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Translational Endocrinology Of Bone

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Translational Endocrinology of Bone

Translational Endocrinology of Bone Book
Author : Gerard Karsenty
Publisher : Academic Press
Release : 2012-10-11
ISBN : 012415784X
Language : En, Es, Fr & De

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Book Description :

The use of model organisms together with the power of genetics has profoundly affected our understanding of the physiology of one organ, the skeleton, in two distinct but complementary ways. First, the use of mouse genetics, guided by clinical observations has revealed, besides the classical regulation by the parathyroid hormone and sex steroid hormones, totally unanticipated ways of regulating bone mass. These include the influence of adipocytes, pancreatic b-cells, and entero-chromaffin cells of the duodenum on the central and peripheral nervous systems. A second major advance of the last decade has been to show that bone has many more functions than the one classically ascribed to it and described in other textbooks. These include but are not limited to the regulation of glucose metabolism, fertility, and phosphate homeostasis. This will be the first translational reference to focus on these major conceptual advances in bone biology and their development in the clinic. Several advances have already been translated into therapies and others are being tested for diseases as different as osteoporosis, type-2 diabetes, and hypo-fertility. Summarizes the latest research and translational applications of how the varied growth and development of bone affects appetite, metabolism, reproduction, and a wide range of endocrine functions Provides a common language for bone biologists, endocrinologists, osteologists, and other researchers, such as neuroscientists, who study appetite, fuel metabolism and diabetes, to discuss the development of translational research and new therapeutic strategies for bone, metabolic, and neuro-endocrine diseases. Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of bone research and therapeutics, as opposed to searching through thousands of journal articles

Diabetic Bone Disease

Diabetic Bone Disease Book
Author : Beata Lecka-Czernik,John L. Fowlkes
Publisher : Unknown
Release : 2016
ISBN : 9783319164038
Language : En, Es, Fr & De

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Book Description :

Providing the most up-to-date research and current clinical knowledge of diabetic bone disease and the challenges still facing the research and clinical care communities, this book unites insights from endocrinology to orthopedics to create a truly unique text. The first part covers clinical and pre-clinical applications and research. The first two chapters present the clinical and epidemiological data about diabetic bone disease, evaluated and reviewed for type 1 and type 2, respectively. This is followed by discussions of how the propensity to fracture in diabetic bone disease can impact fracture risk assessments and how it can be adjusted for using current clinically relevant fracture risk models. A comprehensive overview of orthopedic complications observed in diabetes is next, as well as a focus on the consequences of diabetes on periodontal disease. Other topics include the utility of skeletal biomarkers in assessing diabetic bone disease, how drugs used to treat diabetes may also have skeletal consequences, and the possibility that diabetes may fundamentally impact early progenitor cells of various bone lineages and thus globally impact bone. The second part covers biomechanics and bone quality in diabetes: how diabetes ultimately may impact the architecture, integrity, and quality of bone. Utilizing the expertise of top researchers and clinicians in diabetic bone disease in one comprehensive text, this volume will be a useful and thought-provoking resource for endocrinologists and orthopedic surgeons alike.

Multidisciplinary Approach to Osteoporosis

Multidisciplinary Approach to Osteoporosis Book
Author : Andrea Lenzi,Silvia Migliaccio
Publisher : Springer
Release : 2018-09-04
ISBN : 3319751107
Language : En, Es, Fr & De

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Book Description :

This book describes in detail the multidisciplinary management of osteoporosis, providing readers with a thorough understanding of the rationale for a multidisciplinary approach and with the tools required to implement it effectively. The emphasis is on a translational approach, starting from basic concepts and fundamental mechanisms of the pathology and clinical morbidity. Experts in the field discuss the full range of relevant topics, including the significance of physical activity, nutritional strategies, and pharmacological treatment. Put another way, the book covers all aspects from the bench to the bedside. Physicians, scientists, and postgraduate students will all find it to be invaluable in understanding the causes and optimal management of osteoporosis, the incidence of which is increasing rapidly as populations age.

Principles of Bone Biology

Principles of Bone Biology Book
Author : John P. Bilezikian,Lawrence G. Raisz,T. John Martin
Publisher : Academic Press
Release : 2008-09-29
ISBN : 9780080568751
Language : En, Es, Fr & De

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Book Description :

Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field The essential resource for anyone involved in the study of bones and bone diseases Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics Readers can easily search and locate information quickly as it will be online with this new edition

The Parathyroids

The Parathyroids Book
Author : John P. Bilezikian,Robert Marcus,Michael A. Levine
Publisher : Elsevier
Release : 2001-07-21
ISBN : 9780080525778
Language : En, Es, Fr & De

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Book Description :

Written by world experts, this books follows upon the monumental success of the first edition of The Parathyroids, which was universally acclaimed as the best text on the subject. An authoritative reference that spans the basic science of parathyroid hormone treatment to major clinical disorders in a superb, single compendium, The Parathyroids offers an objective and authoritative view on controversial clinical issues in this rapidly changing field. Every medical school library and virtually every major hospital library will need this book as a reference for students and clinicians. Key Features * Offers objective and authoritative reviews on controversial clinical issues * Written by world experts on parathyroid hormone and its disorders * Superb, state-of-the-art compendium in one convenient volume * Bridges basic science of parathyroid hormone to major clinical disorders * Practical information on clinical management of parathyroid hormone disorders

Advances in Diabetes

Advances in Diabetes Book
Author : Sridhar R Gumpeny
Publisher : JP Medical Ltd
Release : 2016-02-12
ISBN : 9351526453
Language : En, Es, Fr & De

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Book Description :

Advances in Diabetes: Novel Insights is an up-to-date collection of important advances in diabetology, covering the most recent developments in the field and providing insight into future progress in patient management. Illustrated with tables for quick reference, Advances in Diabetes: Novel Insights is an essential book for diabetologists and endocrinologists who wish to keep up to date with developments in their field.

Avery s Neonatology Board Review

Avery s Neonatology Board Review Book
Author : Patricia Chess
Publisher : Elsevier Health Sciences
Release : 2019-03-19
ISBN : 0323553222
Language : En, Es, Fr & De

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Book Description :

Prepare for success on the neonatology boards and in clinical practice with Avery’s Neonatology Board Review: Certification and Clinical Refresher. This highly practical review tool follows the exam blueprint, is based on the trusted content found in Avery’s Diseases of the Newborn, and has been carefully tailored for effective exam review by renowned neonatologist and educator, Patricia Chess, MD. Concise, relevant information is presented in a way that’s easy to study and remember, giving you an important advantage on this challenging exam, as well as in the daily, fast-changing practice of neonatology. Equips residents, fellows, and physicians with an efficient, comprehensive system for study, designed specifically to help you perform at your best on the board exam. Presents information in a high-yield, outline format highlighted by key points, graphs, tables, images, and algorithms. Over 300 questions online Features board-style vignettes in every chapter with full, discursive answers online. Written by experts in the field of Neonatal-Perinatal Medicine, representing a wealth of trusted insight and guidance.

Bone Marrow Adiposity Establishing Harmonized Mechanistic and Multidisciplinary Approaches to Reach Clinical Translation

Bone Marrow Adiposity  Establishing Harmonized  Mechanistic and Multidisciplinary Approaches to Reach Clinical Translation Book
Author : Nathalie Bravenboer,Stephanie Lucas,Clifford James Rosen
Publisher : Frontiers Media SA
Release : 2020-12-28
ISBN : 2889662837
Language : En, Es, Fr & De

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Book Description :

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

The Role of Exosomes in Metabolic and Endocrine Disease

The Role of Exosomes in Metabolic and Endocrine Disease Book
Author : Ling-Qing Yuan,Qifu Li,Zhaohui Lyu,Jufeng Xia
Publisher : Frontiers Media SA
Release : 2022-04-07
ISBN : 2889749126
Language : En, Es, Fr & De

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Book Description :

Download The Role of Exosomes in Metabolic and Endocrine Disease book written by Ling-Qing Yuan,Qifu Li,Zhaohui Lyu,Jufeng Xia, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Pediatric Endocrinology

Pediatric Endocrinology Book
Author : M. Sperling
Publisher : Elsevier Health Sciences
Release : 2008-01-01
ISBN : 1416040900
Language : En, Es, Fr & De

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Book Description :

In a single, convenient volume, Pediatric Endocrinology offers complete coverage of all aspects of basic science and clinical practice, ideal for both pediatricians and endocrinologists. Pediatric endocrinology expert Dr. Mark Sperling teams up with world-renowned authors to bring you up to date with the latest key developments in every area of the field, providing invaluable guidance on how your clinical decision making will be affected by today's technological and scientific advances. The user-friendly text is enhanced by all-new online access to the complete contents of the book and more. "Inclusion of clinical vignettes and supported by ExpertConsult access makes the text almost as good as face-to-face teaching." Reviewed by: Neel Kamal on behalf of BACCH Newsletter, March 2015 Determine the best possible course for every patient with easy-to-follow algorithms in every clinical chapter. Stay up to date with today's hottest topics, including neonatal diabetes mellitus, Type II childhood diabetes, molecular endocrinology, and genetics. Explore the impact of today's advances and challenges, including explosive growth in molecular biology, sophisticated imaging techniques, and an increase in both pediatric diabetes and obesity. NEW! Access the fully searchable contents of the book and new self-assessment questions online at Expert Consult. Quickly access the information you need with a new, streamlined organization (Concepts, Endocrine Disorders of the Newborn, Endocrine Disorders of Childhood and Adolescence, and Laboratory Tests and Imaging).

Osteosarcopenia Bone Muscle and Fat Interactions

Osteosarcopenia  Bone  Muscle and Fat Interactions Book
Author : Gustavo Duque
Publisher : Springer Nature
Release : 2019-11-06
ISBN : 3030258904
Language : En, Es, Fr & De

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Book Description :

This edited work presents the most current evidence on osteosarcopenia from bench to bedside, which is expected to facilitate the understanding of this syndrome and to develop preventive and therapeutic strategies. With our aging population, chronic diseases such as osteoporosis and sarcopenia are becoming highly prevalent. Fortunately, our understanding of the bone and muscle interactions has increased in recent years. This has allowed to the coining of the term osteosarcopenia to describe a syndrome in which these two diseases overlap. This overlap between osteoporosis and sarcopenia has major negative effects not only on our older adults but also on health systems worldwide. Readers will find a highly translational approach that starts with a summary of recent discoveries on stem cells biology, muscle and bone interactions – including the role of local bone and muscle fat – followed by comprehensive reviews on myokines (i.e. myostatin), osteokines (i.e. osteocalcin) and adipokines (i.e. interleukins) as major players and determinants of bone and muscle loss with aging. In addition, the role of sex steroids (i.e. estrogens, androgens), and calciotropic hormones (i.e. parathyroid hormone, vitamin D) in the pathogenesis of this syndrome is also reviewed. Moreover, using practical diagnostic and therapeutic tips, this book summarizes the clinical characteristics of osteosarcopenic patients thus facilitating the diagnosis and treatment of this syndrome in clinical practice. Finally, the book presents the case for the Falls and Fractures Clinic as the optimal model of care for this syndrome, aimed to avoid fragmentation and optimize osteosarcopenia care, and simultaneously prevent falls and fractures in older persons. This book offers relevant information on the mechanisms of osteosarcopenia, and a practical guide on how to identify and treat this geriatric syndrome and its adverse outcomes, which are dramatically affecting our aging population. The work is written by leaders in the field and is especially suited not only to any researcher in the musculoskeletal arena but also to medical specialists and allied health professionals involved in the care of older persons.

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism Book
Author : Juliet E. Compston,Jane B. Lian
Publisher : John Wiley & Sons
Release : 2009-12-22
ISBN : 0470623985
Language : En, Es, Fr & De

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Book Description :

EDITOR-IN-CHIEF: Clifford J. Rosen, M.D., Maine Medical Center Research Institute, Scarborough, Maine SENIOR ASSOCIATE EDITORS: Juliet E. Compston, M.D., FRCP, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom Jane B. Lian, Ph.D., University of Massachusetts Medical School, Worcester, Massachusetts This comprehensive yet concise handbook is an indispensable reference for the many clinicians who see patients with disorders of bone formation, metabolic bone diseases, or disorders of stone formation. It is also a crucial tool for researchers, students, and all other professionals working in the bone field. In a format designed for quick reference, it provides complete information on the symptoms, pathophysiology, diagnosis, and treatment of all common and rare bone and mineral disorders. New in this edition: detailed coverage of osteonecrosis of the jaw, more in-depth coverage of cancer and bone including new approaches to pathogenesis, diagnosis, and treatment; new approaches to anabolic therapy of osteoporosis; the latest research on Vitamin D; expanded coverage of international topics; more on the genetics of bone mass; and newer imaging techniques for the skeleton. In addition, this edition features a free, online-only appendix of medicines used to treat bone disorders and their availability around the world.

Translating Biomaterials for Bone Graft

Translating Biomaterials for Bone Graft Book
Author : Joo L. Ong,Teja Guda
Publisher : CRC Press
Release : 2017-01-06
ISBN : 1315363518
Language : En, Es, Fr & De

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Book Description :

Translating Biomaterials for Bone Graft: Bench-top to Clinical Applications brings together the current translational research in bone tissue engineering, from design to application – from materials, drugs and biologic delivery used for bone graft applications to pre-clinical and clinical considerations. The book also discusses the regulatory approval pathways, which involves consideration of the class of devices; whether they are similar to existing solutions, minimal manipulation of donor tissue or completely novel materials, drugs and biologics. These considerations drive the ability to successfully transition the latest generations of bone graft materials into the clinics. Chapters come from materials scientists, clinicians, researchers, and consultants and provide a holistic understanding of the field. As such, the book is a state-of-the-art reference to bone therapies and should appeal to clinicians, scientists, as well as students interested in the current research and/or practices in the field of bone regeneration and restoration.

The Parathyroids

The Parathyroids Book
Author : John P. Bilezikian,Robert Marcus,Michael A. Levine,Claudio Marcocci,Shonni J Silverberg,John T. Potts Jr.
Publisher : Academic Press
Release : 2014-09-09
ISBN : 0123977908
Language : En, Es, Fr & De

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Book Description :

The third edition of The Parathyroids, led by a new stellar editorial team, has been thoroughly updated to reflect the considerable advances in just about every aspect of PTH biology over the past decade. It continues to be the authoritative reference that spans the basic science of parathyroid hormone treatment to major clinical disorders in a superb, single compendium. This translational resource is invaluable to graduate students, fellows, researchers, and research clinicians in the fields of endocrinology, bone biology, osteology, and rheumatology. Contains chapters and information on noninvasive imaging, fracture healing, secondary diseases such as CKD, Vitamin D, cell signaling pathways, vascular calcification, as well as advances in genetics/genomics Includes essential updates on the critical importance of Vitamin D insufficiency and its relationship to secondary hyperparathyroidism Offers new insights into the underlying mechanisms of parathyroid hormone actions on osteocytes and sclerostin Examines essential updates in the understanding of secondary hyperparathyroidism associated with chronic kidney disease, facture healing, and vascular disease

Nutrition and Bone Health

Nutrition and Bone Health Book
Author : Michael F. Holick,Bess Dawson-Hughes
Publisher : Springer Science & Business Media
Release : 2004-05-03
ISBN : 1592597408
Language : En, Es, Fr & De

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Book Description :

The Nutrition and Health series of books have, as an overriding mission, to provide health professionals with texts that are considered essential because each includes (1) a synthesis of the state of the science; (2) timely, in-depth reviews by the leading research ers in their respective fields; (3) extensive, up-to-date, fully annotated reference lists; (4) a detailed index; (5) relevant tab les and figures; (6) identification of paradigm shifts and the consequences; (7) virtually no overlap of information between chapters, but targeted, interchapter referrals; (8) suggestions of areas for future research; and (9) bal anced, data-driven answers to patient /health professionals' questions that are based on the totality of evidence rather than the findings of any single study. The series volumes are not the outcome of a symposium. Rather, each editor has been asked to examine a chosen area with a broad perspective, both in subject matter as well as in the choice of chapter authors. The international perspective, especially with regard to public health initiatives, is emphasized where appropriate. The editors, whose trainings are both research- and practice-oriented, have the opportunity to develop a primary objective for their book, define the scope and focus, and then invite the leading authorities from around the world to be part of their initiative. The authors are encouraged to provide an overview of the field, discuss their own research, and relate the research findings to potential human health consequences.

How to Pass the FRACP Written Examination

How to Pass the FRACP Written Examination Book
Author : Jonathan Gleadle,Jordan Li,Danielle Wu,Paul Kleinig
Publisher : John Wiley & Sons
Release : 2021-09-27
ISBN : 1119599504
Language : En, Es, Fr & De

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Book Description :

How to Pass the FRACP Written Examination is an indispensable review and study guide for anyone preparing for the challenging Fellow of the Royal Australasian College of Physicians (FRACP) exam. This up-to-date resource fully aligns with the current FRACP core training curriculum, containing a wealth of traditional multiple-choice questions (MCQs) as well as extended-matching questions (EMQs). There are hundreds of questions for every major topic of the written examination, including critical care medicine, cardiology, infectious diseases, immunology and allergy, neurology, and pharmacology. More than a simple practice exam, this guide provides clear and complete explanations of each answer, a mini-review of the subject, and links to the most recent or relevant articles on the topic. Complementing the main body of questions are a number of ‘teaching’ and two-step questions—designed to strengthen clinical reasoning skills, highlight important issues, and expand knowledge of contemporary ‘hot’ topics. Written by an experienced team of physicians and educators, this must-have book: Provides a thorough review of the latest FRACP basic training syllabus Features QR codes embedded in the text to enable quick access to all references Offers tips, hints, advice, and examination strategies from previous candidates Provides numerous questions grounded in clinically relevant cases Covers of areas of medicine that are new, contemporary, and evolving Covering both the ‘Basic Sciences’ and ‘Clinical Practice’ of the latest exam, Passing the FRACP Written Examination is an essential companion for FRACP candidates as well as those looking to refresh, improve, or update their knowledge of the FRACP syllabus.

Assessment of Osteoporotic Fractures and Risk Prediction

Assessment of Osteoporotic Fractures and Risk Prediction Book
Author : Zhi-Feng Sheng,Xiaoguang Cheng,Xiangbing Wang
Publisher : Frontiers Media SA
Release : 2023-01-30
ISBN : 2832512070
Language : En, Es, Fr & De

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Book Description :

Download Assessment of Osteoporotic Fractures and Risk Prediction book written by Zhi-Feng Sheng,Xiaoguang Cheng,Xiangbing Wang, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Skeletal Biology and Medicine II

Skeletal Biology and Medicine II Book
Author : Mone Zaidi
Publisher : Wiley-Blackwell
Release : 2012-01-24
ISBN : 9781573318563
Language : En, Es, Fr & De

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Book Description :

The volume features current basic, clinical, and translational research on aspects of skeletal morphogenesis and remodeling in health and disease. Papers survey vital new insights into the mechanisms of bone development and restructuring, including cellular and mechanical triggers, receptors and signaling pathways. Also covered are the effects of other physiological systems and disease states, such as immune system inflammation, diabetes, infection, and cancer on musculoskeletal health. Recent findings are shaping therapeutic directions that focus on both anti-resorptive and anabolic therapies. Basic scientists, clinical investigators, and clinicians with interests spanning endocrinology, physiology, cell biology, pathology, genetics, molecular biology, rheumatology, oncology, and other areas that relate to bone development and homeostasis will find this a valuable resource for the most recent developments in skeletal biology and medicine. This volume presents manuscripts stemming from the 4th New York Skeletal Biology and Medicine Conference, held at Mount Sinai School of Medicine in New York City on April 27–30, 2011. The papers included in this volume include two of the topic areas presented at the conference; the other topic areas are included in Skeletal Biology and Medicine I. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.1111/(ISSN)1749-6632. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

Skeletal Biology and Medicine I

Skeletal Biology and Medicine I Book
Author : Mone Zaidi
Publisher : Wiley-Blackwell
Release : 2011-12-12
ISBN : 9781573318464
Language : En, Es, Fr & De

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Book Description :

The volume features current basic, clinical, and translational research on aspects of skeletal morphogenesis and remodeling in health and disease. Papers survey vital new insights into the mechanisms of bone development and restructuring, including cellular and mechanical triggers, receptors and signaling pathways. Also covered are the effects of other physiological systems and disease states, such as immune system inflammation, diabetes, infection, and cancer on musculoskeletal health. Recent findings are shaping therapeutic directions that focus on both anti-resorptive and anabolic therapies. Basic scientists, clinical investigators, and clinicians with interests spanning endocrinology, physiology, cell biology, pathology, genetics, molecular biology, rheumatology, oncology, and other areas that relate to bone development and homeostasis will find this a valuable resource for the most recent developments in skeletal biology and medicine. This volume presents manuscripts stemming from the 4th New York Skeletal Biology and Medicine Conference, held at Mount Sinai School of Medicine in New York City on April 27–30, 2011. The papers included in this volume include two of the topic areas presented at the conference; the other topic areas are included in Skeletal Biology and Medicine II. NOTE: Annals volumes are available for sale as individual books or as a journal. For information about institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.1111/(ISSN)1749-6632. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

Genetics of Bone Biology and Skeletal Disease

Genetics of Bone Biology and Skeletal Disease Book
Author : Rajesh V. Thakker,Michael P. Whyte,John Eisman,Takashi Igarashi
Publisher : Academic Press
Release : 2017-10-31
ISBN : 0128041986
Language : En, Es, Fr & De

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Book Description :

Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder