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Toxicological Risk Assessment And Multi System Health Impacts From Exposure

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Toxicological Risk Assessment and Multi System Health Impacts from Exposure

Toxicological Risk Assessment and Multi System Health Impacts from Exposure Book
Author : Aristidis M. Tsatsakis
Publisher : Elsevier
Release : 2021-08-05
ISBN : 0323852157
Language : En, Es, Fr & De

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Book Description :

Toxicological Risk Assessment and Multisystem Health Impacts From Exposure highlights the emerging problems of human and environmental health attributable to cumulative and multiple sources of long-term exposure to environmental toxicants. The book describes the cellular, biological, immunological, endocrinologic, genetic, and epigenetic effects of long-term exposure. It examines how the combined exposure to nanomaterials, metals, pharmaceuticals, multifrequency radiation, dietary mycotoxins, and pesticides accelerates ecotoxicity in humans, animals, plants, and the larger environment. The book goes on to also offer insights into mixture risk assessments, protocols for evaluating the risks, and how this information can serve the regulatory agencies in setting safer exposure limits. The book is a go-to resource for scientists and professionals in the field tackling the current and emerging trends in modern toxicology and risk assessment. Bridges basic research with clinical, epidemiological, regulatory, and translational research, conveying both an introductory understanding and the latest developments in the field Evaluates real-life human health risk assessment for long-term exposures to xenobiotic mixtures and the role they play in contributing to chronic disease Discusses advances in predictive (in silico) toxicology tools and the benefits of using omics technologies in toxicology research

Toxicological Risk Assessment and Multi System Health Impacts from Exposure

Toxicological Risk Assessment and Multi System Health Impacts from Exposure Book
Author : Aristidis M. Tsatsakis
Publisher : Elsevier
Release : 2021-08-01
ISBN : 0323853587
Language : En, Es, Fr & De

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Book Description :

Toxicological Risk Assessment and Multisystem Health Impacts From Exposure highlights the emerging problems of human and environmental health attributable to cumulative and multiple sources of long-term exposure to environmental toxicants. The book describes the cellular, biological, immunological, endocrinologic, genetic, and epigenetic effects of long-term exposure. It examines how the combined exposure to nanomaterials, metals, pharmaceuticals, multifrequency radiation, dietary mycotoxins, and pesticides accelerates ecotoxicity in humans, animals, plants, and the larger environment. The book goes on to also offer insights into mixture risk assessments, protocols for evaluating the risks, and how this information can serve the regulatory agencies in setting safer exposure limits. The book is a go-to resource for scientists and professionals in the field tackling the current and emerging trends in modern toxicology and risk assessment. • Bridges basic research with clinical, epidemiological, regulatory, and translational research, conveying both an introductory understanding and the latest developments in the field • Evaluates real-life human health risk assessment for long-term exposures to xenobiotic mixtures and the role they play in contributing to chronic disease • Discusses advances in predictive (in silico) toxicology tools and the benefits of using omics technologies in toxicology research

Toxicology and Risk Assessment

Toxicology and Risk Assessment Book
Author : Helmut Greim,Robert Snyder
Publisher : John Wiley & Sons
Release : 2018-11-05
ISBN : 1119135915
Language : En, Es, Fr & De

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Book Description :

Provides a complete understanding of how our bodies respond to toxicants, and the principles used to assess the health risks of specific exposure scenarios Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition reflects recent advances in science and technology, and provides the scientific background and methodological issues to enable the reader to understand the basic principles in toxicology and to evaluate the health risks of specific exposure scenarios. Completely updated with the latest information, this book offers a concise introduction to the subject. It is divided into five sections: Principles in Toxicology, Organ Toxicology, Methods in Toxicology, Regulatory Toxicology, and Specific Toxicity. The 2nd Edition adds new chapters that cover recent scientific and technological advances and current topics including the endocrine system, alternatives to animal testing, risk assessment and thresholds for carcinogens, European and international regulation, nanomaterials, fuels, fragrances, and agrochemicals. Concentrates on the basic concepts of toxicology and provides sufficient information for the reader to become familiar with them in order to understand the principles and to evaluate the risks at given exposures 30% new chapters cover recent scientific and technological advances including alternatives to animal testing; genotoxic carcinogens; REACH regulations; nanomaterials; fuels; fragrances; PAHs; and agrochemicals Written by a team of international specialists, and edited by two outstanding scientists in the field Fully updated and expanded, Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition is an essential text for any student or researcher with an interest in toxicology and related risk assessments.

Regulatory Toxicology

Regulatory Toxicology Book
Author : Franz-Xaver Reichl,Michael Schwenk
Publisher : Springer
Release : 2014-03-27
ISBN : 9783642353734
Language : En, Es, Fr & De

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Book Description :

This book will be written by experts for professionals, scientists and all those involved in toxicological data generation and decision-making. It is the updated and expanded version of a monograph published in German in 2004. Chemical safety is regulated on various levels including production, storage, transport, handling, disposal or labelling. This book deals comprehensively with the safety-ensuring methods and concepts employed by regulatory agencies, industry and academics. Toxicologists use experimental and scientific approaches for data collection, e.g. about chemical hazards, physicochemical features or toxicokinetics. The respective experimental methods are described in the book. Toxicologists also deal with much insecurity in the exposure and effect scenarios during risk assessment. To overcome these, they have different extrapolation methods and estimation procedures at their disposal. The book describes these methods in an accessible manner. Differing concepts from one regulation area to another are also covered. Reasons and consequences become evident when reading the book. Altogether, the book Regulatory Toxicology will serve as an excellent reference.

Toxicological Risk Assessment for Beginners

Toxicological Risk Assessment for Beginners Book
Author : José A. Torres,Sol Bobst
Publisher : Springer
Release : 2015-03-27
ISBN : 3319127519
Language : En, Es, Fr & De

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Book Description :

This book serves as a comprehensive introductory guide to the practical aspects of risk assessment. Chapters include clearly defined objectives and summaries. The book includes: hazard identification, dose-response, exposure assessment, risk characterization, chemical mixtures, epidemiology, emerging issues and global perspectives with accessible language. The book concludes with a set of hypothetical case studies. Toxicological Risk Assessment for Beginners aims not to create an expert, but rather to provide readers with their first understanding of the risk assessment topic. This book was designed with the student in mind. We simplify a complex process for beginners and balance theory with practical aspects, but remain fluid enough to increase difficulty with case studies. By incorporating an action based, step by step approach to learning the risk assessment process, this book provides its readers with an elementary understanding of how the risk assessment process is initiated, developed and finished, making it a valuable guide for graduate students, post-doctoral fellows and early career scientists in industry.

Phthalates and Cumulative Risk Assessment

Phthalates and Cumulative Risk Assessment Book
Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on the Health Risks of Phthalates
Publisher : National Academies Press
Release : 2009-01-19
ISBN : 0309128412
Language : En, Es, Fr & De

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Book Description :

People are exposed to a variety of chemicals throughout their daily lives. To protect public health, regulators use risk assessments to examine the effects of chemical exposures. This book provides guidance for assessing the risk of phthalates, chemicals found in many consumer products that have been shown to affect the development of the male reproductive system of laboratory animals. Because people are exposed to multiple phthalates and other chemicals that affect male reproductive development, a cumulative risk assessment should be conducted that evaluates the combined effects of exposure to all these chemicals. The book suggests an approach for cumulative risk assessment that can serve as a model for evaluating the health risks of other types of chemicals.

Mixture Toxicity

Mixture Toxicity Book
Author : Cornelis A. M. van Gestel,Martijs Jonker,Jan E. Kammenga,Ryszard Laskowski,Claus Svendsen
Publisher : CRC Press
Release : 2016-04-19
ISBN : 9781439830093
Language : En, Es, Fr & De

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Book Description :

In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology and classic human toxicology, Mixture Toxicity: Linking Approaches from Ecological and Human Toxicology incorporates extensive reviews of exposure to toxicants, toxicokinetics and toxicodynamics, toxicity of mixtures, and risk assessment. The book examines developments in both fields, compares and contrasts their current state of the art, and identifies where one field can learn from the other. Each chapter provides an essential overview of the state of the art in both human and ecotoxicological mixture risk assessment, focusing on the work published in the last fifteen years. The coverage progresses from exposure to risk assessment, at each step identifying the special complications typically raised by mixtures. Based on in-depth discussions among specialists representing different disciplines and approaches, the chapters each address: Exposure — how to quantify the amounts of chemicals that may enter the living organism Kinetics, dynamics, and metabolism — how the chemicals enter an organism, travel within the organism, how they are metabolized and reach the target site, and explain development of toxicity with time Toxicity — what are the chemicals’ detrimental effects on the organism Test design and complex mixture characterization — how chemicals interact, how to measure effects of mixtures, and how to identify responsible chemicals Risk assessment — how to assess for risks in humans and the environment An unusual combination of different points of view on exposure to and risk assessment of chemical mixtures, this book summarizes current knowledge on combined effects of toxicant mixtures, information that is generally only available in a very fragmented form as individual journal papers. It identifies possible crosslinks and includes recommendations for mutual developments that can improve the state of knowledge on mixture toxicity and ultimately lead to better and more integrated risk assessment.

Oxford Textbook of Global Public Health

Oxford Textbook of Global Public Health Book
Author : Roger Detels,Martin Gulliford,Quarraisha Abdool Karim,Chorh Chuan Tan
Publisher : Oxford University Press
Release : 2017
ISBN : 019881013X
Language : En, Es, Fr & De

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Book Description :

Sixth edition of the hugely successful, internationally recognised textbook on global public health and epidemiology, with 3 volumes comprehensively covering the scope, methods, and practice of the discipline

Toxicological Risk Assessment of Chemicals

Toxicological Risk Assessment of Chemicals Book
Author : Elsa Nielsen,Grete Ostergaard,John Christian Larsen
Publisher : CRC Press
Release : 2008-02-21
ISBN : 1420006940
Language : En, Es, Fr & De

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Book Description :

Unlike many existing books on toxicology that cover either toxicity of a particular substance or toxicity of chemicals on particular organ systems, Toxicological Risk Assessment of Chemicals: A Practical Guide lays out the principle activities of conducting a toxicological risk assessment, including international approaches and methods for the risk

Toxicology and Risk Assessment

Toxicology and Risk Assessment Book
Author : Anna M. Fan,George Alexeeff,Elaine Khan
Publisher : CRC Press
Release : 2015-03-04
ISBN : 9814613398
Language : En, Es, Fr & De

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Book Description :

The presence of chemicals in our environment is a subject of intense interest owing to the many potential adverse health effects to humans following exposure to these chemicals. The principles and practices of risk assessment are used to assess the associated health risks to provide a scientific and health basis for guidance or regulatory standards development and risk management decision making for public health protection. This book compiles, discusses, and presents cutting-edge research data and methodology in performing risk assessment of some major chemicals of concern in our environment. It also discusses the complexity of the scientific databases, the available and updated methodology, emerging issues, limitations in knowledge and methods, considerations of developmental and age sensitivities, use of defaults, case samples on results in risk assessment and risk management, and current and future perspectives. The editors are prominent in the field of environmental toxicology, risk assessment, and chemical regulations. This book will appeal to those interested in evaluating the human health effects of exposure to chemicals in the environment and the associated assessments and findings.

Chemical Mixtures and Combined Chemical and Nonchemical Stressors

Chemical Mixtures and Combined Chemical and Nonchemical Stressors Book
Author : Cynthia V. Rider,Jane Ellen Simmons
Publisher : Springer
Release : 2018-02-16
ISBN : 3319562347
Language : En, Es, Fr & De

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Book Description :

In this book, both basic and advanced concepts are discussed for considering mixtures from initial exposure characterization through evaluation of risk associated with combined exposures. This book will provide an introduction to key issues and multiple options for evaluating both the toxicity of mixtures as well as the risk associated with exposure to mixtures. Additionally, promising tools adapted from other disciplines will be discussed in the context of mixtures toxicology and risk assessment. Finally, the discussion will move beyond chemical mixtures to address incorporating non-chemical stressors into toxicity studies and cumulative risk assessments. Although exposure to multiple chemical and non-chemical stressors is the rule, not the exception, consideration of mixtures in toxicology and risk assessment continues to be a significant challenge. This book will be an essential resource for researchers and professionals in the fields of toxicology, epidemiology, exposure science, risk assessment, and statistics.

Science and Judgment in Risk Assessment

Science and Judgment in Risk Assessment Book
Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Commission on Life Sciences,Committee on Risk Assessment of Hazardous Air Pollutants
Publisher : National Academies Press
Release : 1994-01-01
ISBN : 030904894X
Language : En, Es, Fr & De

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Book Description :

The public depends on competent risk assessment from the federal government and the scientific community to grapple with the threat of pollution. When risk reports turn out to be overblownâ€"or when risks are overlookedâ€"public skepticism abounds. This comprehensive and readable book explores how the U.S. Environmental Protection Agency (EPA) can improve its risk assessment practices, with a focus on implementation of the 1990 Clean Air Act Amendments. With a wealth of detailed information, pertinent examples, and revealing analysis, the volume explores the "default option" and other basic concepts. It offers two views of EPA operations: The first examines how EPA currently assesses exposure to hazardous air pollutants, evaluates the toxicity of a substance, and characterizes the risk to the public. The second, more holistic, view explores how EPA can improve in several critical areas of risk assessment by focusing on cross-cutting themes and incorporating more scientific judgment. This comprehensive volume will be important to the EPA and other agencies, risk managers, environmental advocates, scientists, faculty, students, and concerned individuals.

A Practical Guide to Toxicology and Human Health Risk Assessment

A Practical Guide to Toxicology and Human Health Risk Assessment Book
Author : Laura Robinson
Publisher : John Wiley & Sons
Release : 2018-11-20
ISBN : 1118882024
Language : En, Es, Fr & De

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Book Description :

Toxicology – the study of the adverse effects of chemicals on living organisms is the cornerstone to all aspects of chemical safety and knowledge of the subject is needed in a wide spectrum of fields from the chemical industry to medicine, emergency services, forensics, and regulatory science. Toxicology involves the study of symptoms, mechanisms, treatments and detection of poisoning ... especially the poisoning of people. The many problems arising from a poor understanding of toxicology and its applications in hazard communication and chemical safety motivated the author's training courses and webinars, leading to this valuable book. Providing a practical and accessible guide, A Practical Guide to Toxicology and Human Health Risk Assessment enables readers to quickly build up knowledge and understanding of toxicology and its use in hazard identification, which is a fundamental part of chemical risk assessment. The book also covers current toxicological testing strategies and the use of physicochemical test data in hazard identification and exposure assessment. Examples are provided throughout the book to highlight important issues along with a summary of the key points that have been covered in each of the respective chapters. The book concludes with a listing of online resources on toxicology and risk assessment.

Information Resources in Toxicology

Information Resources in Toxicology Book
Author : Steve Gilbert,Asish Mohapatra,Sara Humes,Sol Bobst
Publisher : Academic Press
Release : 2020-02
ISBN : 9780128137246
Language : En, Es, Fr & De

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Book Description :

Information Resources in Toxicology, Fifth Edition, offers a consolidated entry portal for the study, research and practice of toxicology. An extensive update and revision of the previous edition published 10 years ago, it continues a tradition established in 1982 with the original volume in systematically itemizing, reviewing, and summarizing the current informatics infrastructure of toxicology. This book represents a unique, wide-ranging, curated, international, annotated bibliography and directory of major resources in toxicology and allied fields such as enviromental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology's sub-disciplines. This edition keeps pace with the digital world in directing and linking readers to relevant websites and other online tools. Several chapters focus on the role played by computer technology in facilitating access to toxicology information.

Environmental Risk Assessment

Environmental Risk Assessment Book
Author : Ted Simon
Publisher : CRC Press
Release : 2019-12-06
ISBN : 1000754111
Language : En, Es, Fr & De

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Book Description :

The purpose of risk assessment is to support science-based decisions about how to solve complex societal problems. Indeed, the problems humankind faces in the 21st century have many social, political, and technical complexities. Environmental risk assessment in particular is of increasing importance as health and safety regulations grow and become more complicated. Environmental Risk Assessment: A Toxicological Approach, 2nd Edition looks at various factors relating to exposure and toxicity, human health, and risk. In addition to the original chapters being updated and expanded upon, four new chapters discuss current software and platforms that have recently been developed and provide examples of risk characterizations and scenarios. Features: Introduces the science of risk assessment—past, present, and future Provides environmental sampling data for conducting practice risk assessments Considers how bias and conflict of interest affect science-based decisions in the 21st century Includes fully worked examples, case studies, discussion questions, and suggestions for additional reading Discusses new software and computational platforms that have developed since the first edition Aimed at the next generation of risk assessors and students who need to know more about developing, conducting, and interpreting risk assessments, the book delivers a comprehensive view of the field, complete with sufficient background to enable readers to probe for themselves the science underlying the key issues in environmental risk.

Toxicology and Risk Assessment

Toxicology and Risk Assessment Book
Author : Anna M. Fan,George Alexeeff,Elaine Khan
Publisher : Pan Stanford
Release : 2015-03-04
ISBN : 9789814613385
Language : En, Es, Fr & De

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Book Description :

The presence of chemicals in our environment is a subject of intense interest owing to the many potential adverse health effects to humans following exposure to these chemicals. The principles and practices of risk assessment are used to assess the associated health risks to provide a scientific and health basis for guidance or regulatory standards development and risk management decision making for public health protection. This book compiles, discusses, and presents cutting-edge research data and methodology in performing risk assessment of some major chemicals of concern in our environment. It also discusses the complexity of the scientific databases, the available and updated methodology, emerging issues, limitations in knowledge and methods, considerations of developmental and age sensitivities, use of defaults, case samples on results in risk assessment and risk management, and current and future perspectives. The editors are prominent in the field of environmental toxicology, risk assessment, and chemical regulations. This book will appeal to those interested in evaluating the human health effects of exposure to chemicals in the environment and the associated assessments and findings.

Toxicological Effects of Methylmercury

Toxicological Effects of Methylmercury Book
Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on the Toxicological Effects of Methylmercury
Publisher : National Academies Press
Release : 2000-09-27
ISBN : 9780309171717
Language : En, Es, Fr & De

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Book Description :

Mercury is widespread in our environment. Methylmercury, one organic form of mercury, can accumulate up the aquatic food chain and lead to high concentrations in predatory fish. When consumed by humans, contaminated fish represent a public health risk. Combustion processes, especially coal-fired power plants, are major sources of mercury contamination in the environment. The U.S. Environmental Protection Agency (EPA) is considering regulating mercury emissions from those plants. Toxicological Effects of Methylmercury reviews the health effects of methylmercury and discusses the estimation of mercury exposure from measured biomarkers, how differences between individuals affect mercury toxicity, and appropriate statistical methods for analysis of the data and thoroughly compares the epidemiological studies available on methylmercury. Included are discussions of current mercury levels on public health and a delineation of the scientific aspects and policy decisions involved in the regulation of mercury. This report is a valuable resource for individuals interested in the public health effects and regulation of mercury. The report also provides an excellent example of the implications of decisions in the risk assessment process for a larger audience.

Public Health Risk Assessment for Human Exposure to Chemicals

Public Health Risk Assessment for Human Exposure to Chemicals Book
Author : K. Asante-Duah
Publisher : Springer Science & Business Media
Release : 2002-09-30
ISBN : 9781402009204
Language : En, Es, Fr & De

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Book Description :

In fact, with the control and containment of most infectious conditions and diseases of the past millennium having been achieved in most developed countries, and with the resultant increase in life expectancies, much more attention seems to have shifted to degenerative health problems. Many of the degenerative health conditions have been linked to thousands of chemicals regularly encountered in human living and occupational/work environments. It is important, therefore, that human health risk assessments are undertaken on a consistent basis - in order to determine the potential impacts of the target chemicals on public health.

Environmental Pollutant Exposures and Public Health

Environmental Pollutant Exposures and Public Health Book
Author : R M Harrison
Publisher : Royal Society of Chemistry
Release : 2020-10-27
ISBN : 1839160446
Language : En, Es, Fr & De

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Book Description :

Both genes and environment have profound effects upon our health. While some environmental factors such as polluted air are high in the public consciousness, there are many other pathways for people’s exposure to toxic chemicals, such as through food, water and contaminated land. It is not only chemicals that can affect health; environmental radioactivity, pathogenic organisms and our changing climate also have implications for public health, and all contribute to the global burden of disease, leading to both disability and deaths of millions of people annually across the world. An understanding of the pathways of environmental exposure, and its effects upon health is key to developing regulations and behaviours that reduce or prevent exposure, and the consequent impacts upon health. Covering topics from dietary exposure to chemicals through to the health effects of climate change, this book brings together contributors from around the world to highlight the latest science on the impacts of environmental pollutant exposure upon public health.

Wildlife Toxicity Assessments for Chemicals of Military Concern

Wildlife Toxicity Assessments for Chemicals of Military Concern Book
Author : Marc Williams,Gunda Reddy,Michael Quinn,Mark S Johnson
Publisher : Elsevier
Release : 2015-05-21
ISBN : 0128004800
Language : En, Es, Fr & De

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Book Description :

Wildlife Toxicity Assessments for Chemicals of Military Concern is a compendium of chemical-specific toxicity information with discussions on the rationale and development of Wildlife Toxicity Reference Values (TRVs) intended for use on terrestrial wildlife for risk assessment applications. Substances covered include military-related chemicals including explosives, propellants, pesticides and metals. Wildlife Toxicity Assessments for Chemicals of Military Concern is a much-needed resource designed to meet the needs of those seeking toxicological information for ecological risk assessment purposes. Each chapter targets a specific chemical and considers the current knowledge of the toxicological impacts of chemicals to terrestrial wildlife including mammalian, avian, amphibian and reptilian species. Provides detailed information on how Wildlife Toxicity Values (TRVs) for military chemicals of concern are derived and evaluated. Covers wildlife toxicity assessments of explosives, metals and environmental chemicals. Compiles relevant information on the environmental effects of chemicals on wildlife in relation to public and environmental health.