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Thermal Ablation Therapy

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Percutaneous Tumor Ablation in Medical Radiology

Percutaneous Tumor Ablation in Medical Radiology Book
Author : Thomas J. Vogl,Thomas Helmberger,Martin G. Mack,Maximilian F Reiser
Publisher : Springer Science & Business Media
Release : 2007-12-23
ISBN : 3540682503
Language : En, Es, Fr & De

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Book Description :

This book encompasses the different technologies employed in thermal ablation, its indications and the results achieved in various clinical conditions. It clearly explains the basics of thermal ablative techniques. In the main part of the book, techniques of guiding the applicators to the target structures by use of different imaging tools are discussed. The book, written by acknowledged experts, has a lucid structure and excellent images.

Elasticity Imaging for Monitoring Thermal Ablation Therapy in Liver

Elasticity Imaging for Monitoring Thermal Ablation Therapy in Liver Book
Author : Anonim
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Elasticity Imaging for Monitoring Thermal Ablation Therapy in Liver book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Thermal Ablation Therapy

Thermal Ablation Therapy Book
Author : Amira S. Ashour,Yanhui Guo,Waleed S. Mohamed
Publisher : Academic Press
Release : 2021-06-01
ISBN : 0128231564
Language : En, Es, Fr & De

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Book Description :

Thermal Ablation Therapy: Theory and Simulation includes detailed theoretical and technical concepts of thermal ablation therapy in different body organs. Concepts of ablation technology based on different thermal ablation methods are introduced, along with changes in the tissues’ mechanical properties due to thermal denaturation. The book emphasizes the mathematical and engineering concepts of RF and MW energy propagation through tissues and where high heating rates produced by MW systems can overcome the heat-sink effects from nearby vessels. The design and tuning of the MW antennas to deliver energy efficiently to specific organ systems such as the liver or lung is also covered. Other sections cover the computational modeling of radiofrequency ablation and microwave ablation procedures for developing and implementing new efficient ablation in clinical systems, numerical simulations for different scenarios of different organs with different size using RF and MW ablation systems with different antennas’/probes design and configurations, and numerical techniques for temperature profile in tissues. Presents the latest mathematical models of microwave and RF ablation theories Discusses the biological responses and engineering principles by which thermal ablation techniques can provide temperature-elevation within the organs of the human body, including action mechanisms, required equipment, needle characteristics and treatment techniques Highlights the different techniques of thermal ablation, including radiofrequency ablation, microwave ablation, laser ablation, and ultrasound ablation, nanotechnology, and the different metrics used to evaluate the performance of the used antenna within the ablation needle

Radiofrequency Ablation for Cancer

Radiofrequency Ablation for Cancer Book
Author : Lee M. Ellis,Steven A. Curley,Kenneth K. Tanabe
Publisher : Springer Science & Business Media
Release : 2006-06-03
ISBN : 0387215980
Language : En, Es, Fr & De

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Book Description :

Radiofrequency Ablation of Cancer: Current Indications, Techniques and Outcomes discusses the principles and techniques of safe usage of radiofrequency current for the treatment of malignancies. Throughout the text, indications and outcomes data are stressed. Edited and authored by pioneers in the field, the book features extensive discussion of RFA for hepatic tumors, including treatment of liver metastases from colorectal cancer, combined modality therapy for liver metastases, treatment of hepatocellular carcinoma with RFA, laparoscopic RFA, percutaneous RFA, and hepatic metastases from neuroendocrine tumors. In addition, chapters consider the emerging role of RFA in the management of primary breast cancer, primary bone tumors as well as metastatic bone tumors, renal tumors, and lung tumors. The principles and instrumentation as well as the imaging aspects of RFA are presented with comprehensive chapters on ultrasound, MRI, PET and CT by leaders in the field. Complemented by 90 illustrations, this text is the gold standard reference on the use of RFA in treating a wide variety of malignant processes. It will serve as a valuable reference for all physicians engaged in the care of cancer patients.

Tumor Ablation

Tumor Ablation Book
Author : Eric van Sonnenberg,William McMullen,Luigi Solbiati
Publisher : Springer Science & Business Media
Release : 2008-09-08
ISBN : 0387286748
Language : En, Es, Fr & De

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Book Description :

There is an enormous sense of excitement in the communities of cancer research and cancer care as we move into the middle third of the ?rst decade of the 21st century. For the ?rst time,there is a true sense of c- ?dence that the tools provided by the human genome project will enable cancer researchers to crack the code of genomic abnormalities that allow tumor cells to live within the body and provide highly speci?c, virtually non-toxic therapies for the eradication,or at least ?rm control of human cancers. There is also good reason to hope that these same lines of inquiry will yield better tests for screening, early detection, and prev- tion of progression beyond curability. While these developments provide a legitimate basis for much op- mism, many patients will continue to develop cancers and suffer from their debilitating effects, even as research moves ahead. For these in- viduals, it is imperative that the cancer ?eld make the best possible use of the tools available to provide present day cancer patients with the best chances for cure, effective palliation, or, at the very least, relief from symptoms caused by acute intercurrent complications of cancer. A modality that has emerged as a very useful approach to at least some of these goals is tumor ablation by the use of physical or physiochemical approaches.

Quantitative Ultrasound Imaging of Thermal Ablation Therapy in the Liver

Quantitative Ultrasound Imaging of Thermal Ablation Therapy in the Liver Book
Author : Anonim
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The purpose of this dissertation is to investigate methods for delineating the extent of the thermally coagulated region following thermal ablation therapy of malignant tumors in the liver. In this dissertation, we examine quasistatic elasticity imaging for delineating the extent of the treated region. Next, we characterize scattering in normal, untreated liver and thermally coagulated liver. Finally, we examine attenuation estimation with reference phantom methods in the liver. It has been well established that the Young's modulus of thermally coagulated tissue is much larger than in untreated liver tissue, making elastographic imaging an attractive candidate for delineating the extent of thermal coagulation. In quasistatic elastographic imaging of superficial organs such as the breast, external compression may be performed with a compressor plate or the transducer itself. However, in abdominal imaging, external compression is not effective. In response, our laboratory has developed electrode displacement for strain and modulus imaging. In electrode displacement strain imaging, deformation is applied by displacing the end of the RF electrode or microwave antenna by a small amount following treatment. We present electrode displacement strain images of thermally coagulated regions in in vivo porcine animal models during open surgery. We show that cross-sectional areas of treated regions delineated on electrode displacement strain images correlate well with coagulated areas determined on optical photographs of ablated regions of the excised livers. Additionally, we present electrode displacement strain images of VX2 tumors in rabbit animal models prior to and following thermal ablation. Next, we develop mean scatterer spacing (MSS) estimation in the liver. In the liver, it has been hypothesized that periodic scattering results from a unique arrangement of microvasculature. Indeed, the liver is a unique organ because of its dual vascular supply from the hepatic artery and portal vein. We first show that utilizing a multi-taper spectral calculation results in a lower mean square error in MSS estimates using simulations of periodic tissue. Next, we show that average spectral coherence decreases in thermally coagulated liver compared with untreated liver in a small number of ex vivo RF ablations. Finally, we demonstrate that thermally coagulated regions are best modeled by aperiodic collections of scatterers, while normal liver exhibits periodicity. In the final section of the dissertation we consider attenuation estimation. This is an attractive area of research because the attenuation coefficient is approximately doubles in the liver following thermal ablation. In past works, authors have developed attenuation algorithms with the assumption that the tissue being imaged may be modeled by a collection of a large number of randomly distributed scatterers. We show that in ex vivo bovine liver the scatterer number density is small. We demonstrate that the effect this has on attenuation estimation is to significantly increase the variance in attenuation estimation relative to tissue that may be modeled with a large scatterer number density. Using computer simulation and phantom experiments we show that when the scatterer number density is sufficiently large it is possible to achieve low variance, high resolution attenuation estimates. However, as the scatterer number density decreases either spatial resolution in the attenuation estimate must be sacrificed or attenuation estimate variance will increase. We find a linear attenuation coefficient in thermally coagulated liver that is approximately double the attenuation coefficient of normal, untreated liver. However, we also find a low scatterer number density in these tissues and a correspondingly high attenuation estimation variance.

Tissue Response to Interventional MRI guided Thermal Ablation Therapy

Tissue Response to Interventional MRI guided Thermal Ablation Therapy Book
Author : Michael Scott Breen
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Tissue Response to Interventional MRI guided Thermal Ablation Therapy book written by Michael Scott Breen, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Radiofrequency Thermal Ablation for Sleep related Disordered Breathing

Radiofrequency Thermal Ablation for Sleep related Disordered Breathing Book
Author : Jagdeep Virk,Bhik Kotecha
Publisher : LAP Lambert Academic Publishing
Release : 2015-10-08
ISBN : 9783659790539
Language : En, Es, Fr & De

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Book Description :

Sleep-disordered breathing is rising in prevalence and has a large associated health and socio-economic burden. There has been growing interest, but a poor understanding, regarding the role and mode of action of radiofrequency ablation therapy. This thesis describes the role of radiofrequency thermal ablation in sleep-related breathing disorders and provides current updates in its scientific, cellular basis along with surgical tips and pitfalls. Long term outcomes, management strategies and further avenues for research are considered.

Hyperthermia

Hyperthermia Book
Author : Nagraj Huilgol
Publisher : BoD – Books on Demand
Release : 2013-05-15
ISBN : 9535111299
Language : En, Es, Fr & De

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Book Description :

The book "Hyperthermia", published by InTech, and edited by Dr. Nagraj Huilgol, of the Department of Radiation Oncology, Dr. Balabhai Nanavati Hospital, India, is comprised of 8 Open Access chapters, covering a wide range of Hyperthermia-related scientific research.

A Novel Combination of Thermal Ablation and Heat Inducible Gene Therapy for Breast Cancer Treatment

A Novel Combination of Thermal Ablation and Heat Inducible Gene Therapy for Breast Cancer Treatment Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

High intensity focused ultrasound (HIFU) is a rapidly developing technique for cancer thermal ablation with secondary biological effects, such as heat shock response, that may be harnessed for adjunct therapies. To gain further insight into the potential for HIFU to be utilized in conjunction with gene therapy, a transparent cell-embedded tissue mimicking phantom was developed. Most physical parameters of the agrose-based hydrogel fell within the accepted range of values for soft tissues. Lesions produced under different combinations of HIFU intensity and exposure duration could be visualized inside the phantoms. GFP positive cells were primarily found within a circumferential region surrounding the primary site of lesion formation. The thermal necrosis boundary (EM43=240min) fell into this gene activation zone.

Microwave Ablation Treatment of Solid Tumors

Microwave Ablation Treatment of Solid Tumors Book
Author : Ping Liang,Xiao-ling Yu,Jie Yu
Publisher : Springer
Release : 2014-11-17
ISBN : 9401793158
Language : En, Es, Fr & De

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Book Description :

Microwave ablation is a simple, affordable, and highly precise technique. After its successful application in treating liver tumors, it is now widely used to combat renal tumors, adrenal tumors, thyroid nodes, uterine fibroids and other solid tumors. This book presents 40 successful cases of treating these diseases. A series of picture before treatment, after treatment and from different angles is provided for each kind of tumor treatment. In each chapter, step by step operative techniques and illustrations are included. This book also examines CT, NMR and ultrasonography to evaluate the effect of microwave ablation. Editor Ping Liang, is the Director and Professor at Dept. of Interventional Ultrasound, General Hospital of PLA, Beijing, China. Editor Xiaoling Yu is Professor and Chief physician, Editor Jie Yu is Associate Chief physician at the same department.

Radiofrequency Ablation for Small Hepatocellular Carcinoma

Radiofrequency Ablation for Small Hepatocellular Carcinoma Book
Author : Minshan Chen,Yaojun Zhang,W.Y. Lau
Publisher : Springer
Release : 2015-11-26
ISBN : 9401772584
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive guide to the treatment of small hepatocellular carcinoma (sHCC) using a minimally invasive technique: radiofrequency ablation (RFA). RFA has emerged as a new treatment modality and become the main modality of locoregional therapy. Extensive clinical research indicates that RFA is as effective as surgical resection for sHCC, and it has the advantage of being less invasive. However, the outcomes after RFA are largely dependent on the operators’ experience- known as the “learning curve”. This book presents the characteristics of sHCC and discusses why sHCC is the best candidate for RFA. Then it introduces all the commercially available RFA systems, and their working principles, advantages, disadvantages and so on. It goes on to demonstrate how to perform RFA under the guidance of ultrasound, CT, laparoscopy, or during open operation. Finally, it discusses the radiologic assessment and follow‐up after RFA, as well as adjuvant therapies and clinical trials on RFA. The authors are experts from the fields of pathology, radiology, surgery, and gastroenterology, as well as manufacturers. With this book, readers gain have a clear idea of when and how to do RFA. It aims to standardize and generalize the procedure of RFA, which will be very helpful in improving the outcome of RFA for sHCC.

Validation Platform for Ultrasound based Monitoring of Thermal Ablation

Validation Platform for Ultrasound based Monitoring of Thermal Ablation Book
Author : Hamed Peikari
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

PURPOSE: Thermal ablation therapy is an emerging local cancer treatment to destroy cancer tissue using heat. However variations in blood flow and energy absorption rates make it extremely challenging to monitor thermal changes. Insufficient ablation may lead to recurrence of the cancer while excessive ablation may damage adjacent healthy tissues. Ultrasound could be a convenient and inexpensive imaging modality for real-time monitoring of the ablation. For the development and optimization of these methods, it is essential to have ground truth data and a reliable and quantitative validation technique before beginning clinical trials on humans. In this dissertation, my primary focus was to solve the image-to-physical space registration problem using stereotactic fiducials that provide accurate correlation of ultrasound and pathology (ground truth) images. METHOD: A previously developed validation test-bed prototype was evaluated using phantom experiments to identify the shortcomings and limitations. In order to develop an improved validation platform, a simulator was implemented for evaluating registration methods as well as different line fiducial structures. New fiducial line structures were proposed, and new methods were implemented to overcome the limitations of the old system. The new methods were then tested using simulation results and phantom studies. Phantom experiments were conducted to improve the visibility of fiducials, as well as the quality of acquired ultrasound and pathology image datasets. RESULTS: The new system outperforms the previous one in terms of accuracy, robustness, and simplicity. The new registration method is robust to missing fiducials. I also achieved complete fiducial visibility in all images. Enhancing the tissue fixation medium improved the ultrasound data quality. The quality of pathology images were improved by a new imaging method. Simulation results show improvement in pose recovery accuracy using my proposed fiducial structure. This was validated by phantom studies reducing spatial misalignment between the US and pathology image sets. CONCLUSION: A new generation of test-bed was developed that provides a reliable and quantitative validation technique for evaluating and optimizing ablation monitoring methods.

Radiation Therapy for Liver Tumors

Radiation Therapy for Liver Tumors Book
Author : Jeffrey Meyer,Tracey Schefter
Publisher : Springer
Release : 2017-08-04
ISBN : 3319545310
Language : En, Es, Fr & De

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Book Description :

The management of liver tumors is a nexus of interactions among multiple medical specialties, including radiation oncology. A multitude of liver-directed therapies are available for patients, ranging from surgery and liver transplantation to intra-arterial therapies, thermal ablation procedures, systemic therapies, and radiation treatments. With the introduction of hypofractionated irradiation, particle therapy, and radioembolization, there is growing interest in the use of radiation as a treatment for liver malignancies. This book examines basic principles of the management of liver tumors. The evolving roles of x-ray and particle therapies as well as radioembolization in the treatment of liver tumors is the main focus. A theme of multidisciplinary management is also emphasized, as surgical, interventional and systemic therapies are reviewed. A unique resource that discusses the role of radiation treatment in the context of other liver-directed therapies, Radiation Therapy for Liver Tumors is of broad interest to radiation oncologists, surgeons, hepatologists, medical oncologists, and radiologists.

Physics of Thermal Therapy

Physics of Thermal Therapy Book
Author : Eduardo Moros
Publisher : Taylor & Francis
Release : 2016-04-19
ISBN : 1439848920
Language : En, Es, Fr & De

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Book Description :

The field of thermal therapy has been growing tenaciously in the last few decades. The application of heat to living tissues, from mild hyperthermia to high-temperature thermal ablation, has produced a host of well-documented genetic, cellular, and physiological responses that are being researched intensely for medical applications, particularly fo

Application of Magnetic Resonance guided Focused Ultrasound Thermal Ablation for Drug Delivery

Application of Magnetic Resonance guided Focused Ultrasound Thermal Ablation for Drug Delivery Book
Author : Andrew Wei Ping Wong
Publisher : Unknown
Release : 2015
ISBN : 9781339066820
Language : En, Es, Fr & De

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Book Description :

In Magnetic Resonance-guided Focused Ultrasound (MRgFUS), highly focused ultrasound noninvasively heats tissue under the guidance of magnetic resonance imaging and thermometry. To prevent recurrence, the treatment of cancer requires complete destruction, which is a challenge for noninvasive local therapy. We hypothesize that thermal ablation can enhance the accumulation of nanoparticle chemotherapeutics, and therefore combining chemotherapy and ultrasound is attractive. A combination of ultrasound and chemotherapeutic drugs may allow ultrasound thermal ablation to more effectively treat malignancy. MRgFUS can ablate tissue by raising temperatures to cytotoxic levels. Burn injuries release histamine, VEGF, and other factors which induce local edema and inflammation. Local inflammation prompts invasion by immune cells, while necrotic tumor cells release tumor specific antigen, events which may prompt the immune system to further respond to cancer. Histamine and VEGF also enhance the accumulation of nanoparticles, and preclinical trials using radiofrequency ablation have demonstrated greater accumulation of nanoparticle chemotherapy within tumors. Similar effects can be obtained with MRgFUS, with the added advantages of deeper penetration, a conformal region of interest and improved temperature control. Moreover, use of focused ultrasound provides the opportunity to explore ultrasonic mechanical effects. In this dissertation, we synthesize several types of labeled and chemotherapeutic liposomes, demonstrate the suitability of Positron Emission Tomography (PET) for the assessment of drug delivery, enhance delivery of liposomes with MRgFUS, examine the distribution of nanoparticles in a syngeneic murine model of mammary carcinoma, and examine the effect of this combination therapy on tumor growth and survival. As described in Chapter 3, an initial assessment of 64Cu-labeled long-circulating liposomes as PET contrast agents reveals excellent image contrast and quantitative mapping of tumor drug concentration. The tumor contrast ratio of 64Cu-labeled long-circulating liposomes was compared to 18F-FDG, the dominant clinical tracer. 18F-FDG demonstrated a contrast ratio of 0.88 ± 0.01 (mean ± standard error of the mean), while contrast ratio achieved with 64Cu-labeled long-circulating liposomes ranged from 0.78 ± 0.01 at 6 hours to 0.94 ± 0.01 at 48 hours, increasing over time as liposomes cleared from circulation. PET was then applied in Chapter 4 to evaluate the accumulation of nanoparticles within tumors following MRgFUS ablation. In mouse models, free doxorubicin has demonstrated tumor accumulation of 1-3 %ID/cc; nanoparticle formulations improve this by increasing circulation time and facilitating accumulation only in regions with leaky vasculature. Three strategies for MRgFUS application were compared: grid and circular protocols that mimic conformal ablation strategies and a single point ablation that enhances delivery but incompletely ablates the tumor. All strategies resulted in enhanced accumulation of 64Cu-LCL within tumors, with more than 80% of the accumulation occurring within 3 hours after ablation. At 20 hours after insonation, the spatial maximum accumulation was 33.8 ± 1.9, 39.7 ± 8.6, 27.4 ± 2.1, 8.6 ± 0.8 (%ID/cc, mean ± standard error of the mean), in grid protocol, circle protocol, single point, and untreated tumors, respectively. Autoradiography and fluorescence imaging confirmed the greatly enhanced accumulation in the remaining tumor. Locally-enhanced accumulation of LCL was preserved even after a multi-week protocol of doxorubicin-containing LCL (6 mg/kg) and MRgFUS. Following intraperitoneal injection, gadoteridol was also preferentially retained between 0 and 3 hours after ablation but was cleared after 3 hours and subsequent intravenous injections of contrast did not enhance imaging of the treated tumor. The combination of ultrasound and both long-circulating and thermally-sensitive copper-doxorubicin liposomes results in delayed tumor growth and enhanced survival, as described in Chapter 5. Four weeks of a single point ultrasound thermal ablation and biweekly copper-doxorubicin long-circulating liposomes (6 mg/kg) enhanced median survival from 43 ± 1 days (median ℗ł median absolute deviation) in untreated tumors to 114 ± 19 days. Substantial inhibition of tumor growth was also observed following four weeks of weekly copper-doxorubicin temperature sensitive liposomes (6 mg/kg) and weekly circle-patterned ultrasound. Taken as a whole, the work described here demonstrates the impact of combining chemotherapy with MRgFUS. This dissertation represents a small subset of potential ultrasound exposures, chemotherapeutic nanoparticles, and model systems. Future directions include modification of ultrasound frequency, intensity, and duty factor or inclusion of ultrasound contrast agents to induce mechanical disruption of tumor vasculature to further enhance local drug delivery.

Medical Image Guided Thermal Ablation

Medical Image Guided Thermal Ablation Book
Author : Michael Breen
Publisher : VDM Publishing
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This book is timely because of the increasing popularity of minimally invasive and cost effective methods to ablate solid tumors. Medical image guided ablation using thermal energy sources such as radio-frequency, microwave, laser, high-intensity focused ultrasound, and cyrogenics have received much recent attention as minimally invasive strategies for the ablation of tumors. This text describes novel and practical image registration methods and mathematical models to predict the cellular response from magnetic resonance (MR) images, which guide and monitor therapy. Many clinical and animal model studies seeking to characterize the biological response to thermal ablations, localized drug release, and other MRI-guided therapies would benefit from this book. This text should be especially useful for medical, engineering, applied mathematics, physics, and computer science students, researchers, and clinicians.

Interventional Radiology Techniques in Ablation

Interventional Radiology Techniques in Ablation Book
Author : Timothy Clark,Tarun Sabharwal
Publisher : Springer Science & Business Media
Release : 2012-10-11
ISBN : 0857290932
Language : En, Es, Fr & De

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Book Description :

The Techniques in Interventional Radiology series of handbooks describes in detail the various interventional radiology procedures and therapies that are in current practice. The series comprises a number of titles, which cover procedures in angioplasty and stenting, transcatheter embolization and therapy, biopsy and drainage, ablation, pediatric interventional radiology and neurointerventional radiology. Each book is laid out in bullet point format, so that the desired information can be located quickly and easily. Interventional radiologists at all stages, from trainees through to specialists, will find this book a valuable asset for their practice. Interventional Radiology Techniques in Ablation is a practical and concise guide to contemporary techniques in image-guided tumor ablation. This handbook is intended to serve as a quick reference for physicians in interventional radiology training as well as a resource for IR technologists, nurses, nurse practitioners and physician assistants.