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Towards 4D Bioprinting

Towards 4D Bioprinting Book
Author : Adrian Neagu
Publisher : Academic Press
Release : 2021-08-15
ISBN : 9780128186534
Language : En, Es, Fr & De

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Book Description :

Towards 4D Printing presents the current state of three-dimensional (3D) bioprinting and its recent offspring, 4D bioprinting. These are attractive approaches to tissue engineering because they hold the promise of building bulky tissue constructs with incorporated vasculature. Starting with the discussion of 3D and 4D printing of inanimate objects, the book presents several 3D bioprinting techniques and points out the challenges imposed by living cells on the bioprinting process. It argues that, in order to fine-tune the bioprinter, one needs a quantitative analysis of the conditions experienced by cells during printing. Once the printing is over, the construct evolves according to mechanisms known from developmental biology. These are described in the book along with computer simulations that aim to predict the outcome of 3D bioprinting. In addition, the book provides the latest information on the principles and applications of 4D bioprinting, such as for medical devices and assistive technology. The last chapter discusses the perspectives of the field. This book provides an up-to date description of the theoretical tools developed for the optimization of 3D bioprinting, presents the morphogenetic mechanisms responsible for the post-printing evolution of the bioprinted construct and describing computational methods for simulating this evolution, and discusses the leap from 3D to 4D bioprinting in the light of the latest developments in the field. Most importantly, Towards 4D Printing explains the importance of theoretical modeling for the progress of 3D and 4D bioprinting. Presents theoretical tools needed for the optimization of the bioprinting process Describes the principles and implementation of computer simulations needed to predict the outcome of 3D bioprinting Analyzes the distinctive features of 4D bioprinting along with its applications and perspectives

3D and 4D Printing in Biomedical Applications

3D and 4D Printing in Biomedical Applications Book
Author : Mohammed Maniruzzaman
Publisher : John Wiley & Sons
Release : 2019-03-18
ISBN : 3527344438
Language : En, Es, Fr & De

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Book Description :

Ein professioneller Leitfaden zu 3D- und 4D-Drucktechniken in der Biomedizin und Pharmazie. 3D and 4D Printing in Biomedical Applications führt fundiert in 3D- und 4D-Drucktechniken in der Biomedizin und Pharmazie ein. Dieses Fachbuch enthält Beiträge von internationalen Wissenschaftlern und Industrieexperten und bietet einen Überblick über das Thema, aktuelle Forschungsergebnisse und Innovationen zu Anwendungen in der Pharmazie und Biomedizin. Untersucht werden Prozessoptimierung, Innovationsprozesse, Engineering- und Plattformtechnologien. Darüber hinaus informiert das Werk über Entwicklungen in der Biomedizin, u. a. über Formgedächtnispolymere, Biofabrikation in 4D und Knochen aus dem Drucker. Eine Fülle von Themen werden behandelt und näher beleuchtet: Potenzial des 3D-Drucks für die Wirkstoffverabreichung, neue Fertigungsprozess, Bio-Scaffolding, neueste Trends und Herausforderungen für 3D- und 4D-Bioprinting in der Biofabrikation. Dieses wertvolle Referenzwerk - ist ein umfassender Leitfaden zu 3D- und 4D-Drucktechniken in der Biomedizin und Pharmazie. - informiert u. a. über die erste 3D-Druckplattform mit FDA-Zulassung für ein pharmazeutisches Erzeugnis. - enthält Reviews der derzeit verfügbaren pharmazeutischen Erzeugnisse, die per 3D-Druck hergestellt wurden. - präsentiert die jüngsten Fortschritte bei neuartigen Materialien für den 3D- und 4D-Druck und biomedizinische Anwendungen.

3D Bioprinting in Regenerative Engineering

3D Bioprinting in Regenerative Engineering Book
Author : Ali Khademhosseini,Gulden Camci-Unal
Publisher : CRC Press
Release : 2018-04-17
ISBN : 1315280477
Language : En, Es, Fr & De

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Book Description :

This book is comprehensive in nature with contributions by leading world experts in 3D bioprinting related to regenerative engineering. It includes history, incorporating the process and methods used in bioprinting. Significant sections will be reserved for the applications of the types of tissues generated by using bioprinting, along with an overview of different technologies used in bioprinting. In addition to equipment, the book also describes the different biomaterials and cells used in these approaches. Overall this is a book that includes both entry-level knowledge and advanced methods and techniques. Applications will emphasize engineering and clinical principles.

From Additive Manufacturing to 3D 4D Printing

From Additive Manufacturing to 3D 4D Printing Book
Author : Jean-Claude André
Publisher : John Wiley & Sons
Release : 2018-03-07
ISBN : 1786302322
Language : En, Es, Fr & De

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Book Description :

With a turnover of some 5-15 billion € / year, the additive manufacturing has industrial niches bearers thanks to processes and materials more and more optimized. While some niches still exist on the application of additive techniques in traditional fields (from jewelery to food for example), several trends emerge, using new concepts: collective production, realization of objects at once (without addition Of material), micro-fluidic, 4D printing exploiting programmable materials and materials, bio-printing, etc. There are both opportunities for new markets, promises not envisaged less than 10 years ago, but difficulties in reaching them.

From Additive Manufacturing to 3D 4D Printing

From Additive Manufacturing to 3D 4D Printing Book
Author : Jean-Claude André
Publisher : John Wiley & Sons
Release : 2017-12-27
ISBN : 1119482763
Language : En, Es, Fr & De

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Book Description :

With a turnover of some 5-15 billion € / year, the additive manufacturing has industrial niches bearers thanks to processes and materials more and more optimized. While some niches still exist on the application of additive techniques in traditional fields (from jewelery to food for example), several trends emerge, using new concepts: collective production, realization of objects at once (without addition Of material), micro-fluidic, 4D printing exploiting programmable materials and materials, bio-printing, etc. There are both opportunities for new markets, promises not envisaged less than 10 years ago, but difficulties in reaching them.

3D Printing Technology in Nanomedicine

3D Printing Technology in Nanomedicine Book
Author : Nabeel Ahmad,P. Gopinath,Rajiv Dutta
Publisher : Elsevier
Release : 2019-03-30
ISBN : 0128158913
Language : En, Es, Fr & De

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Book Description :

3D Printing Technology in Nanomedicine provides an integrated and introductory look into the rapidly evolving field of nanobiotechnology. It demystifies the processes of commercialization and discusses legal and regulatory considerations. With a focus on nanoscale processes and biomedical applications, users will find this to be a comprehensive resource on how 3D printing can be utilized in a range of areas, including the diagnosis and treatment of a variety of human diseases. Examines the emerging market of 3D-printed biomaterials and their clinical applications, with a particular focus on both commercial and premarket tools Examines the promising market of 3D-printed nanoparticles, nanomaterial, biomaterials, composite nanomaterial and their clinical applications in the cardiovascular and chemotherapy realms Develops the concept of integrating different technologies along the hierarchical structure of biological systems

Cardiovascular 3D Printing

Cardiovascular 3D Printing Book
Author : Jian Yang,Alex Pui-Wai Lee,Vladimiro L. Vida
Publisher : Springer Nature
Release : 2020-10-19
ISBN : 9811569576
Language : En, Es, Fr & De

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Book Description :

This book offers readers a comprehensive introduction to the techniques and application of 3D printing in cardiovascular medicine. To do so, it addresses the history, concepts, and methods of 3D printing, choice of printing materials for clinical purposes, personalized planning of cardiac surgery and transcatheter interventions with patient-specific models, enhancement of patient-physician communication, simulation of endovascular procedures, and advances in 3D bio-printing. The book particularly focuses on the application of 3D printing to improve the efficacy and safety of cardiac interventions, and to promote the realization of precision medical care. The book gathers contributions by an international team of experts in the field of cardiovascular medicine, who combine the latest findings with their own practical experience in using 3D printing to support the diagnosis and treatment of a wide range of cardiovascular diseases. They present in-depth discussions in the fields of congenital heart disease, valvular disease, coronary artery disease, cardiomyopathy, left atrial appendage occlusion, cardiac tumors and vascular diseases.

Regenerative Engineering

Regenerative Engineering Book
Author : Yusuf Khan,Cato T. Laurencin
Publisher : CRC Press
Release : 2018-04-19
ISBN : 1498738257
Language : En, Es, Fr & De

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Book Description :

This book focuses on advances made in both materials science and scaffold development techniques, paying close attention to the latest and state-of-the-art research. Chapters delve into a sweeping variety of specific materials categories, from composite materials to bioactive ceramics, exploring how these materials are specifically designed for regenerative engineering applications. Also included are unique chapters on biologically-derived scaffolding, along with 3D printing technology for regenerative engineering. Features: Covers the latest developments in advanced materials for regenerative engineering and medicine. Each chapter is written by world class researchers in various aspects of this medical technology. Provides unique coverage of biologically derived scaffolding. Includes separate chapter on how 3D printing technology is related to regenerative engineering. Includes extensive references at the end of each chapter to enhance further study.

From Additive Manufacturing to 3D 4D Printing 1

From Additive Manufacturing to 3D 4D Printing 1 Book
Author : Jean-Claude André
Publisher : John Wiley & Sons
Release : 2017-11-29
ISBN : 1786301199
Language : En, Es, Fr & De

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Book Description :

In 1984, additive manufacturing represented a new methodology for manipulating matter, consisting of harnessing materials and/or energy to create three-dimensional physical objects. Today, additive manufacturing technologies represent a market of around 5 billion euros per year, with an annual growth between 20 and 30%. Different processes, materials and dimensions (from nanometer to decameter) within additive manufacturing techniques have led to 70,000 publications on this topic and to several thousand patents with applications as wide-ranging as domestic uses. Volume 1 of this series of books presents these different technologies with illustrative industrial examples. In addition to the strengths of 3D methods, this book also covers their weaknesses and the developments envisaged in terms of incremental innovations to overcome them.

From Additive Manufacturing to 3D 4D Printing 2

From Additive Manufacturing to 3D 4D Printing 2 Book
Author : Jean-Claude André
Publisher : John Wiley & Sons
Release : 2017-11-01
ISBN : 1119437369
Language : En, Es, Fr & De

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Book Description :

Additive manufacturing, which was first invented in France and then applied in the United States, is now 33 years old and represents a market of around 5 billion euros per year, with annual growth of between 20 and 30%. Today, additive manufacturing is experiencing a great amount of innovation in its processes, software, engineering and materials used. Its strength as a process has more recently allowed for the exploration of new niches, ranging from applications at nanometer and decameter scales, to others in mechanics and health. As a result, the limitations of the process have also begun to emerge, which include the quality of the tools, their cost of manufacture, the multi-material aspects, functionalities and surface conditions. Volume 2 of this series presents the current techniques, improvements and limits of additive manufacturing, providing an up-to-date review of this process.

3D and 4D Printing of Polymer Nanocomposite Materials

3D and 4D Printing of Polymer Nanocomposite Materials Book
Author : Kishor Kumar Sadasivuni,Kalim Deshmukh,Mariam AlAli AlMaadeed
Publisher : Elsevier
Release : 2019-10-11
ISBN : 0128173025
Language : En, Es, Fr & De

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Book Description :

3D and 4D Printing of Polymer Nanocomposite Materials: Processing, Applications, and Challenges covers advanced 3D and 4D printing processes and the latest developments in novel polymer-based printing materials, thus enabling the reader to understand and benefit from the advantages of this groundbreaking technology. The book presents processes, materials selection, and printability issues, along with sections on the preparation of polymer composite materials for 3D and 4D printing. Across the book, advanced printing techniques are covered and discussed thoroughly, including fused deposition modeling (FDM), selective laser sintering (SLS), selective laser melting (SLM), electron beam melting (EBM), inkjet 3D printing (3DP), stereolithography (SLA), and 3D plotting. Finally, major applications areas are discussed, including electronic, aerospace, construction and biomedical applications, with detailed information on the design, fabrication and processing methods required in each case. Provides a thorough, clear understanding of polymer preparation techniques and 3D and 4D printing processes, with a view to specific applications Examines synthesis, formation methodology, the dispersion of fillers, characterization, properties, and performance of polymer nanocomposites Explores the possibilities of 4D printing, covering the usage of stimuli responsive hydrogels and shape memory polymers

Biomaterials for 3D Tumor Modeling

Biomaterials for 3D Tumor Modeling Book
Author : Subhas Kundu,Rui L. Reis
Publisher : Elsevier
Release : 2020-08-22
ISBN : 012818129X
Language : En, Es, Fr & De

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Book Description :

Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening aspects. The book reviews advanced fundamental topics, including the causes of cancer, existing cancer models, angiogenesis and inflammation during cancer progression, and metastasis in 3D biomaterials. Then, the most relevant biomaterials are reviewed, including methods for engineering and fabrication of biomaterials. 3D models for key biological systems and types of cancer are also discussed, including lung, liver, oral, prostate, pancreatic, ovarian, bone and pediatric cancer. This book is suitable for those working in the disciplines of materials science, biochemistry, genetics, molecular biology, drug delivery and regenerative medicine. Reviews key biomaterials topics, including synthetic biomaterials, hydrogels, e-spun materials and nanoparticles Provides a comprehensive overview of 3D cancer models for key biological systems and cancer types Includes an overview of advanced fundamental concepts for an interdisciplinary audience in materials science, biochemistry, regenerative medicine and drug delivery

4D Bioprinting for Regenerative Medicine Solutions

4D Bioprinting for Regenerative Medicine Solutions Book
Author : Fabien Guillemot
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Despite great scientific and clinical successes, few tissue engineering products have so far made their way to the industrial and commercial phase, depriving patients to benefit from innovative treatments. Producing advanced therapy medicinal products remains a cumbersome process with costs, reproducibility and scalability issues. Automation of production processes should be key to achieve quality controlled and repeatable biomanufacturing. Poietis develops biomanufacturing solutions based on bioprinting technologies for the design and the production of tissues, like the full thickness skin model Poieskinu00ae.The fabrication process follows three main steps: (1) tissue design where the 3D patterns of cells and materials are defined through a proprietary tissue CAD software; (2) tissue biofabrication consisting in the layer-by-layer deposition of collagen, fibroblasts and keratinocytes; (3) tissue maturation during which cell patterns evolve towards the final functional tissue architecture. Biofabrication is performed using the proprietary Next-Generation Bioprinting platform combining microvalve and laser assisted bioprinting. Unit controls is performed using embedded image analysis tools to assess production quality. The Quality-by-Design methology is used to determine CMA (critical material attributes) and CPP (critical process parameters).We demonstrate a control over the 3D cell organization and a relation between the initial 3D cell pattern and the cell reorganization dynamics. The use of the Quality-By-Design methodology enabled to hierarchize the CMA and CPP and consequently incrementaly improve the reproducibility and quality of the produced tissues. The biofabrication strategy described here is generic and can be applied to the design and production of any tissue. The routine production of Poieskinu00ae for in vitro research applications demonstrates the industrial maturity of bioprinting and is a key milestone towards the development of clinical bioprinters for the production of tissue grafts.

Current Applications of Pharmaceutical Biotechnology

Current Applications of Pharmaceutical Biotechnology Book
Author : Ana Catarina Silva,João Nuno Moreira,José Manuel Sousa Lobo,Hugo Almeida
Publisher : Springer Nature
Release : 2020-02-06
ISBN : 3030404641
Language : En, Es, Fr & De

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Book Description :

This book offers an authoritative review of biopharmaceuticals and their clinical relevance. Biopharmaceuticals have been showing high therapeutic potential by means of biological and biosimilar medicines, particularly for the treatment of cancer, chronic diseases (e.g. diabetes, Crohn's disease, psoriasis and rheumatoid arthritis), neurodegenerative disorders (e.g. multiple sclerosis), and they have also been contributing to the progress of innovative therapies such as assisted reproductive medicine. Since the eighties, several biopharmaceuticals have been approved and, due to patents expiration, many biosimilars are also marketed. In this book, readers will find the most relevant updated information about the main clinical applications of pharmaceutical biotechnology. The authors provide expert analysis about the industrial challenges of recombinant proteins and the different classes of biopharmaceuticals, including monoclonal antibodies, vaccines, growth factors and stem cells. Topics such as bioprinting technologies in tissue engineering, gene therapy and personalized medicine are also covered in this book. Professionals, students and researchers interested in this field will find this work an important account.

3D Bioprinting

3D Bioprinting Book
Author : Ibrahim Tarik Ozbolat
Publisher : Academic Press
Release : 2016-11-21
ISBN : 0128030305
Language : En, Es, Fr & De

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Book Description :

3D Bioprinting: Fundamentals, Principles and Applications provides the latest information on the fundamentals, principles, physics, and applications of 3D bioprinting. It contains descriptions of the various bioprinting processes and technologies used in additive biomanufacturing of tissue constructs, tissues, and organs using living cells. The increasing availability and decreasing costs of 3D printing technologies are driving its use to meet medical needs, and this book provides an overview of these technologies and their integration. Each chapter discusses current limitations on the relevant technology, giving future perspectives. Professor Ozbolat has pulled together expertise from the fields of bioprinting, tissue engineering, tissue fabrication, and 3D printing in his inclusive table of contents. Topics covered include raw materials, processes, machine technology, products, applications, and limitations. The information in this book will help bioengineers, tissue and manufacturing engineers, and medical doctors understand the features of each bioprinting process, as well as bioink and bioprinter types. In addition, the book presents tactics that can be used to select the appropriate process for a given application, such as tissue engineering and regenerative medicine, transplantation, clinics, or pharmaceutics. Describes all aspects of the bioprinting process, from bioink processing through design for bioprinting, bioprinting techniques, bioprinter technologies, organ printing, applications, and future trends Provides a detailed description of each bioprinting technique with an in-depth understanding of its process modeling, underlying physics and characteristics, suitable bioink and cell types printed, and major accomplishments achieved thus far Explains organ printing technology in detail with a step-by-step roadmap for the 3D bioprinting of organs from isolating stem cells to the post-transplantation of organs Presents tactics that can be used to select the appropriate process for a given application, such as tissue engineering and regenerative medicine, transplantation, clinics, or pharmaceutics

Rapid Prototyping of Biomaterials

Rapid Prototyping of Biomaterials Book
Author : Roger Narayan
Publisher : Woodhead Publishing
Release : 2019-10-18
ISBN : 0081026641
Language : En, Es, Fr & De

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Book Description :

Rapid Prototyping of Biomaterials: Techniques in Additive Manufacturing, Second Edition, provides a comprehensive review of emerging rapid prototyping technologies, such as bioprinting, for biomedical applications. Rapid prototyping, also known as additive manufacturing, solid freeform fabrication, or 3D printing, can be used to create complex structures and devices for medical applications from solid, powder or liquid precursors. Sections explore a variety of materials, look at applications, and consider the use of rapid prototyping technologies for constructing organs. With its distinguished editor and international team of renowned contributors, this book is a useful, technical resource for scientists and researchers in academia, biomaterials and tissue regeneration. Presents a comprehensive review of established and emerging additive manufacturing technologies (such as bioprinting) for medical applications Contains chapters that explore the additive manufacturing of nanoscale biomaterials for a range of applications, from drug delivery, to organ printing Includes new information on 3D printing on a variety of material classes

Study on Microextrusion based 3D Bioprinting and Bioink Crosslinking Mechanisms

Study on Microextrusion based 3D Bioprinting and Bioink Crosslinking Mechanisms Book
Author : Liliang Ouyang
Publisher : Springer
Release : 2019-08-10
ISBN : 9811394555
Language : En, Es, Fr & De

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Book Description :

This book presents a comprehensive study on microextrusion-based 3D bioprinting technologies for bioinks with various crosslinking mechanisms, chiefly focusing on the bioprinting process and bioink properties to provide readers with a better understanding of this state-of-the-art technology. Further, it summarizes a number of general criteria and research routes for microextrusion-based 3D bioprinting using three experimental studies based on shear-thinning, thermo-sensitive and non-viscous hydrogel bioinks. The book also presents sample applications in the areas of stem cells and cell matrix interaction. The book highlights pioneering results in the development of bioprinting technologies and bioinks, which were published in high-quality journals such as Advanced Materials, Biofabrication and ACS Biomaterials Science & Engineering. These include an in-situ crosslinking strategy that overcomes the viscosity limits for bioinks, which is virtually impossible using conventional strategies, and can be generalized for other bioink formulations.

Applications of 3D Printing in Biomedical Engineering

Applications of 3D Printing in Biomedical Engineering Book
Author : Neeta Raj Sharma
Publisher : Springer Nature
Release : 2021-09-27
ISBN : 9813368888
Language : En, Es, Fr & De

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Book Description :

Download Applications of 3D Printing in Biomedical Engineering book written by Neeta Raj Sharma, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biopharmaceuticals

Biopharmaceuticals Book
Author : Basanta Kumara Behera
Publisher : CRC Press
Release : 2020-12-08
ISBN : 1351013130
Language : En, Es, Fr & De

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Book Description :

Biopharmaceuticals: Challenges and Opportunities This book highlights how the traditional microbial process technology has been upgraded for the production of biologic drugs how manufacturing processes have evolved to meet the global market demand with quality products under the guidelines of internally recognized regulatory bodies. It also carries information on how, armed with a deeper understanding of life-threatening diseases, biopharmaceutical companies and the life sciences industry have developed formal and informal partnerships with researchers in institutes, universities, and other R&D organizations to fulfil timely, quality production with perfect safety and security. One of the most interesting aspects of this book is the conceptual development of personalized medicine (or precision medicine) to provide the right treatment to the right patient, at the right dose at an earlier stage of development, for genetic diseases. Besides this, it also highlights the most challenging aspects of modern biopharmaceutical science, focusing on the hot topics such as design and development of biologic drugs; the use of diversified groups of host cells belonging to animals, plants, microbes, insects, and mammals; stem cell therapy and gene therapy; supply chain management of biopharmaceuticals; and the future scope of biopharmaceutical industry development. This book is the latest resource for a wide circle of scientists, students, and researchers involved in understanding and implementing the knowledge of biopharmaceuticals to develop life-saving biologic drugs and to bring awareness to the development of personalized treatment that can potentially offer patients a faster diagnosis, fewer side effects, and better outcomes. Features: Explains how the traditional cell culture methodology has been changed to a fully continuous or partially continuous process Explains how to design and fabricate living organs of body by 3D bioprinting technology Focuses on how a biopharmaceutical company deals with various problems of regulatory bodies and develops innovative biologic drugs Narrates in detail the updated information on stem cell therapy and gene therapy Explains the development strategies and clinical significance of biosimilars and biobetters Highlights the supply chain management of biopharmaceuticals

Regenerative Approaches in Dentistry

Regenerative Approaches in Dentistry Book
Author : Sepanta Hosseinpour
Publisher : Springer Nature
Release : 2021-09-27
ISBN : 3030598098
Language : En, Es, Fr & De

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Book Description :

Download Regenerative Approaches in Dentistry book written by Sepanta Hosseinpour, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.