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Translational Glycobiology In Human Health And Disease

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Translational Glycobiology in Human Health and Disease

Translational Glycobiology in Human Health and Disease Book
Author : Michelle Kilcoyne,Lokesh Joshi
Publisher : Academic Press
Release : 2020-11-15
ISBN : 9780128196557
Language : En, Es, Fr & De

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Book Description :

Along with nucleic acids, proteins, and lipids, carbohydrates stand as one of four main components of cellular architecture. However, glycobiology (or carbohydrate bioscience) is little understood by non-experts, partly because carbohydrates are a complex, diverse class of molecules structurally and functionally. In recent years, advances in computational analytics (glycomics) have allowed us to better interpret and realize the importance of glycobiology in human health and disease, and glycans and their associated processes have been shown to play a significant role across a variety of disease types. As the biomedical sciences continue to adopt multi-omic and precision medicine approaches, a greater understanding of glycobiology is essential for maintaining healthy physiology and advancing disease treatment. Translational Glycobiology in Human Health and Disease offers a deep examination of glycobiology for experts and non-experts alike in areas ranging from the role of glycobiology in chronic and infectious diseases to advances in technologies for higher throughput analysis and diagnosis. While keeping human health in the forefront, this book integrates a thorough discussion of glycobiology fundamentals with its growing areas of application and societal impact. With emphasis throughout on the interdisciplinary nature of glycosciences, this book also features perspectives from the health, computational (glycoanalytics), materials, biopharmaceutical, and diagnostic sciences. Disease and speciality areas addressed include gycoimmunology, neuroglycobiology, commensal glycobiology, gut health, regenerative medicine and glycobiology, glycobiology and cancer, congenital disorders of glycosylation, infectious disease glycobiology, and parasite glycobiology. Computational approaches discussed, supporting the advance of new research, include advanced glycoanalytics, glycomics microarrays, glycoengineering, and glycol systems biology. Additionally, authors consider impact areas for society and public health, such as glycobiology and entrepreneurship, policy and regulatory requirements for glycosylation, future research, and translation to new diagnostics and drug discovery. Provides a deep, foundational overview of glycoscience and its translational potential, highlighting glycobiology's growing role in human health and disease study Examines a broad range of relevant disease areas and applications of glycobiology in policy and public health Features chapter contributions from leading, international experts in the field, fully integrating perspectives from the health, computational, materials, biopharmaceutical, and diagnostic sciencess

Post Translational Modifications in Health and Disease

Post Translational Modifications in Health and Disease Book
Author : Cecilio J. Vidal
Publisher : Springer Science & Business Media
Release : 2010-10-13
ISBN : 9781441963826
Language : En, Es, Fr & De

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Book Description :

Post-translational modifications serve many different purposes in several cellular processes such as gene expression, protein folding and transport to appropriate cell compartment, protein-lipid and protein-protein interactions, enzyme regulation, signal transduction, cell proliferation and differentiation, protein stability, recycling and degradation. Although several-hundred different modifications are known, the significance of many of them remains unknown. The enormous versatility of the modifications which frequently alter the physico-chemical properties of the respective proteins represents an extraordinary challenge in understanding their physiological role. Since essential cellular functions are regulated by protein modifications, an improvement of current understanding of their meaning might allow new avenues to prevent and/or alleviate human and animal diseases.

Progress in Molecular Biology and Translational Science

Progress in Molecular Biology and Translational Science Book
Author : N.A
Publisher : Academic Press
Release : 2019-03-22
ISBN : 012817739X
Language : En, Es, Fr & De

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Book Description :

Glycans and Glycosaminoglycans as Clinical Biomarkers and Therapeutics - Part A, Volume 162 in the Progress in Molecular Biology and Translational Science series provides informative monographs on a variety of research topics related to Glycans and glycosaminoglycans as clinical biomarkers and therapeutics. Topics in this update include Glycan-based Biomarkers for Diagnosis of Cancers and Other Diseases: Past, Present and Future, Desialylation in Diseases and its Application in Diagnostic and Therapeutic Development, Proteoglycans as Miscommunication Biomarkers for Cancer Diagnosis, Fucosylation in Cancer Biology and Its Clinical Applications, Retrospective Analysis of Glycan-Related Biomarkers Based on Clinical Laboratory Data in Two Medical Centers, and many related topics. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field

Genome Plasticity in Health and Disease

Genome Plasticity in Health and Disease Book
Author : N.A
Publisher : Academic Press
Release : 2020-04-08
ISBN : 0128178205
Language : En, Es, Fr & De

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Book Description :

Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-number variations, mobile elements, DNA methylation, histone modifications, transcription factors, non-coding RNAs, telomere dynamics and RNA editing. Later chapters explore disease relevance for cancer, as well as cardiovascular, neuropsychiatric, inflammatory, and endocrine disease, and associated pathways for drug discovery. Examines the role of genome plasticity across a range of disease types, from cardiovascular disease, to cancer and neuropsychiatric disorders Adopts an interdisciplinary approach, with expert contributions across the spectrum of basic science and disease relevance to drug discovery

Proceedings of 3rd Glycobiology World Congress 2017

Proceedings of 3rd Glycobiology World Congress 2017 Book
Author : ConferenceSeries
Publisher : ConferenceSeries
Release :
ISBN :
Language : En, Es, Fr & De

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Book Description :

June 26-28, 2017 London, UK Key Topics : Glycoprotein Technologies, Glyco Bioinformatics, Glycans in Drug Design, Glyco Immunology, Glyco Biomarkers, Glycobiology and Biotechnology, Glycans in Diseases and Therapeutics, Glycobiology in Personalized Medicine, Glycans in Genetic Disorders, Glycobiology and Structural Biology, Glyco Proteomics, Glycomics and Metabolomics, Mass Spectrometry in Proteome Research, Glycobiology, Genomics and Computational Systems Biology, Glycobiochemistry,

Bioinformatics for Glycobiology and Glycomics

Bioinformatics for Glycobiology and Glycomics Book
Author : Claus-Wilhelm von der Lieth,Thomas Luetteke,Martin Frank
Publisher : John Wiley & Sons
Release : 2009-10-01
ISBN : 9780470029602
Language : En, Es, Fr & De

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Book Description :

This book is the first to be dedicated to the bioinformatics of carbohydrates and glycoproteins. It provides an introduction to this emerging field of science both for the experimentalist working in glycobiology and glycomics, and also for the computer scientist looking for background information for the development of highly sophisticated algorithmic approaches. The book provides an overview of the state-of-the-art in the field, with reviews on databases, and the tools in use for analysis, interpretation, and prediction of the structures of complex carbohydrates, and demonstrates the value of bioinformatics for glycobiology. The availability of comprehensive databases and corresponding bioinformatics tools, to access and analyse the large amounts of experimental data relating to the structure of carbohydrates, will be a prerequisite for the success of the large-scale glycomics projects that aim to decipher new, so far unknown, biological functions of glycans. Efficient bioinformatics descriptions and tools can considerably enhance the efficiency of glycomics research, in terms of data quality, analysis and experimental costs. For a complete understanding of the molecular processes in which carbohydrates are involved, such as protein–carbohydrate interactions and the impact of glycosylation on protein function, knowledge of the 3D structure of the carbohydrate, the protein–carbohydrate complex, or the glycoprotein is often indispensable. This book provides a thorough introduction into methods used for conformational analysis of carbohydrates. Key features: Describes bioinformatic approaches to handle carbohydrate-active enzymes and glycosylation. Provides an overview on bioinformatics tools that facilitate analysis of carbohydrate structures. Gives introduction into molecular modelling of carbohydrate 3D structure and carbohydrates contained in the Protein Databank. Assumes only a basic knowledge of biology and bioinformatics.

Glycobiology

Glycobiology Book
Author : Joseph K. Welply,Ernest Jaworski
Publisher : Wiley-Liss
Release : 1990-03-19
ISBN :
Language : En, Es, Fr & De

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Book Description :

Focusing on the synthesis and structure of protein and lipid-bound oligosaccharides, Glycobiology describes the mechanisms that cause these substances and carbohydrate-binding proteins to influence biological recognition and communication. Comprehensive chapters offer new and informative data on topics such as: the synthesis, structural characterization and biological functions of glycophosphoinositol lipids; the role of lectin-like molecules and carbohydrate receptors in cell-cell recognition events; the function of protein- and lipid-glycosylation in such diseases; and the concerns of pharmaceutical and biotechnological companies within this field.

Cellular and Molecular Pathobiology of Cardiovascular Disease

Cellular and Molecular Pathobiology of Cardiovascular Disease Book
Author : Monte Willis,Jonathon W. Homeister,James R. Stone
Publisher : Academic Press
Release : 2013-12-23
ISBN : 0124055257
Language : En, Es, Fr & De

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Book Description :

Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research Gives concise explanations of key issues and background reading suggestions Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology

Harper s Illustrated Biochemistry 28th Edition

Harper s Illustrated Biochemistry  28th Edition Book
Author : Robert Murray,Victor Rodwell,David Bender,Kathleen M. Botham,P. Anthony Weil,Peter J. Kennelly
Publisher : Mcgraw-hill
Release : 2009-06-02
ISBN : 9780071625913
Language : En, Es, Fr & De

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Book Description :

The biochemistry text that every medical student must own--now in full color! A Doody's Core Title ESSENTIAL PURCHASE for 2011! Comprehensive, concise, and up-to-date, Harper's is unrivaled in its ability to clarify the link between biochemistry and the molecular basis of health and disease. The Twenty-Eighth Edition has undergone sweeping changes -- including a conversion to full-color artwork and the substantial revision and updating of every chapter -- all to reflect the latest advances in knowledge and technology and to make the text as up-to-date and clinically relevant as possible. Combining outstanding full-color illustrations with integrated coverage of biochemical diseases and clinical information, Harper's Illustrated Biochemistry offers an organization and clarity not found in any other text on the subject. Striking just the right balance between detail and brevity, Harpers Illustrated Biochemistry is essential for USMLE review and is the single best reference for learning the clinical relevance of a biochemistry topic. NEW to this edition: Full-color presentation, including 600+ illustrations Every chapter opens with a Summary of the Biomedical Importance and concludes with a Summary reviewing the topics covered Two all-new chapters: "Free Radicals and Antioxidant Nutrients" and "Biochemical Case Histories" which offers an extensive presentation of 16 clinical conditions A new appendix containing basic clinical laboratory results and an updated one with a list of important websites and online journals NEW or updated coverage of important topics including the Human Genome Project and computer-aided drug delivery

Cancer Research

Cancer Research Book
Author : N.A
Publisher :
Release : 2008-10
ISBN :
Language : En, Es, Fr & De

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Book Description :

Science

Science Book
Author : John Michels (Journalist)
Publisher :
Release : 2006
ISBN :
Language : En, Es, Fr & De

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Book Description :