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Toxoplasma Gondii

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Toxoplasma Gondii

Toxoplasma Gondii Book
Author : Louis M. Weiss,Kami Kim
Publisher : Academic Press
Release : 2013
ISBN : 9780123964816
Language : En, Es, Fr & De

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Book Description :

Toxoplasmosis is caused by a one-celled protozoan parasite known as Toxoplasma gondii. In the United States, it is estimated that approximately 30% of cats, the primary carriers, have been infected by T. gondii. Most humans contract toxoplasmosis by eating cyst-contaminated raw or undercooked meat, vegetables, or milk products or when they come into contact with the T. gondii eggs from cat feaces while cleaning a cat's litterbox, gardening, or playing in a sandbox. Approx 1 in 4 (more than 60 million) people in the USA are infected with the parasite, and in the UK between 0.5 and 1% of indivi.

Toxoplasma Gondii

Toxoplasma Gondii Book
Author : Christopher J. Tonkin
Publisher : Unknown
Release : 2020
ISBN : 9781493998586
Language : En, Es, Fr & De

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Book Description :

This volume covers a diverse collection of protocols currently being used by the Toxoplasma research community, and also looks at innovative methods that are pushing the boundaries of possibilities. Chapters in this book discuss topics such as isolation and genotyping of Toxoplasma gondii strains; assessing rhoptry secretion in T. gondii; plate-based quantification of stimulated Toxoplasma egress; methods to study ocular toxoplasmosis; and metabolic analysis of Toxoplasma gondii tachyzoites. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Toxoplasma gondii: Methods and Protocols is a valuable resource for students or groups starting off in the field, as well as laboratories interested in implementing the latest techniques described in the book.

Toxoplasmosis of Animals and Humans

Toxoplasmosis of Animals and Humans Book
Author : J. P. Dubey
Publisher : CRC Press
Release : 2016-04-19
ISBN : 1420092375
Language : En, Es, Fr & De

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Book Description :

Found worldwide from Alaska to Australasia, Toxoplasma gondii knows no geographic boundaries. The protozoan is the source of one of the most common parasitic infections in humans, livestock, companion animals, and wildlife, and has gained notoriety with its inclusion on the list of potential bioterrorism microbes. In the two decades since the publi

The Neurobiological Basis of Suicide

The Neurobiological Basis of Suicide Book
Author : Yogesh Dwivedi
Publisher : CRC Press
Release : 2012-06-25
ISBN : 143983881X
Language : En, Es, Fr & De

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Book Description :

With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

The Role of Inflammatory Cytokines in Immune Responses to Toxoplasma Gondii

The Role of Inflammatory Cytokines in Immune Responses to Toxoplasma Gondii Book
Author : Anthony Joseph Marshall
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Role of Inflammatory Cytokines in Immune Responses to Toxoplasma Gondii book written by Anthony Joseph Marshall, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Toxoplasma Gondii Host Interactions A Story of Immune Attack and Parasite Counterattack

Toxoplasma Gondii Host Interactions  A Story of Immune Attack and Parasite Counterattack Book
Author : Jeroen P. J. Saeij,Eva Frickel,Kirk Jensen,Nicolas Blanchard
Publisher : Frontiers Media SA
Release : 2020-08-10
ISBN : 2889634027
Language : En, Es, Fr & De

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Book Description :

Toxoplasma gondii is an obligate intracellular parasite that can infect all warm-blooded animals, including an estimated ~30% of humans. It can cause severe disease in immune-suppressed individuals and in fetuses as well as blinding chorioretinitis in adults and children. Toxoplasma-innate immune system interactions determine early parasite control and activation of the adaptive immune system by the host and are therefore critical in determining host survival during the acute phase of infection. However, induction of an exaggerated inflammatory response can also lead to pathology. Only the chronic tissue cyst form of Toxoplasma is orally infectious. It is therefore critical for the parasite’s survival during the chronic phase to escape immune responses at this stage as well. Toxoplasma exists as genetically divergent strains mostly depending on geography, with the most strain diversity being found in South America. The key to Toxoplasma’s successful co-option of the host are proteins secreted from its rhoptry and dense granule secretory organelles. Rhoptry proteins (ROPs) are secreted into the host cell cytoplasm upon invasion while dense granule proteins (GRAs) are secreted once the parasite establishes itself in its parasitophorous vacuole (PV). GRAs can localize to the PV, the PV membrane, or are secreted beyond the PVM into the host cytoplasm. Many ROPs and GRAs are involved in modulating host cell signaling pathways and evasion of host immune responses and play important roles in Toxoplasma virulence. Polymorphisms in Toxoplasma’s ROPs and GRAs, likely determine how well these effectors bind to the divergent substrates in different host species, which can explain Toxoplasma strain differences in virulence in a particular host species. By studying Toxoplasma we have not only started to unravel how the parasite modulates immune responses to enhance its survival, replication, and transmission but we have also learned a lot about the immune system. Many unique mechanisms of immunity have indeed been defined using Toxoplasma and this parasite has aided our understanding of tissue-specific immune responses in the brain and intestine. This Research Topic will give a comprehensive overview of Toxoplasma-host immune response interactions. Most Toxoplasma virulence determinants to date have been established in murine systems and it is unclear how the parasite interacts with other intermediate hosts and humans. In addition, the interactions of Toxoplasma with some of the most relevant cell types during infection, including dendritic cells, neurons, intestinal epithelial cells or vascular endothelial cells, remain poorly understood.

Toxoplasma Gondii

Toxoplasma Gondii Book
Author : Erica S. Martins-Duarte
Publisher : Nova Science Publishers
Release : 2021-10-28
ISBN : 9781685072919
Language : En, Es, Fr & De

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Book Description :

"Toxoplasma gondii is a globally spread protozoan parasite responsible for causing toxoplasmosis. Infection by T. gondii shows high seroprevalence in humans, especially in South America. Written by specialists, this book brings important contributions and information on parasite biology, including its life cycle, ultrastructural features of tachyzoite, bradyzoite and their main specific organelles, mechanisms of host cell invasion, parasite replication and epigenetics regulation. Moreover, the book will encompass mechanisms of pathogenesis and host immune response to the infection, including purinergic signaling, and mechanisms of immune evasion by the parasite. Finally, this book also addresses relevant aspects of disease, information about the current chemotherapy of toxoplasmosis and perspectives for a future chronic disease treatment, epidemiology, and methods for visualization of the parasite by optical and electron microscopy"--

Parasites Pussycats and Psychosis

Parasites  Pussycats and Psychosis Book
Author : E. Fuller Torrey
Publisher : Springer Nature
Release : 2021-11-29
ISBN : 3030868117
Language : En, Es, Fr & De

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Book Description :

This open access book analyzes the evidence linking Toxoplasma gondii to the increasing incidence of schizophrenia and bipolar disorder in the United States. Initially establishing that infectious agents are regularly transmitted from animals to humans, lead to human disease, and that infectious agents can cause psychosis, it then examines the protozoan parasite Toxoplasma gondii in detail. Infecting 40 million Americans, Toxoplasma gondii is known to cause congenital infections, eye disease, and encephalitis for individuals who are immunosuppressed. It has also been shown to change the behavior of nonhuman mammals, as well as to alter some personality traits in humans. After discussing the clinical evidence linking Toxoplasma gondii to human psychosis, the book elucidates the epidemiological evidence further supporting this linkage; including the proportional increase in incidence of human psychosis as cats transitioned to domestication over 800 years. Finally, the book assesses the magnitude of the problem and suggests solutions. Parasites, Pussycats and Psychosis: The Unknown Dangers of Human Toxoplasmosis provides a comprehensive review of the evidence linking human psychosis in the United States to infections of Toxoplasma gondii. It will be of interest to infectious disease specialists, general practitioners, scientists, historians, and cat-lovers.

Toxoplasma Gondii

Toxoplasma Gondii Book
Author : Louis M. Weiss,Kami Kim
Publisher : Elsevier
Release : 2011-04-28
ISBN : 9780080475011
Language : En, Es, Fr & De

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Book Description :

Toxoplasmosis is caused by a one-celled protozoan parasite known as Toxoplasma gondii. In the United States, it is estimated that approximately 30% of cats, the primary carriers, have been infected by T. gondii. Most humans contract toxoplasmosis by eating cyst-contaminated raw or undercooked meat, vegetables, or milk products or when they come into contact with the T. gondii eggs from cat feaces while cleaning a cat's litterbox, gardening, or playing in a sandbox. Approx 1 in 4 (more than 60 million) people in the USA are infected with the parasite, and in the UK between 0.5 and 1% of individuals become infected each year. By the age of 50, 40% of people test positive for the parasite. The predilection of this parasite is for the central nervous system (CNS) causing behavioral and personality alterations as well as fatal necrotizing encephalitis, and is especially dangerous for HIV infected patients. Though there have been tremendous strides in our understanding of the biology of Toxoplasma gondii in the last decade, there has been no systemic review of all of the information that has accumulated. Toxoplasma gondii provides the first comprehensive summary of literature on this organism by leading experts in the field who were responsible for organising the 7th International Congress on Toxoplasmosis in May 2003. It offeres systematic reviews of the biology of this pathogen as well as descriptions of the methods and resources used. Within the next year the T. gondii genome will be completed making this an indispensable research resource for biologists, physicians, parasitologists, and for all those contemplating experiments using T. gondii. * Serves as a model for understanding invasion of host cells by parasites, immune response, motility, differentiation, phylogenetics, evolution and organelle acquisition * Discusses the protocols related to genetic manipulation, cell biology and animal models while also providing reference material on available resources for working with this organism

Human Emerging and Re emerging Infections

Human Emerging and Re emerging Infections Book
Author : Sunit Kumar Singh
Publisher : John Wiley & Sons
Release : 2015-10-29
ISBN : 1118644824
Language : En, Es, Fr & De

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Book Description :

Emerging and re-emerging pathogens pose several challenges to diagnosis, treatment, and public health surveillance, primarily because pathogen identification is a difficult and time-consuming process due to the “novel” nature of the agent. Proper identification requires a wide array of techniques, but the significance of these diagnostics is anticipated to increase with advances in newer molecular and nanobiotechnological interventions and health information technology. Human Emerging and Re-emerging Infections covers the epidemiology, pathogenesis, diagnostics, clinical features, and public health risks posed by new viral and microbial infections. The book includes detailed coverage on the molecular mechanisms of pathogenesis, development of various diagnostic tools, diagnostic assays and their limitations, key research priorities, and new technologies in infection diagnostics. Volume 1 addresses viral and parasitic infections, while volume 2 delves into bacterial and mycotic infections. Human Emerging and Re-emerging Infections is an invaluable resource for researchers in parasitologists, microbiology, Immunology, neurology and virology, as well as clinicians and students interested in understanding the current knowledge and future directions of infectious diseases.

Parasitic Protozoa of Farm Animals and Pets

Parasitic Protozoa of Farm Animals and Pets Book
Author : Monica Florin-Christensen,Leonhard Schnittger
Publisher : Springer
Release : 2018-04-17
ISBN : 3319701320
Language : En, Es, Fr & De

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Book Description :

This book provides an in-depth yet concise overview of the most common and emerging protozoa that cause diseases in both farm animals and companion animals. As outlined in the concise introduction, pathogenic protozoans represent an evolutionary highly diverse and little understood group of disease-causing microorganisms. For each of the featured parasitic unicellular eukaryotes, it discusses the morphology, lifecycle, epidemiology and host-pathogen interactions. In addition, the book highlights the latest developments in diagnostic methods, as well as prevention and treatment strategies. Thorough information on genomes and genetic manipulation strategies for some of the protozoa covered in this book is also included. Infections involving parasitic protozoa can cause productivity losses and/or reduce the quality of life of infected animals. Some infections are zoonotic, posing an on-going public health threat. In most cases, prevention and treatment are either non-existent or need considerable improvement. On the other hand, a great deal of research has recently been conducted on these organisms, yielding valuable new information on their global distribution and revealing the mechanisms of host-pathogen interactions at the molecular level – and essential insights that can be used for the development of new control tools. This book includes extensive information on both basic aspects and recent scientific discoveries on these protozoa and thus constitutes a unique resource for students, veterinarians, and researchers alike.

Toxoplasma gondii

Toxoplasma gondii Book
Author : Uwe Gross
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 3642510140
Language : En, Es, Fr & De

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Book Description :

For years, toxoplasmosis has been known as disease mostly affecting newborns. Since immunocompromised patients (AIDS) present a high risk of reactivation of chronic toxoplasmosis this parasitic disease has gained increasing interest. Besides presenting clinical and therapeutical concepts, this volume provides current knowledge about genetics and immunology of T. gondii and the interaction with its 'host'. Since in vivo and in vitro models of toxoplasmosis exist, and genetic manipulation has become possible, this protozoan parasite has recently been accepted as a model for understanding the pathogenesis and persistance of other intracellular parasites. The articles of the book compromise both reviewing current concepts and reporting on yet unpublished results of leading scientists in this field.

Case Studies in Infectious Disease Toxoplasma Gondii

Case Studies in Infectious Disease  Toxoplasma Gondii Book
Author : Peter Lydyard,Michael Cole,John Holton,Will Irving,Nino Porakishvili,Pradhib Venkatesan,Kate Ward
Publisher : Garland Science
Release : 2009-12
ISBN : 1136985433
Language : En, Es, Fr & De

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Book Description :

Case Studies in Infectious Disease: Toxoplasma gondii presents the natural history of this infection from point of entry of the pathogen through pathogenesis, clinical presentation, diagnosis, and treatment. A set of core questions explores the nature, causation, host response, manifestations, and management of this infectious process. This case also includes summary bullet points, questions and answers, and references.

Toxoplasma Gondii

Toxoplasma Gondii Book
Author : Sean L. Hall
Publisher : Unknown
Release : 2023-02-01
ISBN : 9781536110678
Language : En, Es, Fr & De

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Book Description :

Download Toxoplasma Gondii book written by Sean L. Hall, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Toxoplasmosis

Toxoplasmosis Book
Author : Olgica Djurković Djaković
Publisher : Unknown
Release : 2012
ISBN : 9789535170280
Language : En, Es, Fr & De

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Book Description :

A ubiquitous organism able to infect all mammals and birds, which has been estimated to infect one third of the global human population, Toxoplasma gondii is the most successful parasite on Earth, and toxoplasmosis a major zoonotic disease. A current approach to this zoonosis is the "one health" concept, based on the understanding that a disease occurring between animals and man in a specific environment can only be dealt with at the interface of all "players" involved. This book, composed of a series of articles which integrate human and animal data on toxoplasmosis, by authors from all over the world, offers its readers a view on the current research interests and achievements.

Toxoplasma Gondii

Toxoplasma Gondii Book
Author : Melvin B. Goodson,Don Winslow
Publisher : Nova Science Pub Incorporated
Release : 2013-01-01
ISBN : 9781626183490
Language : En, Es, Fr & De

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Book Description :

Toxoplasma gondii is a parasite of the phylum Apicomplexa, Coccidia order, being an obligate intracellular protozoan that affects humans and diverse vertebrate hosts. In this book, the authors discuss its prevalence in humans and animals, genetic structure and role in disease distribution. Topics include the congenital transmission of toxoplasma gondii in ovine; the role of chickens in the transmission of toxoplasmosis to humans; updates on the serological and molecular diagnosis of toxoplasmosis; epidemiology and control of toxoplasmosis in dogs, cats, bovine, and in public health.

Illinois Biological Monographs

Illinois Biological Monographs Book
Author : Anonim
Publisher : Unknown
Release : 1978
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Illinois Biological Monographs book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Molecular Mechanisms of Parasite Invasion

Molecular Mechanisms of Parasite Invasion Book
Author : Barbara A. Burleigh,Dominique Soldati
Publisher : Springer Science & Business Media
Release : 2008-12-05
ISBN : 0387782672
Language : En, Es, Fr & De

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Book Description :

All of the parasitic organisms highlighted in this new book represent medically important human pathogens that contribute significantly to the global burden of disease. As such there is intense interest in understanding the molecular basis of infection by these pathogens—not only with regard to their clinical relevance but also the fascinating biology they reveal. For most of the parasites discussed here the ability to penetrate biological barriers and/or to establish intracellular residence is critical to survival of the pathogen in the mammalian hosts. For other parasites, a tissue invasive phenotype is a key virulence determinant. In the ensuing 18 chapters, select members of this diverse set of protozoan parasites, as well as some examples of the extremely reduced fungal parasites classified as Microsporidia, are discussed within the context of the fascinating molecular strategies employed by these organisms to migrate across biological barriers and to establish residence within target host cells.

Host Manipulation by Parasites

Host Manipulation by Parasites Book
Author : David P. Hughes,Jacques Brodeur,Frédéric Thomas
Publisher : Oxford University Press
Release : 2012-06-07
ISBN : 0199642230
Language : En, Es, Fr & De

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Book Description :

Parasites that manipulate the behaviour of their hosts represent striking examples of adaptation by natural selection. This text provides an authoritative review of host manipulation by parasites that assesses developments in the field and lays out a framework for future research.

The Neurology of HIV Infection

The Neurology of HIV Infection Book
Author : Anonim
Publisher : Elsevier
Release : 2018-03-29
ISBN : 0444638504
Language : En, Es, Fr & De

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Book Description :

The Neurology of HIV Infection covers all aspects of nervous system involvement and pathology in HIV-infected individuals. Specialists in this field cover epidemiology, global aspects, pathology and pathogenesis of nervous system disease in HIV-infection. All complications, including the pathology caused by HIV itself and all opportunistic infections of the nervous system are reviewed in detail. Both central nervous and peripheral nervous system complications, including neuropathies and myopathies, are discussed. Key chapters on global developments, HIV-associated neurocognitive disorders, IRIS, stroke and neuro-aids in children complete this volume. Covers all aspects of nervous system involvement and pathology in HIV-infected individuals Includes the pathology caused by HIV and all opportunistic infections of the nervous system Presents key chapters that focus on global developments, HIV-associated neurocognitive disorders, IRIS, stroke and neuro-aids in children