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Toxicoepigenetics

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Toxicoepigenetics

Toxicoepigenetics Book
Author : Shaun D. McCullough,Dana Dolinoy
Publisher : Academic Press
Release : 2018-11-02
ISBN : 0128124342
Language : En, Es, Fr & De

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Book Description :

Toxicoepigenetics: Core Principles and Applications examines the core aspects of epigenetics, including chromatin biology, DNA methylation, and non-coding RNA, as well as fundamental techniques and considerations for studying each of these mechanisms of epigenetic regulation. Although its integration into the field of toxicology is in its infancy, epigenetics have taken center stage in the study of diseases such as cancer, diabetes, and neurodegeneration. Increasing the presence of epigenetics in toxicological research allows for a more in-depth understanding of important aspects of toxicology such as the role of the environment and lifestyle influencing the individual susceptibility to these effects and the trans-generational transmission of these health effects and susceptibilities. Methods chapters are included to help improve efficacy and efficiency of protocols in both the laboratory and the classroom. Toxicoepigenetics: Core Principles and Applications is an essential book for researchers and academics using epigenetics in toxicology research and study. Introduces the fundamental principles and practices for understanding the role of the epigenome in toxicology Presents the foundation of epigenetics for toxicologists with a broad range of backgrounds Discusses the incorporation of epigenetics and epigenomics into current toxicological studies and interpretation of epigenetic data in toxicological applications

Translational Toxicology and Therapeutics

Translational Toxicology and Therapeutics Book
Author : Michael D. Waters,Claude L. Hughes
Publisher : John Wiley & Sons
Release : 2018-01-04
ISBN : 1119023602
Language : En, Es, Fr & De

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Book Description :

Written by leading research scientists, this book integrates current knowledge of toxicology and human health through coverage of environmental toxicants, genetic / epigenetic mechanisms, and carcinogenicity. Provides information on lifestyle choices that can reduce cancer risk Offers a systematic approach to identify mutagenic, developmental and reproductive toxicants Helps readers develop new animal models and tests to assess toxic impacts of mutation and cancer on human health Explains specific cellular and molecular targets of known toxicants operating through genetic and epigenetic mechanisms

Epigenetic Toxicology

Epigenetic Toxicology Book
Author : Shaun D. McCullough,Dana Dolinoy
Publisher : Academic Press
Release : 2018-11-15
ISBN : 9780128124338
Language : En, Es, Fr & De

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Book Description :

Epigenetic Toxicology: Core Principles and Applications examines epigenetics, including chromatin biology, DNA methylation and non-coding RNA, along with fundamental techniques and considerations for studying each of these mechanisms of epigenetic regulation. Epigenetics have taken center stage in the study of diseases, such as cancer, diabetes and neurodegeneration. However, the integration of epigenetics in the field of toxicology is still in its infancy. This book presents unified, practical and easy to follow protocols to help improve their effectiveness and efficiency. In addition, it includes online protocols (as PDFs) to help increase practical applicability and facilitate incorporation of epigenetics into toxicology research programs. It is an essential book for advanced students and researchers using epigenetics in toxicology research and study. Presents toxicologists with a broad range of backgrounds with the fundamental principles of epigenetics Discusses the incorporation of epigenetics and epigenomics into current toxicological studies Includes basic protocols covering most epigenetic endpoints

Pharmacoepigenetics

Pharmacoepigenetics Book
Author : Anonim
Publisher : Academic Press
Release : 2019-06-04
ISBN : 0128139404
Language : En, Es, Fr & De

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Book Description :

Pharmacoepigenetics, Volume Eleven provides a comprehensive volume on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible, view of the field, from basic principles, to applications in disease therapeutics. Leading international researchers from across academia, clinical settings and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the book, chapter authors offer a balanced and objective discussion of the future of pharmacoepigenetics and its crucial contribution to the growth of precision and personalized medicine. Fully examines the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, treatment, current epigenetic drugs and the application of epigenetic procedures in drug development Features chapter contributions from leading international researchers in academia, clinical settings and the pharmaceutical industry Instructs researchers, students and clinicians on how to better interpret and employ pharmacoepigenetics in drug development, efficiency and safety Provides a balanced and objective discussion of the future of pharmacoepigenetics and its crucial role in precision medicine

Toxicology and Epigenetics

Toxicology and Epigenetics Book
Author : Saura C. Sahu
Publisher : John Wiley & Sons
Release : 2012-08-23
ISBN : 1118349067
Language : En, Es, Fr & De

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Book Description :

Epigenetics is the study of both heritable and non-heritablechanges in the regulation of gene activity and expression thatoccur without an alteration in the DNA sequence. Thisdynamic and rapidly developing discipline is making its impactacross the biomedical sciences, in particular in toxicology whereepigenetic differences can mean that different individuals responddifferently to the same drug or chemical. Toxicology and Epigenetics reflects the multidimensionalcharacter of this emerging area of toxicology, describingcutting-edge molecular technologies to unravel epigenetic changes,the use of in vivo and in vitro models, as well asthe potential use of toxicological epigenetics in regulatoryenvironments. An international team of experts consider theinterplay between epigenetics and toxicology in a number of areas,including environmental, nutritional, pharmacological, andcomputational toxicology, nanomaterials, proteomics andmetabolomics, and cancer research. Topics covered include: environment, epigenetics and diseases DNA methylation and toxicogenomics chromatin at the intersection of disease and therapy epigenomic actions of environmental arsenicals environment, epigenetics and cardiovascular health toxicology, epigenetics and autoimmunity ocular epigenomics: potential sites of environmental impact indevelopment and disease nuclear RNA silencing and related phenomena in animals epigenomics – impact for drug safety sciences methods of global epigenomic profiling transcriptomics: applications in epigenetic toxicology Toxicology and Epigenetics is an essential insight intothe current trends and future directions of research in thisrapidly expanding field for investigators, toxicologists, riskassessors and regulators in academia, industry and government.

Personalized Epigenetics

Personalized Epigenetics Book
Author : Trygve Tollefsbol
Publisher : Academic Press
Release : 2015-04-28
ISBN : 0128004363
Language : En, Es, Fr & De

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Book Description :

Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics. Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management. Discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures Details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the consequent diagnostic, prognostic and therapeutic potential of the field Reviews the impact of the environment on epigenetic variations among individuals and the roles of pharmacology and drug development Devotes several chapters to the advances made in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management

Translational Toxicology and Therapeutics

Translational Toxicology and Therapeutics Book
Author : Michael D. Waters,Claude L. Hughes
Publisher : John Wiley & Sons
Release : 2017-11-10
ISBN : 1119023718
Language : En, Es, Fr & De

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Book Description :

Written by leading research scientists, this book integrates current knowledge of toxicology and human health through coverage of environmental toxicants, genetic / epigenetic mechanisms, and carcinogenicity. Provides information on lifestyle choices that can reduce cancer risk Offers a systematic approach to identify mutagenic, developmental and reproductive toxicants Helps readers develop new animal models and tests to assess toxic impacts of mutation and cancer on human health Explains specific cellular and molecular targets of known toxicants operating through genetic and epigenetic mechanisms

Pharmacokinetics and Toxicokinetic Considerations Vol II

Pharmacokinetics and Toxicokinetic Considerations   Vol II Book
Author : Rakesh Kumar Tekade
Publisher : Academic Press
Release : 2022-02-17
ISBN : 0323913164
Language : En, Es, Fr & De

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Book Description :

Pharmacokinetics and Toxicokinetic Considerations explains the central principles, cutting-edge methodologies, and incipient thought processes applied to toxicology research. As part of the Advances in Pharmaceutical Product Development and Research series, the book provides expert literature on dose, dosage regimen and dose adjustment, medication errors, and approaches for its prevention, the concept of pharmacotherapy, and managed care in clinical interventions. It expounds on strategies to revamp the pharmacokinetics of the drug and the factors affecting the stability of drugs and their metabolites in biological matrices. Finally, the book offers focused elaborations on various bioanalytical methods for bioavailability and bioequivalence assessment and integrates the wide-ranging principles and concepts shared by toxicokinetics and pharmacodynamics as mutual crosstalk rather than isolated observations. It will be helpful to researchers and advanced students working in the pharmaceutical, cosmetics, biotechnology, food, and related industries including toxicologists, pharmacists, and pharmacologists. Allows readers to systematically integrate up-to-date research findings into their laboratory work Presents focused explorations of bioanalytical methods for bioavailability and bioequivalence assessment Provides clinical applications of concepts

Epigenetic Variation Influences on Livestock Production and Disease Traits

Epigenetic Variation Influences on Livestock Production and Disease Traits Book
Author : Eveline M. Ibeagha-Awemu,Hélène Kiefer,Stephanie McKay,George E. Liu
Publisher : Frontiers Media SA
Release : 2022-07-07
ISBN : 2889765334
Language : En, Es, Fr & De

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Book Description :

Download Epigenetic Variation Influences on Livestock Production and Disease Traits book written by Eveline M. Ibeagha-Awemu,Hélène Kiefer,Stephanie McKay,George E. Liu, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Environmental Epigenetics

Environmental Epigenetics Book
Author : L. Joseph Su,Tung-chin Chiang
Publisher : Springer
Release : 2015-05-18
ISBN : 1447166787
Language : En, Es, Fr & De

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Book Description :

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Aminoglycosides Advances in Research and Application 2011 Edition

Aminoglycosides  Advances in Research and Application  2011 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-01-09
ISBN : 1464947015
Language : En, Es, Fr & De

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Book Description :

Aminoglycosides: Advances in Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Aminoglycosides in a compact format. The editors have built Aminoglycosides: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Aminoglycosides in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Aminoglycosides: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Epigenetics Methods

Epigenetics Methods Book
Author : Trygve Tollefsbol
Publisher : Academic Press
Release : 2020-07-08
ISBN : 0128194154
Language : En, Es, Fr & De

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Book Description :

In recent years, the field of epigenetics has grown significantly, driving new understanding of human developmental processes and disease expression, as well as advances in diagnostics and therapeutics. As the field of epigenetics continues to grow, methods and technologies have multiplied, resulting in a wide range of approaches and tools researchers might employ. Epigenetics Methods offers comprehensive instruction in methods, protocols, and experimental approaches applied in field of epigenetics. Here, across thirty-five chapters, specialists offer step-by-step overviews of methods used to study various epigenetic mechanisms, as employed in basic and translational research. Leading the reader from fundamental to more advanced methods, the book begins with thorough instruction in DNA methylation techniques and gene or locus-specific methylation analyses, followed by histone modification methods, chromatin evaluation, enzyme analyses of histone methylation, and studies of non-coding RNAs as epigenetic modulators. Recently developed techniques and technologies discussed include single-cell epigenomics, epigenetic editing, computational epigenetics, systems biology epigenetic methods, and forensic epigenetic approaches. Epigenetics methods currently in-development, and their implication for future research, are also considered in-depth. In addition, as with the wider life sciences, reproducibility across experiments, labs, and subdisciplines is a growing issue for epigenetics researchers. This volume provides consensus-driven methods instruction and overviews. Tollefsbol and contributing authors survey the range of existing methods; identify best practices, common themes, and challenges; and bring unity of approach to a diverse and ever-evolving field. Includes contributions by leading international investigators involved in epigenetic research and clinical and therapeutic application Integrates technology and translation with fundamental chapters on epigenetics methods, as well as chapters on more novel and advanced epigenetics methods Written at verbal and technical levels that can be understood by scientists and students alike Includes chapters on state-of-the-art techniques such as single-cell epigenomics, use of CRISPR/Cas9 for epigenetic editing, and epigenetics methods applied to forensics

Nutritional Epigenomics

Nutritional Epigenomics Book
Author : Anonim
Publisher : Academic Press
Release : 2019-07-20
ISBN : 0128173106
Language : En, Es, Fr & De

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Book Description :

Nutritional Epigenomics offers a comprehensive overview of nutritional epigenomics as a mode of study, along with nutrition’s role in the epigenomic regulation of disease, health and developmental processes. Here, an expert team of international contributors introduces readers to nutritional epigenomic regulators of gene expression, our diet’s role in epigenomic regulation of disease and disease inheritance, caloric restriction and exercise as they relate to recent epigenomic findings, and the influence of nutritional epigenomics over circadian rhythms, aging and longevity, and fetal health and development, among other processes. Disease specific chapters address metabolic disease (obesity and diabetes), cancer, and neurodegeneration, among other disorders. Diet-gut microbiome interactions in the epigenomic regulation of disease are also discussed, as is the role of micronutrients and milk miRNAs in epigenetic regulation. Finally, chapter authors examine ongoing discussions of race and ethnicity in the social-epigenomic regulation of health and disease. Empowers the reader to employ nutritional epigenomics approaches in their own research Discusses the latest topics in nutritional epigenomics in the regulation of aging, circadian rhythm, inheritance and fetal development, as well as metabolism and disease Offers a full grounding in epigenetic reprogramming and nutritional intervention in the treatment and prevention of disease, as informed by population-based studies

HiC Pro an Optimized and Flexible Pipeline for Hi C Data Processing

HiC Pro  an Optimized and Flexible Pipeline for Hi C Data Processing Book
Author : Oldenburg Oldenburg Press
Publisher : Unknown
Release : 2016-01-29
ISBN : 9781523764426
Language : En, Es, Fr & De

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Book Description :

HiC-Pro is an optimized and flexible pipeline for processing Hi-C data from raw reads to normalized contact maps. HiC-Pro maps reads, detects valid ligation products, performs quality controls and generates intra- and inter-chromosomal contact maps. It includes a fast implementation of the iterative correction method and is based on a memory-efficient data format for Hi-C contact maps. In addition, HiC-Pro can use phased genotype data to build allele-specific contact maps. We applied HiC-Pro to different Hi-C datasets, demonstrating its ability to easily process large data in a reasonable time. Source code and documentation are available at http://github.com/nservant/HiC-Pro.

Drug Metabolism

Drug Metabolism Book
Author : Katherine Dunnington
Publisher : BoD – Books on Demand
Release : 2021-12-22
ISBN : 1839688793
Language : En, Es, Fr & De

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Book Description :

Drug metabolism comprises the identification, characterization, and quantification of the chemicals or compounds produced in an animal or human upon administration of a drug. Research practices not only require the chemical structure but also aim to determine the pharmacological activities and/or toxicity of these compounds. This is first performed in animals, as studies attempt to identify and quantify metabolites, and later in humans, with care to further characterize metabolites that are either unique to or produced disproportionately in humans compared to animals. Characterization includes the determination of enzyme systems or other biological mechanisms that produce each identified metabolite; this information is used to predict potential drug-drug interactions with other compounds that increase or decrease metabolite formation and sources of biological variability in response or toxicity with varying patient genetics, which affect CYP isoform expression. This book’s purpose is to provide some understanding of the biology and current technology applied in the field of drug metabolism.

Histone Modifications in Therapy

Histone Modifications in Therapy Book
Author : Pedro Castelo-Branco,Carmen Jeronimo
Publisher : Academic Press
Release : 2020-08-21
ISBN : 0128167408
Language : En, Es, Fr & De

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Book Description :

Histone Modifications in Therapy provides an in-depth analysis of the role of histone mechanisms in major diseases and the promise of targeting histone modifications for disease prevention and treatment. Here, researchers, clinicians and students will discover a thorough, evidence-based discussion of the biology of histones, the diseases engaged by aberrant histone modifications, and pathways with therapeutic potential. Expert chapter addresses the role of histone modifications across a variety of disorders, including cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, autoimmune and inflammatory disorders, among others. In relation to these disease types, histone modifications are discussed, both as mechanisms of prevention and possible treatment. A concluding chapter brings together future perspectives for targeting histone modifications in therapy and next steps in research. Examines the use of histone modifications in disease prevention and therapy Explores the role of histone modifications in cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, and inflammatory disease, among others Features chapters from a broad range of international authors and disease specialists

Engineering Technologies and Clinical Translation

Engineering Technologies and Clinical Translation Book
Author : Mansoor M. Amiji,Lara Scheherazade Milane
Publisher : Academic Press
Release : 2021-08-25
ISBN : 0323909507
Language : En, Es, Fr & De

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Book Description :

Engineering Technologies and Clinical Translation: Volume 3: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies, focusing specifically on the development of solutions for drug delivery and its clinical outcomes. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. This volume of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy discusses biomaterial, microfluidic, and biodegradable devices, engineered microbes, personalized medicine, clinical approval process, and many other IO technologies. Engineering Technologies and Clinical Translation: Volume 3: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. Explores engineering technologies and their clinical translation in a comprehensive way Presents forecasting on the future of nanotechnology and drug delivery for IO Engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side

Regenerative Medicine and Stem Cell Biology

Regenerative Medicine and Stem Cell Biology Book
Author : Nagwa El-Badri
Publisher : Springer Nature
Release : 2020-11-27
ISBN : 3030553590
Language : En, Es, Fr & De

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Book Description :

This textbook covers the basic aspects of stem cell research and applications in regenerative medicine. Each chapter includes a didactic component and a practical section. The book offers readers insights into: How to identify the basic concepts of stem cell biology and the molecular regulation of pluripotency and stem cell development. How to produce induced pluripotent stem cells (iPSCs) and the basics of transfection. The biology of adult stem cells, with particular emphasis on mesenchymal stromal cells and hematopoietic stem cells, and the basic mechanisms that regulate them. How cancer stem cells arise and metastasize, and their properties. How to develop the skills needed to isolate, differentiate and characterize adult stem The clinical significance of stem cell research and the potential problems that need to be overcome. Evaluating the use of stem cells for tissue engineering and therapies (the amniotic membrane) The applications of bio-nanotechnology in stem cell research. How epigenetic mechanisms, including various DNA modifications and histone dynamics, are involved in regulating the potentiality and differentiation of stem cells. The scientific methods, ethical considerations and implications of stem cell research.

Cellular and Molecular Approaches in Fish Biology

Cellular and Molecular Approaches in Fish Biology Book
Author : Ignacio Fernandez,Jorge Fernandes
Publisher : Academic Press
Release : 2021-12-01
ISBN : 0128222743
Language : En, Es, Fr & De

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Book Description :

Cellular and Molecular Approaches in Fish Biology is a highly interdisciplinary resource that will bring industry professionals up-to-date on the latest developments and information on fish biology research. The book combines an historical overview of the different research areas in fish biology with detailed descriptions of cellular and molecular approaches and recommendations for research. It provides different points-of-view on how researchers have addressed timely issues, while also describing and dissecting some of the new experimental/analytical approaches used to answer key questions at cellular and molecular levels. Provides detailed descriptions of each research approach, highlighting the tricks of the trade for its effective and successful application Includes the latest developments in fish reproduction, fish nutrition, fish wellbeing, ecology and toxicology Presents hot topic areas of research, including genetic editing, epigenetics and eDNA

Veterans and Agent Orange

Veterans and Agent Orange Book
Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Eleventh Biennial Update)
Publisher : National Academies Press
Release : 2018-12-20
ISBN : 0309477190
Language : En, Es, Fr & De

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Book Description :

From 1962 to 1971, the U.S. military sprayed herbicides over Vietnam to strip the thick jungle canopy that could conceal opposition forces, to destroy crops that those forces might depend on, and to clear tall grasses and bushes from the perimeters of US base camps and outlying fire-support bases. Mixtures of 2,4-dichlorophenoxyacetic acid (2,4-D), 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), picloram, and cacodylic acid made up the bulk of the herbicides sprayed. The main chemical mixture sprayed was Agent Orange, a 50:50 mixture of 2,4-D and 2,4,5-T. At the time of the spraying, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most toxic form of dioxin, was an unintended contaminant generated during the production of 2,4,5-T and so was present in Agent Orange and some other formulations sprayed in Vietnam. Because of complaints from returning Vietnam veterans about their own health and that of their children combined with emerging toxicologic evidence of adverse effects of phenoxy herbicides and TCDD, the National Academies of Sciences, Engineering, and Medicine was asked to perform a comprehensive evaluation of scientific and medical information regarding the health effects of exposure to Agent Orange, other herbicides used in Vietnam, and the various components of those herbicides, including TCDD. Updated evaluations were conducted every two years to review newly available literature and draw conclusions from the overall evidence. Veterans and Agent Orange: Update 11 (2018) examines peer-reviewed scientific reports concerning associations between various health outcomes and exposure to TCDD and other chemicals in the herbicides used in Vietnam that were published between September 30, 2014, and December 31, 2017, and integrates this information with the previously established evidence database.