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Transgenerational Epigenetics

Transgenerational Epigenetics Book
Author : Anonim
Publisher : Academic Press
Release : 2019-05-18
ISBN : 0128167335
Language : En, Es, Fr & De

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Book Description :

Transgenerational Epigenetics, Second Edition, offers the only up-to-date, comprehensive analysis of the inheritance of epigenetic phenomena between generations with an emphasis on human disease relevance, drug discovery, and next steps in clinical translation. International experts discuss mechanisms of epigenetic inheritance, its expression in animal and plant models, and how human ailments, such as metabolic disorders and cardiovascular disease are influenced by transgenerational epigenetic inheritance. Where evidence is sufficient, epigenetic clinical interventions are proposed that may help prevent or reduce the severity of disease before offspring are born. This edition has been thoroughly revised in each disease area, featuring newly researched actors in epigenetic regulation, including long noncoding RNA in addition to histone modifications and DNA methylation. Therapeutic pathways in treating cancer and extending human longevity are also considered, as are current debates and future directions for research. Presents a fully-updated and expanded release addressing transgenerational epigenetics, epigenetic mechanisms of gene regulation, and the role of epigenetics in human longevity and cancer Examines the field from "bench-to-bedside", discussing basic science, disease management, current debates, and next steps in epigenetic research and drug discovery Features chapter contributions from international experts

The Role of Transgenerational Epigenetics in the Culmination of Phenotype

The Role of Transgenerational Epigenetics in the Culmination of Phenotype Book
Author : Anonim
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Role of Transgenerational Epigenetics in the Culmination of Phenotype book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Transgenerational Epigenetics

Transgenerational Epigenetics Book
Author : Hope Kramer
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Transgenerational Epigenetics book written by Hope Kramer, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Environmental Epigenomics in Health and Disease

Environmental Epigenomics in Health and Disease Book
Author : Randy L Jirtle,Frederick L. Tyson
Publisher : Springer Science & Business Media
Release : 2013-05-16
ISBN : 3642233805
Language : En, Es, Fr & De

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Book Description :

There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome.

Epigenetics and Reproductive Health

Epigenetics and Reproductive Health Book
Author : Anonim
Publisher : Academic Press
Release : 2020-09-12
ISBN : 0128197544
Language : En, Es, Fr & De

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Book Description :

Epigenetics and Reproductive Health, a new volume in the Translational Epigenetics series, provides a thorough overview and discussion of epigenetics in reproduction and implications for reproductive medicine. Twenty international researchers discuss epigenetic mechanisms operating during the formation of male and female gametes, fertilization and subsequent embryo and placental development, particularly in mammals and transgenerational epigenetic inheritance. This volume also addresses aberrant epigenetic changes influencing male and female infertility, pregnancy related disorders, and those potentially linked to therapeutic manipulations and assisted reproductive technologies. Emphasis is placed on identifying biomarkers for early detection of aberrant epigenetic mechanisms. Later chapters examine the possibility of correcting these epigenetic dysfunctions, as well as current challenges and next steps in research, enabling new translational discoveries and efforts towards developing therapeutics. Thoroughly examines the influence of aberrant epigenetics during gametogenesis and embryogenesis, affecting parents, gametes and embryos, offspring and future generations Explores health outcomes for reproductive senescence, endocrine disruption, testicular cancer, prostrate cancer, breast cancer, ovarian, cancer, endometrial cancer and cervical cancers Features chapter contributions from international researchers in the field

Epigenetics for Beginners and Intermediate 2 Books in 1

Epigenetics for Beginners and Intermediate  2 Books in 1  Book
Author : Frank Brown
Publisher : Youcanprint
Release : 2021-09-15
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

You Are About To Develop A Comprehensive Understanding Of The Concept Of Epigenetics, Its Place In Modern Day Medicine, And Health Optimization And Why It Is Literally Changing How We Approach The Treatment Of Various Health Problems! Modern research has now confirmed that the behavior of your genes doesn't always depend on their DNA sequence, but also on factors referred to epigenetics, and that changes in these factors can play a critical role in disease, life structures, behavior and all aspects of life. And that's not all; research also shows that therapies based on these factors have proven effective in reversing some conditions, boosting the immune system, optimizing psychology and human adaptation. Epigenetics have thus taken the center stage in understanding human biology at a deeper level, life, and evolution. But what are epigenetics, and how to they work? How does the environment affect them, and how is this "remembered" in the body? How does epigenetic therapy work? What does it treat? Isn't it risky? What is the relationship between epigenetics and the human psychology? How can we benefit from the discovery and understanding of epigenetics? If you have these and other related questions, this 2 in 1 book is for you so keep reading. Here is a bit of what you'll learn from this 2 in 1 book: • What epigenetics are, why they're important and how they work • How epigenetics relate with our experiences • How cells divide, and how genes control the growth and division of cells • The difference between the DNA, gene and chromosomes • The existing evidence of epigenetic changes, including in transgenerational epigenetic inheritance • The ins and outs of epigenetics mechanisms • The types of epigenetic therapies available today, including their risks, benefits and research on them • The effect of epigenetic control in transcriptional regulation in pluripotency and early differentiation, DNA methylation and Demethylation, nucleosome remodeling and chromatin looping • How epigenetics work at the molecular level and the effect of DNA damage in epigenetic change • The functions of epigenetics, and how they boost mindfulness training, healthy eating and exercise • How epigenetic therapy and modifications affects diabetic retinopathy, emotional disorders, cardiac dysfunction, cancer and schizophrenia, mesothelioma and many more • How epigenetic modifications are used in understanding plant and animal evolution • How epigenetic mechanisms are used in understanding human adaptation, boosting memory formation, growth and reinforcing infant neurobehavior. • The role of epigenetic mechanisms in maternal care • The role of environmental chemicals in epigenetics • How epigenetics are involved in neurodegenerative diseases, drug formation, human development, the development of Hox genes and many more. • The role of environmental exposures in pathophysiology of IPF • Modulation of epigenetic marks by environmental exposures • How epigenetic regulation affects the immune system …And so much more! Whether you are a beginner or an intermediate in epigenetics, you will find this book educative, as you learn the A-Z of factors that are quickly changing our understanding of the structure of life. Don't wait…. Scroll up and click Buy Now with 1-Click or Buy Now to get started!

Epigenetics Explained How Modern Biology is Changing the Concepts of Genetics and Inheritance How the environment can affect our genes

Epigenetics Explained  How Modern Biology is Changing the Concepts of Genetics and Inheritance  How the environment can affect our genes  Book
Author : Frank Brown
Publisher : Youcanprint
Release : 2021-09-15
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

You Are About To Develop A Comprehensive Understanding Of The Concept Of Epigenetics, Its Place In Modern Day Medicine, And Health Optimization And Why It Is Literally Changing How We Approach The Treatment Of Various Health Problems! Modern research has now confirmed that the behavior of your genes doesn't always depend on their DNA sequence, but also on factors referred to epigenetics, and that changes in these factors can play a critical role in disease, life structures, behavior and all aspects of life. And that's not all; research also shows that therapies based on these factors have proven effective in reversing some conditions, boosting the immune system, optimizing psychology and human adaptation. Epigenetics have thus taken the center stage in understanding human biology at a deeper level, life, and evolution. But what are epigenetics, and how to they work? How does the environment affect them, and how is this "remembered" in the body? How does epigenetic therapy work? What does it treat? Isn't it risky? What is the relationship between epigenetics and the human psychology? How can we benefit from the discovery and understanding of epigenetics? If you have these and other related questions, this 2 in 1 book is for you so keep reading. Here is a bit of what you'll learn from this 2 in 1 book: • What epigenetics are, why they're important and how they work • How epigenetics relate with our experiences • How cells divide, and how genes control the growth and division of cells • The difference between the DNA, gene and chromosomes •The existing evidence of epigenetic changes, including in transgenerational epigenetic inheritance • The ins and outs of epigenetics mechanisms • The types of epigenetic therapies available today, including their risks, benefits and research on them • The effect of epigenetic control in transcriptional regulation in pluripotency and early differentiation, DNA methylation and Demethylation, nucleosome remodeling and chromatin looping • How epigenetics work at the molecular level and the effect of DNA damage in epigenetic change • The functions of epigenetics, and how they boost mindfulness training, healthy eating and exercise • How epigenetic therapy and modifications affects diabetic retinopathy, emotional disorders, cardiac dysfunction, cancer and schizophrenia, mesothelioma and many more • How epigenetic modifications are used in understanding plant and animal evolution • How epigenetic mechanisms are used in understanding human adaptation, boosting memory formation, growth and reinforcing infant neurobehavior. • The role of epigenetic mechanisms in maternal care • The role of environmental chemicals in epigenetics • How epigenetics are involved in neurodegenerative diseases, drug formation, human development, the development of Hox genes and many more. • The role of environmental exposures in pathophysiology of IPF • Modulation of epigenetic marks by environmental exposures • How epigenetic regulation affects the immune system …And so much more! Whether you are a beginner or an intermediate in epigenetics, you will find this book educative, as you learn the A-Z of factors that are quickly changing our understanding of the structure of life. Don't wait…. Scroll up and click Buy Now with 1-Click or Buy Now to get started!

Transgenerational Epigenetic Inheritance in Drosophila Melanogaster

Transgenerational Epigenetic Inheritance in Drosophila Melanogaster Book
Author : Joseph Joudrey
Publisher : Unknown
Release : 2012
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Transgenerational Epigenetic Inheritance in Drosophila Melanogaster book written by Joseph Joudrey, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Epigenetics in Psychiatry

Epigenetics in Psychiatry Book
Author : Jacob Peedicayil,Dennis R. Grayson,Dimitri Avramopoulos
Publisher : Academic Press
Release : 2021-08-16
ISBN : 0128235780
Language : En, Es, Fr & De

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Book Description :

Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth. Fully revised to discuss new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics in psychiatric disease Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteins Catalyzes knowledge discovery in both basic epigenetic biology and epigenetic targets for drug discovery Provides guidance in research methods and protocols, as well how to employ data from consortia, single cell analysis, and epigenome-wide association studies (EWAS) Features chapter contributions from international leaders in the field

Epigenetics the Environment and Children s Health Across Lifespans

Epigenetics  the Environment  and Children   s Health Across Lifespans Book
Author : David Hollar
Publisher : Springer
Release : 2016-02-08
ISBN : 3319253255
Language : En, Es, Fr & De

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Book Description :

This stimulating volume addresses vital questions about gene/environment interactions as they affect cell health from the prenatal period through later life. Beginning with a tour of epigenetic processes in the human body, the book assembles current theoretical and empirical developments across the discipline, among them transgenerational epigenetic inheritance, the effects of maternal nutrition on epigenetic change, and possible links between epigenetics and childhood obesity. Public health and policy aspects of the field are discussed in depth, with the understanding that much can be done to improve our epigenetic health as a species. And in this vein, contributors consider future possibilities, such as the reprogramming of genes to reverse cancer and other diseases. Included in the coverage: The role of environmental epigenetics in perinatal and neonatal development The epigenetic biomarker γH2AX: from bench science to clinical trials What’s the risk? Dental amalgam, mercury exposure, and human health risks throughout the lifespan Post-traumatic stress disorder: neurological, genetic, and epigenetic bases Children’s exposure to alcohol, tobacco, and drugs: long-term outcomes Ethical implications of epigenetics Epigenetics, the Environment, and Children’s Health Across Lifespans brings real-world knowledge and applications of this increasingly important field to public health practitioners, maternal and child health researchers, and environmental health experts.

The Epigenome and Developmental Origins of Health and Disease

The Epigenome and Developmental Origins of Health and Disease Book
Author : Cheryl S Rosenfeld
Publisher : Academic Press
Release : 2015-10-10
ISBN : 0128016728
Language : En, Es, Fr & De

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Book Description :

The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or to conversely promote the health of the offspring. The book mines the existing literature from a variety of disciplines from toxicology to nutrition to epigenetics to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and the resulting deleterious phenotypic and physiological effects in our offspring. It is increasingly becoming apparent that even subtle changes in the mother’s diet, stress, and exposure to low concentrations of toxic chemicals at levels deemed safe by the EPA and FDA, such as endocrine disrupting compounds (EDC), can dramatically impact the health of our children, possibly leading to metabolic, cardiovascular, immunological, neurobehavioral disorders, and increased risk for cancer to list but a few examples. Informs how everyday choices pregnant women make can impact child development Ties together how in utero environmental changes may be inducing epigenetic changes in the offspring leading to overlapping phenotypes regardless of the initial insult (toxic, nutrition, or stress) Includes a boxed-in area in each chapter for further references and resources to keep up with the field Features video interviews with the authors and other key leaders in the field

Epigenetics and Complex Traits

Epigenetics and Complex Traits Book
Author : Anna K. Naumova,Celia M.T. Greenwood
Publisher : Springer Science & Business Media
Release : 2013-09-17
ISBN : 1461480787
Language : En, Es, Fr & De

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Book Description :

This book will provide an overview of basic epigenetic phenomena; interaction between epigenetic and genetic factors; and the influence of epigenetic factors on inheritance. Epigenetic states may contribute to the penetrance of genetic polymorphisms or mutations and thereby modify inheritance patterns. This may result in non‐Mendelian inheritance of genetic traits such as observed in common human disease. The relationship between epigenetics and genetics, however, has not been comprehensively summarized yet. The topic is being more and more appreciated lately due to considerable advances in genomic and epigenomic approaches to study the origins of human disease. The editors will focus not only on describing epigenetic characteristics, mechanisms and results, but also on how considerations of epigenetics can alter interpretation and analysis of risks for complex traits. This book will be a resource for those who have been working in human genetics or analysis of human genetic data and are studying the impact of epigenetics on inheritance. An overview will be given of the impacts of inter‐individual variation in epigenetic states from major changes (errors in genomic imprinting) that cause congenital developmental defects to subtle changes and their impact on complex traits. The editors will discuss the relationship between epigenetic changes and genetic changes in human disease. Several chapters will also focus on statistical analysis of epigenetics effects, either in human disease genetic studies, or in population genetics. ​

Epigenetics How Environment Shapes Our Genes

Epigenetics  How Environment Shapes Our Genes Book
Author : Richard C. Francis
Publisher : W. W. Norton & Company
Release : 2011-06-13
ISBN : 0393080323
Language : En, Es, Fr & De

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Book Description :

Goodbye, genetic blueprint. . . . The first book for general readers on the game-changing field of epigenetics. The burgeoning new science of epigenetics offers a cornucopia of insights—some comforting, some frightening. For example, the male fetus may be especially vulnerable to certain common chemicals in our environment, in ways that damage not only his own sperm but also the sperm of his sons. And it’s epigenetics that causes identical twins to vary widely in their susceptibility to dementia and cancer. But here’s the good news: unlike mutations, epigenetic effects are reversible. Indeed, epigenetic engineering is the future of medicine.

Lysenko s Ghost

Lysenko s Ghost Book
Author : Loren Graham
Publisher : Harvard University Press
Release : 2016-04-11
ISBN : 0674969049
Language : En, Es, Fr & De

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Book Description :

Lysenko became one of the most notorious figures in twentieth-century science after his genetic theories were discredited decades ago. Yet some scientists now claim that discoveries in epigenetics prove that he was right after all. Loren Graham reopens the case, to determine whether new developments in molecular biology validate Lysenko’s claims.

Epigenetic Gene Expression and Regulation

Epigenetic Gene Expression and Regulation Book
Author : Suming Huang,Michael D Litt,C. Ann Blakey
Publisher : Academic Press
Release : 2015-10-19
ISBN : 0128004711
Language : En, Es, Fr & De

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Book Description :

Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring Chapters are replete with clinical examples to empower the basic biology with translational significance Offers more than 100 illustrations to distill key concepts and decipher complex science

Epigenetics

Epigenetics Book
Author : Anonim
Publisher : Academic Press
Release : 2014-08-12
ISBN : 0128014725
Language : En, Es, Fr & De

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Book Description :

This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume concentrates on Epigenetics This book looks at Epigeneticsin the light of the newest scholarly discoveries and insights

Epigenetics for Beginners How Epigenetics Can Potentially Revolutionize Our Understanding of the Structure and Behavior of Biological Life on Ea

Epigenetics for Beginners  How Epigenetics Can Potentially Revolutionize Our Understanding of the Structure and Behavior of Biological Life on Ea Book
Author : Frank Brown
Publisher : Charlie Creative Lab
Release : 2020-10-06
ISBN : 9781801094962
Language : En, Es, Fr & De

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Book Description :

You Are A Step Away From Opening Your Eyes And Mind To The World Of Epigenetics In A Manner That Will Help You Appreciate The Complexity Of The Human Cell, Genes And Other Components And How That Knowledge Is Being Applied In Transforming Lives! Apparently, they were found to have less DNA methylation (addition of methyl groups to the DNA molecule to change a segment without affecting the DNA's sequence) of the imprinted Insulin-like Growth Factor 2 gene compared to their siblings who had not been exposed, which shows the role of a powerful factor that doesn't require the change of the genetic sequence in organisms in development and evolution. That factor is epigenetics, and has been singled out by experts as a very important factor in evolution, yet so much underestimated in modern biology. If you have these questions now, or have been having them before you landed here, then you are at the right place. This book answers these and many more questions to give you an insight into a mechanism that has become of central importance in modern day genetics research in the most straightforward, simple and comprehensive way. The aim is to see how gene expression can successfully be altered without touching the DNA sequence, and what that means for the resultant expression of traits; and how this phenomenon can be tapped in understanding life, and improving it. Here's a bit of what you'll find in this concise book: - What epigenetics are and how they work - Why epigenetics are important and how they relate with our experiences - The basics of body cells, including what cells really are and how they divide - The ins and outs of DNA, genes and chromosomes - How epigenetics are conceptualized today - The existing evidence of epigenetic changes; within indirect epigenetics, across indirect epigenetics and transgenerational epigenetic inheritance - The mechanisms of epigenetics and methodological insights - How epigenetic therapy is used to treat mesothelioma - The types of epigenetic therapies available today - The risks, benefits and research on epigenetic therapy - How epigenetic control affects transcriptional regulation in pluripotency and early differentiation, DNA methylation and Demethylation, nucleosome remodeling and chromatin looping - The impact of epigenetic changes in diabetes and cardiovascular risk ...And much more! Even if you are completely new to genetics or epigenetics in particular, this book will be useful and valuable to you even if everything sounds like complex/advanced science because the book takes a beginner friendly approach to the topic.

Epigenetics and Public Policy The Tangled Web of Science and Politics

Epigenetics and Public Policy  The Tangled Web of Science and Politics Book
Author : Shea K. Robison
Publisher : ABC-CLIO
Release : 2018-04-19
ISBN : 1440844704
Language : En, Es, Fr & De

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Book Description :

The exciting field of epigenetics offers novel and unanticipated science-based insights into human origins and development. This book presents one of the first detailed examinations of the political implications of epigenetics. • Focuses on the latest developments in epigenetics, a subject that is attracting increased attention among scientists and researchers yet is practically unknown among policymakers and members of the general public • Explains how epigenetics works, how it is related to genetics, how it differs from conventional genetics, the different kinds of epigenetic mechanisms, and the political history of genetics and epigenetics • Addresses the latest research on epigenetics within the context of hot public policy topics such as cancer, obesity, and the environment and identifies potential policy recommendations

Epigenetics

Epigenetics Book
Author : Jeffrey Craig,Nicholas C. Wong
Publisher : Horizon Scientific Press
Release : 2011
ISBN : 9781904455882
Language : En, Es, Fr & De

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Book Description :

Epigenetics is the study of changes in gene expression caused by mechanisms other than changes in the DNA sequence. Epigenetics is a rapidly advancing field with an increasing impact on biological and medical research. The editors of this book have assembled top-quality scientists from diverse fields of epigenetics to produce a major new volume. Comprehensive and cutting-edge, the 26 chapters in this book constitute a key reference manual for everyone involved in epigenetics, DNA methylation, cancer epigenetics, and related fields. Topics include: early life environment * DNA methylation and behavior * histone acetyltransferase biology * transgenerational epigenetic inheritance * mammalian X inactivation * epigenetic memory in plants * polycomb-group regulation * centromeres and telomeres * DNA sequence contribution to nucleosome distribution * macrosatellite epigenetics * histones * cell-fate specification and reprogramming * DNA methylation in cancer * variant histone H2A and cancer development * RNA modification * paramutation in plants * DNMT3L dependent methylation during gametogenesis * non-coding RNA * bisulphite-enabled technologies * rapid analysis of DNA methylation * microarray mapping * DNA methylation profiling * ChIP-sequencing * genome-wide DNA methylation analysis * epigenetics in maize. In addition there are useful chapters on bioinformatics in epigenomics, online resources and tools for epigeneticists, and educational resources for epigenetics. This up-to-date reference manual is an essential book for those working in the field and for scientists in other disciplines. It represents a major information resource on the fascinating and fast-moving field of epigenetics.