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Therapeutic Strategies In Cancer Biology And Pathology

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Therapeutic Strategies in Cancer Biology and Pathology

Therapeutic Strategies in Cancer Biology and Pathology Book
Author : Gajanan V. Sherbet
Publisher : Elsevier
Release : 2013-07-26
ISBN : 0124165907
Language : En, Es, Fr & De

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Book Description :

Currently, intensive effort is being directed toward the identification of molecular targets that can provide approaches to the development of novel therapeutic strategies in cancer management. This book focuses on metastasis-associated genes, metastasis promoter and suppressor genes, which relate specifically to behavioral alterations of cancer cells in epithelial mesenchymal transition, cancer stem cell maintenance and propagation, and to the acquisition of invasive and metastasis faculty. The function of these genes has implications for cell cycle regulation and cell proliferation and so constitute an essential element in cancer growth and dissemination. The emphasis in this book is on how appropriate these genes are as molecular targets and how practicable are the constituents of their signal transduction systems as potential candidates and how accessible they are to targeted therapy. Written in a straightforward and clear style with background information supporting the new research, this book will be useful for students and researchers in cancer therapies. Identifies molecular targets and their accessibility for therapeutic intervention Provides information on biological features of tumor development and dissemination Background information provided for each topic

Molecular Approach to Cancer Management

Molecular Approach to Cancer Management Book
Author : Gajanan V. Sherbet
Publisher : Academic Press
Release : 2017-06-15
ISBN : 0128128976
Language : En, Es, Fr & De

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Book Description :

Molecular Approach to Cancer Management discusses molecular mechanisms of cancer initiation, growth and secondary spread, emphasizing how this information can be used to devise new modes of treatment of cancer, especially in combatting secondary spread. The book addresses the basic concepts relating to cancer biology, the genetic determinants, and the signal transduction cascades associated with tumor growth, EMT, stem cell maintenance and propagation, and invasion and metastasis. The salient features of the signaling systems that are amenable to targeted manipulation are emphasized to facilitate research and development in the design of novel therapies and for the planning of new trials. This book is the only unique volume with coverage of topics that target therapy. As such, it is a valuable source for cancer researchers, molecular oncologists and members of the biomedical field who are interested in knowing more about molecular approaches to cancer therapy. Covers all relevant topics with a defined aim of targeted therapy Encompasses the basic aspects of cancer invasion and metastasis Discusses signaling systems operating in normal cells and their deregulation in cancer cells Directs attention to the foci in signaling systems that can be targeted with a new and conventional drug-based approach

The Genetics of Cancer

The Genetics of Cancer Book
Author : Gajanan V. Sherbet,M. S. Lakshmi
Publisher : Academic Press
Release : 1997-06-22
ISBN : 9780080542485
Language : En, Es, Fr & De

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Book Description :

Written by internationally recognized experts, The Genetics of Cancer provides up-to-date information and insight into the genetic basis of cancer and the mechanisms involved in cancer invasion and its secondary spread. This volume presents the deregulation of the cell cycle in tumor development and integrates the function of tumor suppressor genes, oncogenes, and metastasis-associated genes in the pathogenesis and progression of cancer. The Genetics of Cancer will be useful to all graduate students, clinicians, and researchers working in the fields of cancer biology, genetics, and molecular biology. Clonal evolution of the metastasis phenotype Cell Cycle regulation Apoptosis in tumour growth and metastasis Angiogenesis in cancer Cell surface glycoproteins and their receptors Proteinases and their inhibitors in cancer invasion Oncogenes and cancer metastasis Developmental genes Tumour suppressor genes Metastasis suppressor genes Dominant metastasis-associated genes

Genetic Recombination in Cancer

Genetic Recombination in Cancer Book
Author : Gajanan V. Sherbet
Publisher : Elsevier
Release : 2003-07-24
ISBN : 9780080521909
Language : En, Es, Fr & De

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Book Description :

Genetic recombination is a process of combining genes that leads to the generation of cell variants that possess different characteristics. This process is important to the evolution of a species and to embryonic growth and differentiation. However, this process can also lead to the development of abnormal, cancerous cells. This book reviews the role of genetic recombination in the generation of various cancers and how genetic alterations have been or could be employed to elicit clinically useful information. * Provides detailed discussion of the genetic mechanisms that result in the generation of normal and abnormal cells * Examines the role of genetic recombination in cancer including cancer invasion and metastasis * Information is presented in a manner that is useful and accessible to everyone from graduate students to established cancer researchers

Cancer

Cancer Book
Author : Gary S. Stein,Kimberly P. Luebbers
Publisher : John Wiley & Sons
Release : 2019-10-01
ISBN : 1118962885
Language : En, Es, Fr & De

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Book Description :

A guide to recent insights into the genetic and epigenetic parameters of cancer biology and pathology and emerging clinical applications The thoroughly updated second edition of The Biology and Treatment of Cancer, now titled Cancer: Prevention, Early Detection, Treatment and Recovery, goes beyond reviewing the fundamental properties of cancer biology and the relevant issues associated with treatment of the disease. The new edition contains coverage of additional "patient centric" topics and presents cancer biology with selection of topics, facts, and perspectives written in easy-to-understand terms. With contributions from noted experts, the book explores recent advances in the understanding of cancer including breakthroughs in the molecular and cellular basis of cancer and provides strategies for approaching cancer prevention, early detection, and treatment. The authors incorporate recent information on the genetic and epigenetic parameters of cancer biology and pathology with indications of emerging clinical applications. The text offers a unique guide to cancer prevention, early detection, treatment, and recovery for students, caregivers, and most importantly cancer patients. This significant book: Incorporates current insight into the genetic and epigenetic parameters of cancer biology and pathology and information on emerging clinical applications Contains contributions from leaders in cancer research, care, and clinical trials Offers an accessible guide to an accurate and balanced understanding of cancer and the cancer patient Focuses on the importance of cancer prevention, early detection, treatment, and survivorship Written for medical students, students of cancer biology, and caregivers and cancer patients, Cancer: Prevention, Early Detection, Treatment and Recovery offers an authoritative overview of the challenges and opportunities associated with cancer biology, cancer research, and the spectrum of clinical considerations.

Precision Molecular Pathology of Uterine Cancer

Precision Molecular Pathology of Uterine Cancer Book
Author : Michael T. Deavers,Donna M. Coffey
Publisher : Springer
Release : 2017-10-28
ISBN : 3319579851
Language : En, Es, Fr & De

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Book Description :

This text provides a comprehensive review for practicing pathologists to understand the molecular biology, diagnostics, and predictive markers and implications for therapy of uterine cancer. While molecular based therapeutic strategies for uterine cancer are not as well developed as for some other organ sites, these are the most common gynecologic malignancies and there have been many important recent developments that are discussed in this volume. Comprehensive chapters address essential information about endometrial carcinoma, uterine mesenchymal tumors, and cervical carcinoma and include the pathogenesis of carcinoma and discuss molecular based classification, biomarkers, therapy, prevention, and hereditary cancers of the uterus. Precision Molecular Pathology of Uterine Cancer is a unique and one of a kind resource for practicing pathologists, pathologists in training and gynecologists.

Personalized Cancer Chemotherapy

Personalized Cancer Chemotherapy Book
Author : Da Yong Lu
Publisher : Woodhead Publishing
Release : 2014-12-05
ISBN : 0081003471
Language : En, Es, Fr & De

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Book Description :

Personalized Cancer Chemotherapy separately describes and addresses "individualized cancer chemotherapy" (ICC) strategies new and old, to provide readers with new insights into their characteristics and techniques, as well as key debates and future trends in this area. The book devotes chapters to drug sensitivity testing, cancer biomarkers and bioinformatics detection, pharmacogenetics, individualized antimetastatic therapy, drug combinations, assistant chemotherapy, and cost-effectiveness considerations. A major obstacle to controlling cancer growth and metastases in patients is the inappropriate use of anticancer and antimetastatic drugs. Researchers and clinicians are now beginning to focus on ICC also called "personalized cancer chemotherapy" (PCC), to improve therapeutic quality and outcomes by selecting and prescribing the most appropriate and effective drugs. Using genetic, molecular, and bioinformatics data and modern experimental techniques, known tumor genes can be detected more easily than ever before; the average speed of genetic sequencing has increased 15,000 to 50,000 times since the Human Geonme Project was completed. This book will help readers understand the pros and cons of each individualized cancer chemotherapy strategy from different angles so as to make good judgments and predictions of drug responses and clinical outcomes. Explores the central components of cancer treatment Investigates new developments in cancer treatment Discusses the many strategies of individualized cancer chemotherapy

Molecular Pathology

Molecular Pathology Book
Author : William B. Coleman,Gregory J. Tsongalis
Publisher : Academic Press
Release : 2009-02-10
ISBN : 0080922198
Language : En, Es, Fr & De

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Book Description :

Molecular Pathology: The Molecular Basis of Human Disease provides a current and comprehensive view of the molecular basis and mechanisms of human disease. Combining accepted principles with broader theoretical concepts and with contributions from a group of experts, the book looks into disease processes in the context of traditional pathology and their implications for translational molecular medicine. It also discusses concepts in molecular biology and genetics, recent scientific and technological advances in modern pathology, the concept of ""molecular pathogenesis"" of disease, and how disease evolves from normal cells and tissues due to perturbations in molecular pathways. The book describes the integration of molecular and cellular pathogenesis using a bioinformatics approach and a systems biology approach to disease pathogenesis. It also discusses current and future strategies in molecular diagnosis of human disease, and the impact of molecular diagnosis on treatment decisions and the practice of personalized medicine. This book is a valuable resource for students, biomedical researchers, practicing physician-scientists who undertake disease-related basic science and translational research, and pathology residents and other postdoctoral fellows. Exam Master® web site will host "Self-assessment" questions that students can use to study for the molecular section of the board exam Teaches from the perspective of “integrative systems biology, which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease Outlines the principles and practice of molecular pathology Explains the practice of “molecular medicine and the translational aspects of molecular pathology

Hematologic Cancers From Molecular Pathobiology to Targeted Therapeutics

Hematologic Cancers  From Molecular Pathobiology to Targeted Therapeutics Book
Author : Jianguo Tao,Eduardo Sotomayor
Publisher : Springer Science & Business Media
Release : 2012-11-13
ISBN : 9400750285
Language : En, Es, Fr & De

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Book Description :

In the last decade, there has been a remarkable explosion of knowledge in hematologic cancer from basic molecular biology and pathology to clinical therapy. This has led to many new advance and insights in the understanding of pathobiology of malignant hematology. New knowledge of disease molecular pathology, cytogenetic, epigenetic and genomic alterations have provided new strategies to attack and eradicate tumor cells at molecular level and significantly impacted our current therapeutics for hematological malignancies. The recent and ongoing rapid expansion of knowledge in this area has become extensive, dynamic and diffuse over the literature and research publications. This has led to the need to capture and compile the new and current information about hematologic cancer with special emphasis on translation from molecular pathobiology to targeted therapeutics. In this book experts from around the world share their thoughts and knowledge about the pathobiology of hematologic cancer, as well as their view on current treatment approaches and future development in these malignant hematologic diseases. This book is well suited for hematology residents, fellows and hematology-oncology physicians, hematopathologist as well as basic research scientist in the area of hematologic malignancies.

The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies

The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies Book
Author : Michael Molls,Peter Vaupel,Carsten Nieder,Mitchell Steven Anscher
Publisher : Springer
Release : 2010-11-16
ISBN : 9783540868491
Language : En, Es, Fr & De

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Book Description :

Te rapidly changing concepts in radiation oncology with the development of more precise - strumentation for delivery of radiation therapy and a greater emphasis on hypofractionation technologies require a very intimate knowledge of tumor biology and the infuence of various biologic factors on dose distribution within the tumor in terms of homogeneity as well as prev- tion of any late efects on normal tissue surrounding the tumor itself. Not only are these major factors in clinical practice but also the known factors of inhomogeneity of cancer cells, the impact of microenvironment in terms of radiation efect, and host factors make it mandatory to design therapeutic strategies to improve the outcome and to diminish any potential short-term or lo- term risks from the radiation therapy. Te authors have developed an outstanding text that deals with these strategies and how they would impact on established and emerging new technologies and treatment. Te context of the presentations within a multidisciplinary combined modality therapy program is incredibly - portant. In this volume, various topics are reviewed including tumor genesis, cell proliferation, - giogenesis, the physiologic characteristics of malignant tissues, invasion and adhesion, the route and role pursued in the development of metastasis, and the role of the human immune system in cancer prevention and development.

Molecular and Cell Biology of Cancer

Molecular and Cell Biology of Cancer Book
Author : Rita Fior,Rita Zilhão
Publisher : Springer
Release : 2019-06-27
ISBN : 3030118126
Language : En, Es, Fr & De

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Book Description :

This textbook takes you on a journey to the basic concepts of cancer biology. It combines developmental, evolutionary and cell biology perspectives, to then wrap-up with an integrated clinical approach. The book starts with an introductory chapter, looking at cancer in a nut shell. The subsequent chapters are detailed and the idea of cancer as a mass of somatic cells undergoing a micro-evolutionary Darwinian process is explored. Further, the main Hanahan and Weinberg “Hallmarks of Cancer” are revisited. In most chapters, the fundamental experiments that led to key concepts, connecting basic biology and biomedicine are highlighted. In the book’s closing section all of these concepts are integrated in clinical studies, where molecular diagnosis as well as the various classical and modern therapeutic strategies are addressed. The book is written in an easy-to-read language, like a one-on-one conversation between the writer and the reader, without compromising the scientific accuracy. Therefore, this book is suited not only for advanced undergraduates and master students but also for patients or curious lay people looking for a further understanding of this shattering disease

The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies

The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies Book
Author : Michael Molls,Peter Vaupel,Carsten Nieder,Mitchell Steven Anscher
Publisher : Springer Science & Business Media
Release : 2009-03-25
ISBN : 3540743863
Language : En, Es, Fr & De

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Book Description :

Te rapidly changing concepts in radiation oncology with the development of more precise - strumentation for delivery of radiation therapy and a greater emphasis on hypofractionation technologies require a very intimate knowledge of tumor biology and the infuence of various biologic factors on dose distribution within the tumor in terms of homogeneity as well as prev- tion of any late efects on normal tissue surrounding the tumor itself. Not only are these major factors in clinical practice but also the known factors of inhomogeneity of cancer cells, the impact of microenvironment in terms of radiation efect, and host factors make it mandatory to design therapeutic strategies to improve the outcome and to diminish any potential short-term or lo- term risks from the radiation therapy. Te authors have developed an outstanding text that deals with these strategies and how they would impact on established and emerging new technologies and treatment. Te context of the presentations within a multidisciplinary combined modality therapy program is incredibly - portant. In this volume, various topics are reviewed including tumor genesis, cell proliferation, - giogenesis, the physiologic characteristics of malignant tissues, invasion and adhesion, the route and role pursued in the development of metastasis, and the role of the human immune system in cancer prevention and development.

Understanding Cancer

Understanding Cancer Book
Author : Malcolm Alison,Catherine Elizabeth Sarraf
Publisher : Cambridge University Press
Release : 1997
ISBN : 9780521561549
Language : En, Es, Fr & De

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Book Description :

A clear, concise and well-illustrated introduction to cancer cell biology and cancer treatment/prevention.

Molecular Pathology

Molecular Pathology Book
Author : William B. Coleman,Gregory J. Tsongalis
Publisher : Unknown
Release : 2009
ISBN : 9780123744197
Language : En, Es, Fr & De

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Book Description :

Molecular Pathology: The Molecular Basis of Human Disease provides a current and comprehensive view of the molecular basis and mechanisms of human disease. Combining accepted principles with broader theoretical concepts and with contributions from a group of experts, the book looks into disease processes in the context of traditional pathology and their implications for translational molecular medicine. It also discusses concepts in molecular biology and genetics, recent scientific and technological advances in modern pathology, the concept of ""molecular pathogenesis"" of disease, and how disease evolves from normal cells and tissues due to perturbations in molecular pathways. The book describes the integration of molecular and cellular pathogenesis using a bioinformatics approach and a systems biology approach to disease pathogenesis. It also discusses current and future strategies in molecular diagnosis of human disease, and the impact of molecular diagnosis on treatment decisions and the practice of personalized medicine. This book is a valuable resource for students, biomedical researchers, practicing physician-scientists who undertake disease-related basic science and translational research, and pathology residents and other postdoctoral fellows. * Exam Master® web site will host "Self-assessment" questions that students can use to study for the molecular section of the board exam * Companion Web Site - will host a complete set of PowerPoint slides: to include images from the book and additional images for teaching; course materials; lecture materials * Teaches from the perspective of "integrative systems biology," which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease * Outlines the principles and practice of molecular pathology * Explains the practice of "molecular medicine" and the translational aspects of molecular pathology

Mechanisms of Molecular Carcinogenesis

Mechanisms of Molecular Carcinogenesis     Book
Author : Johannes Haybaeck
Publisher : Springer
Release : 2017-05-22
ISBN : 3319536613
Language : En, Es, Fr & De

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Book Description :

Together with Volume 1, this book provides an inclusive overview of the molecular and cellular mechanisms of carcinogenesis and offers comprehensive insights into related clinical and therapeutic aspects. This second volume complements the first by presenting and concisely explaining the carcinogenesis of various tumor entities such as non-melanoma skin cancers, bone and soft tissue tumors, pancreatic cancers, hepatocellular cancer and neuroendocrine tumors. As in volume one, each chapter illuminates the similarities and dissimilarities of changed signaling pathways in the different organ systems and depicts potential therapeutic strategies. The focus of volume two lies on the presentation of modern molecular biological techniques for diagnosis, as well as strategies for biomarker identification and validation. Furthermore, it discusses potential therapeutic targets and individualized treatment strategies, offering a valuable resource for all basic scientists and medical researchers interested in translational cancer research.

Understanding Cancer

Understanding Cancer Book
Author : Malcolm R. Alison,Catherine E. Sarraf
Publisher : Cambridge University Press
Release : 1997-02-28
ISBN : 9780521567510
Language : En, Es, Fr & De

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Book Description :

This informative and fully illustrated new textbook covers all aspects of cancer biology, from the cellular processes underlying tumorigenesis, all the way through to the development of new agents and strategies to improve cancer treatment and prevention. No prior medical knowledge is assumed, and each chapter provides an authoritative self-contained account. Uniquely, this book extends a broad net over the whole subject, and is not restricted to the ferociously advancing field of cancer genetics only. It describes how cancer is diagnosed and classified, how causes are identified, how tumours behave and how the flawed fundamental biological processes drive them. It explains how clinicians assess tumours, it explores well-established therapeutic options and evaluates the potential for innovative new treatments in the future. The text concludes with a helpful glossary of terminology. Every detail of information is clearly described from first principles and the book will, thus, provide an ideal introductory account for students of medicine, cell biology and pathology, as well as health-care professionals working on cancer and drug development.

Anti Angiogenesis Strategies in Cancer Therapies

Anti Angiogenesis Strategies in Cancer Therapies Book
Author : Shaker Mousa,Paul Davis
Publisher : Academic Press
Release : 2016-11-28
ISBN : 0128026731
Language : En, Es, Fr & De

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Book Description :

Anti-angiogenesis Strategies in Cancer Therapeutics provides a detailed look at the current status and future directions in the discovery and development of novel anti-angiogenesis strategies in oncology. This book highlights the different mechanisms involved in the modulation of angiogenesis, including inflammation, thrombosis, and microRNA, and shows how nanotechnology can further enhance the potential of existing and new anti-angiogenesis approaches. Written for industry scientists, researchers, oncologists, hematologists, and professors and students in the field, this comprehensive book covers all aspects of anti-angiogenesis strategies and their differences. Covers important preclinical models and clinical trials in the discovery and development of novel anti-angiogenesis agents Reviews FDA-approved anti-angiogenesis agents Illustrates the value of nanotechnology in improving the utility of anti-angiogenesis agents Offers insight into the development of novel anti-angiogenesis agents and future direction in this area

Brain Tumors

Brain Tumors Book
Author : Francis Ali-Osman
Publisher : Springer Science & Business Media
Release : 2007-10-28
ISBN : 1592598439
Language : En, Es, Fr & De

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Book Description :

Exciting new developments and discoveries of the last two decades are beginning to shed light on the complex biology of brain tumors and are advancing our understa- ing of the cellular and molecular processes involved in their initiation, progression, and clinical and biological behavior. The disease process in brain tumors is quite complex and the resulting tumors are characterized by a high degree of biological and clinical diversity. Thus, despite the advances of the last two decades, prognosis for patients with malignant brain tumors remains abysmal. Significant progress in the diagnosis, treatment and, ultimately, prevention of these tumors will require both the timely h- nessing of the advances in basic and clinical brain tumor research, and a continuing concerted effort at increasing our understanding of brain tumor biology, in particular, the molecular genetic changes and perturbations of cellular pathways involved in brain oncogenesis and which drive the biological and clinical behavior of the tumors. Brain tumor diagnosis and prognosis, which is still largely based on histopathology and other clinical criteria, will, in the future, acquire a significant molecular component, with the incorporation of knowledge of genes that are mutated, over-expressed, deleted, silenced, or functionally altered in the tumors. Treatment strategies for brain tumors, rather than being empirical, will be rationally developed based on an understanding of the cellular and molecular mechanisms and targets that have been activated, suppressed, or otherwise altered.

The Heterogeneity of Cancer Metabolism

The Heterogeneity of Cancer Metabolism Book
Author : Anne Le
Publisher : Springer
Release : 2018-06-26
ISBN : 331977736X
Language : En, Es, Fr & De

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Book Description :

Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Breast Cancer

Breast Cancer Book
Author : Daniel F. Roses
Publisher : Churchill Livingstone
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This updated New Edition provides a complete yet concise understanding of breast cancer-from biology, pathology, and screening through diagnosis, treatment, long-term follow-up, and adjuvant care. Its practical, multidisciplinary focus addresses the concerns of every member of the health care team. A unique question-and-answer format offers clear answers to clinical questions, enhancing communication among physicians, nurses, and patients. Considers the full range of management options, including radiation therapy, chemotherapy, hormone therapy, and monoclonal antibody therapy. Uses a question-and-answer format to make reference easy. Saves time by examining only well-established, proven diagnostic and therapeutic strategies. Incorporates new chapters on needle biopsy, lymph node pathology, sonography, new diagnostic imaging modalities, MRI, emerging surgical approaches (such as radiofrequency and cryoablative techniques), and medicolegal issues. Offers brand-new coverage of lymphatic mapping and sentinel node biopsy, molecular pathology, and the latest chemotherapeutic options. Presents 50% new contributors who are international leaders in molecular biology, genetics, radiology, pathology, surgery, and oncology. Delivers nearly 300 new clinical photographs and line illustrations. With 60 additional contributing experts.