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Therapeutic Drug Monitoring

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Therapeutic Drug Monitoring

Therapeutic Drug Monitoring Book
Author : Amitava Dasgupta
Publisher : Academic Press
Release : 2012-06-07
ISBN : 0123854687
Language : En, Es, Fr & De

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Book Description :

Therapeutic Drug Monitoring: Newer Drugs and Biomarkers features timely topics such as the monitoring of classical and newer drugs, pharmacogenomics and the application of biomarkers in therapeutic drug monitoring. This reference also discusses the limitations of current commercially available immunoassays for therapeutic monitoring. It presents new and sophisticated techniques used for proper determination of blood levels and the clinical utility of therapeutic drug monitoring of contemporary drugs. Written by leading international experts and geared toward clinical pathologists, toxicologists, clinical chemists, laboratory professionals and physicians, this book is an essential resource on the current practice of therapeutic drug monitoring in improving patient safety. Includes both the technical and clinical issues associated with therapeutic drug monitoring Discusses the utility of therapeutic drug monitoring of newer drugs such as antiretroviral agents, anticonvulsants, antidepressants etc. Provides up-to-date information on issues in pharmacogenomics and personalized medicine with emphasis on therapy with warfarin, certain anticancer drugs and antidepressants Covers important content on the limitations of commercially available immunoassays (chemical tests) for therapeutic drug monitoring and additional analytical techniques

Therapeutic Drug Monitoring Data

Therapeutic Drug Monitoring Data Book
Author : Amitava Dasgupta,Matthew Krasowski
Publisher : Academic Press
Release : 2019-09-14
ISBN : 0128158506
Language : En, Es, Fr & De

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Book Description :

Therapeutic Drug Monitoring Data: A Concise Guide, Fourth Edition serves as a ready resource of information on commonly monitored drugs that will help readers make decisions relating to the monitoring and interpretation of results. It is an easy-to-read source of information on intended use, pharmacokinetics, therapeutic range, and toxic concentrations, as well as bioavailability, disposition, metabolism and the excretion of commonly monitored therapeutic drugs. This fully updated fourth edition includes sections on new anticonvulsants, anti-depressant and anti-HIV drugs, new drugs for advanced cancer treatment, and thoroughly updated chapters that address new pitfalls and problems in the lab. Serves as a ready resource of information for commonly monitored drugs Presents a useful, quick guide for those making decisions related to monitoring and interpretation of results Provides concise, easily digestible content for clinical laboratory scientists, toxicologists and clinicians

Clinical Challenges in Therapeutic Drug Monitoring

Clinical Challenges in Therapeutic Drug Monitoring Book
Author : William Clarke,Amitava Dasgupta
Publisher : Elsevier
Release : 2016-07-21
ISBN : 0128020520
Language : En, Es, Fr & De

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Book Description :

Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomics focuses on critical issues in therapeutic drug monitoring including special requirements of therapeutic drug monitoring important to special populations (infants and children, pregnant women, elderly patients, and obese patients). The book also covers issues of free drug monitoring and common interferences in using immunoassays for therapeutic drug monitoring. This book is essential reading for any clinician, fellow, or trainee who wants to gain greater insight into the process of therapeutic drug monitoring for individual dosage adjustment and avoiding drug toxicity for certain drugs within a narrow therapeutic window. The book is written specifically for busy clinicians, fellows, and trainees who order therapeutic drug monitoring and need to get more familiar with testing methodologies, issues of interferences, and interpretation of results in certain patient populations. Offers busy clinicians, pathologists, and trainees a concise resource on the key aspects and critical issues in therapeutic drug monitoring Focuses on patient populations such as infants and children, pregnant women, elderly patients, and obese patients, who have special requirements in therapeutic drug monitoring Explores special topics in therapeutic drug monitoring including free drug monitoring and common immunoassay interference Explains how individual dosage adjustments can prevent drug toxicity for certain drugs within a narrow therapeutic window

Methods of Therapeutic Drug Monitoring Including Pharmacogenetics

Methods of Therapeutic Drug Monitoring Including Pharmacogenetics Book
Author : Georg Hempel
Publisher : Elsevier
Release : 2019-10-17
ISBN : 0444640673
Language : En, Es, Fr & De

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Book Description :

Methods of Therapeutic Drug Monitoring Including Pharmacogenetics, Second Edition, Volume Seven in the Handbook of Analytical Separations series, covers all aspects of drug monitoring, including laboratory work, pharmacokinetic analysis and clinical aspects, thus enabling readers from different fields to understand the whole process of therapeutic drug monitoring and how to avoid common pitfalls. The book contains analytical techniques for the quantification of drugs, along with pharmacogenetic and pharmacogenomic methods. Also included are updates on sample preparation, including dried blood spot technology and microextraction methods. In addition, the book includes new drugs, such as tyrosine kinase inhibitors and the monitoring of immunosuppressant drugs. Presents a unique, interdisciplinary approach that appeals to a wide range of users Written by authors from international labs, providing a global perspective that can be applied in various regulatory environments Features additional therapeutic drugs to reflect the rising number of immunocompromised patients Includes a new mass spectroscopic methods chapter to capture the frequent use in TDM and the improved availability of LC-MS across laboratories

Analytical Methods for Therapeutic Drug Monitoring and Toxicology

Analytical Methods for Therapeutic Drug Monitoring and Toxicology Book
Author : Q. Alan Xu,Timothy L. Madden
Publisher : John Wiley & Sons
Release : 2011-04-12
ISBN : 9780470922798
Language : En, Es, Fr & De

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Book Description :

This book is a compilation of summarized analytical methods designed to serve the needs of pharmacologists, toxicologists, and other allied health professionals involved the development, use, or monitoring of pharmaceuticals. The summaries are structured monographs on 511 different drug entities detailing 964 different analytical methods, providing the reader with a thorough description of method validation. These analytical methods include not only high performance liquid chromatography (HPLC), but also gas chromatography (GC), immunoassay, electrophoresis, ultra performance liquid chromatography (UPLC) coupled with UV (UPLC-UV) detection and mass spectrometry (UPLC-MS/MS). With more detailed and complete summaries than sketchy and abbreviated formats used in the other books, this book provides a thorough description of method validation and results, as well as the operating parameters.

Handbook of Drug Monitoring Methods

Handbook of Drug Monitoring Methods Book
Author : Amitava Dasgupta
Publisher : Springer Science & Business Media
Release : 2007-10-23
ISBN : 1588297802
Language : En, Es, Fr & De

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Book Description :

In Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse, authors discuss the different analytical techniques used in today’s practice of therapeutic drug monitoring and drugs of abuse as well as alcohol testing with relevant theory, mechanism, and in-depth scientific discussion on each topic. This volume is the perfect handbook and quick reference for any clinical laboratory, allowing clinicians to find the potential source of a false-positive or a false-negative result in the daily operation of a toxicology laboratory. At the same time, this book can also be used as a reference for medical technologists, supervisors, laboratory directors, clinical chemists, toxicologists, and pathologists to find in-depth cause of a potential interference and what tests can be ordered to circumvent such problem. The volume’s first half focuses on various issues of therapeutic drug monitoring. Additional chapters cover analysis of heavy metals, alcohol testing, and issues of drugs of abuse testing. These chapters are written by experts in their relative sub-specialties and also by the editor. Comprehensive and timely, Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse is the ideal text for clinicians and researchers monitoring alcohol and drug testing and other important tasks of toxicological laboratory services.

Therapeutic Drug Monitoring

Therapeutic Drug Monitoring Book
Author : Gerald E. Schumacher
Publisher : McGraw-Hill/Appleton & Lange
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Therapeutic Drug Monitoring book written by Gerald E. Schumacher, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Recent Developments in Therapeutic Drug Monitoring and Clinical Toxicology

Recent Developments in Therapeutic Drug Monitoring and Clinical Toxicology Book
Author : Irving Sunshine
Publisher : CRC Press
Release : 2019-10-07
ISBN : 9780367402839
Language : En, Es, Fr & De

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Book Description :

Papers from the Second International Conference on TDM Toxicology (date and place not stated) describe research on various aspects of therapeutic monitoring pharmacology, selected high-performance liquid chromatographic methods, antiepileptics, substances subject to abuse, inorganics. Over 100 contr

Surviving Prescribing

Surviving Prescribing Book
Author : Anonim
Publisher : Remedica
Release : 2006-11
ISBN : 1901346935
Language : En, Es, Fr & De

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Book Description :

Prescribing medicine on the ward or in the clinic can be a daunting task. New doctors will recognise how easy it is to cause a patient harm, and also how hard it is to find helpful information. Hospital formularies are often excellent resources for drug doses, but what about the practical stuff? A patient is suffering from alcohol withdrawal...what regimens are available? How is 'patient-controlled analgesia' managed? This pocket-sized book, written by clinical pharmacists and doctors with years of experience, is a collection of handy hints, tips and protocols that will help doctors to prescribe simply, safely and with confidence.

Mass Spectrometry for the Clinical Laboratory

Mass Spectrometry for the Clinical Laboratory Book
Author : Hari Nair,William Clarke
Publisher : Academic Press
Release : 2016-11-02
ISBN : 0128009926
Language : En, Es, Fr & De

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Book Description :

Mass Spectrometry for the Clinical Laboratory is an accessible guide to mass spectrometry and the development, validation, and implementation of the most common assays seen in clinical labs. It provides readers with practical examples for assay development, and experimental design for validation to meet CLIA requirements, appropriate interference testing, measuring, validation of ion suppression/matrix effects, and quality control. These tools offer guidance on what type of instrumentation is optimal for each assay, what options are available, and the pros and cons of each. Readers will find a full set of tools that are either directly related to the assay they want to adopt or for an analogous assay they could use as an example. Written by expert users of the most common assays found in a clinical laboratory (clinical chemists, toxicologists, and clinical pathologists practicing mass spectrometry), the book lays out how experts in the field have chosen their mass spectrometers, purchased, installed, validated, and brought them on line for routine testing. The early chapters of the book covers what the practitioners have learned from years of experience, the challenges they have faced, and their recommendations on how to build and validate assays to avoid problems. These chapters also include recommendations for maintaining continuity of quality in testing. The later parts of the book focuses on specific types of assays (therapeutic drugs, Vitamin D, hormones, etc.). Each chapter in this section has been written by an expert practitioner of an assay that is currently running in his or her clinical lab. Provides readers with the keys to choosing, installing, and validating a mass spectrometry platform Offers tools to evaluate, validate, and troubleshoot the most common assays seen in clinical pathology labs Explains validation, ion suppression, interference testing, and quality control design to the detail that is required for implementation in the lab

Handbook of Analytical Therapeutic Drug Monitoring and Toxicology 1996

Handbook of Analytical Therapeutic Drug Monitoring and Toxicology  1996  Book
Author : Steven H.Y. Wong,Irving Sunshine
Publisher : CRC Press
Release : 2017-11-22
ISBN : 1351364278
Language : En, Es, Fr & De

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Book Description :

Adapting modern advances in analytical techniques to daily laboratory practices challenges many toxicologists, clinical laboratories, and pharmaceutical scientists. The Handbook of Analytical Therapeutic Drug Monitoring and Toxicology helps you keep abreast of the innovative changes that can make your laboratory - and the studies undertaken in it - a success. This volume simplifies your search for appropriate techniques, describes recent contributions from leading investigators, and provides valuable evaluations and advice.

Applied Pharmacokinetics Pharmacodynamics

Applied Pharmacokinetics   Pharmacodynamics Book
Author : Michael E. Burton
Publisher : Lippincott Williams & Wilkins
Release : 2006
ISBN : 9780781744317
Language : En, Es, Fr & De

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Book Description :

The definitive advanced-level clinical pharmacokinetics text is now in its Fourth Edition, with new emphasis on the relationship between pharmacokinetics and pharmacodynamics. Written by 70 leading researchers and practitioners, this book is a rigorous yet practical text on the application of pharmacokinetic methods, pharmacodynamic principles, and pharmacotherapeutic data for optimal, individualized drug therapy. This edition includes case studies that apply concepts to actual patient problems. New chapters cover tacrolimus, mycophenolic acid, sirolimus, antipsychotics, and critical evaluation of therapeutic drug monitoring methods. Other new features include more drawings and reference tables and an appendix on outcome studies with therapeutic drug monitoring.

Advances in Chromatographic Techniques for Therapeutic Drug Monitoring

Advances in Chromatographic Techniques for Therapeutic Drug Monitoring Book
Author : Amitava Dasgupta
Publisher : CRC Press
Release : 2009-10-06
ISBN : 1420067591
Language : En, Es, Fr & De

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Book Description :

For drugs with a narrow therapeutic index, therapeutic drug monitoring methods are essential for patient management. Although immunoassays are commercially available for many drugs and most laboratories use these assays for routine therapeutic monitoring, they have many limitations which hinder their efficacy. Providing practical guidelines for imp

Applied Pharmacokinetics

Applied Pharmacokinetics Book
Author : William E. Evans,Jerome J. Schentag,William J. Jusko
Publisher : Applied Therapeutics, Incorporated
Release : 1992
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The Third Edition of Applied Pharmacokinetics remains the gold standard by which all other clinical pharmacokinetics texts are measured. Written by leading pharmacokinetics researchers and practitioners, this book is the most advanced kinetics reference available. All chapters have been extensively updated or completely rewritten for this edition, and six new chapters have been added on pharmacodynamics, pharmacogenetics, pharmacokinetic considerations in the obese, dietary influences on drug disposition, zidovudine, and corticosteroids. Each chapter is tightly focused on the most important concepts and issues. Chapters on specific drugs are organized in a consistent format for quick, easy information retrieval. Major subheadings include Clinical Pharmacokinetics, Pharmacodynamics, Clinical Application of Pharmacokinetic Data, Analytical Methods, and Prospectus.

Drug Monitoring and Clinical Chemistry

Drug Monitoring and Clinical Chemistry Book
Author : Georg Hempel
Publisher : Elsevier
Release : 2004-05-15
ISBN : 0080530540
Language : En, Es, Fr & De

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Book Description :

Drug Monitoring and Clinical Chemistry, the 5th volume in the Handbook of Analytical Separations series, gives an overview about methods to analyse drugs in biological fluids. The most widely used methods to analyse drugs in biological fluids. i.e. chromatographic methods, CE and immunoassays are described in detail. For important drugs, an overview about the methods available and a comparison of the techniques should be given to enable the reader to choose the right method depending on laboratory equipment, staff, the aim of the investigation etc. Other general aspects important for conducting therapeutic drug monitoring or pharmacokinetics studies are also covered, i.e. sample preparation, validation of the analytical methods and pharmacokinetic methods for interpreting the data. Areas where therapeutic drug monitoring is used frequently such as antibiotics, immunosuppressant drugs, antipsychotic and anticancer drugs will be discussed in detail. In addition, the important field of phenotyping and genotyping for therapy optimisation with special focus on real-life applications is also covered. The book contains important information for analyst working on drug analysis in clinical chemistry, hospital pharmacists involved in therapeutic drug monitoring, other pharmacists, chemists or physicians working on pharmacokinetic studies in industry or academia. In contrast to other books in this field, this book provides up-to-date information regarding both methodology and clinical applications. For the applications, only fields are described where therapeutic drug monitoring is used in clinical routine and provides benefit to the patients. Overview of all important field where therapeutic drug monitoring is applied All relevant analytical and computational methods are discussed Written by experts with a lot of practical experience in the field

Anti Tumor Necrosis Factor Therapy in Inflammatory Bowel Disease

Anti Tumor Necrosis Factor Therapy in Inflammatory Bowel Disease Book
Author : G. Rogler,H. Herfarth,T. Hibi,O.H. Nielsen
Publisher : Karger Medical and Scientific Publishers
Release : 2015-07-09
ISBN : 3318054747
Language : En, Es, Fr & De

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Book Description :

The introduction of anti-tumour necrosis factor (TNF) antibodies into the treatment of patients with IBD about fifteen years ago has dramatically improved the quality of life for patients with severe Crohn's disease and ulcerative colitis. But despite the fact this therapeutic approach has been around for quite some time, there has been no comprehensive overview to date. The book at hand aims to amend this shortcoming, presenting for the first time a thorough overview on TNF action, mechanisms of anti-TNF therapy, treatment strategies, side effects, monitoring, biosimilars and related issues. Including state-of-the-art information and research results, this publication will be a valuable source of information and guide clinicians to the optimal treatment decision, improving the quality of life of patients with inflammatory bowel disease. Moreover, rheumatologists or even dermatologists might also find this book of interest.

Clinical Pharmacy Education Practice and Research

Clinical Pharmacy Education  Practice and Research Book
Author : Dixon Thomas
Publisher : Elsevier
Release : 2018-11-23
ISBN : 0128142774
Language : En, Es, Fr & De

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Book Description :

Clinical Pharmacy Education, Practice and Research offers readers a solid foundation in clinical pharmacy and related sciences through contributions by 83 leading experts in the field from 25 countries. This book stresses educational approaches that empower pharmacists with patient care and research competencies. The learning objectives and writing style of the book focus on clarifying the concepts comprehensively for a pharmacist, from regular patient counseling to pharmacogenomics practice. It covers all interesting topics a pharmacist should know. This book serves as a basis to standardize and coordinate learning to practice, explaining basics and using self-learning strategies through online resources or other advanced texts. With an educational approach, it guides pharmacy students and pharmacists to learn quickly and apply. Clinical Pharmacy Education, Practice and Research provides an essential foundation for pharmacy students and pharmacists globally. Covers the core information needed for pharmacy practice courses Includes multiple case studies and practical situations with 70% focused on practical clinical pharmacology knowledge Designed for educational settings, but also useful as a refresher for advanced students and researchers

Clinical Toxicology Testing

Clinical Toxicology Testing Book
Author : Barbarajean Magnani,Tai C. Kwong,Gwendolyn A. McMillin,Alan H. B. Wu
Publisher : Unknown
Release : 2020
ISBN : 9781941096512
Language : En, Es, Fr & De

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Book Description :

"A comprehensive overview of clinical laboratory toxicology services and analytes"--

Interpretation of Equine Laboratory Diagnostics

Interpretation of Equine Laboratory Diagnostics Book
Author : Nicola Pusterla,Jill Higgins
Publisher : John Wiley & Sons
Release : 2017-12-18
ISBN : 1118739795
Language : En, Es, Fr & De

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Book Description :

Interpretation of Equine Laboratory Diagnostics offers a comprehensive approach to equine laboratory diagnostics, including hematology, clinical chemistry, serology, body fluid analysis, microbiology, clinical parasitology, endocrinology, immunology, and molecular diagnostics. Offers a practical resource for the accurate interpretation of laboratory results, with examples showing real-world applications Covers hematology, clinical chemistry, serology, body fluid analysis, microbiology, clinical parasitology, endocrinology, immunology, and molecular diagnostics Introduces the underlying principles of laboratory diagnostics Provides clinically oriented guidance on performing and interpreting laboratory tests Presents a complete reference to establish and new diagnostic procedures Offers a practical resource for the accurate interpretation of laboratory results, with examples showing real-world applications Covers hematology, clinical chemistry, serology, body fluid analysis, microbiology, clinical parasitology, endocrinology, immunology, and molecular diagnostics Introduces the underlying principles of laboratory diagnostics Provides clinically oriented guidance on performing and interpreting laboratory tests Presents a complete reference to established and new diagnostic procedures

UCL Hospitals Injectable Medicines Administration Guide

UCL Hospitals Injectable Medicines Administration Guide Book
Author : University College London Hospitals
Publisher : John Wiley & Sons
Release : 2013-07-19
ISBN : 1118277392
Language : En, Es, Fr & De

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Book Description :

"I would definitely recommend this book to all staff with an interest and involvement in intravenous drug therapy." —The Pharmaceutical Journal "There is no doubt that nurses will find this small book useful. It should be available for consultation in any clinical area where drugs are administered to patients by the injectable routes." —Journal of Clinical Nursing The safe administration of injectable medicines is key to patient safety. The NPSA recognises the use of injectable medicines is a high risk activity and recommends written information about injectables to be available at the point of preparation. The UCL Hospitals Injectable Medicines Administration Guide is a practical, accessible guide covering many important aspects of administering medicines by injection. It provides clear, concise information on the preparation and administration of over 245 injectable medicines for adults, paediatrics and neonates. It is an essential resource for nurses and other healthcare professionals: it provides the key information and advice needed for the safe and effective administration of injectable medicines. The Guide’s introductory section provides a concise yet comprehensive overview of injectable therapy, including the risks and benefits of IV administration, infusion devices, and pharmaceutical aspects of injectable therapy. For each drug the alphabetically tabulated monographs provide: A practical method of preparation and administration via the IV, IM and SC routes, with risk reduction in mind at every step Expert advice from the team of specialist pharmacists at UCLH to ensure safe and pragmatic use of each medicine Monitoring advice for the management of reactions that may occur during administration Y-site and syringe driver compatibility data Minimum infusion volume data for fluid restricted patients Extravasation warnings, pH, sodium content, displacement values, stability and flush data New to this edition: 40 new monographs including recently marketed, unlicensed, rarely used and specialist medicines Detailed advice for the administration of high risk medicines such as heparin, with access to UCLH’s medicine related guidelines at www.wiley.com/go/UCLH A colour-coded NPSA risk assessment for every mode of administration for every medicine, to highlight the safest method of administration A user guide and tutorial to give new readers confidence in using and understanding the Guide Revised chapters on administration methods and devices, aseptic non-touch technique, and latex allergy Fully revised and expanded Y-site compatibility section Spiral binding to allow the book to be left open at the relevant page The Guide is also available electronically at www.uclhguide.com.