Translational Cardiometabolic Genomic Medicine

Book Description :

Translational Cardiometabolic Genomic Medicine, edited by Dr. Annabelle Rodriguez-Oquendo, is an important resource to postgraduate (medical, dental and graduate) students, postdoctoral fellows, basic scientists, and physician scientists seeking to understand and expand their knowledge base in the field of genomic medicine as it is applied to cardiometabolic diseases. This handbook integrates cutting-edge experimental approaches such as chromatin immunoprecipitation paired end tagging (CHIA-PET), to population studies such as the Multi-Ethnic Study of Atherosclerosis. It encompasses a range of book chapters that highlight bioinformatic approaches to better understanding functionality of the noncoding regions of the human genome to the use of molecular diagnostic testing in predicting increased risk of cardiovascular diseases. Where applicable, this reference also includes chapters related to therapeutic options specifically aligned to molecular targets. Provides comprehensive research on translational genomic medicine Explains state-of-the-art genome editing for stem cells and mouse models with significant relevance to human cardiometabolic disease Includes discussions on the functional effects of single nucleotide polymorphisms and cardiometabolic diseases, stratified by sex and race Encompasses a range of book chapters that highlight bioinformatic approaches to better understanding functionality of the noncoding regions of the human genome

Book Description :

The world is beset by a pandemic of obesity and type 2 diabetes and the need for new drugs is startlingly clear; recent years have seen a huge increase in research activity to fill this gap. The development of new drugs for diabetes and obesity must be founded upon a sound appreciation of the pathophysiology of these common disorders. The dual defects of insulin resistance and impaired insulin secretion are fundamental to the pathogenesis and progression of obesity-associated type 2 diabetes. There is a need to explain how new drugs can counter insulin resistance and insulin deficiency to a broad range of professionals, from clinical scientists active in early (and later) phase drug development to specialist physicians and increasingly primary care doctors who must tailor drug regimens to the individual patient. Clinical research methods for measuring insulin action and insulin secretion have become well-established in proof-of-mechanism studies; however, selection of the best techniques is by no means straightforward. The purpose of the book is to aid the selection of the most appropriate techniques for assessing insulin action, insulin secretion and body composition in humans (with particular reference to new drugs) in phase 1 and 2 studies and aid the understanding of drug effects and non-drug treatment strategies on key biochemical-hormonal defects of obesity and type 2 diabetes. The book will assume a working knowledge of human physiology relating to glucose metabolism and will be of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.

Book Description :

Containing cutting edge research on the hot topic of nanobiosensor, this book will become highly read Biosensor research has recently re-emerged as most vibrant area in recent years particularly after the advent of novel nanomaterials of multidimensional features and compositions. Nanomaterials of different types and striking properties have played a positive role in giving the boost and accelerated pace to biosensors development technology. Nanobiosensors - From Design to Applications covers several aspects of biosensors beginning from the basic concepts to advanced level research. It will help to bridge the gap between various aspects of biosensors development technology and applications. It covers biosensors related material in broad spectrum such as basic concepts, biosensors & their classification, biomarkers & their role in biosensors, nanostructures-based biosensors, applications of biosensors in human diseases, drug detection, toxins, and smart phone based biosensors. Nanobiosensors - From Design to Applications will prove a source of inspiration for research on biosensors, their local level development and consequently using for practical application in different industries such as food, biomedical diagnosis, pharmaceutics, agriculture, drug discovery, forensics, etc. Discusses the latest technology and advances in the field of nanobiosensors and their applications in human diseases, drug detection, toxins Offers a broad and comprehensive view of cutting-edge research on advanced materials such as carbon materials, nitride based nanomaterials, metal and metal oxide based nanomaterials for the fast-developing nanobiosensors research Goes to a wide scientific and industry audience Nanobiosensors - From Design to Applications is a resource for polymer chemists, spectroscopists, materials scientists, physical chemists, surface chemists, and surface physicists.

Book Description :

Provides a timely update to a key textbook on human drug metabolism The third edition of this comprehensive book covers basic concepts of teaching drug metabolism, starting from extreme clinical consequences to systems and mechanisms and toxicity. It provides an invaluable introduction to the core areas of pharmacology and examines recent progress and advances in this fast moving field and its clinical impact. Human Drug Metabolism, 3rd Edition begins by covering basic concepts such as clearance and bioavailability, and looks at the evolution of biotransformation, and how drugs fit into this carefully managed biological environment. More information on how cytochrome P450s function and how they are modulated at the sub-cellular level is offered in this new edition. The book also introduces helpful concepts for those struggling with the relationship of pharmacology to physiology, as well as the inhibition of biotransformational activity. Recent advances in knowledge of a number of other metabolizing systems are covered, including glucuronidation and sulphation, along with the main drug transporters. Also, themes from the last edition are developed in an attempt to chart the progress of personalized medicine from concepts towards practical inclusion in routine therapeutics. The last chapter focuses on our understanding of how and why drugs injure us, both in predictable and unpredictable ways. Appendix A highlights some practical approaches employed in both drug metabolism research and drug discovery, whilst Appendix B outlines the metabolism of some drugs of abuse. Appendix C advises on formal examination preparation and Appendix D lists some substrates, inducers and inhibitors of the major human cytochrome P450s. Fully updated to reflect advances in the scientific field of drug metabolism and its clinical impact Reflects refinements in the author's teaching method, particularly with respect to helping students understand biological systems and how they operate Illustrates the growing relationship between drug metabolism and personalized medicine Includes recent developments in drug discovery, genomics, and stem cell technologies Human Drug Metabolism, 3rd Edition is an excellent book for advanced undergraduate and graduate students in molecular biology, biochemistry, pharmacology, pharmacy, and toxicology. It will also appeal to professionals interested in an introduction to this field, or who want to learn more about these bench-to-bedside topics to apply it to their practice.

Book Description :

Autophagy and Cardiometabolic Diseases: From Moleculer Mechanisms to Translational Medicine covers the science of autophagy in relation to cardiometabolic diseases and the future therapeutic potentials of autophagy regulation in these processes. Processes are not described in isolation, but in concert with other cellular and/or metabolic processes, such as lipogenesis, glucose, energy metabolism and apoptosis. This approach recognizes the multifactorial nature of cardiometabolic diseases, including obesity, diabetes, insulin resistance, hypertension and dyslipidemia. The book provides explanations, while also distinguishing the delicate role for autophagy in pathogenesis and exploring complications for cardiometabolic diseases. By targeting autophagy, it offers new avenues for drug discovery and treatment for cardiometabolic anomalies. It is a perfect resource for cardiology researchers, scientists and medical practitioners. Explains the processes inherent in the protein quality control for pathogenesis and complications of cardiometabolic diseases Provides knowledge from internationally recognized contributors in the field Incorporates a translational approach, covering the basic cellular biology of autophagy and presenting the role of autophagy regulation for both pathogenesis and complication in cardiometabolic diseases Contains access to a companion website with additional illustrations

Book Description :

Breastfeeding and Human Lactation, Sixth Edition is the ultimate reference for the latest clinical techniques and research findings that direct evidence-based clinical practice for lactation consultants and specialists. It contains everything a nurse, lactation consultant, midwife, women’s health nurse practitioner, physician assistant, or Ob/Gyn needs to know about the subject. Topics include placing breastfeeding in its historical context, workplace-related issues, anatomical and biological imperatives of lactation, the prenatal and perinatal periods and concerns during the postpartum period, the mother’s health, sociocultural issues, and more vital information.

Book Description :

Precision Medicine, Volume 190 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Evolution of Biomarkers and Strategies for Integrating the Precision Philosophy to Guide Monitoring of Individualized Autoimmunity Conditions and to Implement the Philosophy into Clinical Practice, Precision Medicine in Epilepsy, The use of ASOs for personized medicine, Adult medicine, EGFR, NF-KB signal and regulatory noncoding RNAs in cancer, Precision medicine with multi-omics strategies, deep phenotyping, and predictive analysis, The Paradox of Personalized Medicine, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Progress in Molecular Biology and Translational Science series Updated release includes the latest information on the precision medicine

Book Description :

Download New Drug Targets for Proteotoxicity in Cardiometabolic Diseases book written by Jun Ren,Xin Wang,Ying Mei Zhang, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Book Description :

Advances in Blood Research and Application / 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Plasma. The editors have built Advances in Blood Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Plasma in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Blood Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Book Description :

In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the “epigenome,” comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach. This book, written by respected cardiologist José Marín-García, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA. Offers updated discussion of cutting-edge molecular techniques including new genomic sequencing / NGS / Hap-Map / bioinformatics / systems biology approaches Analyzes mitochondria dynamics and their role in cardiac dysfunction, up-to-date analysis of cardio-protection, and cardio-metabolic syndrome Presents recent translational studies, gene therapy, transplantation of stem cells, and pharmacological treatments in CVDs

Book Description :

This rich resource provides a thorough overview of current knowledge and new directions in the study of the biological, psychological, social, and cultural factors that affect health, health behavior, and illness. Chapters review the latest theories and research with an emphasis on how research is translated into behavioral medicine interventions. Featuring contributions from top researchers and rising stars in the field, authors provide a theoretical foundation; evaluate the empirical evidence; and make suggestions for future research, clinical practice, and policy. The handbook reflects the latest approaches to health psychology today, including: Emphasis throughout on the socio-cultural aspects of health, including socioeconomic status, gender, race/ethnicity, sexual orientation, and age/developmental stage A new section on emerging areas in health psychology, including behavioral genomics, military veterans' health, and digital health Coverage of prevention, interventions, and treatment in the applications section An expansion of the biopsychosocial model across several levels of analysis, including cultural, macro-social, and cellular factors Sustained emphasis on translating research into practice and policy The handbook considers the intersections of concepts (behavior change), populations (women's and sexual minority health), cultural groups (African American, Asian American, and Latino), risk and protective factors (obesity, coping), and diseases (cancer, diabetes, HIV), making it essential reading for scholars of health psychology, public health, epidemiology, and nursing. Novices to the field appreciate the accessibly written chapters, while seasoned professionals appreciate the book's deep, cutting-edge coverage.

Book Description :

This book aims to aid the selection of the most appropriate methods for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, non-alcoholic fatty liver disease (NAFLD) and related cardiometabolic disorders. Clinical research methods to assess the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycemic clamp technique, have become well-established in proof-of-mechanism studies. However, selection of the most appropriate techniques is by no means straightforward. Moreover, the application of such methods must conform to the regulatory requirements for new drugs. This book discusses the need for new pharmacotherapies for diabetes, obesity and NAFLD and the molecular targets of drugs currently in development. Emerging technologies including functional imaging, circulating biomarkers and omics are considered together with practical and ethical issues pertaining to early phase clinical trials in subjects with cardiometabolic disorders. Translational Research Methods in Diabetes, Obesity, and Non-Alcoholic Fatty Liver Disease is of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.

Book Description :

This book examines ethical and social issues that arise in the conduct of genetic research, from the discovery phase, through development and delivery research, to health outcomes. The authors argue that research at every phase needs to be responsive to community needs to assure public health benefits and reduce, rather than exacerbate, health disparities.

Book Description :

The Pacific Symposium on Biocomputing (PSB) 2015 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2015 will be held from January 4 - 8, 2015 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference.PSB 2015 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's “hot topics.” In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.

Book Description :

Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before. With contributions from leading experts, Network Medicine introduces this rapidly evolving field of research, which promises to revolutionize the diagnosis and treatment of human diseases.

Book Description :

The Pacific Symposium on Biocomputing (PSB) 2021 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2021 will be held on a virtual platform at psb.stanford.edu/ on January 5-7, 2021. Tutorials and workshops will be offered prior to the start of the conference.PSB 2021 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's 'hot topics.' In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.

Book Description :

This title reflects the exponential growth in the knowledge and information on this subject and defines the extensive clinical translation of cardiovascular genetics and genomics in clinical practice. This concise, clinically oriented text is targeted at a broad range of clinicians who manage patients and families with a wide range of heterogeneous inherited cardiovascular conditions. Cardiovascular Genetics and Genomics: Principles and Clinical Practice includes a concise and clear account on selected topics written by a team of leading experts on clinical cardiovascular genetics. Each chapter include key information to assist the clinician and case histories have been incorporated to reflect contemporary practice in clinical cardiovascular genetics and genomics. Therefore this will be of key importance to all professionals working in the discipline, from clinicians and trainees in cardiology, cardiac surgery, electrophysiology, immunology through geneticists, nursing staff and those involved in precision medicine.

Book Description :

This book provides comprehensive information on transcatheter aortic valve implantation (TAVI), which was introduced for the treatment of aortic valve disease less than two decades ago. It explains how TAVI has delivered satisfactory results even in high and intermediate risk patients and outlines how it continues to evolve, thus requiring awareness of state of the art approaches to indication, risk stratification, device choice, procedure, and follow-up. In addition, it reports on the complex and multidisciplinary approach needed to maximize the efficacy, safety, and appropriateness of TAVI, providing detailed clinical, interventional and surgical perspectives focusing on the development of this cardiovascular intervention. Starting with the history of TAVI, addressing the interventional anatomy of aortic valve disease, and reporting on the expert authors’ day-to-day experiences, this highly informative book offers an essential update for all cardiologists and surgeons interested in transcatheter aortic valve implantation, as well as any clinician, decision-maker and stakeholder involved in patient selection, procedural management, and follow-up.

Book Description :

The result of a collaboration between the National Academy of Medicine (NAM) and the Office of the National Coordinator for Health Information Technology, this NAM Special Publication summarizes and builds upon a meeting series in which a multistakeholder group of experts discussed the potential of clinical decision support (CDS) to transform care delivery by ameliorating the burden that expanding clinical knowledge and care and choice complexity place on the finite time and attention of clinicians, patients, and members of the care team. This summary also includes highlights from discussions about addressing the barriers to realizing the full benefits of CDS-facilitated value improvement. Optimizing Strategies for Clinical Decision Support: Summary of Meeting Series identifies the need for a continuously learning health system driven by the seamless and rapid generation, processing, and practical application of the best available evidence for clinical decision-making, and lays out a series of actionable, collaborative next steps to optimize strategies for adoption and use of clinical decision support.

Book Description :

"This book explores important chapters of past and recent African history from a multidisciplinary perspective. It covers an extensive time range from the evolution of early humans to the complex cultural and genetic diversity of modern-day populations in Africa. Through a comprehensive list of chapters, the book focuses on different time-periods, geographic regions and cultural and biological aspects of human diversity across the continent. Each chapter summarises current knowledge with perspectives from a varied set of international researchers from diverse areas of expertise. The book provides a valuable resource for scholars interested in evolutionary history and human diversity in Africa. Contributors are Shaun Aron, Ananyo Choudhury, Bernard Clist, Cesar Fortes-Lima, Rosa Fregel, Jackson S. Kimambo, Faye Lander , Marlize Lombard, Fidelis T. Masao, Ezekia Mtetwa, Gilbert Pwiti, Michèle Ramsay, Thembi Russell, Carina Schlebusch, Dhriti Sengupta, Plan Shenjere-Nyabezi, Mário Vicente"--