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The Zebrafish In Biomedical Research

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The Zebrafish in Biomedical Research

The Zebrafish in Biomedical Research Book
Author : Samuel Cartner,Judith S. Eisen,Susan F. Farmer,Karen J. Guillemin,Michael L. Kent,George E. Sanders
Publisher : Academic Press
Release : 2019-11-22
ISBN : 0128124326
Language : En, Es, Fr & De

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Book Description :

The Zebrafish in Biomedical Research: Biology, Husbandry, Diseases, and Research Applications is a comprehensive work that fulfills a critical need for a thorough compilation of information on this species. The text provides significant updates for working vivarium professionals maintaining zebrafish colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators using the species to gain critical insights into human physiology and disease. As the zebrafish has become an important model organism for the study of vertebrate development and disease, organ function, behavior, toxicology, cancer, and drug discovery, this book presents an important resource for future research. Presents a complete view of the zebrafish, covering their biology, husbandry, diseases and research applications Includes the work of world-renowned authors Provides the first authoritative and comprehensive treatment of zebrafish in biomedical research as part of the ACLAM series

Zebrafish in Biomedical Research

Zebrafish in Biomedical Research Book
Author : Yusuf Bozkurt
Publisher : Unknown
Release : 2020-03
ISBN : 9781789859850
Language : En, Es, Fr & De

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Book Description :

Download Zebrafish in Biomedical Research book written by Yusuf Bozkurt, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Laboratory Fish in Biomedical Research

Laboratory Fish in Biomedical Research Book
Author : Livia d'Angelo,Paolo de Girolamo
Publisher : Academic Press
Release : 2021-09-18
ISBN : 9780128210994
Language : En, Es, Fr & De

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Book Description :

Fish, and particularly zebrafish, have become the fastest-growing segment of the research population. They offer several advantages, in terms of biology and technologies to apply, and thus are employed in numerous research fields. Laboratory Fish in Biomedical Research: Biology, Husbandry and Research Applications for Zebrafish, Medaka, Killifish, Swordtail Fish, Cavefish, Stickleback, Goldfish and Danionella Translucida addresses the relevant and increasing need to collect cutting-edge knowledge on husbandry, maintenance, welfare and experimental protocols of the most common freshwater species under standard laboratory conditions. Provides husbandry and management protocols, devices and water systems Shows strength and weakness of breeding Explores potential scientific applications and experimental protocols. with regards to the most used freshwater fish used for scientific purposes

Sourcebook of Models for Biomedical Research

Sourcebook of Models for Biomedical Research Book
Author : P. Michael Conn
Publisher : Springer Science & Business Media
Release : 2008
ISBN : 1588299333
Language : En, Es, Fr & De

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Book Description :

The collection of systems represented in this volume is a unique effort to reflect the diversity and utility of models used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. This volume is therefore a comprehensive and extensive collection of these important medical parallels.

Embryonic and Larval Zebrafish Bioassays for Biomedical Research

Embryonic and Larval Zebrafish Bioassays for Biomedical Research Book
Author : Joseph A. Fisher
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Laboratories around the world are using the zebrafish model for biomedical research and conducting investigations using morphological, physiological, behavioral, and genomic endpoints. All assays provide information, but physiological and behavioral endpoints or phenotypes are a fast way to understand how an animal is responding to its environment. We investigate the zebrafish model and its relevant assays with particular focus on the photomotor response screening assays. Behavioral time series data is often non-Gaussian distributed and presents a challenge for valid statistical analysis. As such, we have developed both single measure (SM) and repeated measure (RM) nonparametric permutation methods, and compared them to traditional parametric and nonparametric methods. Our proposed methods are sensible for both the zebrafish embryonic photomotor response (EPR) and larval photomotor response (LPR) locomotor screening assays, and they integrate with other zebrafish assays. The SM permutation test does notpreserve the time series aspect of the data, while the RM permutation test does. Both tests provide robust methods for the analysis of in vivo chemical hazard identification in a high throughput research environment.

Laboratory Fish in Biomedical Research

Laboratory Fish in Biomedical Research Book
Author : Livia d'Angelo,Paolo de Girolamo
Publisher : Academic Press
Release : 2021-09-04
ISBN : 0128212144
Language : En, Es, Fr & De

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Book Description :

Fish, and particularly zebrafish, have become the fastest-growing segment of the research population. They offer several advantages, in terms of biology and technologies to apply, and thus are employed in numerous research fields. Laboratory Fish in Biomedical Research: Biology, Husbandry and Research Applications for Zebrafish, Medaka, Killifish, Swordtail Fish, Cavefish, Stickleback, Goldfish and Danionella Translucida addresses the relevant and increasing need to collect cutting-edge knowledge on husbandry, maintenance, welfare and experimental protocols of the most common freshwater species under standard laboratory conditions. Provides husbandry and management protocols, devices and water systems; Shows strength and weakness of breeding; Explores potential scientific applications and experimental protocols. with regards to the most used freshwater fish used for scientific purposes.

Advancements of Mass Spectrometry in Biomedical Research

Advancements of Mass Spectrometry in Biomedical Research Book
Author : Alisa G. Woods,Costel C. Darie
Publisher : Springer
Release : 2014-06-20
ISBN : 3319060686
Language : En, Es, Fr & De

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Book Description :

This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease and psychiatry. Additional chapters focus on methodology as well as new technologies and instrumentation. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research but also to initiate and improve their own work. Thus the book acts as a technical guide but also a conceptual guide to the newest information in this exciting field. Mass spectrometry is the central tool used in proteomic research today and is rapidly becoming indispensable to the biomedical scientist. With the completion of the human genome project and the genomic revolution, the proteomic revolution has followed closely behind. Understanding the human proteome has become critical to basic and clinical biomedical research and holds the promise of providing comprehensive understanding of human physiological processes. In addition, proteomics and mass spectrometry are bringing unprecedented biomarker discovery and are helping to personalize medicine.

Advances in Biomedical Sciences and Engineering

Advances in Biomedical Sciences and Engineering Book
Author : S. C. Tjong
Publisher : Bentham Science Publishers
Release : 2010-06-10
ISBN : 1608050408
Language : En, Es, Fr & De

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Book Description :

"This authoritative reference provides updated information on the fundamental aspects and applications of biomaterials and biomedical sciences. It includes nickel-titanium alloys with superelasticity and shape memory effect, bioactive bone cement for ortho"

Zebrafish Protocols for Neurobehavioral Research

Zebrafish Protocols for Neurobehavioral Research Book
Author : Allan V. Kalueff, Laporte,Adam Michael Stewart
Publisher : Humana Press
Release : 2016-05-01
ISBN : 9781493960026
Language : En, Es, Fr & De

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Book Description :

Zebrafish play an integral role in biomedical research, enabling scientists to examine physiological mechanisms and pathways relevant to human pathogenesis and its therapy. Written by experts, this volume sets out protocols for both larval and adult models.

Stem Cell Genetics for Biomedical Research

Stem Cell Genetics for Biomedical Research Book
Author : Raul Delgado-Morales
Publisher : Springer
Release : 2018-06-27
ISBN : 331990695X
Language : En, Es, Fr & De

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Book Description :

This book looks at where stem cell technology is presently and how it is instrumental in advancing the field of disease modeling and cell transplantation. By focusing on major human disorders such as Alzheimer’s disease, cancer, and heart disorders, the book summarizes the major findings in the field of human stem cells and dissect the current limitations on our understanding of stem cells biology. The chapters focus on the genetics, genomics, epigenetics and physiology of stem cells models, together with technological advances on molecular biology such as CRISPR/Cas9 or epigenetic editing, that will be instrumental in the future of human disease modeling and treatment. In base of the limitations of current disease models and in front of the unmet necessity of finding therapeutical interventions for human disorders, the availability of stem cell technology has opened new doors for several fields. The unlimited self-renewal capacity and more extensive differentiation potential of stem cells offers a theoretically inexhaustible and replenishable source of any cell subtype. Since Professor Shinya Yamanaka described it, 10 years ago in his seminal paper, that somatic cells could be reprogrammed to inducible stem cells (iPSC) just by expressing four transcription factors, the field of has exploded, especially its applications in biomedical research.

Nonhuman Primates in Biomedical Research

Nonhuman Primates in Biomedical Research Book
Author : Christian R. Abee,Keith Mansfield,Suzette D. Tardif,Timothy Morris
Publisher : Academic Press
Release : 2012-06-07
ISBN : 0123978386
Language : En, Es, Fr & De

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Book Description :

The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The Diseases volume provides thorough reviews of naturally occurring diseases of nonhuman primates, with a section on biomedical models reviewing contemporary nonhuman primate models of human diseases. Each chapter contains an extensive list of bibliographic references, photographs, and graphic illustrations to provide the reader with a thorough review of the subject. Fully revised and updated, providing researchers with the most comprehensive review of the use of nonhuman primates in bioledical research Addresses commonly used nonhuman primate biomedical models, providing researchers with species-specific information Includes four color images throughout

Logic and Critical Thinking in the Biomedical Sciences

Logic and Critical Thinking in the Biomedical Sciences Book
Author : Jules J. Berman
Publisher : Academic Press
Release : 2020-07-03
ISBN : 012821371X
Language : En, Es, Fr & De

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Book Description :

Science is not a collection of facts. Science is the process by which we draw inferences from facts. Volume I of Logic and Critical Thinking in the Biomedical Sciences invites readers to linger over a collection of common observations to see what inferences can be drawn, when one applies a bit of deductive logic. If we just think about what we observe, it is often possible to discover profound biomedical insights. Volumes 1 and 2 of Logic and Critical Thinking in the Biomedical Sciences are written for biomedical scientists and college-level students engaged in any of the life sciences, including bioinformatics and related data sciences. Provides a strong introduction to deductive methods that can be directly applied to the biomedical sciences Using hundreds of examples, shows how creative scientists draw important inferences from observations that are often ignored by their peers Discusses complex biological and medical concepts in a relaxed manner, intended to focus the reader’s attention on the deductive process, without dwelling excessively on details

The Experimental Animal in Biomedical Research

The Experimental Animal in Biomedical Research Book
Author : Bernard E. Rollin
Publisher : CRC Press
Release : 1995-03-13
ISBN : 9780849349829
Language : En, Es, Fr & De

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Book Description :

This volume focuses on considerations that maximize both scientific benefit and animal well-being for major species of animals used in biomedical research. Each species is discussed in terms of uses in research; basic biology; husbandry requirements; proper handling; disease control; anesthesia, analgesia, and stress control; natural behavior, behavioral needs, psychological needs, and social needs; and ideal environment for the animals. This book is a must for anyone working with experimental animals.

Biomedical Research

Biomedical Research Book
Author : G. Jagadeesh
Publisher : Wolters kluwer india Pvt Ltd
Release : 2019-01-01
ISBN : 8184732007
Language : En, Es, Fr & De

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Book Description :

Specially designed for aspiring researchers, this book presents a systematic exposition of the basic principles and methodologies involved in biomedical research. The book covers the entire research process from the conception of an idea, its development, investigation and execution and finally to its publication. Various research methodologies including study design and statistical approaches to data analysis are also discussed in detail. The importance of ethics and integrity in research is highlighted extensively. In addition, the book discusses relevant issues relating to the commercialization of research innovations and outlines the steps necessary for successful entrepreneurship.

Challenges and Opportunities of Next Generation Sequencing for Biomedical Research

Challenges and Opportunities of Next Generation Sequencing for Biomedical Research Book
Author : Anonim
Publisher : Academic Press
Release : 2012-10-04
ISBN : 0123982731
Language : En, Es, Fr & De

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Book Description :

Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. This volume features articles on Challenges and Opportunities of Next-Generation Sequencing for Biomedical Research. Covers reviews of methodology and research in all aspects of protein chemistry Brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics

Model Organisms in Drug Discovery

Model Organisms in Drug Discovery Book
Author : Pamela M. Carroll,Kevin Fitzgerald
Publisher : John Wiley & Sons
Release : 2003-11-21
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Fruit flies are "little people with wings" goes the saying in the scientific community, ever since the completion of the Human Genome Project and its revelations about the similarity amongst the genomes of different organisms. It is humbling that most signalling pathways which "define" humans are conserved in Drosophila, the common fruit fly. Feed a fruit fly caffeine and it has trouble falling asleep; feed it antihistamines and it cannot stay awake. A C. elegans worm placed on the antidepressant flouxetine has increased serotonin levels in its tiny brain. Yeast treated with chemotherapeutics stop their cell division. Removal of a single gene from a mouse or zebrafish can cause the animals to develop Alzheimer’s disease or heart disease. These organisms are utilized as surrogates to investigate the function and design of complex human biological systems. Advances in bioinformatics, proteomics, automation technologies and their application to model organism systems now occur on an industrial scale. The integration of model systems into the drug discovery process, the speed of the tools, and the in vivo validation data that these models can provide, will clearly help definition of disease biology and high-quality target validation. Enhanced target selection will lead to the more efficacious and less toxic therapeutic compounds of the future. Leading experts in the field provide detailed accounts of model organism research that have impacted on specific therapeutic areas and they examine state-of-the-art applications of model systems, describing real life applications and their possible impact in the future. This book will be of interest to geneticists, bioinformaticians, pharmacologists, molecular biologists and people working in the pharmaceutical industry, particularly genomics.

The Mouse in Biomedical Research

The Mouse in Biomedical Research Book
Author : Anonim
Publisher : Elsevier
Release : 2006-12-04
ISBN : 9780080469065
Language : En, Es, Fr & De

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Book Description :

History, Wild Mice, and Genetics, the first volume in the four volume set, The Mouse in Biomedical Research, provides information about the history, biology and genomics of the laboratory mouse (Mus musculus), as well as basic information on maintenance and use of mouse stocks. Mouse origins and relationships are covered in chapters on history, evolutionary taxonomy and wild mice. Genetics and genomics of the mouse are covered in chapters on genetic nomenclature, gene mapping, cytogenetics and the molecular organization of the mouse genome. Maintenance of laboratory mice is described in chapters on breeding systems for various types of strains and stocks and genetic monitoring. Use of the mouse as a model system for basic biomedical research is described in chapters on chemical mutagenesis, gene trapping, pharmacogenetics and embryo manipulation. The information in Volume 1 serves as a primer for scientists new to the field of mouse research.

Nanotechnology for Environmental and Biomedical Research

Nanotechnology for Environmental and Biomedical Research Book
Author : Giada Frenzilli
Publisher : MDPI
Release : 2021-05-26
ISBN : 3036507183
Language : En, Es, Fr & De

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Book Description :

Do you care about your environment and your health? Contamination by hazardous substances in environmental matrices, including landfills, oil fields, and manufacturing and industrial sites, represents a global concern and needs to be remediated since it poses a serious risk to the environment and human health. Particular attention should also be paid to the use of medical devices and recent developments in the use of nanoparticles expressed as drug delivery systems designed to treat a wide variety of diseases. This Special Issue collects a compilation of articles that strongly demonstrate the continuous efforts made in developing advanced and safe nanomaterial-based technologies for nano-remediation and for drug delivery and other biomedical applications. It covers the most recent advances in the safe nanomaterials synthesis field as well as in environmental applications, in the use of restorative materials, drug delivery and other clinical applications, in order to lay the foundations for a cleaner and healthier future.

Animal centric Care and Management

Animal centric Care and Management Book
Author : Dorte Bratbo Sørensen,Sylvie Cloutier,Brianna N. Gaskill
Publisher : CRC Press
Release : 2020-10-14
ISBN : 0429602057
Language : En, Es, Fr & De

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Book Description :

The concept of the 3Rs (Refinement, Reduction and Replacement) has been used as a framework for improving the welfare of laboratory animals for the last half century. By establishing an animal-centric view on housing and management, Animal-centric Care and Management: Enhancing Refinement in Biomedical Research takes Russell and Burch’s definition of Refinement as "elimination of inhumanities" and goes further. Rather than fitting animals into experimental conditions, it encourages readers to adjust conditions to better meet the behavioral, emotional, physical, and physiological needs and preferences of the animals. The team of expert authors, from the fields of laboratory animal science, ethology, biology as well as animal training, provide ideas for creating housing conditions and handling procedures that induce, to the best of current abilities and knowledge, a long-term positive state of mind in the animals under our care. This book is written for animal caretakers, animal health technicians, researchers, animal facility managers, laboratory animal veterinarians, and anyone who engages in work with living experimental animals or is interested in the continuous improvement of laboratory animal welfare. This interdisciplinary guide will act as a catalyst, resulting in multiple viewpoints and fields collaborating to optimize laboratory animal welfare.