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Third Generation EGFR Inhibitors

Third Generation EGFR Inhibitors Book
Author : Harun M. Patel,Rahul Pawara,Sanjay J. Surana
Publisher : Elsevier
Release : 2018-11-27
ISBN : 0081026625
Language : En, Es, Fr & De

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Book Description :

Third Generation EGFR Inhibitors: Overcoming EGFR Resistance and Toxicity Problems reviews current issues relating to the design of reversible and irreversible third generation EGFR inhibitors, highlighting the types of mutation responsible for resistance, and providing different chemical starting points for researchers to optimize and develop in designing the next generation of drugs. Beginning with an introduction to EGFR inhibitors and a review of inhibitors currently approved or in clinical trials, the book goes on to discuss current approaches in the development of both covalent irreversible and covalent reversible EGFR Inhibitors. In addition, mechanisms of resistance to third generation inhibitors, and discovery of fourth generation allosteric C797S inhibitors are explored before a discussion of potential future trends. This comprehensive coverage of the design and development of improved analogues to overcome the problems of resistance and toxicity associated with third generation EGFR inhibitors makes Third Generation EGFR Inhibitors a crucial resource for medicinal chemists, drug developers, and researchers investigating cancer therapeutics. Includes full synthetic schemes of all approved and in-trial third generation inhibitors Highlights the emergence of fourth generation EGFR inhibitors and the possibilities of them overcoming constraints of third generation compounds Provides a structural correlation of third and fourth generation EGFR inhibitors, reviewing both their design strategies and typical anticancer activity

Molecular Mechanisms of Acquired Resistance to Third generation EGFR TKIs in EGFR T790M mutant Lung Cancer

Molecular Mechanisms of Acquired Resistance to Third generation EGFR TKIs in EGFR T790M mutant Lung Cancer Book
Author : Anonim
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Abstract Lung cancer represents the leading cause of cancer-related deaths worldwide. Despite great advances in its management with the recent emergence of molecular targeted therapies for non-small-cell lung cancer (NSCLC), relapse of the metastatic disease always occurs within approximately one year. Epidermal growth factor receptor (EGFR) mutant tumours are the prime example of oncogene addiction and clonal evolution in oncology, regarding the emergence of resistance to first- and second-generation EGFR inhibitors. Multiple studies have revealed that the EGFR-T790M gatekeeper mutation is the main cause of tumour escape. Recently, irreversible pyrimidine-based EGFR inhibitors especially designed for this particular setting have shown robust clinical activity. However, similar to first- and second-generation inhibitors, the development of a diversified set of resistance mechanisms in response to these new compounds is an emerging issue. To date, clinical management of this growing number of patients has not been clearly established, even if anecdotal responses to subsequent molecularly guided therapies have been observed. By exhaustively reviewing and classifying all the preclinical and clinical data published on resistance to third-generation EGFR inhibitors in NSCLC, this work reveals the heterogeneity of the mechanisms that a tumour can develop to evade therapeutic pressure. Strategies currently being tested in clinical trials are discussed in light of these findings.

Osimertinib and Other Third generation EGFR TKI in EGFR mutant NSCLC Patients

Osimertinib and Other Third generation EGFR TKI in EGFR mutant NSCLC Patients Book
Author : Anonim
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Abstract Osimertinib was the first third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) to receive FDA and EMA approval for metastatic EGFR-mutant non-small-cell lung cancer (NSCLC) patients that have acquired the EGFR T790M resistance mutation. Clinical trials have demonstrated the efficacy of osimertinib in this patient population and clinical trials of other third-generation EGFR TKI are currently under way. Additional challenges in this patient population, such as the upfront efficacy of osimertinib, validation of T790M in liquid biopsies as a dynamic predictive marker of efficacy, along with combination with immune checkpoint inhibitors are being explored, representing an extraordinary time of development for EGFR-mutant NSCLC.

Frontiers in Anti Cancer Drug Discovery Volume 11

Frontiers in Anti Cancer Drug Discovery  Volume 11 Book
Author : Atta-ur-Rahman ,Muhammad Iqbal Choudhary
Publisher : Bentham Science Publishers
Release : 2020-09-01
ISBN : 9811422125
Language : En, Es, Fr & De

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Book Description :

Frontiers in Anti-Cancer Drug Discovery is a book series devoted to publishing the latest advances in anti-cancer drug design and discovery. In each volume, eminent scientists contribute reviews relevant to all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The book series should prove to be of interest to all pharmaceutical scientists involved in research in anti-cancer drug design and discovery. The book series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field. The eleventh volume of the series focuses on reviews on targeted therapies and drug delivery systems. This volume covers the following topics: - PI3K/Akt/mTOR Pathway in Acute Lymphoblastic Leukemia Targeted Therapies - Polymeric Nanomedicines in Treatment of Breast Cancer: Review of Contemporary Research - Treatment of Lung Cancer in the New Era - Oral Administration of Cancer Chemotherapeutics Exploiting Self-Nanoemulsifying Drug Delivery System: Recent Progress and Application - Targeting Approaches for the Diagnosis and Treatment of Cancer.

Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC

Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC Book
Author : Anthony Faber
Publisher : Academic Press
Release : 2021-03-15
ISBN : 9780128228333
Language : En, Es, Fr & De

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Book Description :

Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC, Volume 17 presents updated information on how EGFR mutant lung cancers evolve to evade EGFR inhibitors, clinical strategies that identify these mechanisms, and how to implement newer therapeutic strategies to combat resistance and improve patient survival. As resistance to EGFR inhibitors is often through re-activation of MEK/ERK and PI3K pathways, or through loss of cell death responses, there is much overlap with resistance to targeted therapies in other paradigms, such as BRAF inhibitors in BRAF mutant melanoma, and HER2 inhibitors in HER2 amplified breast cancer. This book is a valuable resource for cancer researchers, clinicians, graduate students and other members of the biomedical field who are interested in promising treatments for lung cancer. Presents historical context on how NSCLC and SCLC has been treated, with an emphasis on NSCLC and how the concept of EGFR inhibitors has been implemented Discusses critical resistant mechanisms seen in the clinic to 1st, 2nd and 3rd generation EGFR inhibitors Encompasses the current state of affairs in clinical trials to address resistance

Nature

Nature Book
Author : Sir Norman Lockyer
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Nature book written by Sir Norman Lockyer, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Lung Cancer Standards of Care

Lung Cancer  Standards of Care Book
Author : Goetz Kloecker,Mostafa Fraig,Susanne M. Arnold,Cesar A. Perez
Publisher : McGraw Hill Professional
Release : 2021-01-08
ISBN : 1260136213
Language : En, Es, Fr & De

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Book Description :

An essential guide to the treatment and management of lung cancer Lung cancer remains the leading cause of cancer deaths worldwide, attributed mostly to environmental and behavioral factors. However, a diagnosis of lung cancer no longer means inevitable death. The new standards of care and a greater understanding of the etiology and biology of the disease has led to breakthroughs in patient survival rates that were not seen in the past. Standards of Care: Lung Cancer provides a solid foundation in the new principles approaching this disease. Presented in an accessible, quick-to-digest format, and written by leading experts in a variety of medical fields, this authoritative guide covers all the new procedures and treatment options and the latest advances in diagnosis and treatment, including immunotherapy and oncogene inhibition, and more. This is an essential resource for both practitioners and students studying for the boards or certification. Features Covers the most current treatments Continuous online updates on guidelines, new therapies, and studies Includes checklists, case studies, learning objectives, and clinical pearls Bibliography with listings of studies and trials Serves as an ideal resource for practice and board review

Pharmacotherapy A Pathophysiologic Approach Eleventh Edition

Pharmacotherapy  A Pathophysiologic Approach  Eleventh Edition Book
Author : Joseph T. DiPiro,Gary C. Yee,L. Michael Posey
Publisher : McGraw Hill Professional
Release : 2020-07-03
ISBN : 1260116824
Language : En, Es, Fr & De

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Book Description :

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. 25+ additional chapters available online! The classic guide to driving optimal patient outcomes using evidence-based medication therapies—updated with the latest advances and guidelines Presented in full color, Pharmacotherapy: A Pathophysiologic Approach, 11th Edition helps you deliver the highest-quality patient care through evidence-based medication therapy derived from sound pharmacotherapeutic principles. It takes you beyond drug indications and dosages, showing how to properly select, administer, and monitor drugs—everything you need to provide safe, effective drug therapy across all therapeutic categories. With all-new monitoring tables and authoritative content from 300 expert contributors, this new edition has been fully updated to reflect the latest evidence-based information and recommendations. You’ll find Key Concepts at the beginning of each chapter, Clinical Presentation tables that summarize disease signs and symptoms, and Clinical Controversies boxes that examine the complicated issues faced by students and clinicians in providing drug therapy. Why Pharmacotherapy: A Pathophysiologic Approach is perfect for students, pharmacists, and other healthcare providers: • All chapters provide the most current, reliable, and relevant information available. • Key concepts kick off every chapter. • Clinical Presentation Tables summarize disease signs and symptoms. • The majority of sections include personalized pharmacotherapy content. • Clinical Controversies Boxes clarify the most complex drug therapy issues you’ll face. • Diagnostic flow diagrams, treatment algorithms, dosing recommendations, and monitoring approaches have been updated in full color to distinguish treatment pathways. • Most disease-oriented chapters are enhanced by updated evidence-based treatment guidelines, which often include ratings of the level of evidence to support key therapeutic approaches. • Instructors who adopt this text are eligible for a PowerPoint presentation of all images and answers to Self-Assessment Questions! The most trusted guide of its kind for decades, Pharmacotherapy: A Pathophysiologic Approach is the go-to text for students and practitioners seeking clear, objective coverage of core pathophysiologic and therapeutic elements.

The Basic Science of Oncology Sixth Edition

The Basic Science of Oncology  Sixth Edition Book
Author : Lea Harrington,Robert E. Bristow,Ian F. Tannock,Richard Hill
Publisher : McGraw Hill Professional
Release : 2021-01-08
ISBN : 1259862089
Language : En, Es, Fr & De

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Book Description :

Complete coverage of the basis of cancer and molecular biology – from globally recognized experts The Basic Science of Oncology is an accessible and thorough introduction to cancer causation, cancer biology, and the biology underlying cancer treatment. You’ll find everything you need to know about the latest critical thinking in oncology, as well ready to apply information about state-of-the-art science and therapeutic applications. Written by leading oncology researchers and clinicians, this is an essential resource for health professionals, students, advanced undergraduates and graduates in biological sciences, and clinicians needing an understanding of cancer cells. Presented in full-color, The Basic Science of Oncology reflects the latest research and developments in the field. Features NEW chapters: Epigenetics and Principles of Genome Regulation and Targeted Cancer Diagnosis and Treatment Thoroughly revised content, with expanded coverage of key topics such as immune system and immunotherapy, tumor growth and metabolism, vaccine development, methods of molecular analysis, tumor environment, and more The most current, evidence-based oncology primer—one that encapsulates the science of cancer causation, cancer biology, and cancer therapy Key insights into molecular and genetic aspects of cancer familiarize you with cancer biology as applied to prognosis and personalized cancer medicine In-depth focus on the discovery, evaluation, and biology of anti-cancer drugs, immunotherapy, and molecularly-targeted agents Up-to-date coverage of the basic science of radiation therapy

Anticancer Research

Anticancer Research Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Anticancer Research book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Comprehensive medicinal chemistry II

Comprehensive medicinal chemistry II Book
Author : John B. Taylor,D. J. Triggle
Publisher : Elsevier Science Ltd
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The first edition of Comprehensive Medicinal Chemistry was published in 1990 and very well received. Comprehensive Medicinal Chemistry II is much more than a simple updating of the contents of the first edition. Completely revised and expanded, this new edition has been refocused to reflect the significant developments and changes over the past decade in genomics, proteomics, bioinformatics, combinatorial chemistry, high-throughput screening and pharmacology, and more. The content comprises the most up-to-date, authoritative and comprehensive reference text on contemporary medicinal chemistry and drug research, covering major therapeutic classes and targets, research strategy and organisation, high-throughput technologies, computer-assisted design, ADME and selected case histories. It is this coverage of the strategy, technologies, principles and applications of medicinal chemistry in a single work that will make Comprehensive Medicinal Chemistry II a unique work of reference and a single point of entry to the literature for pharmaceutical and biotechnology scientists of all disciplines and for many industry executives as well.Comprehensive Medicinal Chemistry II will be available online in 2007 via the proven platform ScienceDirect providing the user with enhanced features such as cross-referencing and dynamic linking. * Comprehensively reviews - for the first time in one single work - the strategies, technologies, principles and applications of modern medicinal chemistry * Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets * Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs

Goodman and Gilman s The Pharmacological Basis of Therapeutics 13th Edition

Goodman and Gilman s The Pharmacological Basis of Therapeutics  13th Edition Book
Author : Laurence Brunton,Bjorn Knollman,Randa Hilal-Dandan
Publisher : McGraw Hill Professional
Release : 2017-10-26
ISBN : 1259584747
Language : En, Es, Fr & De

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Book Description :

The gold-standard of pharmacology texts – completely updated to reflect the latest research and developments A Doody’s Core Title for 2019! Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, Thirteenth Edition represents the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. Goodman & Gilman’s careful balance of basic science and clinical application has guided thousands of practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing, and treating disease. The Thirteenth Edition includes more than 500 color illustrations, with many new figures emphasizing mechanisms of drug action. More than 30 new contributors have added to this edition, while the focus on basic principles is undiminished. This edition is enhanced by timely new content: •NEW chapters including Treatment of Pulmonary Arterial Hypertension, Immunity and Inflammation, Immunoglobulins and Vaccines, and Treatment of Viral Hepatitis •Expanded coverage of cardiovascular disease, with separate chapters on myocardial ischemia, hypertension, and heart failure •Increased emphasis on cellular signaling pathways involved in drug action •Summary tables at the end of each chapter that organize drugs discussed in that chapter into relevant categories and detail therapeutic usage, clinical pharmacology, and tips •Chapter Content Outlines at the beginning of each chapter •Abbreviation boxes in every chapter to easily identify the abbreviations appearing in that chapter More than a textbook, Goodman & Gilman’s is a working template for the effective and rational prescribing of drugs in daily practice.

Cancer Prevention

Cancer Prevention Book
Author : Michael P. Osborne
Publisher : Unknown
Release : 2001
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This volume reviews advances in molecular biology and their applications to cancer prevention. The book presents papers important for both clinicians and researchers, written by experts in cancers of the colon, breast, skin, lung, bladder, and digestive tract.

Reviews on Endocrine related Cancer

Reviews on Endocrine related Cancer Book
Author : Anonim
Publisher : Unknown
Release : 1993
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Reviews on Endocrine related Cancer book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The CenterWatch Directory of Drugs in Clinical Trials

The CenterWatch Directory of Drugs in Clinical Trials Book
Author : Anonim
Publisher : Unknown
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The CenterWatch Directory of Drugs in Clinical Trials book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

CURRENT Medical Diagnosis and Treatment 2021

CURRENT Medical Diagnosis and Treatment 2021 Book
Author : Maxine A. Papadakis,Stephen J. McPhee,Michael W. Rabow
Publisher : McGraw Hill Professional
Release : 2020-09-09
ISBN : 1260469875
Language : En, Es, Fr & De

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Book Description :

The 60th anniversary edition of the most popular, relied-upon guide to internal medicine For 60 years, CURRENT Medical Diagnosis and Treatment—the flagship volume of the renowned Lange medical series—has been delivering the authoritative information students, residents, and clinicians need to build their medical knowledge, expertise, and confidence. Covering the latest clinical developments in all facets of medicine and fully focused on bedside clinical issues, this new edition provides completely the latest guidelines, reference, drug prices, approved drugs, and evidence-based coverage of more than 1,000 diseases and disorders—all formatted to enable you to find the answers you need quickly and effortlessly. This landmark guide covers inpatient and outpatient care, focusing on the diagnostic tools relevant to daily practice, and reviews all primary care topics, including gynecology/obstetrics, dermatology, ophthalmology, geriatrics, preventive medicine, psychiatry, and neurology. Now includes a “year in review” feature highlighting what’s new in CMDT! Includes essentials of diagnosis for most diseases/disorders Hundreds of quick-access drug treatment tables with indexed trade names Diagnostic and treatment algorithms present important information in an at-a-glance style Up-to-date references provide peer-reviewed, evidence-based information Seven bonus chapters available online to all book purchasers, featuring expanded content and annual review of advances in HIV treatment and critical information on emerging viral infections

Australian Recommendations for EGFR T790M Testing in Advanced Non small Cell Lung Cancer

Australian Recommendations for EGFR T790M Testing in Advanced Non   small Cell Lung Cancer Book
Author : Anonim
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Abstract: First‐generation epidermal growth factor receptor ( EGFR ) tyrosine kinase inhibitors (TKIs) are used as first‐line therapy in patients with non–small cell lung cancer (NSCLC) harboring a sensitizing mutation in the EGFR gene. Unfortunately, resistance to these therapies often occurs within 10 months of commencing treatment and is mostly commonly due to the development of the EGFR T790M mutation. Treatment with the third‐generation EGFR TKI, osimertinib can prolong progression free survival in patients with the T790M mutation, so it is important to determine the resistance mechanism in order to plan ongoing therapeutic strategies. Here we review the evidence and make recommendations for the timing of T790M mutation testing, the most appropriate specimens to test and the available testing methods in patients progressing during treatment with first line EGFR TKIs for NSCLC.

Oncology

Oncology Book
Author : Anonim
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Oncology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cancer Research

Cancer Research Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Cancer Research book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.