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Therapeutic Applications Of Quadruplex Nucleic Acids

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Therapeutic Applications of Quadruplex Nucleic Acids

Therapeutic Applications of Quadruplex Nucleic Acids Book
Author : Stephen Neidle
Publisher : Academic Press
Release : 2011
ISBN : 0123751381
Language : En, Es, Fr & De

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Book Description :

New found interest in the chromosome G-quadruplexes has emerged as an important focus of research in nucleic acids and as a potential target for cancer therapeutics. Existing literature concerning nucleic acids concentrates on aspects of quadruplex structure and historical research. There exists no single comprehensive resource addressing recent advances in therapeutic application and targeting strategies, until now. Quadruplex Nucleic Acids as Therapeutic Targets will be a vital resource for researchers in biochemistry, molecular biology, chemistry, biotechnology, biophysics, medicine, translational science and pharmacology. This timely publication is the first to offer practical application and direct strategies to meet the needs of emerging research.

G Quadruplex Nucleic Acids

G Quadruplex Nucleic Acids Book
Author : Danzhou Yang,Clement Lin
Publisher : Humana
Release : 2020-09-07
ISBN : 9781493996681
Language : En, Es, Fr & De

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Book Description :

This volume covers the structures, properties, and functions of G-quadruplexes in a wide range of biological disciplines, including therapeutic intervention and biomaterial application. The chapters in this book explore a wide range of vital and new experimental techniques used in the study of G-quadruplexes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and cutting-edge, G-Quadruplex DNA: Methods and Protocols is a valuable resource for both novice and experienced researchers who work in biophysics, structural biology, computational biology, biochemistry, and molecular and cell biology, and who want to learn more about the potential roles and effects of G-quadruplex in these fields.

Anticancer Research

Anticancer Research Book
Author : Anonim
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Philosophical Transactions

Philosophical Transactions Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Chemical Biology of Nucleic Acids

Chemical Biology of Nucleic Acids Book
Author : Volker A. Erdmann,Wojciech T. Markiewicz,Jan Barciszewski
Publisher : Springer Science & Business
Release : 2014-04-22
ISBN : 3642544525
Language : En, Es, Fr & De

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Book Description :

This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular transport; molecular crowding by the use of ionic liquids; new technologies enabling the modification of gene expression via editing of therapeutic genes; the use of riboswitches; the modification of mRNA cap regions; new approaches to detect appropriately modified RNAs with EPR spectroscopy and the use of parallel and high-throughput techniques for the analysis of the structure and new functions of nucleic acids. This volume discusses how chemistry can add new frontiers to the field of nucleic acids in molecular medicine, biotechnology and nanotechnology and is not only an invaluable source of information to chemists, biochemists and life scientists but will also stimulate future research.

Dissertation Abstracts International

Dissertation Abstracts International Book
Author : Anonim
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Journal

Journal Book
Author : American Chemical Society
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Medicinal Chemistry of Nucleic Acids

Medicinal Chemistry of Nucleic Acids Book
Author : Li-He Zhang,Zhen Xi,Jyoti Chattopadhyaya
Publisher : John Wiley & Sons
Release : 2011-08-10
ISBN : 9781118092811
Language : En, Es, Fr & De

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Book Description :

Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biology Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids presents a thorough overview of nucleic acid chemistry—a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs. This reliable resource delves into a multitude of subject areas involving the study of nucleic acids—such as the new advances in genome sequencing, and the processes for creating RNA interference (RNAi) based drugs—to assist pharmaceutical researchers in removing roadblocks that hinder their ability to predict drug efficacy. Offering the latest cutting-edge science in this growing field, Medicinal Chemistry of Nucleic Acids includes: In-depth coverage of the development and application of modified nucleosides and nucleotides in medicinal chemistry A close look at a large range of current topics on nucleic acid chemistry and biology Essential information on the use of nucleic acid drugs to treat diseases like cancer A thorough exploration of siRNA for RNAi and the regulation of microRNA, non-coding RNA (ncRNA), a newly developing and exciting research area Thorough in its approach and promising in its message, Medicinal Chemistry of Nucleic Acids probes the new domains of pharmaceutical research—and exposes readers to a wealth of new drug discovery opportunities emerging in the dynamic field of nucleic acid chemistry.

Nucleic Acids Chemistry

Nucleic Acids Chemistry Book
Author : Ramon Eritja
Publisher : Walter de Gruyter GmbH & Co KG
Release : 2021-01-18
ISBN : 311063953X
Language : En, Es, Fr & De

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Book Description :

This book compiles recent research on the modification of nucleic acids. It covers backbone modifications and conjugation of lipids, peptides and proteins to oligonucleotides and their therapeutic use. Synthesis and application in biomedicine and nanotechnology of aptamers, fluorescent and xeno nucleic acids, DNA repair and artificial DNA are discussed as well.

Canadian Journal of Chemistry

Canadian Journal of Chemistry Book
Author : Anonim
Publisher : Unknown
Release : 2008-07
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Index to Theses with Abstracts Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards

Index to Theses with Abstracts Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Index to Theses with Abstracts Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Drug Discovery and Development

Drug Discovery and Development Book
Author : H. P. Rang,Daniel Vasella
Publisher : Churchill Livingstone
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

'Drug Discovery and Development' describes the huge complexities involved in bringing a drug to market and how new molecular understanding and techniques can make the process more targeted and successful.

Bibliography of Agriculture

Bibliography of Agriculture Book
Author : Anonim
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Chemical Abstracts

Chemical Abstracts Book
Author : Anonim
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Wiley Encyclopedia of Chemical Biology Volume 4

Wiley Encyclopedia of Chemical Biology  Volume 4 Book
Author : Tadhg P. Begley
Publisher : Wiley-Blackwell
Release : 2009-02-03
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The first major reference at the interface of chemistry, biology, and medicine Chemical biology is a rapidly developing field that uses the principles, tools, and language of chemistry to answer important questions in the life sciences. It has enabled researchers to gather critical information about the molecular biology of the cell and is the fundamental science of drug discovery, playing a key role in the development of novel agents for the prevention, diagnosis, and treatment of disease. Now students and researchers across the range of disciplines that use chemical biology techniques have a single resource that encapsulates what is known in the field. It is an excellent place to begin any chemical biology investigation. Major topics addressed in the encyclopedia include: Applications of chemical biology Biomolecules within the cell Chemical views of biology Chemistry of biological processes and systems Synthetic molecules as tools for chemical biology Technologies and techniques in chemical biology Some 300 articles range from pure basic research to areas that have immediate applications in fields such as drug discovery, sensor technology, and catalysis. Novices in the field can turn to articles that introduce them to the basics, whereas experienced researchers have access to articles exploring the cutting edge of the science. Each article ends with a list of references to facilitate further investigation. With contributions from leading researchers and pioneers in the field, the Wiley Encyclopedia of Chemical Biology builds on Wiley's unparalleled reputation for helping students and researchers understand the crucial role of chemistry and chemical techniques in the life sciences.

Nucleic Acids Abstracts

Nucleic Acids Abstracts Book
Author : Anonim
Publisher : Unknown
Release : 1995-11
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Textbook of Biochemistry with Clinical Correlations

Textbook of Biochemistry with Clinical Correlations Book
Author : Thomas M. Devlin
Publisher : Wiley-Liss
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This book presents the biochemistry of mammalian cells, relates events at the cellular level to the subsequent physiological processes in the whole animal, and cites examples of human diseases derived from aberrant biochemical processes.

Cancer Research

Cancer Research Book
Author : Anonim
Publisher : Unknown
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Human Retroviruses and AIDS

Human Retroviruses and AIDS Book
Author : Anonim
Publisher : Unknown
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Multicolor Fluorescence Optical Tweezers Methods and Applications to Nucleic Acid Folding

Multicolor Fluorescence Optical Tweezers Methods and Applications to Nucleic Acid Folding Book
Author : Cho-Ying Chuang
Publisher : Unknown
Release : 2019
ISBN : 9780438864726
Language : En, Es, Fr & De

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Book Description :

Nucleic acids and proteins are fundamental molecular units of life. To understand their properties, we need powerful tools that allow investigation at the single-molecule level. Over the past three decades, the development of single-molecule force and fluorescence techniques has provided us new knowledge that was previously unattainable through ensemble measurements. However, we lack methods that allow us to precisely measure the mechanical properties of these molecules while visually detecting multiple molecules at the same time. In this dissertation, we maximize the information obtained in single-molecule measurements by pushing the techniques to be more precise and more complex. We then utilize our instrument to directly observe the folding and unfolding of the nucleic acid G-quadruplex structure. Among the single-molecule force techniques, angstrom-resolution has been achieved by optical tweezers using the dual-trap instrument design. Dual-traps can be produced by acousto-optic (AO) devices, which have many advantages, but trap positioning inaccuracies have limited their usage at high-resolution. We have designed a method to remove the inaccuracies by randomizing the phase of the radio frequency that drives the AO device. We demonstrated that the trap inaccuracies are completely eliminated and high-resolution trapping quality is achieved. This advance allows us to perform long duration measurements with reduced drift in trap measurement over time. Next, we present instrumentation advances that combine high-resolution optical tweezers and multicolor confocal fluorescence spectroscopy along with automated single molecule assembly. Multicolor not only allows the detection of multiple observables but also increases the flexibility in the choice of fluorophores. We demonstrated the ability to simultaneously measure angstrom-scale changes in tether extension and single fluorophore signals. The biggest challenge in integrating optical tweezers and fluorescence is the potential for greatly enhanced photobleaching which can make experiments impossible. We showed that the mean number of photons emitted before bleaching is unaffected by the trap laser when interlacing the fluorescence and optical trap lasers. We investigated the photostability of quantum dots and fluorophores. Finally, we devised computer-controlled automation to conserve the fluorophore lifetime. This advance enables us to observe multiple molecules or multiple degrees of freedom within a molecular complex while mechanically manipulate and detect them. Taking advantage of these method and instrumentation advances, we investigate the folding and unfolding of a DNA secondary structure: thrombin-binding aptamer G-quadruplex (TBA-GQ). Studying the kinetics of G-quadruplex formation is essential for understanding telomere regulation (the ends of chromosomes) and therapeutic approaches for disease. TBA-GQ is the smallest G-quadruplex. Although many experiments and simulations have been done on G-quadruplex, the small size and low stability make it very difficult to observe folding and unfolding of TBA-GQ directly. Our high-resolution optical tweezers have the sensitivity and stability to directly observe TBA-GQ at very low forces. We found that with increasing force, the folding rate decreased and the unfolding rate increased. Our work demonstrates that at a given force, the TBA-GQ formation is facilitated by metal ions and is stabilized by thrombin. It also indicates that the equilibrium force increased as KCl concentration increased. From a detailed analysis of the folding and unfolding rate constants vs applied force, we were able to detect a single transition state conserved across all conditions and identify the structure of the transition state as the G-triplex structure.