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Translating Regenerative Medicine To The Clinic

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Translating Regenerative Medicine to the Clinic

Translating Regenerative Medicine to the Clinic Book
Author : Jeffrey Laurence,Pedro Baptista,Anthony Atala
Publisher : Academic Press
Release : 2015-11-18
ISBN : 0128005521
Language : En, Es, Fr & De

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Book Description :

Translating Regenerative Medicine to the Clinic reviews the current methodological tools and experimental approaches used by leading translational researchers, discussing the uses of regenerative medicine for different disease treatment areas, including cardiovascular disease, muscle regeneration, and regeneration of the bone and skin. Pedagogically, the book concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field. It promotes cross-disciplinary communication between the sub-specialties of medicine, but remains unified in theme by emphasizing recent innovations, critical barriers to progress, the new tools that are being used to overcome them, and specific areas of research that require additional study to advance the field as a whole. Volumes in the series include Translating Gene Therapy to the Clinic, Translating Regenerative Medicine to the Clinic, Translating MicroRNAs to the Clinic, Translating Biomarkers to the Clinic, and Translating Epigenetics to the Clinic. Encompasses the latest innovations and tools being used to develop regenerative medicine in the lab and clinic Covers the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field Contains extensive pedagogical updates aiming to improve the education of translational researchers in this field Provides a transdisciplinary approach that supports cross-fertilization between different sub-specialties of medicine

Engineering Biomaterials for Regenerative Medicine

Engineering Biomaterials for Regenerative Medicine Book
Author : Sujata K. Bhatia
Publisher : Springer
Release : 2014-01-25
ISBN : 9781489991041
Language : En, Es, Fr & De

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Book Description :

Regeneration of tissues and organs remains one of the great challenges of clinical medicine, and physicians are constantly seeking better methods for tissue repair and replacement. Tissue engineering and regenerative medicine have been investigated for virtually every organ system in the human body, and progress is made possible by advances in materials science, polymer chemistry, and molecular biology. This book reviews the current status of biomaterials for regenerative medicine, and highlights advances in both basic science and clinical practice. The latest methods for regulating the biological and chemical composition of biomaterials are described, together with techniques for modulating mechanical properties of engineered constructs. Contributors delineate methods for guiding the host response to implantable materials, and explain the use of biologically-inspired materials for optimal biological functionality and compatibility. The book culminates in a discussion of the clinical applications of regenerative medicine. By integrating engineering and clinical medicine, Engineering Biomaterials for Regenerative Medicine examines how tissue engineering and regenerative medicine can be translated into successful therapies to bridge the gap between laboratory and clinic. The book will aid materials scientists and engineers in identifying research priorities to fulfill clinical needs, and will also enable physicians to understand novel biomaterials that are emerging in the clinic. This integrated approach also gives engineering students a sense of the excitement and relevance of materials science in the development of novel therapeutic strategies.

Enabling Late stage Translation of Regenerative Medicine Based Products

Enabling Late stage Translation of Regenerative Medicine Based Products Book
Author : Pawanbir Singh
Publisher : Unknown
Release : 2010
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The primary aim of the thesis is to contribute to demonstrating how established and emerging science in the regenerative medicine (RM) domain can be translated into profitable commercial practice, and generate clinically- and cost-effective therapies. It achieves this by exploring and assessing underlying economics, including investment readiness and economic assessment, exploring regulatory and reimbursement frameworks, developing stem cell culture systems and assessing fit with clinical practice. The thesis is the first public domain wide-ranging analysis of business trends in the production, manufacturing and supply segments of the RM industry. It analyses the clinical potential of the domain as well as the translational and commercial challenges facing the industry. The industry is at a turning point as big pharmaceutical companies engage with RM in order to explore technologies as potential therapeutics and discovery tools. This unlocks the industry by confirming an exit path for RM based small- and medium-sized enterprises. Translation has come to be recognised as a core issue in the overall space and translation of regenerative therapies into the clinic is presently challenging, high-risk and expensive. This research addresses the question what are the mechanisms required to enable translation of emerging scientific knowledge into commercially viable clinical RM products? These mechanisms are particularly important as their creation involves and requires major investment decisions, which can determine the success or failure of RM developments and indeed of the companies concerned. The lack of well-established business models and the complexity of the domain suggested a conceptual approach drawing upon relevant literature from product and process development, applied business and revenue models, technological evolution and capital market ingenuity. The research was carried out in two phases. The first phase was concerned with identification of key challenges and mapping the overall industry emergence including emergence of related regulations to provide a context and framework for understanding the domain. Based on the emergence mapping a timeline of key parallel factors was identified, and their inherent connections explored to identify transforming events affecting and influencing multiple factors on the journey to clinical success within a business environment. This creates the reference model. The second phase was concerned with manufacturing a stem cell based therapeutic and applying health economic principles to determine available headroom for investment, cost of goods and return on investment, taking hearing disorders as a case exemplar, and exploring the behaviour of the net present value curve to identify key parameters affecting the economic positioning of this novel regime. A key output of the research is the investment readiness reference model. It integrates key RM business issues against reducing uncertainty and increasing value. The model argues that the complex nature of RM products means that the issues affecting industry emergence and development go well beyond the primarily scientific and technological concerns on which much current research focuses. The performance of RM firms ultimately hinges upon the successful clinical application of their developed products, the key step for creating and realising value, and their ability to deal with the fundamental business issues specific to the area. The framework deals with these business issues, which are investment & technology readiness, business models, organisational challenges, public policy and industry emergence. This thesis explores ideas that may bridge the chasm between the promise and reality of RM i.e. mechanisms to enable late stage translation of RM products. It links technological capability and business models for firms in the domain. Furthermore, it offers a unique perspective on the nature and characteristics of investment readiness and financial assessment, specifically identifying key parameters affecting economic positioning. The key contributions are therefore: New insights into the key challenges involved in realising the commercial potential of cell based therapeutics. Technology road mapping to link fundamental enabling technological capability for developing RM products with robust business plans integrating strategy, technology development and the regulatory and reimbursement framework. A generic investment readiness reference model generated from the enabling technology, value and supply chain structures to identify key indicators and characteristics of industry readiness. A novel experimental programme demonstrating expansion, maintenance and differentiation of human embryonic stem cells by manual and automated methods. New insights into economic positioning by mapping net present value, and economic analysis by estimating available headroom, cost of goods and return on investment for a putative hearing therapeutic.

Perinatal Tissue Derived Stem Cells

Perinatal Tissue Derived Stem Cells Book
Author : Babak Arjmand
Publisher : Springer
Release : 2016-12-01
ISBN : 3319464108
Language : En, Es, Fr & De

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Book Description :

This book covers several aspects of perinatal tissue-derived stem cells, from theoretical concepts to clinical applications. Topics include functions and different sources, immunomodulatory properties, translational point of view, GMP facility design and manufacturing for clinical translation, therapeutic potentials, and finally ethical considerations. The text provides a brief review of each type of perinatal stem cells and then focuses on their multi- or pluripotent properties, regenerative capacity, and future therapeutic potential in regenerative medicine. Additionally, the book discusses GMP compliance in stem cell facilities and the manufacture of stem cells for clinical translation. The chapters are authored by world-renowned experts in the perinatal stem cell field. Perinatal Tissue-Derived Stem Cells: Alternative Sources of Fetal Stem Cells, part of Springer’s Stem Cell Biology and Regenerative Medicine series, is essential reading for basic and clinical scientists, clinicians, and pharmaceutical experts working or conducting research in the fields of stem cell biology, molecular aspects of stem cell research, tissue engineering, regenerative medicine, and cellular therapy.

A Roadmap to Nonhematopoietic Stem Cell Based Therapeutics

A Roadmap to Nonhematopoietic Stem Cell Based Therapeutics Book
Author : Xiao-Dong Chen
Publisher : Academic Press
Release : 2018-08-31
ISBN : 0128119217
Language : En, Es, Fr & De

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Book Description :

A Roadmap to Non-hematopoietic Stem Cell-Based Therapeutics: From the Bench to the Clinic is a resource that provides an overview of the principles of stem cell therapy, the promises and challenges of using stem cells for treating various clinical conditions, and future perspectives. The overall goal is to facilitate the translation of basic research on stem cells to clinical applications. The properties of stem cells from various sources are reviewed and the advantages and disadvantages of each for clinical use are discussed. Modifying stem cell properties through preconditioning strategies using physical, chemical, genetic, and molecular manipulation to improve cell survival, increase cell differentiation potential, enhance production of paracrine factors, and facilitate homing to the site of injury or disease upon transplantation are reviewed. Various routes of stem cell administration and dosing, and the duration of effects, are explored. Individual chapters are written by experts in the field and focus on the use of stem cells in treating various degenerative diseases, autoimmune diseases, wound healing, cardiovascular disease, spinal cord injury, oral and dental diseases, and skeletal disorders. Finally, experts in the regulatory arena discuss mechanisms used in different countries for approving the use of stem cells to treat diseases and many common issues that are typically encountered while seeking approval for this class of therapeutic agent. Offers advanced students, as well as new researchers, an overview of the principles of stem cell therapy Discusses a wide array of pressing clinical issues with stem cell-based therapies so that new ideas in the laboratory can be efficiently translated to the clinic through better designed clinical trials Helps clarify current regulatory mechanisms so that the safe use of stem cells for treating a variety of diseases can move forward Fosters cross-disciplinary dialogue between research scientists and physicians to accelerate the safe implementation of efficacious cell therapies

Translating Gene Therapy to the Clinic

Translating Gene Therapy to the Clinic Book
Author : Jeffrey Laurence,Michael Franklin
Publisher : Academic Press
Release : 2014-11-14
ISBN : 0128005645
Language : En, Es, Fr & De

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Book Description :

Translating Gene Therapy to the Clinic, edited by Dr. Jeffrey Laurence and Michael Franklin, follows the recent, much-lauded special issue of Translational Research in emphasizing clinical milestones and critical barriers to further progress in the clinic. This comprehensive text provides a background for understanding the techniques involved in human gene therapy trials, and expands upon the disease-specific situations in which these new approaches currently have the greatest therapeutic application or potential, and those areas most in need of future research. It emphasizes methods, tools, and experimental approaches used by leaders in the field of translational gene therapy. The book promotes cross-disciplinary communication between the sub-specialties of medicine, and remains unified in theme. Presents impactful and widely supported research across the spectrum of science, method, implementation and clinical application Offers disease-based coverage from expert clinician-scientists, covering everything from arthritis to congestive heart failure, as it details specific progress and barriers for current translational use Provides key background information from immune response through genome engineering and gene transfer, relevant information for practicing clinicians contemplating enrolling patients in gene therapy trials

Handbook of Innovations in Central Nervous System Regenerative Medicine

Handbook of Innovations in Central Nervous System Regenerative Medicine Book
Author : António Salgado
Publisher : Elsevier
Release : 2020-06-10
ISBN : 0128180854
Language : En, Es, Fr & De

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Book Description :

Handbook of Innovations in CNS Regenerative Medicine provides a comprehensive overview of the CNS regenerative medicine field. The book describes the basic biology and anatomy of the CNS and how injury and disease affect its balance and the limitations of the present therapies used in the clinics. It also introduces recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies. Finally, the book presents successful cases of translation of basic research to first-in-human trials and the steps needed to follow this path. Areas such as cell transplantation approaches, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies are key in regenerative medicine are covered in the book, along with regulatory and ethical issues. Describes the basic biology and anatomy of the CNS and how injury and disease affect its balance Discusses the limitations of present therapies used in the clinics Introduces the recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies, and enabling technologies Presents successful cases of translation of basic research to first-in-human trials, along with the steps needed to follow this path

Essentials of Mesenchymal Stem Cell Biology and Its Clinical Translation

Essentials of Mesenchymal Stem Cell Biology and Its Clinical Translation Book
Author : Robert Chunhua Zhao
Publisher : Springer Science & Business Media
Release : 2013-06-05
ISBN : 9400767161
Language : En, Es, Fr & De

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Book Description :

Mesenchymal stem cells (MSCs), a type of adult stem cells, have attracted the attention of scientists and physicians alike due to their unique biological properties and potential for disease treatment. As stem cell research is complex and progressing rapidly, it is important that the experts in this field share their views and perspectives. This book, co-edited by leading global researchers, is divided into three major sections and covers a broad range of topics concerning MSCs during their transition from benchside to bedside. The book is intended for researchers and clinicians in the field of stem cells. Dr. Robert Chunhua Zhao, MD. Ph.D is Cheung Kong Professor of Stem Cell Biology, Professor of Cell Biology at the Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, China Director of Center for Tissue Engineering, PUMC Chief scientist of 973 program Regional Editor of Stem Cells and Development.

Frontiers in Stem Cell and Regenerative Medicine Research

Frontiers in Stem Cell and Regenerative Medicine Research Book
Author : Atta-ur Rahman,Shazia Anjum
Publisher : Bentham Science Publishers
Release : 2017-05-11
ISBN : 1681084759
Language : En, Es, Fr & De

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Book Description :

Stem cell and regenerative medicine research is a hot area of research which promises to change the face of medicine as it will be practiced in the years to come. Challenges in the 21st century to combat diseases such as cancer, Alzheimer and related diseases may well be addressed employing stem cell therapies and tissue regeneration. Frontiers in Stem Cell and Regenerative Medicine Research is essential reading for researchers seeking updates in stem cell therapeutics and regenerative medicine. The fifth volume of this series features reviews on vascular regeneration, neuronal tissue grafting in animal CNS disease models, template mediated biomineralization in bones, corneal endothelium differentiation and stem cell uses for managing hepatocellular carcinoma.

Debating Modern Medical Technologies The Politics of Safety Effectiveness and Patient Access

Debating Modern Medical Technologies  The Politics of Safety  Effectiveness  and Patient Access Book
Author : Karen J. Maschke,Michael K. Gusmano
Publisher : ABC-CLIO
Release : 2018-09-14
ISBN : 1440861900
Language : En, Es, Fr & De

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Book Description :

This book analyzes policy fights about what counts as good evidence of safety and effectiveness when it comes to new health care technologies in the United States and what political decisions mean for patients and doctors. • Helps readers to understand the political, economic, and ideological dimensions of disputes about health technology assessment and the implications of various policy approaches for patients and the health care system • Includes discussion of disputes related to hot topics such as stem cell therapies, mammography screening, genomic tests, breast cancer drugs, and Hepatitis C medications • Discusses interest group pressure on government from large pharmaceutical companies and medical device manufacturers • Connects to current political rhetoric about speeding up the availability of technology

Plurixcel Emerging Technologies of Regenerative Medicine

Plurixcel  Emerging Technologies of Regenerative Medicine Book
Author : Xuejun H. Parsons
Publisher : Independently Published
Release : 2017-07-24
ISBN : 9781521929131
Language : En, Es, Fr & De

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Book Description :

The limit capacity of heart muscle and brain cells for self-repair constitutes a significant challenge to traditional medicine for tissue and function restoration in seeking cures for a wide range of heart diseases and neurological disorders. Given their limited capacity for self-repair, cell-based therapy represents a promising therapeutic approach closest to provide a cure to restore normal tissue and function. However, the existing markets lack a scalable clinically-suitable human neuronal or heart cell source with adequate regenerative potential, which has been the major setback in developing safe and effective cell-based therapies. To date, the need to restore vital tissue and function for a wide range of neurological and heart diseases remains a daunting challenge to the conventional mode of drugs and treatments. The pluripotent human embryonic stem cells (hESC), the nature source of human pluripotent stem cells (hPSC), have unlimited expansion and differentiation capabilities, offering a practically inexhaustible source of replacement cells for tissue and function restoration. Therefore, they have been regarded as an ideal source to provide an unlimited supply of clinically-relevant functional human cells to heal the damaged or lost tissues that have naturally limited capacity for self-repair, such as the human brain and heart. As neurological and heart diseases incur exorbitant costs on the healthcare system worldwide, there is a strong focus on translating hPSC research to provide newer, more efficient solutions for these unmet therapeutic needs. However, a persistent challenge for clinical translation is to enable a well-controlled and efficient induction of non-functional hPSC exclusively and uniformly to a specific clinically relevant functional lineage. PluriXcel is a pioneer in stem cell therapeutics and remarkable advancement in stem cell research related to the differentiation of non-functional hPSC into specific functional lineages by small molecule induction. The PluriXcel technology platforms offer currently the only available human cell products with the pharmacological capacity to regenerate neurons and contractile heart muscles that allow restitution of function in the clinic. PluriXcel technological breakthroughs allow the achievement of a highly efficient direct conversion of clinical-grade hPSC into a large supply of high-purity human neuronal cells or heart muscle cells with adequate capacity to regenerate neurons or contractile heart muscles for cell regeneration or replacement therapies, as well as for tissue or organ biofabrication. The PluriXcel platforms not only constitute clinically representative progresses in both human neuronal and cardiac therapeutic products for treating a wide range of incurable or hitherto untreatable neurological and heart diseases, but also offer manufacturing innovations for production scale-up and creation of replacement human tissue and organ products. Medical innovations of PluriXcel technology provide scalable platforms to ensure a high degree of efficacy and safety of hPSC-derived cellular products, thus robust clinical benefits leading to therapies, for treating major human diseases challenging traditional medicine. Manufacturing innovations of PluriXcel technology provide scale-up cGMP manufacturing capability for production of large quantities of high quality clinical-grade hPSC-based cell therapy products to support clinical trials and tissue or organ engineering/biofabrication, improving the availability, reproducibility, accessibility, and standardization of manufacturing materials, technologies, and processes to create human repairing or replacing cell, tissue, and organ products. Medical and manufacturing innovations of PluriXcel technology provide life scientists and clinicians with novel, efficient, and powerful resources and tools to address major health concerns, which will shape the future of medicine and bring new therapeutics into the market.

Exploring Sources of Variability Related to the Clinical Translation of Regenerative Engineering Products

Exploring Sources of Variability Related to the Clinical Translation of Regenerative Engineering Products Book
Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Regenerative Medicine
Publisher : National Academies Press
Release : 2019-07-19
ISBN : 0309489091
Language : En, Es, Fr & De

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Book Description :

The emerging multidisciplinary field of regenerative engineering is devoted to the repair, regeneration, and replacement of damaged tissues or organs in the body. To accomplish this it uses a combination of principles and technologies from disciplines such as advanced materials science, developmental and stem cell biology, immunology, physics, and clinical translation. The term "regenerative engineering" reflects a new understanding of the use of tissue engineering for regeneration and also the growing number of research and product development efforts that incorporate elements from a variety of fields. Because regenerative engineered therapies rely on live cells and scaffolds, there are inherent challenges in quality control arising from variability in source and final products. Furthermore, each patient recipient, tissue donor, and product application is unique, meaning that the field faces complexities in the development of safe and effective new products and therapies which are not faced by developers of more conventional therapies. Understanding the many sources of variability can help reduce this variability and ensure consistent results. The Forum on Regenerative Medicine hosted a public workshop on October 18, 2018, in Washington, DC, to explore the various factors that must be taken into account in order to develop successful regenerative engineering products. Invited speakers and participants discussed factors and sources of variability in the development and clinical application of regenerative engineering products, characteristics of high-quality products, and how different clinical needs, models, and contexts can inform the development of a product to improve patient outcomes. This publication summarizes the presentation and discussion of the workshop.

The Immunological Barriers to Regenerative Medicine

The Immunological Barriers to Regenerative Medicine Book
Author : Paul J. Fairchild
Publisher : Springer Science & Business Media
Release : 2012-10-17
ISBN : 1461454794
Language : En, Es, Fr & De

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Book Description :

This volume offers an analysis of the scale and nature of the immunological issues facing regenerative medicine, drawing on the expertise of laboratories around the world who have taken up the challenge of applying their expertise in immunology to the vagaries of stem cell biology. In Part I, we explore the extent to which the principles of allograft rejection, learned over several decades from our experiences of whole organ transplantation, apply within the unique context of cell replacement therapy. Part II discusses various innovative ways of addressing the issues of immunogenicity, while, in Part III, we focus exclusively on the induction of immunological tolerance through a variety of novel approaches. It is our hope that this systematic analysis of the current state of the field will galvanise efforts to solve an issue which has so far remained intractable.

Stem Cells Basics and Clinical Translation

Stem Cells  Basics and Clinical Translation Book
Author : Robert Chunhua Zhao
Publisher : Springer
Release : 2015-09-14
ISBN : 9401772738
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive review of the properties of various stem cell types, the mechanisms of their behaviors and their potential clinical application. Stem cells have a great capacity of self-renewal and differentiation. They represent new paradigms for disease treatment in the field of regenerative medicine since the day they were discovered. As stem cell research is complicated and making progress rapidly, it is important to have expertise in this field to share their views and perspectives. This book provides a wonderful platform for those who are interested in stem cells to learn from and communicate with experts. Particularly, it highlights the roles of stem cell based therapy for a variety of diseases. Furthermore, this book gives a detailed introduction to the great works related to stem cells in China. The readers could gain a profound knowledge of the state-of-art research done by scientists in the field of stem cells. Overall, this book will be a valuable reference resource for both experienced investigators pursuing stem cell research as well as those are just entering into this field. Dr. Robert Chunhua Zhao, a Cheung Kong Professor of Stem Cell Biology, is Professor of Cell Biology at the Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College (PUMC), Beijing, China. He is Director of the Center for Tissue Engineering, PUMC and Chief Scientist of the National Basic Research Program of China (“973 Program”). He also serves as Regional Editor of Stem Cells and Development.

Quality Assurance Practices Ensure Safety in Human Embryonic Stem Cell Programs

Quality Assurance Practices Ensure Safety in Human Embryonic Stem Cell Programs Book
Author : Rachelle (Shelly) Tannenbaum
Publisher : Unknown
Release : 2010
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Quality Assurance Practices Ensure Safety in Human Embryonic Stem Cell Programs book written by Rachelle (Shelly) Tannenbaum, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Stem Cells Regenerative Medicine

Stem Cells   Regenerative Medicine Book
Author : Krishnarao Appasani,Raghu K. Appasani
Publisher : Springer Science & Business Media
Release : 2010-11-01
ISBN : 9781607618607
Language : En, Es, Fr & De

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Book Description :

Defined as, “The science about the development of an embryo from the fertilization of the ovum to the fetus stage,” embryology has been a mainstay at universities throughout the world for many years. Throughout the last century, embryology became overshadowed by experimental-based genetics and cell biology, transforming the field into developmental biology, which replaced embryology in Biology departments in many universities. Major contributions in this young century in the fields of molecular biology, biochemistry and genomics were integrated with both embryology and developmental biology to provide an understanding of the molecular portrait of a “development cell.” That new integrated approach is known as stem-cell biology; it is an understanding of the embryology and development together at the molecular level using engineering, imaging and cell culture principles, and it is at the heart of this seminal book. Stem Cells and Regenerative Medicine: From Molecular Embryology to Tissue Engineering is completely devoted to the basic developmental, cellular and molecular biological aspects of stem cells as well as their clinical applications in tissue engineering and regenerative medicine. It focuses on the basic biology of embryonic and cancer cells plus their key involvement in self-renewal, muscle repair, epigenetic processes, and therapeutic applications. In addition, it covers other key relevant topics such as nuclear reprogramming induced pluripotency and stem cell culture techniques using novel biomaterials. A thorough introduction to stem-cell biology, this reference is aimed at graduate students, post-docs, and professors as well as executives and scientists in biotech and pharmaceutical companies.

Cardiac Extracellular Matrix

Cardiac Extracellular Matrix Book
Author : Eric G. Schmuck,Peiman Hematti,Amish N. Raval
Publisher : Springer
Release : 2018-09-20
ISBN : 3319974211
Language : En, Es, Fr & De

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Book Description :

This book on cardiac extracellular matrix (ECM) features three sections, Fundamental Science, Pre-Clinical and Translational Science, and Clinical Applications. In the Fundamental Science section, we will cover the spectrum of basic ECM science from ECM’s role in development, biomechanical properties, cardiac ECM influence of cardiomyocyte biology, pathophysiology of ECM in heart disease, and ECM in tissue engineering. Section two, Preclinical and Translational Science, will discuss cardiac ECM technologies in the clinical pipeline including approaches to ECM as a therapeutic, animal models of cardiac research, tracking and imaging methods of cardiac ECM, and cGMP manufacturing and regulatory considerations for ECM based therapeutics. Finally, the third section, Clinical Applications, will highlight the clinical experience around cardiac ECM including therapeutic strategies targeting scar tissue in the heart, Clinical trial design and regulatory considerations, current human clinical trials in cardiovascular medicine and the role of pharmaceutical and biotech companies in the commercialization of ECM technologies for cardiovascular indications. This book provides a comprehensive review for basic and translational researchers as well as clinical practitioners and those involved in commercialization, regulatory and entrepreneurial activities.

Neural Regeneration

Neural Regeneration Book
Author : Kwok Fai So,Xiao-Ming Xu
Publisher : Academic Press
Release : 2015-02-03
ISBN : 0128018348
Language : En, Es, Fr & De

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Book Description :

Neural Regeneration provides an overview of cutting-edge knowledge on a broad spectrum of neural regeneration, including: Neural regeneration in lower vertebrates Neural regeneration in the peripheral nervous system Neural regeneration in the central nervous system Transplantation-mediated neural regeneration Clinical and translational research on neural regeneration The contributors to this book are experts in their fields and work at distinguished institutions in the United States, Canada, Australia, and China. Nervous system injuries, including peripheral nerve injuries, brain and spinal cord injuries, and stroke affect millions of people worldwide every year. As a result of this high incidence of neurological injuries, neural regeneration and repair is becoming a rapidly growing field dedicated to the new discoveries to promote structural and functional recoveries based on neural regeneration. The ultimate goal is to translate the most optimal regenerative strategies to treatments of human nervous system injuries. This valuable reference book is useful for students, postdoctors, and basic and clinical scientists who are interested in neural regeneration research. Provides an overview of cutting-edge knowledge on a broad spectrum of neural regeneration Highly translational and clinically-relevance International authors who are leaders in their respective fields Vivid art work making the chapters easily understood

Stem Cell Bioprocessing

Stem Cell Bioprocessing Book
Author : Tiago G Fernandes,Maria Margarida Diogo,Joaquim M. S. Cabral
Publisher : Elsevier
Release : 2013-11-15
ISBN : 1908818301
Language : En, Es, Fr & De

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Book Description :

Stem cell bioprocessing describes the main large-scale bioprocessing strategies for both stem cell culture and purification, envisaging the application of these cells for regenerative medicine and drug screening. Bioreactor configurations are described, including their applications for stem cell expansion, and stem cell separation techniques such as isolation and purification are discussed. Basic definitions are provided concerning the different types of stem cells, from adult stem cells to the more recent induced pluripotent stem cells. The main characteristics of these different stem cell types are described, alongside the molecular mechanisms underlying their self-renewal and differentiation. The book also focuses on methodologies currently used for in vitro stem cell culture under static conditions, including the challenge of xeno-free culture conditions, as well as culture parameters that influence stem cell culture. Approaches for both stem cell culture and separation in micro-scale conditions are presented, including the use of cellular microarrays for high-throughput screening of the effect of both soluble and extracellular matrix molecules. A further section is dedicated to application of stem cells for regenerative medicine. Maintains a unique focus on both the basic stem cell biology concepts, and their translation to large-scale bioprocessing approaches Envisages the use of stem cells in regenerative medicine and drug screening applications Discusses the application of microscale techniques as a tool to perform basic stem cell biology studies

Stem Cells in Clinical Practice and Tissue Engineering

Stem Cells in Clinical Practice and Tissue Engineering Book
Author : Rakesh Sharma
Publisher : BoD – Books on Demand
Release : 2018-05-02
ISBN : 1789230101
Language : En, Es, Fr & De

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Book Description :

Stem Cells in Clinical Practice and Tissue Engineering is a concise book on applied methods of stem cell differentiation and optimization using tissue engineering methods. These methods offer immediate use in clinical regenerative medicine. The present volume will serve the purpose of applied stem cell differentiation optimization methods in clinical research projects, as well as be useful to relatively experienced stem cell scientists and clinicians who might wish to develop their stem cell clinical centers or research labs further. Chapters are arranged in the order of basic concepts of stem cell differentiation, clinical applications of pluripotent stem cells in skin, cardiac, bone, dental, obesity centers, followed by tissue engineering, new materials used, and overall evaluation with their permitted legal status.