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Therapeutic Application Of Nitric Oxide In Cancer And Inflammatory Disorders

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Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders Book
Author : Lucia Morbidelli,Benjamin Bonavida
Publisher : Academic Press
Release : 2019-02-09
ISBN : 0128172797
Language : En, Es, Fr & De

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Book Description :

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated reviews on the chemistry, signaling, pre-clinical and clinical activities on the role of nitric oxide donors/inhibitors used alone and in combination with other therapeutic agents for the treatment of a variety of diseases. This book examines various studies related to the application of novel therapeutic NO (donors/inhibitors) compounds in the treatment of various cancers. These studies have been shown to exert significant therapeutic activities against various cancers and various inflammatory diseases such as rheumatoid arthritis, Crohn’s disease, allergies, and asthma, where no current effective therapies exist. Pathologies based on functional and structural vascular alterations are also taken into consideration. Edited and written by internationally renowned experts in the field of novel therapeutics for cancer, this book is a valuable source for cancer researchers, medical scientists, clinicians, clinical pharmacologists, and graduate students. Provides readers with a clear overview of the recent findings and references as well as summaries, significant molecular pathways, and conclusions Discusses new ideas proposed and makes suggestions for further investigations that will advance the field Presents introductory and summary information on the contributions of the field, all the findings of the studies discussed, and projects future goals for research

Nitric Oxide NO and Cancer

Nitric Oxide  NO  and Cancer Book
Author : Benjamin Bonavida
Publisher : Springer
Release : 2012-09-05
ISBN : 9781461426110
Language : En, Es, Fr & De

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Book Description :

Nitric Oxide (NO) is a pleitropic, ubiquitous modulator of cellular functions. Aryl nitrite and glyceryl trinitrate, representative intravasadilators, were introduced as therapeutic agents more than a century ago for relief from acute attacks of angina. The vasodilator action is mediated by the release of NO following treatment. NO has important therapeutic applications in several diseases such as inflammatory diseases, erectile dysfunction, inflammation, pain and neural protective activity. However, the role of NO in cancer and its application in therapy has received little attention. This monograph will be the first to focus on studies that investigate the role of NO in tumor cell pathogenesis, growth, angiogenesis, response to cytotoxic therapies and NO translational applications in cancer therapy, alone or in conjunction with other therapies.

The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease

The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease Book
Author : Bharat B. Aggarwal,Young-Joon Surh,S. Shishodia
Publisher : Springer Science & Business Media
Release : 2007-08-06
ISBN : 0387464018
Language : En, Es, Fr & De

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Book Description :

The medicinal uses of Curcumin (also called turmeric) have been known and described for more than 5000 years. A large body of recent research suggests that curcumin is potentially useful in the treatment of inflammatory diseases, through modulation of numerous molecular targets. This is the first monograph to focus on the potential use of curcumin in the treatment of cancer, diabetes, cardiovascular diseases, arthritis, Alzheimer’s, psoriasis and more.

Nitric Oxide Donors

Nitric Oxide Donors Book
Author : Amedea Seabra
Publisher : Academic Press
Release : 2017-03-17
ISBN : 0128134593
Language : En, Es, Fr & De

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Book Description :

Nitric Oxide Donors: Biomedical Applications and Perspectives presents the current state of art, challenges and innovations in the design of therapeutics nitric oxide donors with great impact in several aspects of human physiology and pathophysiology. Although considerable innovative progress has been achieved using Nitric Oxide donors in biomedical applications, certain drawbacks still need to be overcome to successfully translate these research innovations into clinical applications. This book encompasses several topics on nitric oxide such as its sources and biological properties; its performance in the cardiovascular and neurologic systems, in the human skin and its application in the treatment of neglected diseases, neurodegenerative disorders, and cancer. Additionally, it covers its role in inflammation and immunity, penile erection function, photodynamic therapy, antimicrobial activities. It also discusses the future of nitric oxide donors in combination with other therapeutic drugs, in implantable sensors, and nitric oxide releasing hydrogels and medical devices for topical applications. The book is a valuable source for researchers on different areas of biomedical field who are interested in the improvements that these molecules can make in the treatment of several conditions. Provides background information about biology and chemistry of nitric oxide Discusses the state-of-the-art in the design of nitric oxide releasing nanomaterials for biomedical applications Covers the usage of nitric oxide donors in the treatment of several conditions, such as cancer, human skin, cardiovascular system, and immunity Discusses the future of nitric oxide donors and their FDA approval

Inflammation in the Pathogenesis of Chronic Diseases

Inflammation in the Pathogenesis of Chronic Diseases Book
Author : Randall E. Harris
Publisher : Springer Science & Business Media
Release : 2007-05-09
ISBN : 1402056885
Language : En, Es, Fr & De

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Book Description :

In this book, a worldwide panel of leading experts discuss the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives.

Nitric Oxide and Cancer Pathogenesis and Therapy

Nitric Oxide and Cancer  Pathogenesis and Therapy Book
Author : Benjamin Bonavida
Publisher : Springer
Release : 2015-05-12
ISBN : 3319136119
Language : En, Es, Fr & De

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Book Description :

Advances in Nitric Oxide and Cancer is a volume that serves to give the latest research on nitric oxide (NO) and cancer. More specifically, the volume reviews significant advances in the application of NO-mediated drugs. The volume explores nitric oxide and its relationship to cancer spanning from its roles in the pathogenesis, prognosis, gene and protein modifications, regulation of resistance to cytotoxics, and therapeutic applications. With chapters written by leading experts, the volume addresses the burgeoning interest in a rapidly advancing field and provides a valuable resource to scientists who have initiated research as well as clinical investigations in their laboratories on the various roles of NO and cancer.

Regulation of Inducible Nitric Oxide Synthase Expression in Human Cells

Regulation of Inducible Nitric Oxide Synthase Expression in Human Cells Book
Author : Martin Lee
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Nitric oxide (NO) is a bioactive gas that has multiple roles in innate and adaptive immune responses and dysregulated expression of its production by inducible nitric oxide synthase (iNOS) is implicated in the pathogenesis of various inflammatory diseases and cancer. The mechanisms by which the expression of iNOS is regulated in human cells is incompletely understood. I show that NO positively regulates iNOS expression through a positive feedback mechanism that involves S-nitrosylation and activation of the small Ras GTPase, which in turn activates downstream PI3K/Akt and mTOR pathways. This feedback mechanism acts in a post-translational manner to increase iNOS protein levels by reducing its ubiquitination and proteasomal degradation. In addition to examining the feedback regulation of iNOS protein expression, I also studied how gene expression of this enzyme is controlled. I focused on the hypoxia inducible factor (HIF) because of the central role of this transcription factor in controlling many aspects of cell biology. The human iNOS gene promoter has three predicted HIF binding sites and mutation of one of these sites at -4.9 kb reduced the induction of iNOS gene promoter activity by cytokines. Further, HIF-1a gene editing by CRISPR/Cas9 eliminated HIF activity and reduced the induction of iNOS mRNA and protein expression by cytokines. Altogether, I discovered two mechanisms whereby iNOS expression is positively regulated at the protein and gene expression levels in an inflammatory setting. The role of NO and HIF in augmenting iNOS expression may provide insight into new therapeutic strategies for inflammatory diseases and cancer.

Molecular Biochemical Aspects of Cancer

Molecular Biochemical Aspects of Cancer Book
Author : Undurti N. Das
Publisher : Springer Nature
Release : 2020-05-30
ISBN : 1071607413
Language : En, Es, Fr & De

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Book Description :

This book discusses the role of genes, oncogenes, anti-oncogenes, free radicals, PUFAs, anti-oxidants, lipid peroxidation process, telomere, and angiogenesis on the origin of cancer, cell proliferation, and cancer in general. It includes a broad introduction to cancer cells; genes, oncogenes, and anti-oncogenes; and free radicals. In later chapters, it discusses in depth the relationship among free radicals, lipid peroxidation and anti-oxidants in cell proliferation. It also discusses aerobic and anaerobic metabolism and their relationship to cancer, as well as the Warburg effect and its potential in the development of new targets for cancer management. Based on these and other evidences, Molecular Biochemical Aspects of Cancer introduces a novel concept that suggests that selective enhancement of free radical generation in tumor cells could form a strategy to induce apoptosis of cancer cells employing bioactive lipids. It presents a new method of treatment of cancer using in vitro, in vivo and clinical data. This book will interest oncologists, scientists, molecular biologists, life scientists.

Nitric Oxide

Nitric Oxide Book
Author : Louis J. Ignarro
Publisher : Academic Press
Release : 2009-11-05
ISBN : 9780080920443
Language : En, Es, Fr & De

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Book Description :

Nitric oxide (NO) is a gas naturally found in the body that conveys information between cells. In the last decade researchers have found that NO is a signaling molecule of key importance for the cardiovascular system, regulating blood pressure and blood flow to different organs. In addition, discoveries surrounding nitric oxide’s role as a principal neurotransmitter moderating erectile function, a pathophysiological negotiator and messenger in inflammation, and a weapon against infections have increased research attention across the fields of biochemistry, chemistry, molecular biology, gene therapy, cell biology, immunology, pharmacology, neuroscience, and physiology. Edited by Nobel Laureate Louis J. Ignarro Up-to-date therapeutic implications of nitric oxide research Authored by world experts on nitric oxide Detailed research of the biochemistry and synthesis of nitric oxide

L Arginine in Clinical Nutrition

L Arginine in Clinical Nutrition Book
Author : Vinood B. Patel,Victor R. Preedy,Rajkumar Rajendram
Publisher : Humana Press
Release : 2016-08-23
ISBN : 331926009X
Language : En, Es, Fr & De

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Book Description :

This text presents the application of current nutritional knowledge by physicians and dietitians and incorporates emerging fields of science and important discoveries. It contains seven major sections. Section 1: Basic Processes at the Cellular Levels, Section 2: Arginine Metabolism and Functions, Section 3: Arginine Status in Cells Related to Organ Damage and Disease, Section 4: Arginine Status and Use in Healthy Individuals, Section 5: Arginine and Diseases of the Gastrointestinal Tract, Section 6: Therapeutic uses of Arginine: Diabetes, Obesity and Cardiovascular Diseases and Section 7: Therapeutic Uses of Arginine: Cancer, Wound Healing and Infectious Disease. Written by authors of international and national standing, leaders in the field and trendsetters, Arginine in Clinical Nutrition is essential reading for nutritionists and dietitians, public health scientists, doctors, epidemiologists, health care professionals of various disciplines, policy makers and marketing and economic strategists.

Oxidative Stress Inflammation and Angiogenesis in the Metabolic Syndrome

Oxidative Stress  Inflammation and Angiogenesis in the Metabolic Syndrome Book
Author : Raquel Soares,Carla Costa
Publisher : Springer Science & Business Media
Release : 2009-02-25
ISBN : 1402097018
Language : En, Es, Fr & De

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Book Description :

Metabolic Syndrome (MS) is a highly prevalent condition in developed countries and is a cluster of several risk factors for type 2 diabetes and cardiovascular disease that includes increased body mass index/waist circumference, visceral obesity, insulin resistance, hyperclycaemia, dyslipidaemia and hypertension, which are all major causes of morbidity and death. This volume provides a critical review and discussion of the knowledge gathered on MS and analyzes the interplay between oxidative stress, chronic inflammation and angiogenesis features. There is a special focus on recent discoveries and progress toward possible therapeutic strategies, such as the role of glucose transporters within MS; the effects of polyphenols as anti-oxidant, anti-inflammatory and anti-angiogenic compounds. The role of NFkB, nitric oxide synthases, hypoxia-inducible factors, and many other molecules that play a part in the development of oxidative stress and inflammation as well as angiogenesis is also covered. This book fills the gap between basic science and medical care, and provides the reader with the skills to apply rigorous basic science to clinical settings of metabolic syndrome-associated disorders.

Prognostic and Therapeutic Applications of Rkip in Cancer

Prognostic and Therapeutic Applications of Rkip in Cancer Book
Author : Benjamin Bonavida,Stavroula Baritaki
Publisher : Academic Press
Release : 2020-03-02
ISBN : 0128196122
Language : En, Es, Fr & De

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Book Description :

Prognostic and Therapeutic Applications of RKIP in Cancer provides updated reviews on the chemistry, signaling, pre-clinical and clinical activities, and role of RKIP expression levels for diagnostics, prognosis and potential interventions. The development of novel compounds and conjugates that selectively induce RKIP expression in cancer open a novel era of new therapeutics and their potential in the treatment of highly resistant cancers and metastases. Edited and written by internationally renowned experts in the field of novel therapeutics for cancer, this book is a valuable source for cancer researchers, medical scientists, clinicians, clinical pharmacologists, and graduate students. Provides an update from experts in the field on diagnostics, prognostics and therapeutics Brings a clear overview of recent findings and references, as well as summaries, significant molecular pathways, and conclusions in each chapter Provides a general introductory chapter on contributions in the field and a chapter summary, with synthesized findings and a projection of future goals

The regulation of angiogenesis by tissue cell macrophage interactions

The regulation of angiogenesis by tissue cell macrophage interactions Book
Author : Michal Amit Rahat,Bernhard Hemmerlein,Vijaya Iragavarapu-Charyulu
Publisher : Frontiers E-books
Release : 2014-11-03
ISBN : 2889193179
Language : En, Es, Fr & De

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Book Description :

Angiogenesis is the physiological process where new blood vessels grow from existing ones, in order to replenish tissues suffering from inadequate blood supply. Perhaps the most studied angiogenic process occurs in solid tumors whose growing mass and expanding cells create a constant demand for additional supply of oxygen and nutrients for survival. However, other physiological and clinical conditions, such as wound healing, ischemic events, autoimmune and age-related diseases also involve angiogenesis. Angiogenesis is a well-structured process that begins when oxygen and nutrients are depleted, leading to the release of chemokines and growth factors that attract immune cells, particularly macrophages and endothelial cells to the site. Macrophages that are recruited to the site, as well as tissue cells and endothelial cells, secrete pro-angiogenic mediators that affect endothelial cells and promote angiogenesis. These mediators include growth factors such as vascular endothelial cell growth factor (VEGF), matrix metalloproteinases (MMPs), as well as low levels of mediators that are usually seen as pro-inflammatory but are pro-angiogenic when secreted in low levels (e.g. nitric oxide (NO) and TNFa). Thus, macrophages play a major role in angiogenesis. Macrophages exhibit high plasticity and are capable of shifting between different activation modes and functions according to their changing microenvironment. Small differences in the composition of activating factors (e.g. TLR ligands such as LPS, anti-inflammatory cytokines, ECM molecules) in the microenvironment may differently activate macrophages to yield classically activated macrophages (or M1 macrophages) that can kill pathogen and tumor cells, alternatively activated macrophages (or M2 macrophages) that secrete antiinflammatory cytokines, resolution macrophages (rM?) that are involved in the resolution of inflammation, or regulatory macrophages (e.g. Myeloid-Derived Suppressor Cells - MDSCs) that control the function of other immune cells. In fact, macrophages may be activated in a spectrum of subsets that may differently contribute to angiogenesis, and in particular non-classically activated macrophages such as tumor-associated macrophages (TAMs) and Tie2-expressing monocytes (TEMs) can secrete high amounts of pro-angiogenic factors (e.g. VEGF, MMPs) or low levels of pro-inflammatory mediators (e.g. NO or TNFa) resulting in pro-angiogenic effects. Although the importance of macrophages as major contributors and regulators of the angiogenic process is well documented, less is known about the interactions between macrophages and other cell types (e.g. tumor cells, normal epithelial cells, endothelial cells) that regulate angiogenesis. We still have only limited understanding which proteins or complexes mediate these interactions and whether they require cell-cell contact (e.g. through integrins) or soluble factors (e.g. the EGF-CSF-1 loop), which signaling pathways are triggered in each of the two corresponding cell types, and how this leads to secretion of pro- or antiangiogenic factors in the microenvironment. The regulation of such interactions and through them of angiogenesis, whether through post-translational modifications of proteins or via the involvement of microRNA, is still unclear. The goal of this Research Topic is to highlight these interactions and their regulation in the context of both physiological and pathological conditions.

Melatonin

Melatonin Book
Author : Venkatramanujan Srinivasan,Gabriella Gobbi,Samuel D. Shillcutt,Sibel Suzen
Publisher : CRC Press
Release : 2014-10-15
ISBN : 1482220091
Language : En, Es, Fr & De

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Book Description :

There is growing interest in the field of melatonin research regarding its neurobiological mechanisms as well as its repercussions in clinical practice. Melatonin: Therapeutic Value and Neuroprotection explores melatonin’s neuroprotective effects and discusses the therapeutic potential of melatonin and melatonin agonists in treating neurodegenerative diseases and other ailments. Topics include: The basic aspects of melatonin’s physiology, including its production, bioavailability, and metabolism The functional importance of melatonin receptors and their role in mediating the therapeutic effectiveness of melatonin in cancer Melatonin’s effect on the regulation of blood pressure, sleep, and circadian rhythms The cardioprotective role of melatonin The neuroprotective role in glaucoma, Alzheimer’s disease, Parkinson’s disease, and neurodegenerative diseases Use as a therapeutic agent for treating epilepsy and degenerative discs Treatment for obesity, diabetes mellitus, and other metabolic disorders Protective role in peri-natal hypoxic-ischemia The contributors also examine the discovery of a number of melatonergic agonists, their potential role as antioxidants, and their therapeutic applications in treating glaucoma, Parkinson’s disease, Alzheimer’s disease, primary insomnia, and psychiatric disorders. Opening new vistas in our understanding of etiology, pharmacotherapy, and treatment, the book is a significant milestone in our knowledge about advances in melatonin’s physiology and its therapeutic application in a number of disorders.

Pathophysiology and Clinical Applications of Nitric Oxide

Pathophysiology and Clinical Applications of Nitric Oxide Book
Author : Gabor M. Rubanyi
Publisher : CRC Press
Release : 2003-09-02
ISBN : 0203303725
Language : En, Es, Fr & De

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Book Description :

Research on the key mediator nitric oxide has increased exponentially over the last ten years. It is now clear that, in addition to its role within the cardiovascular system, this mediator is also implicated in the normal physiological function and disease pathology of several organs and systems. A number of the fundamental research observations are now being developed into therapeutic principles and these are being pursued through clinical trials. This is the first work summarizing, in its two volumes, the quantum leap from basic science to clinical applications emerging from this decade of research.

Biomarkers as Targeted Herbal Drug Discovery

Biomarkers as Targeted Herbal Drug Discovery Book
Author : Mahfoozur Rahman,Sarwar Beg,Mazin A. Zamzami,Hani Choudhry,Aftab Ahmad,Khalid S. Alharbi
Publisher : CRC Press
Release : 2021-07-05
ISBN : 1000067556
Language : En, Es, Fr & De

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Book Description :

This new volume looks at the applications of biomarkers as important tools for herbal drug discovery, presenting research on phytoconstituents with advanced nanotechnological applications for healthcare benefits. Herbal drug discovery based on biomarkers is an emerging area in complementary and alternative medicine that has tremendous potential in healthcare. Conventional medications have limited efficacy and high toxicity, whereas herbal drugs are said to provide wide structural diversity that is not usually seen with conventional/synthetic drug molecules. Recognition of various herbal constituents, such as terpenoids, fatty acids, flavonoids and steroids, are well explored in the management and treatment of various disorders in this volume. These agents target various biomarkers such as nitric oxide (NO), cytokines, chemokines, adhesion molecules, NF- kβ, lipoxygenase (LOX), and arachidonic acid. Biomarkers as Targeted Herbal Drug Discovery: A Pharmacological Approach to Nanomedicines discusses phytoconstituent-based nanotherapeutics with applications for some specific health issues, such as arthritis, leishmanicidal, cardiovascular diseases, cancer, ocular disorders, etc.

Molecular Targets and Therapeutic Uses of Spices

Molecular Targets and Therapeutic Uses of Spices Book
Author : Bharat B. Aggarwal,Ajaikumar B. Kunnumakkara
Publisher : World Scientific
Release : 2009
ISBN : 9812837906
Language : En, Es, Fr & De

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Book Description :

Traditional uses of spices : an overview / Ajaikumar B. Kunnumakkara ... [et al.] -- Black pepper (Piper nigrum) and its bioactive compound, piperine / Krishnapura Srinivasan -- Cardamom (Elettaria cardamomum) and its active constituent, 1,8-cineole / Archana Sengupta and Shamee Bhattacharjee -- Molecular targets and health benefits of cinnamon / Kiran Panickar ... [et al.] -- Cloves (eugenol) / Yoshinori Kadoma ... [et al.] -- Coriander / Sanjeev Shukla and Sanjay Gupta -- Fenugreek (diosgenin) / Jayadev Raju and Chinthalapally V. Rao -- Diallyl sulfide from garlic / Girija Kuttan and Punathil Thejass -- Ginger (6-gingerol) / Nidhi Nigam, Jasmine George, and Yogeshwer Shukla -- Kalonji (thymoquinone) / Ahmed O. Kaseb and Abdel-Hafez A. Selim -- Kokum (garcinol) / Manoj K. Pandey, Ajaikumar B. Kunnumakkara, and Bharat B. Aggarwal -- Capsaicin : a hot spice in the chemoprevention of cancer / Joydeb Kumar Kundu and Young-Joon Surh -- Rosemary (rosmarinic acid) / Jongsung Lee ... [et al.] -- Mint and its constituents / Ajaikumar B. Kunnumakkara ... [et al.] -- Turmeric (curcumin) / Jen-Kun Lin and Shoei-Yn Lin Shiau.

Cumulated Index Medicus

Cumulated Index Medicus Book
Author : Anonim
Publisher : Unknown
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Cumulated Index Medicus book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biomarkers as Targeted Herbal Drug Discovery

Biomarkers as Targeted Herbal Drug Discovery Book
Author : Mahfoozur Rahman,Sarwar Beg,Mazin A. Zamzami,Hani Choudhry,Aftab Ahmad,Khalid S. Alharbi
Publisher : CRC Press
Release : 2021-07-05
ISBN : 1000067513
Language : En, Es, Fr & De

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Book Description :

This new volume looks at the applications of biomarkers as important tools for herbal drug discovery, presenting research on phytoconstituents with advanced nanotechnological applications for healthcare benefits. Herbal drug discovery based on biomarkers is an emerging area in complementary and alternative medicine that has tremendous potential in healthcare. Conventional medications have limited efficacy and high toxicity, whereas herbal drugs are said to provide wide structural diversity that is not usually seen with conventional/synthetic drug molecules. Recognition of various herbal constituents, such as terpenoids, fatty acids, flavonoids and steroids, are well explored in the management and treatment of various disorders in this volume. These agents target various biomarkers such as nitric oxide (NO), cytokines, chemokines, adhesion molecules, NF- kβ, lipoxygenase (LOX), and arachidonic acid. Biomarkers as Targeted Herbal Drug Discovery: A Pharmacological Approach to Nanomedicines discusses phytoconstituent-based nanotherapeutics with applications for some specific health issues, such as arthritis, leishmanicidal, cardiovascular diseases, cancer, ocular disorders, etc.

Transforming Growth Factor Beta in Cancer Therapy Volume I

Transforming Growth Factor Beta in Cancer Therapy  Volume I Book
Author : Sonia B. Jakowlew
Publisher : Springer Science & Business Media
Release : 2008-02-28
ISBN : 1588297144
Language : En, Es, Fr & De

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Book Description :

Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. This volume’s companion, Cancer Treatment in Therapy, examines transforming growth factor- ß in other developing and advanced cancers and methods of treatment and therapy.