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Translational Cardiometabolic Genomic Medicine

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Translational Cardiometabolic Genomic Medicine

Translational Cardiometabolic Genomic Medicine Book
Author : Annabelle Rodriguez-Oquendo
Publisher : Academic Press
Release : 2015-09-07
ISBN : 0128004746
Language : En, Es, Fr & De

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Book Description :

Translational Cardiometabolic Genomic Medicine, edited by Dr. Annabelle Rodriguez-Oquendo, is an important resource to postgraduate (medical, dental and graduate) students, postdoctoral fellows, basic scientists, and physician scientists seeking to understand and expand their knowledge base in the field of genomic medicine as it is applied to cardiometabolic diseases. This handbook integrates cutting-edge experimental approaches such as chromatin immunoprecipitation paired end tagging (CHIA-PET), to population studies such as the Multi-Ethnic Study of Atherosclerosis. It encompasses a range of book chapters that highlight bioinformatic approaches to better understanding functionality of the noncoding regions of the human genome to the use of molecular diagnostic testing in predicting increased risk of cardiovascular diseases. Where applicable, this reference also includes chapters related to therapeutic options specifically aligned to molecular targets. Provides comprehensive research on translational genomic medicine Explains state-of-the-art genome editing for stem cells and mouse models with significant relevance to human cardiometabolic disease Includes discussions on the functional effects of single nucleotide polymorphisms and cardiometabolic diseases, stratified by sex and race Encompasses a range of book chapters that highlight bioinformatic approaches to better understanding functionality of the noncoding regions of the human genome

Translational Research Methods for Diabetes Obesity and Cardiometabolic Drug Development

Translational Research Methods for Diabetes  Obesity and Cardiometabolic Drug Development Book
Author : Andrew J. Krentz,Lutz Heinemann,Marcus Hompesch
Publisher : Springer
Release : 2014-11-29
ISBN : 1447149203
Language : En, Es, Fr & De

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Book Description :

The world is beset by a pandemic of obesity and type 2 diabetes and the need for new drugs is startlingly clear; recent years have seen a huge increase in research activity to fill this gap. The development of new drugs for diabetes and obesity must be founded upon a sound appreciation of the pathophysiology of these common disorders. The dual defects of insulin resistance and impaired insulin secretion are fundamental to the pathogenesis and progression of obesity-associated type 2 diabetes. There is a need to explain how new drugs can counter insulin resistance and insulin deficiency to a broad range of professionals, from clinical scientists active in early (and later) phase drug development to specialist physicians and increasingly primary care doctors who must tailor drug regimens to the individual patient. Clinical research methods for measuring insulin action and insulin secretion have become well-established in proof-of-mechanism studies; however, selection of the best techniques is by no means straightforward. The purpose of the book is to aid the selection of the most appropriate techniques for assessing insulin action, insulin secretion and body composition in humans (with particular reference to new drugs) in phase 1 and 2 studies and aid the understanding of drug effects and non-drug treatment strategies on key biochemical-hormonal defects of obesity and type 2 diabetes. The book will assume a working knowledge of human physiology relating to glucose metabolism and will be of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.

Nanobiosensors

Nanobiosensors Book
Author : Aiguo Wu,Waheed S. Khan
Publisher : John Wiley & Sons
Release : 2020-02-11
ISBN : 3527345140
Language : En, Es, Fr & De

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Book Description :

Containing cutting edge research on the hot topic of nanobiosensor, this book will become highly read Biosensor research has recently re-emerged as most vibrant area in recent years particularly after the advent of novel nanomaterials of multidimensional features and compositions. Nanomaterials of different types and striking properties have played a positive role in giving the boost and accelerated pace to biosensors development technology. Nanobiosensors - From Design to Applications covers several aspects of biosensors beginning from the basic concepts to advanced level research. It will help to bridge the gap between various aspects of biosensors development technology and applications. It covers biosensors related material in broad spectrum such as basic concepts, biosensors & their classification, biomarkers & their role in biosensors, nanostructures-based biosensors, applications of biosensors in human diseases, drug detection, toxins, and smart phone based biosensors. Nanobiosensors - From Design to Applications will prove a source of inspiration for research on biosensors, their local level development and consequently using for practical application in different industries such as food, biomedical diagnosis, pharmaceutics, agriculture, drug discovery, forensics, etc. Discusses the latest technology and advances in the field of nanobiosensors and their applications in human diseases, drug detection, toxins Offers a broad and comprehensive view of cutting-edge research on advanced materials such as carbon materials, nitride based nanomaterials, metal and metal oxide based nanomaterials for the fast-developing nanobiosensors research Goes to a wide scientific and industry audience Nanobiosensors - From Design to Applications is a resource for polymer chemists, spectroscopists, materials scientists, physical chemists, surface chemists, and surface physicists.

Human Drug Metabolism

Human Drug Metabolism Book
Author : Michael D. Coleman
Publisher : John Wiley & Sons
Release : 2020-02-19
ISBN : 1119458560
Language : En, Es, Fr & De

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Book Description :

Provides a timely update to a key textbook on human drug metabolism The third edition of this comprehensive book covers basic concepts of teaching drug metabolism, starting from extreme clinical consequences to systems and mechanisms and toxicity. It provides an invaluable introduction to the core areas of pharmacology and examines recent progress and advances in this fast moving field and its clinical impact. Human Drug Metabolism, 3rd Edition begins by covering basic concepts such as clearance and bioavailability, and looks at the evolution of biotransformation, and how drugs fit into this carefully managed biological environment. More information on how cytochrome P450s function and how they are modulated at the sub-cellular level is offered in this new edition. The book also introduces helpful concepts for those struggling with the relationship of pharmacology to physiology, as well as the inhibition of biotransformational activity. Recent advances in knowledge of a number of other metabolizing systems are covered, including glucuronidation and sulphation, along with the main drug transporters. Also, themes from the last edition are developed in an attempt to chart the progress of personalized medicine from concepts towards practical inclusion in routine therapeutics. The last chapter focuses on our understanding of how and why drugs injure us, both in predictable and unpredictable ways. Appendix A highlights some practical approaches employed in both drug metabolism research and drug discovery, whilst Appendix B outlines the metabolism of some drugs of abuse. Appendix C advises on formal examination preparation and Appendix D lists some substrates, inducers and inhibitors of the major human cytochrome P450s. Fully updated to reflect advances in the scientific field of drug metabolism and its clinical impact Reflects refinements in the author's teaching method, particularly with respect to helping students understand biological systems and how they operate Illustrates the growing relationship between drug metabolism and personalized medicine Includes recent developments in drug discovery, genomics, and stem cell technologies Human Drug Metabolism, 3rd Edition is an excellent book for advanced undergraduate and graduate students in molecular biology, biochemistry, pharmacology, pharmacy, and toxicology. It will also appeal to professionals interested in an introduction to this field, or who want to learn more about these bench-to-bedside topics to apply it to their practice.

Translational Research Methods in Diabetes Obesity and Nonalcoholic Fatty Liver Disease

Translational Research Methods in Diabetes  Obesity  and Nonalcoholic Fatty Liver Disease Book
Author : Andrew J. Krentz,Christian Weyer,Marcus Hompesch
Publisher : Springer
Release : 2019-04-02
ISBN : 3030117480
Language : En, Es, Fr & De

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Book Description :

This book aims to aid the selection of the most appropriate methods for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, non-alcoholic fatty liver disease (NAFLD) and related cardiometabolic disorders. Clinical research methods to assess the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycemic clamp technique, have become well-established in proof-of-mechanism studies. However, selection of the most appropriate techniques is by no means straightforward. Moreover, the application of such methods must conform to the regulatory requirements for new drugs. This book discusses the need for new pharmacotherapies for diabetes, obesity and NAFLD and the molecular targets of drugs currently in development. Emerging technologies including functional imaging, circulating biomarkers and omics are considered together with practical and ethical issues pertaining to early phase clinical trials in subjects with cardiometabolic disorders. Translational Research Methods in Diabetes, Obesity, and Non-Alcoholic Fatty Liver Disease is of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.

Post Genomic Cardiology

Post Genomic Cardiology Book
Author : José Marín-García
Publisher : Academic Press
Release : 2014-05-09
ISBN : 0124046428
Language : En, Es, Fr & De

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Book Description :

In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the “epigenome,” comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach. This book, written by respected cardiologist José Marín-García, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA. Offers updated discussion of cutting-edge molecular techniques including new genomic sequencing / NGS / Hap-Map / bioinformatics / systems biology approaches Analyzes mitochondria dynamics and their role in cardiac dysfunction, up-to-date analysis of cardio-protection, and cardio-metabolic syndrome Presents recent translational studies, gene therapy, transplantation of stem cells, and pharmacological treatments in CVDs

Autophagy and Cardiometabolic Diseases

Autophagy and Cardiometabolic Diseases Book
Author : Jun Ren,James R. Sowers,Yingmei Zhang
Publisher : Academic Press
Release : 2018-04-12
ISBN : 0128054425
Language : En, Es, Fr & De

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Book Description :

Autophagy and Cardiometabolic Diseases: From Moleculer Mechanisms to Translational Medicine covers the science of autophagy in relation to cardiometabolic diseases and the future therapeutic potentials of autophagy regulation in these processes. Processes are not described in isolation, but in concert with other cellular and/or metabolic processes, such as lipogenesis, glucose, energy metabolism and apoptosis. This approach recognizes the multifactorial nature of cardiometabolic diseases, including obesity, diabetes, insulin resistance, hypertension and dyslipidemia. The book provides explanations, while also distinguishing the delicate role for autophagy in pathogenesis and exploring complications for cardiometabolic diseases. By targeting autophagy, it offers new avenues for drug discovery and treatment for cardiometabolic anomalies. It is a perfect resource for cardiology researchers, scientists and medical practitioners. Explains the processes inherent in the protein quality control for pathogenesis and complications of cardiometabolic diseases Provides knowledge from internationally recognized contributors in the field Incorporates a translational approach, covering the basic cellular biology of autophagy and presenting the role of autophagy regulation for both pathogenesis and complication in cardiometabolic diseases Contains access to a companion website with additional illustrations

Breastfeeding and Human Lactation

Breastfeeding and Human Lactation Book
Author : Karen Wambach,Becky Spencer
Publisher : Jones & Bartlett Learning
Release : 2019-10-01
ISBN : 1284151565
Language : En, Es, Fr & De

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Book Description :

Breastfeeding and Human Lactation, Sixth Edition is the ultimate reference for the latest clinical techniques and research findings that direct evidence-based clinical practice for lactation consultants and specialists. It contains everything a nurse, lactation consultant, midwife, women’s health nurse practitioner, physician assistant, or Ob/Gyn needs to know about the subject. Topics include placing breastfeeding in its historical context, workplace-related issues, anatomical and biological imperatives of lactation, the prenatal and perinatal periods and concerns during the postpartum period, the mother’s health, sociocultural issues, and more vital information.

Advances in Blood Research and Application 2013 Edition

Advances in Blood Research and Application  2013 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2013-06-21
ISBN : 1481694065
Language : En, Es, Fr & De

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Book Description :

Advances in Blood Research and Application / 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Plasma. The editors have built Advances in Blood Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Plasma in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Blood Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

The Foundation of Precision Medicine Integration of Electronic Health Records with Genomics Through Basic Clinical and Translational Research

The Foundation of Precision Medicine  Integration of Electronic Health Records with Genomics Through Basic  Clinical  and Translational Research Book
Author : Mariza de Andrade,Helena Kuivaniemi,Marylyn D. Ritchie
Publisher : Frontiers Media SA
Release : 2016-06-30
ISBN : 2889198723
Language : En, Es, Fr & De

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Book Description :

This eBook contains the 19 articles that were part of a Special Topic in Frontiers in Genetics entitled “Genetics Research in Electronic Health Records Linked to DNA Biobanks”. The Special Issue was published on-line in 2014-2015 and contained papers representing the diverse research ongoing in the integration of electronic health records (EHR) with genomics through basic, clinical, and translational research. We have divided the eBook into four Chapters. Chapter 1 describes the Electronic Medical Records and Genomics (eMERGE) network and its contri-bution to genomics. It highlights methodological questions related to large data sets such as imputation and population stratification. Chapter 2 describes the results of genetic studies on different diseases for which all the phenotypic information was extracted from the EHR with highly specific ePhenotyping algorithms. Chapter 3 focuses on more complex analyses of the genome including copy number variants (CNV), pleiotropy com-bined with phenome-wide association studies (PheWAS), and epistasis (gene-gene interactions). Chapter 4 discusses the use of genetic data together with EHR-derived clinical data in clinical settings, and how to return genetic results to patients and providers. It also contains a comprehensive review on genetic risk scores. We have included mostly Original Research Articles in the eBook, but also Reviews and Methods papers on the relevant topics of analyzing and integrating genomic data. The release of this eBook is timely, since several countries are launching Precision Medicine initiatives. Precision Medicine is a new concept in patient care taking into account individual variability in genetic, environmental and lifestyle factors, when treating diseases or trying to prevent them from developing. It has become an important focus for biomedical, clinical and translational informatics. The papers presented in this eBook are well positioned to educate the readers about Precision Medicine and to demonstrate the potential study designs, methods, strategies, and applications where this type of research can be performed successfully. The ultimate goal is to improve diagnostics and provide better, more targeted care to the patient.

Handbook of Health Psychology

Handbook of Health Psychology Book
Author : Tracey A. Revenson,Regan A. R. Gurung
Publisher : Routledge
Release : 2018-12-18
ISBN : 1351683268
Language : En, Es, Fr & De

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Book Description :

This rich resource provides a thorough overview of current knowledge and new directions in the study of the biological, psychological, social, and cultural factors that affect health, health behavior, and illness. Chapters review the latest theories and research with an emphasis on how research is translated into behavioral medicine interventions. Featuring contributions from top researchers and rising stars in the field, authors provide a theoretical foundation; evaluate the empirical evidence; and make suggestions for future research, clinical practice, and policy. The handbook reflects the latest approaches to health psychology today, including: Emphasis throughout on the socio-cultural aspects of health, including socioeconomic status, gender, race/ethnicity, sexual orientation, and age/developmental stage A new section on emerging areas in health psychology, including behavioral genomics, military veterans' health, and digital health Coverage of prevention, interventions, and treatment in the applications section An expansion of the biopsychosocial model across several levels of analysis, including cultural, macro-social, and cellular factors Sustained emphasis on translating research into practice and policy The handbook considers the intersections of concepts (behavior change), populations (women's and sexual minority health), cultural groups (African American, Asian American, and Latino), risk and protective factors (obesity, coping), and diseases (cancer, diabetes, HIV), making it essential reading for scholars of health psychology, public health, epidemiology, and nursing. Novices to the field appreciate the accessibly written chapters, while seasoned professionals appreciate the book's deep, cutting-edge coverage.

Non coding RNAs at the Cross Road of Cardiometabolic Diseases and Cancer

Non coding RNAs at the Cross Road of Cardiometabolic Diseases and Cancer Book
Author : Paul Holvoet
Publisher : Springer Nature
Release : 2021-07-24
ISBN : 3030688445
Language : En, Es, Fr & De

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Book Description :

Download Non coding RNAs at the Cross Road of Cardiometabolic Diseases and Cancer book written by Paul Holvoet, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Medicine for MRCP

Medicine for MRCP Book
Author : Rupa Bessant
Publisher : Oxford Specialty Training: Revision Texts
Release : 2020-03-23
ISBN : 019877950X
Language : En, Es, Fr & De

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Book Description :

Medicine for MRCP provides a comprehensive review of the material that you need to pass the MRCP Parts 1 and 2 written papers. The twenty-seven chapters mapped out to the RCP syllabus, cover all areas from molecular medicine and genetics, through to medical law and ethics. Written by specialist contributors and educational experts, the content is carefully crafted to build your understanding for both papers. Each chapter begins with the basic science required for Part 1, before covering clinical medicine for Part 1, Part 2 and the PACES examinations. To ensure effective revision, material is presented in short sections with bullet lists, tables, and boxes. Over 150 drawings and photos illustrate key principles and clinical topics making them easier to retain. References to evidence-based protocols and directions to further reading allow for deeper understanding. Candidates can review their progress via the 180 end-of chapter self-assessment questions. Drawing on the authors' expertise, Medicine for MRCP is the ideal companion for the MRCP as well as a useful reference guide for practicing medical doctors.

Understanding Nutrition

Understanding Nutrition Book
Author : Eleanor Noss Whitney,Sharon Rady Rolfes
Publisher : Cengage Learning
Release : 2018-01-01
ISBN : 1337672378
Language : En, Es, Fr & De

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Book Description :

Chosen by more than 1 million readers, Whitney/Rolfes' UNDERSTANDING NUTRITION dispels nutrition myths, empowering you to make better nutrition choices--and enact lasting behavior change. Updated with the latest research and the 2015-2020 Dietary Guidelines, the 15th Edition of this bestseller emphasizes strong science and nutrition basics. With their lively, reader-friendly writing style, the authors walk you step by step through the science of nutrition, while vivid illustrations and quick-reference tables make even the most difficult concepts easy to understand. The text also includes expansive weight loss information and thorough coverage of fitness and energy systems. Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version.

Pacific Symposium On Biocomputing 2015

Pacific Symposium On Biocomputing 2015 Book
Author : Russ B Altman,A Keith Dunker,Lawrence Hunter,Marylyn D Ritchie,Tiffany A Murray,Teri E Klein
Publisher : World Scientific
Release : 2014-11-11
ISBN : 9814644749
Language : En, Es, Fr & De

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Book Description :

The Pacific Symposium on Biocomputing (PSB) 2015 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2015 will be held from January 4 - 8, 2015 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference.PSB 2015 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's “hot topics.” In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.

Annual Review of Nursing Research Volume 34 2016

Annual Review of Nursing Research  Volume 34  2016 Book
Author : Susanne W. Gibbons, PhD, C-ANP/C-GNP,Michaela Shafer, PhD, RN (ret. USAF)
Publisher : Springer Publishing Company
Release : 2015-12-20
ISBN : 0826140890
Language : En, Es, Fr & De

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Book Description :

Annotation This groundbreaking annual review has provided over three decades of knowledge, insight, and research on topics critical to the field of nursing. The 34th volume presents abundant new research devoted to examining and forwarding the field of modern ethics in nursing. It reflects the rapid acceleration of change in the roles and responsibilities of nurses and the concurrent need for reexamination of professional ethical values. Articles focus on creating nurses who are able to negotiate, adapt, and provide excellent care to patients as they take on greater administrative duties, rely more on technology, and assume some of the roles and responsibilities of physicians.Chapters are comprised of carefully selected articles that underscore the importance of in-depth ethical education and professional character development in the nursing classroom, and its continued evolution as nurses adapt to a changing health care environment throughout their careers. They include examples of contemporary health care dilemmas and how nurses have used ethical values to guide their behavior in situations where they encounter highy vulnerable patients; address ethical problems relating to family issues such as self-neglect and the wellbeing of children in military families; and the systems-of-care issues regarding genetics, smart home technologies for older adults, interprofessional collaboration, and post-deloyment reintegration.Key Topics:Nursing Ethics: A Lifelong CommitmentEthical Analysis of Family Impact of Mental Health StigmaEthical issues in Family CareEthical Considerations in Self-NeglectThe Effects of Parental Service on teh WEllbeing of our Youngest Military MembersEthics of Genetics in Primary CareEthics of Smart Home Technologies for Older AdultsPost-Deployment Reintegration: The Ethics of Embodied Personal Presence and hte Formation of Military MeaningEthical Issues Encountered by Military Nurses.

Principles of Nutrigenetics and Nutrigenomics

Principles of Nutrigenetics and Nutrigenomics Book
Author : Raffaele De Caterina,J. Alfredo Martinez,Martin Kohlmeier
Publisher : Academic Press
Release : 2019-09-22
ISBN : 0128045876
Language : En, Es, Fr & De

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Book Description :

Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is the most comprehensive foundational text on the complex topics of nutrigenetics and nutrigenomics. Edited by three leaders in the field with contributions from the most well-cited researchers conducting groundbreaking research in the field, the book covers how the genetic makeup influences the response to foods and nutrients and how nutrients affect gene expression. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is broken into four parts providing a valuable overview of genetics, nutrigenetics, and nutrigenomics, and a conclusion that helps to translate research into practice. With an overview of the background, evidence, challenges, and opportunities in the field, readers will come away with a strong understanding of how this new science is the frontier of medical nutrition. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is a valuable reference for students and researchers studying nutrition, genetics, medicine, and related fields. Uniquely foundational, comprehensive, and systematic approach with full evidence-based coverage of established and emerging topics in nutrigenetics and nutrigenomics Includes a valuable guide to ethics for genetic testing for nutritional advice Chapters include definitions, methods, summaries, figures, and tables to help students, researchers, and faculty grasp key concepts Companion website includes slide decks, images, questions, and other teaching and learning aids designed to facilitate communication and comprehension of the content presented in the book

Nutrition for Health and Health Care

Nutrition for Health and Health Care Book
Author : Linda Kelly DeBruyne,Kathryn Pinna
Publisher : Cengage Learning
Release : 2018-12-17
ISBN : 0357390725
Language : En, Es, Fr & De

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Book Description :

How does nutrition factor into nursing and health care careers? Find out with NUTRITION FOR HEALTH AND HEALTH CARE, 7th Edition! Packed with the latest clinical know-how, this resource enables you to leverage the power of diet therapy to make a real impact on patient lives. You’ll uncover the science behind macro-nutrients, vitamins, minerals and metabolism, along with the many ways nutrition affects drugs, diseases and the human life cycle. And to support your success, the interactive MindTap platform features nutrition and diet therapy case studies, N.C.L.E.X.-style practice problems, the Diet & Wellness Plus app for setting and tracking nutritional goals--even an ebook that can read aloud to you! Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version.

Clinical and Translational Science

Clinical and Translational Science Book
Author : David Robertson,Gordon H. Williams
Publisher : Academic Press
Release : 2016-11-25
ISBN : 012802111X
Language : En, Es, Fr & De

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Book Description :

Clinical and Translational Science: Principles of Human Research, Second Edition, is the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, a field that is devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science. Introduces novel physiological and therapeutic strategies for engaging the fastest growing scientific field in both the private sector and academic medicine Brings insights from international leaders into the discipline of clinical and translational science Addresses drug discovery, drug repurposing and development, innovative and improved approaches to go/no-go decisions in drug development, and traditional and innovative clinical trial designs

Effects of Exercise on Hypertension

Effects of Exercise on Hypertension Book
Author : Linda S. Pescatello
Publisher : Springer
Release : 2015-07-08
ISBN : 3319170767
Language : En, Es, Fr & De

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Book Description :

As the first primer on the effects of exercise on human hypertension, Effects of Exercise on Hypertension: From Cells to Physiological Systems provides the state-of-the-art effects of exercise on the many possible mechanisms underlying essential hypertension in humans. The book contains chapters by distinguished experts on the effects of exercise on physiological systems known to be involved in hypertension development and maintenance as well as less well known aspects of hypertension such as 24-hour ambulatory blood pressure profile and oxidative stress. An emerging area, the effects of resistance exercise training on blood pressure is also covered. A unique aspect of the book is that it covers the effects of exercise mimetics on vascular cell adaptations in order to begin to elucidate some of the cellular mechanisms that may underlie blood pressure reductions with exercise training. Lastly, the book will end with a chapter on the interactive effects of genes and exercise on blood pressure. Chapters are grouped by physiological system or mechanism. The text begins with two overview chapters; one on the general effects of aerobic exercise training and the second on the general effects of resistance exercise training on blood pressure. Each chapter begins with a bulleted list of key points. Effects of Exercise on Hypertension: From Cells to Physiological Systems will be of great value to professional individuals in cardiovascular medicine, the cardiovascular sciences, allied health care professionals, and medical and graduate students in the cardiovascular sciences and medicine.