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Therapeutic Strategies To Overcome Alk Resistance In Cancer

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Therapeutic Strategies to Overcome ALK Resistance in Cancer

Therapeutic Strategies to Overcome ALK Resistance in Cancer Book
Author : Luc Friboulet
Publisher : Academic Press
Release : 2021-01-29
ISBN : 9780128217740
Language : En, Es, Fr & De

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Book Description :

Therapeutic Strategies to Overcome ALK Resistance in Cancer, Volume 13, presents current strategies to improve and prolong clinical benefit in ALK driven cancers. Most patients with ALK-driven cancer are sensitive to tyrosine kinase inhibitor (TKI) therapy, but resistance invariably develops. This book discusses topics such as structure and function of ALK, ALK rearranged lung cancer, resistance mechanisms to ALK TKI tumors, and novel therapeutic strategies to enhance crizotinib anti-tumor efficacy in ALCL. Additionally, it encompasses information on drug combinations to enhance ALK TKI anti-tumor efficacy in neuroblastoma and future perspectives in the field. This book is a valuable resource for cancer researchers, clinicians and several members of biomedical field who need to understand more about how to fight ALK resistance in cancer treatment. Explains the biology of ALK RTK, focusing on its tissue expression, structure and functionality Presents an overview of current treatments and the benefits of ALK TKI in lung and other cancer types, such as ALCL, neuroblastoma and inflammatory myofibroblastic tumor Encompasses information on systemic treatments other than TKI, including chemotherapy, immunotherapy and antiangiogenic agents in ALK-driven NSCLC

Drug Resistance in Colorectal Cancer Molecular Mechanisms and Therapeutic Strategies

Drug Resistance in Colorectal Cancer  Molecular Mechanisms and Therapeutic Strategies Book
Author : Chi Hin Cho,Tao Hu
Publisher : Academic Press
Release : 2020-05-24
ISBN : 0128199385
Language : En, Es, Fr & De

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Book Description :

Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Volume Eight, summarizes the molecular mechanisms of drug resistance in colorectal cancer, along with the most up-to-date therapeutic strategies available. The book discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explains how drug resistance occurs during chemotherapy. In addition, users will find the current therapeutic strategies used by clinicians in their practice in treating colorectal cancer. The combination of conventional anticancer drugs with chemotherapy-sensitizing agents plays a pivotal role in improving the outcome of colorectal cancer patients, in particular those with drug-resistant cancer cells. From a clinical point-of-view, the content of this book provides clinicians with updated therapeutic strategies for a better choice of drugs for drug-resistant colorectal cancer patients. It will be a valuable source for cancer researchers, oncologists and several members of biomedical field who are dedicated to better treat patients with colorectal cancer. Presents a systemic summary of molecular mechanisms for a quick and in-depth understanding Updates current trends in the field with pioneering information on drug resistance Encompasses both basic and clinical approaches for a better understanding of unsolved problems from a holistic point-of-view

Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance

Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance Book
Author : Andrew Freywald,Franco Vizeacoumar
Publisher : Academic Press
Release : 2020-12-04
ISBN : 0128213116
Language : En, Es, Fr & De

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Book Description :

Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance, Volume 12, discusses new approaches that are being undertaken to counteract tumor plasticity, understand and tackle the interactions with the microenvironment, and disrupt the rewiring of malignant cells or bypass biological mechanism of resistance by using targeted radionuclide therapies. This book provides a unique opportunity to the reader to understand the fundamental causes of drug resistance and how different approaches are applied. It is a one-stop-shop to understand why it is so difficult to treat cancer, and why only a very few patients respond to therapy and a significant portion develop resistance. Despite a rapid development of more effective anti-cancer drugs and combination therapies, cancer remains the leading cause of lethality in the developed world. The main reason for this is the ability of heterogeneous subpopulations of tumor cells interacting with constantly evolving tumor microenvironment to resist elimination and eventually, trigger cancer relapse. In this book, experts review current concepts explaining molecular and biological mechanisms of cancer drug resistance and discussing advancing approaches for overcoming these therapeutic challenges. Provides the most updated knowledge on the mechanisms of cancer drug resistance and the emerging therapeutic approaches reviewed by experts in the field Brings detailed analyses of most important recently reported developments related to drug resistance and their relevance to overcoming it in cancer patients Discusses in-depth molecular mechanisms and novel concepts of cancer resistance to conventional and advanced therapies

Overcoming Ovarian Cancer Chemoresistance

Overcoming Ovarian Cancer Chemoresistance Book
Author : Goli Samimi,Christina Annunziata
Publisher : Academic Press
Release : 2020-11-19
ISBN : 0128198419
Language : En, Es, Fr & De

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Book Description :

Overcoming Ovarian Cancer Chemoresistance presents non-overlapping review chapters that discuss the state of the field in overcoming chemoresistance of ovarian cancer and treatment options before and following recurrence, considering the genetic makeup of the ovarian cancer patient and her tumor. With the uptake of both germline and somatic gene testing, clinicians can obtain a more comprehensive understanding of ovarian tumors and this book provides information to link the genetic makeup of a tumor (or patient) with the best available treatment. The book discusses topics such as strategies to fight chemo-resistance in ovarian cancer, circulating DNA as a monitor of response, BRCA mutations, ovarian cancer stem cells, immunotherapy and vaccines. Additionally, it brings a list of promising agents at clinical and pre-clinical stage that will impact the treatment in the near future. This book is a valuable source for cancer researchers, oncologists and several members of biomedical field who need to understand how to battle chemoresistance in ovarian cancer. Provides a comprehensive view of both biological and genetic determinants of resistance, as well as technical approaches to monitor response Discusses genetic reversions as a unique alteration and a new field of study Includes a chapter on upcoming and promising agents that are in the pre-clinical and early clinical space, to set the stage for future directions in the field

Drug Efflux Pumps in Cancer Resistance Pathways From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy

Drug Efflux Pumps in Cancer Resistance Pathways  From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy Book
Author : N.A
Publisher : Academic Press
Release : 2019-11-07
ISBN : 0128141417
Language : En, Es, Fr & De

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Book Description :

Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy, Volume Seven, describes the fundamental aspects of efflux pumps of the ATP-binding cassette superfamily in cancer resistance pathways, along with strategies to target and improve chemotherapy efficacy. Pumps of the ATP-binding cassette superfamily (ABCs) regulate the access of drugs to the intracellular space. In this context, the overexpression of ABCs is a well-known mechanism of multidrug resistance in cancer and is associated with therapeutic failure. Cancer types discussed include breast, endocrine, hematologic, gastrointestinal, musculoskeletal, lung, skin and central nervous system cancers. The book is a valuable source for researchers and advanced students in cancer, biology, pharmacology, pharmaceutical sciences, biomaterials and medical/clinical sciences that are interested in accessing a comprehensive compendium on efflux pumps in mechanisms of cancer resistance. Offers comprehensive and detailed descriptions of the basic aspects of efflux pumps in a very schematic and didactic manner Describes the involvement of efflux pumps in cancer resistance in different cancer types Encompasses an updated overview on state-of-the-art approaches that capitalize on their inhibition to improve chemotherapy and overcome resistance

pH Interfering Agents as Chemosensitizers in Cancer Therapy

pH Interfering Agents as Chemosensitizers in Cancer Therapy Book
Author : Claudiu Supuran,Simone Carradori
Publisher : Academic Press
Release : 2020-09-15
ISBN : 0128209283
Language : En, Es, Fr & De

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Book Description :

pH Interfering Agents as Chemosensitizers In Cancer Therapy, Volume Thirteen, provides a detailed overview of the chemosensitizers for the treatment of cancer spanning from biochemical and structural features to pharmacology and drug-design, including technological applications. The book is structured with innovative outlines and a distinction between experimental and clinical results. The continuous discovery and assessment of the role played by old/new synthetic drugs, natural compounds and technological applications has led to the urgent need of classification in terms of biological activity, mechanism of action, clinical outcomes, cancer cell lines sensible to the treatment, and potentialities to better orient research in this field. Moreover, all the aspects relevant for medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, and molecular modeling studies) are strictly considered. Presents a broad view of the topic according to a medicinal chemistry-based approach beyond syntheses and biological assays, focusing on SAR studies, chemoinformatic, drug targeting and molecular modeling Explains the mechanism of action of the chemosensitizers by means of schemes and figures to facilitate comprehension Discusses novel targets to explore new possibilities that enhance research in the field

Lung Cancer

Lung Cancer Book
Author : N.A
Publisher : Demos Medical Publishing
Release : 2012-05-18
ISBN : 1617050970
Language : En, Es, Fr & De

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Book Description :

With contributions from internationally recognized experts, Lung Cancer details the current management of lung cancer and reviews new therapies in development for lung cancer, with an emphasis on therapeutic exploitation of the heterogeneous nature of lung tumors at the molecular level. Coverage includes discussion of multiple new agents that have been shown to impact overall survival as well as articles covering molecular biology of lung cancer, chemotherapy regimens for lung cancer, the emergence of maintenance therapy, the complexity of radiotherapy in the chest, the impact of adjuvant chemotherapy for resected non-small cell lung cancer, surgical considerations for early-stage lung cancer, and more. This book is a valuable tool for clinicians, nurses, researchers, medical students, residents, and fellows. Emerging Cancer Therapeutics features: Editorial board of nationally recognized experts across the spectrum of Cancer Therapeutics In-depth, up-to-date expert reviews and analysis of major new developments in all areas of Cancer Therapeutics Issues edited by an authority in specific subject area Focuses on major topics in Cancer Therapeutics with in-depth articles covering advances in clinical and translational research developments, as well as clinical applications and experience Emphasizes multidisciplinary approaches to research and practice

Successes and Limitations of Targeted Cancer Therapy

Successes and Limitations of Targeted Cancer Therapy Book
Author : S. Peters,R.A. Stahel
Publisher : Karger Medical and Scientific Publishers
Release : 2014-02-19
ISBN : 3318025429
Language : En, Es, Fr & De

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Book Description :

The treatment of patients with advanced malignancies has undergone remarkable change in the last few years. While in the past decisions about systemic therapy were largely based on the performance status of a patient, oncologists today also take into account the pathological and molecular characteristics of the patient’s tumor. Targeting specific molecular pathways important for tumorigenesis has become the preferred way of treatment for many types of malignancies. With these advances come new challenges including the optimization of therapy, recognizing and dealing with side effects and, importantly, the development of resistance. This book provides an up-to-date overview of the advances and limitations of targeted therapy for several tumor entities including breast cancer, colon cancer, gastrointestinal stromal tumors, lung cancer, melanoma, ovarian cancer and renal cell carcinoma. Written by over a dozen internationally renowned scientists, the book is suitable for advanced students, postdoctoral researchers, scientists and clinicians who wish to update their knowledge of the latest approaches to targeted cancer therapies.

Targeted Therapies in Lung Cancer Management Strategies for Nurses and Practitioners

Targeted Therapies in Lung Cancer  Management Strategies for Nurses and Practitioners Book
Author : Marianne Davies,Beth Eaby-Sandy
Publisher : Springer
Release : 2019-07-16
ISBN : 3030165507
Language : En, Es, Fr & De

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Book Description :

This book aims to educate nurses and advanced practice providers (APP’s) about known mutations, availability of targeted therapy and the management of patients with non-small cell lung cancer (NSCLC). It will educate nurses and practitioners about the scope of therapy to assure safe and effective lung cancer treatment. In this era of personalized medicine, nurses and APP’s are responsible for guiding patients from diagnosis through treatment. This starts with the identification of patients that can benefit from these therapies, the key role of biopsy acquisition (ie. what to test, when and how often) and treatment selection based on the mutation identified. Readers will learn about the mechanisms of action, administration, potential adverse side effects and unique management strategies for these targeted agents. Lung cancer continues to be the leading cause of cancer death in the United States and worldwide. Recent advances in the identification of specific oncogenic mutations that drive cancer development, growth and metastasis have led to major paradigm shifts in lung cancer treatment. Sophisticated methods are required to identify specific mutations at the time of diagnosis. This book explains how molecularly targeted therapies have been developed that target these drivers. To date, several tyrosine kinase inhibitors have been approved to target the epidermal growth factor receptor (EGFR), EML4-ALK ,ROS1 and BRAF. Most recently, immune checkpoint inhibitors have been approved with some indication that efficacy may be enhanced for patients who overexpress PD-L1. While some driver mutations have been identified, there is ongoing investigation into additional mutations. In the case of driver mutations, lung cancers will develop resistance to therapy. This book provides nurses and APP’s with the mechanisms of resistance that have been identified such as T790 mutation and many others in the EGFR mutation, and shows how the next level of drug development is focused on identifying mechanisms of resistance and development of new agents that overcome these mutations. With this book in hand, nurses and practitioners will be able to navigate patients through this ever expanding field of lung cancer treatment.

Ashcraft s Pediatric Surgery E Book

Ashcraft s Pediatric Surgery E Book Book
Author : George W. Holcomb,J. Patrick Murphy,Daniel J Ostlie
Publisher : Elsevier Health Sciences
Release : 2014-01-31
ISBN : 0323187366
Language : En, Es, Fr & De

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Book Description :

Acclaimed for its unsurpassed readability and manageable scope, Ashcraft’s Pediatric Surgery presents authoritative, practical guidance on treating the entire range of general surgical and urological problems in infants, children, and adolescents. State-of-the-art, expert coverage equips you to implement all the latest approaches and achieve optimal outcomes for all of your patients. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Make the most effective use of today’s best open and minimally invasive techniques, including single-site umbilical laparoscopic surgery, with guidance from internationally recognized experts in the field. Focus on evidence-based treatments and outcomes to apply today’s best practices. Stay current with timely topics thanks to brand-new chapters on Choledochal Cyst and Gallbladder Disease, Tissue Engineering, and Ethics in Pediatric Surgery, plus comprehensive updates throughout. Hone and expand your surgical skills by watching videos of minimally invasive procedures for recto urethral fistula, biliary atresia, laparoscopic splenectomy, uterine horn, and more. Grasp the visual nuances of surgery from over 1,000 images depicting today’s best surgical practices.

The MD Anderson Manual of Medical Oncology Second Edition

The MD Anderson Manual of Medical Oncology  Second Edition Book
Author : Hagop M. Kantarjian,Robert A. Wolff
Publisher : McGraw Hill Professional
Release : 2011-04-22
ISBN : 0071701052
Language : En, Es, Fr & De

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Book Description :

State-of-the-art approaches to cancer management from the world's #1 oncology center The perfect clinical desk manual from the experts at MD Anderson Cancer Center Read the outstanding reviews of the previous edition: "As a detailed guide, [the book] offers practitioners a clear, user-friendly approach to the care of patients with cancer." -- New England Journal of Medicine "The portions of the text that summarize the chemotherapeutic literature are helpful and potentially useful to a busy medical oncologist. The graphic representations and flow charts are of high quality, are well designed and easy to follow, and are clinically useful. A number of good photographs have been provided that illustrate pathologic conditions....the Manual is well written, has extremely useful graphics, and represents a useful entry point for those interested in the management of malignant diseases." -- International Journal of Radiation Oncology, Biology, Physics "...[MD Anderson Manual of Medical Oncology] fulfills its goals of helping clinicians quickly evaluate therapeutic regimens and possibilities. Surgeons and radiation oncologists will find the text useful as a reference guide to what the medical oncologist can do and how the medical oncologist views their disciplines. The text is also of considerable help for physicians studying for board certification or recertification in medical oncology. Practicing medical oncologists would do well to have it in their personal libraries." -- Journal of the American Medical Association MD Anderson Manual of Medical Oncology offers clinicians an authoritative, easy-to-follow guide to the medical management of patients with cancer and its complications. Featuring concise but practical text and a large number of decision-making algorithms, the book gives physicians a current, templated approach to each disease and situation -- backed by the clincal expertise and authority of world recognized oncology researchers/practitioners. Key Features REVISED: competely updated coverage of the quickly evolving world of cancer therapeutics NEW: chapters include "Expert Commentary Sidebars" that provide clinical insights from leading subspecialists in radiation therapy, surgical oncology, pathology, and laboratory medicine NEW: brand new chapters on myelodysplasia, myeloproliferative diseases, and appendiceal cancer NEW: a brand new chapter on the important and underpublished topic of psycho-social issues in oncology Consistently formatted for a unified patient management strategy Packed with time-saving features, including The MD Anderson Work-Up Box and The MD Anderson Preferred Treatment Box

Harrison s Hematology and Oncology 3E

Harrison s Hematology and Oncology  3E Book
Author : Dan L. Longo
Publisher : McGraw Hill Professional
Release : 2016-09-22
ISBN : 1259835820
Language : En, Es, Fr & De

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Book Description :

Hematology and Oncology – backed by the unmatched authority of Harrison’s A Doody's Core Title for 2019! Featuring a superb compilation of chapters related to hematology and oncology derived from Harrison’s Principles of Internal Medicine, Nineteenth Edition (including content from the acclaimed Harrison’s DVD, now available here in print), this concise, full-color clinical companion delivers the latest knowledge in the field backed by the scientific rigor and authority that have defined Harrison’s. You will find 57 chapters from more than 75 renowned editors and contributors in a carry-anywhere presentation that is ideal for the classroom, clinic, ward, or exam/certification preparation. Features: • Each chapter contains relevant information on the genetics, cell biology, pathophysiology, and treatment of specific disease entities • Chapters on hematopoiesis, cancer cell biology, and cancer prevention reflect the rapidly growing knowledge in these areas • Integration of pathophysiology with clinical management • High-yield board review questions make this text ideal for keeping current or preparing for the boards • Valuable appendix of laboratory values of clinical importance

Harrison s Principles of Internal Medicine 18th Edition

Harrison s Principles of Internal Medicine  18th Edition Book
Author : Dan Longo,Anthony Fauci,Dennis Kasper,Stephen Hauser,J. Jameson,Joseph Loscalzo
Publisher : McGraw Hill Professional
Release : 2011-07-22
ISBN : 0071748903
Language : En, Es, Fr & De

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Book Description :

The most widely read textbook in the history of medicine – made more essential to practice and education by an unmatched array of multi-media content Through six decades, no resource has matched the encyclopedic scope, esteemed scholarship, and scientific rigor of Harrison’s Principles of Internal Medicine, both as a textbook and as a clinical reference. It remains the most universally respected textbook in all of medical publishing and the pinnacle of current medical knowledge. The eighteenth edition of Harrison’s features expanded and more in-depth coverage of key issues in clinical medicine, pathophysiology, and medical education. The acclaimed Harrison’s DVD has been updated to include 53 chapters not found in the text; 14 all-new how-to videos commissioned specifically for Harrison’s; PowerPoint presentations on essential topics in medical education; and hundreds of bonus illustrations. Presented in two volumes NEW text design greatly enhances readability NEW chapters on cutting-edge topics in clinical medicine Expanded focus on global considerations of health and disease Editor-in-Chief: Dan Longo, MD (Boston, MA) is Professor of Medicine, Brigham and Women’s Hospital/Harvard Medical School.

Overcoming Resistance to Targeted Therapies in NSCLC Current Approaches and Clinical Application

Overcoming Resistance to Targeted Therapies in NSCLC  Current Approaches and Clinical Application Book
Author : N.A
Publisher :
Release : 2015
ISBN :
Language : En, Es, Fr & De

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Book Description :

The discovery that a number of aberrant tumorigenic processes and signal transduction pathways are mediated by druggable protein kinases has led to a revolutionary change in nonsmall cell lung cancer (NSCLC) treatment. Epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) are the targets of several tyrosine kinase inhibitors (TKIs), some of them approved for treatment and others currently in clinical development. First-generation agents offer, in target populations, a substantial improvement of outcomes compared with standard chemotherapy in the treatment of advanced NSCLC. Unfortunately, drug resistance develops after initial benefit through a variety of mechanisms. Novel generation EGFR and ALK inhibitors are currently in advanced clinical development and are producing encouraging results in patients with acquired resistance to previous generation agents. The search for new drugs or strategies to overcome the TKI resistance in patients with EGFR mutations or ALK rearrangements is to be considered a priority for the improvement of outcomes in the treatment of advanced NSCLC.

Harrisons Manual of Oncology 2 E

Harrisons Manual of Oncology 2 E Book
Author : Bruce A. Chabner,Thomas J. Lynch,Dan L. Longo
Publisher : McGraw Hill Professional
Release : 2014-03-22
ISBN : 0071793267
Language : En, Es, Fr & De

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Book Description :

A CONCISE YET THOROUGH OVERVIEW OF THE MEDICATIONS AND APPROACHES USED IN CANCER CARE--BACKED BY THE AUTHORITY OF HARRISON'S Harrison's Manual of Oncology is a carry-anywhere guide to the care of patients with cancer. Enhanced by the latest published results, this valuable clinical companion features numerous tables and succinct, outline-style text that puts important information at your fingertips. You will find content that goes beyond the treatment of primary or metastatic disease to encompass the treatment of all therapeutic complications. The opening sections of Harrison's Manual of Oncology are devoted to the classes of agents used to treat cancer and reviews their pharmacology and mechanisms of action. This section is followed by a detailed discussion of the diagnosis, staging, and treatment of all major types of cancer. There is a strong focus on symptom management and complications of treatment, including pain, nausea and vomiting, anemia, febrile neutropenia, metabolic emergencies, thrombosis, psychological issues, and end-of-life care.