M. Bender
Publisher : Springer
Release : 2017-04-21
ISBN : 3319500422
Language : En, Es, Fr & De

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Book Description :

Tackling translational medicine with a focus on the drug discovery development-interface, this book integrates approaches and tactics from multiple disciplines, rather than just the pharmaceutical aspect of the field. The authors of each chapter address the paradox between the molecular understanding of diseases, drug discovery, and drug development. Laying out the detailed trends from various fields, different chapters are dedicated to target engagement, toxicological safety assessments, and the compelling relationship of optimizing early clinical studies with design strategies. The book also highlights the importance of balancing the three pillars: sufficient efficacy, acceptable safety and appropriate pharmacokinetics, all of which are crucial to successful efforts in discovery and development. With discussions regarding the combined approaches of molecular research, personalized medicine, pre-clinical and clinical development, as well as targeted therapies—this compendium is a flexible fit, perfect for professionals in the pharmaceutical industry and related academic fields.

Neurotherapeutics in the Era of Translational Medicine

Neurotherapeutics in the Era of Translational Medicine Book
Author : Richard A. Smith,Brian K. Kaspar,Clive N. Svendsen
Publisher : Academic Press
Release : 2020-11-28
ISBN : 0128172746
Language : En, Es, Fr & De

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Book Description :

For the first time in history, there is now hope for treating neurological disorders that had previously been considered untreatable. The remarkable confluence of events that has heralded this is the focus of Neurotherapeutics in the Era of Translational Medicine. This anthology, written by many of the prominent scientists and researchers in the field of biotechnology, recounts the breathtaking advances that are revolutionizing treatment for disorders such as amyotrophic lateral sclerosis‎, spinal muscular atrophy, multiple sclerosis, Parkinson’s disease, myasthenia gravis, migraine, and glioblastoma. The "story behind the story" of these translational efforts is told, with authors depicting the ups and downs encountered on the path of their drug discovery and development effort. In parallel with this path, advances in identifying novel biomarkers and disease models are summarized, as are contemporary issues focusing on clinical trial design, bioethics, innovative funding strategies, and collaborations between government and academia in an effort to facilitate breakthrough treatments. The book is written by members of the biotech and pharmaceutical ecosystem for those who belong to it and aspire to become part of it. Comprehensive review on the progress of translational research in neurotherapeutics for neurologic disorders Discusses important issues in clinical trials such as design and ethical issues Written for neuroscientists, neurologists and pharmacologists

Drug Discovery Technology

Drug Discovery Technology Book
Author : Arjun Singh
Publisher : LAP Lambert Academic Publishing
Release : 2013
ISBN : 9783659415029
Language : En, Es, Fr & De

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Book Description :

Drug Discovery Technology is versatile research area in the field of medicine, biotechnology, and pharmacology. Drug Discovery Technologies has been established to provide comprehensive overviews of all the major modern techniques, tools and technologies used in drug discovery and development technology. The major techniques and tools are used in drug discovery, drug design, clinical trial studies and thematic issues describing novel approaches and cutting edge technologies used in all stages of drug discovery. The Book addresses the multidimensional challenges of drug discovery science including integration issues of the drug discovery process. This Book is essential for all science students, biological scientists and researchers involved in drug discovery who wish to keep abreast of all the modern techniques and technologies used in drug discovery and development. The major topics of discussion related to drug, discovery and therapy will included in the next volume: Pharmaceutical Research & Development, Translational Medicine, Regenerative Medicine, Enabling Technologies, Structural Biology, Drug Delivery & Targeting, Antiinfectives, Biologics, CNS Drug Discovery & Therapy.

Translational Neuroimaging

Translational Neuroimaging Book
Author : Robert A. McArthur
Publisher : Academic Press
Release : 2012-10-05
ISBN : 0123869978
Language : En, Es, Fr & De

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Book Description :

Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment combines the experience of academic, clinical and industrial neuroimagers in a unique collaborative approach to provide an integrated perspective of the use of small animal and human brain imaging in developing and validating translational models and biomarkers for the study and treatment of neuropsychiatric disorders. Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment examines the translational role of neuroimaging in model development from preclinical animal models, to human experimental medicine, and finally to clinical studies. The focus of this book is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This book covers methodical issues in human and animal neuroimaging translational research as well as detailed applied examples of the use of neuroimaging in neuropsychiatric disorders and the development of drugs for their treatment. Offering an accompanying website with illustrations and text available for further knowledge and presentations, Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment appeals to non-clinical and clinical neuroscientists working in and studying neuropsychiatric disorders and their treatment as well as providing the novice researcher or researcher outside of his/her expertise the opportunity to understand the background of translational research and the use of imaging in this field. Provides a background to translational research and the use of brain imaging in neuropsychiatric disorders Critical discussion of the potential and limitations of neuroimaging as a translational tool for identifying and validating biomarkers Identifies cross species neurosystems and common endpoints necessary to help accelerate CNS drug discovery and development for the treatment of neuropsychiatric disorders Features an accompanying website with additional images and text

Animal and Translational Models for CNS Drug Discovery Neurological Disorders

Animal and Translational Models for CNS Drug Discovery  Neurological Disorders Book
Author : Robert A. McArthur,Franco Borsini
Publisher : Academic Press
Release : 2008-11-18
ISBN : 9780080920382
Language : En, Es, Fr & De

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Book Description :

Neurological Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for neurological disorders such as neurofibromatosis, Alzheimer’s disease, Parkinson’s disease, Huntington disease, ALS, and the epilepsies. Neurological Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the second volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, which is also available for purchase individually. Clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process Critical evaluation of animal and translational models improving transition from drug discovery and clinical development Emphasis on what results mean to the overall drug discovery process Exploration of issues in clinical trial design and conductance in each therapeutic area

Translational Medicine

Translational Medicine Book
Author : James Mittra,Christopher-Paul Milne
Publisher : CRC Press
Release : 2016-04-19
ISBN : 9814364843
Language : En, Es, Fr & De

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Book Description :

This book brings together a range of academic, industry and practitioner perspectives on translational medicine (TM). It enhances conceptual and practical understanding of the emergence and progress of the field and its potential impact on basic research, therapeutic development, and institutional infrastructure. In recognition of the various implications TM has for public health policy and commercial innovation, the book addresses the major systemic aspects of the field. The contributors explore the dynamic interactions and key challenges in translating new science into viable therapies for the clinic, which includes recognizing the importance of social, commercial, and regulatory environments in addition to good science.

Peptide Drug Discovery and Development

Peptide Drug Discovery and Development Book
Author : Miguel Castanho,Nuno Santos
Publisher : John Wiley & Sons
Release : 2011-10-24
ISBN : 3527636749
Language : En, Es, Fr & De

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Book Description :

Filling a real knowledge gap, this handbook and ready reference is both modern and forward-looking in its emphasis on the "bench to bedside" translational approach to drug development. Clearly structured into three major parts, the book stakes out the boundaries of peptide drug development in the preclinical as well as clinical stages. The first part provides a general background and focuses on the characteristic strengths and weaknesses of peptide drugs. The second section contains five cases studies of peptides from diverse therapeutic fields, and the lessons to be learned from them, while the final part looks at new targets and opportunities, discussing several drug targets and diseases for which peptide drugs are currently being developed.

Animal and Translational Models for CNS Drug Discovery Reward deficit disorders

Animal and Translational Models for CNS Drug Discovery  Reward deficit disorders Book
Author : Robert A. McArthur,Franco Borsini
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Animal and Translational Models for CNS Drug Discovery Reward deficit disorders book written by Robert A. McArthur,Franco Borsini, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Animal and Translational Models for CNS Drug Discovery Reward Deficit Disorders

Animal and Translational Models for CNS Drug Discovery  Reward Deficit Disorders Book
Author : Robert A. McArthur,Franco Borsini
Publisher : Academic Press
Release : 2009-02-24
ISBN : 0080920403
Language : En, Es, Fr & De

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Book Description :

Reward Deficit Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for reward deficit disorders such as alcohol dependence, nicotine dependence, heroin and cocaine addiction, obesity, and gambling and impulse control disorders. Reward Deficit Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. Reward Deficit Disorders also has a section dedicated to the specifics of the regulatory aspects to abuse liability testing. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the third volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, which is also available for purchase individually. Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process Critical evaluation of animal and translational models improving transition from drug discovery and clinical development Emphasizes what results mean to the overall drug discovery process Explores issues in clinical trial design and conductance in each therapeutic area Neurological Disorders is available for purchase individually.

Drug Discovery and Translational Medicine

Drug Discovery and Translational Medicine Book
Author : Wilfried Dimpfel
Publisher : BoD – Books on Demand
Release : 2015-05-29
ISBN : 3739271590
Language : En, Es, Fr & De

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Book Description :

In collaboration with physicist and mathematician Hans Carlos Hofmann he developed the hard-software combination CATEEM® in 1989, which allows cartography of electric changes of the human brain in real time, not only for diagnostic purposes but also for therapy control in medicine and psychology. Recently, the technology has also been introduced into market research under the topic of “Neuromarketing”, where a combination of these brain maps “(enkephaloglyphs” obtained by Neurocode-Tracking) together with Eye-Tracking opens a new dimension of brain research. More than 100 publications proof the benefit of the technology in research and practice. The current book provides a representative overview on the use of neurophysiological methods during drug discovery aiming also at the need of saving animals. The holistic approach describes the feasibility of this goal and emphasizes the possibility to carry over parameters of drug effectiveness in rats to testing in humans. The use of identical parameters of drug induced changes of electric activity in rats and humans documents a very good example of translational medicine, which is not reached easily by use of any other method. In addition, large databases in rats and humans meanwhile allow yet unknown classifications of herbal medicines as well as elucidation of their mechanisms of action.

Drug Discovery and Translational Medicine

Drug Discovery and Translational Medicine Book
Author : Wilfried Dimpfel
Publisher : BoD – Books on Demand
Release : 2015-05-15
ISBN : 3738670394
Language : En, Es, Fr & De

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Book Description :

In collaboration with physicist and mathematician Hans Carlos Hofmann he developed the hard-software combination CATEEM® in 1989, which allows cartography of electric changes of the human brain in real time, not only for diagnostic purposes but also for therapy control in medicine and psychology. Recently, the technology has also been introduced into market research under the topic of “Neuromarketing”, where a combination of these brain maps “(enkephaloglyphs” obtained by Neurocode-Tracking) together with Eye-Tracking opens a new dimension of brain research. More than 100 publications proof the benefit of the technology in research and practice. The current book provides a representative overview on the use of neurophysiological methods during drug discovery aiming also at the need of saving animals. The holistic approach describes the feasibility of this goal and emphasizes the possibility to carry over parameters of drug effectiveness in rats to testing in humans. The use of identical parameters of drug induced changes of electric activity in rats and humans documents a very good example of translational medicine, which is not reached easily by use of any other method. In addition, large databases in rats and humans meanwhile allow yet unknown classifications of herbal medicines as well as elucidation of their mechanisms of action.

Translational Neuroscience

Translational Neuroscience Book
Author : James E. Barrett,Joseph T. Coyle,Michael Williams
Publisher : Cambridge University Press
Release : 2012-06-28
ISBN : 1139510304
Language : En, Es, Fr & De

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Book Description :

Translational neuroscience is at the heart of clinical advancement in the fields of psychiatry, neurology and neurodevelopmental disorders. Written and edited by leading scientists and clinicians, this is a comprehensive and authoritative analysis of this emerging strategy for developing more effective treatments for brain disorders. Introductory chapters bring together perspectives from both academia and industry, while subsequent sections focus on disease groups, including bipolar disorder and depression, attention deficit hyperactivity disorder, substance abuse, autism, Alzheimer's disease, pain, epilepsy, Parkinson's disease and multiple sclerosis. Each section includes topical introductory and summary chapters, providing an overview and synthesis of the field. Translational Neuroscience: Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders is an important text for clinicians, scientists and students in academic settings, government agencies and industry, as well as those working in the fields of public health and the behavioural sciences.

Essential CNS Drug Development

Essential CNS Drug Development Book
Author : Amir Kalali
Publisher : Cambridge University Press
Release : 2012-06-07
ISBN : 0521766060
Language : En, Es, Fr & De

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Book Description :

Presents the complicated process of CNS drug development in a way that is engaging and informative for professionals and students.