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The World of Nano Biomechanics

The World of Nano Biomechanics Book
Author : Atsushi Ikai
Publisher : Elsevier
Release : 2016-12-15
ISBN : 9780444636867
Language : En, Es, Fr & De

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Book Description :

"The World of Nano-Biomechanics, Second Edition, "focuses on the remarkable progress in the application of force spectroscopy to molecular and cellular biology that has occurred since the book's first edition in 2008. The initial excitement of seeing and touching a single molecule of protein/DNA is now culminating in the development of various ways to manipulate molecules and cells almost at our fingertips, enabling live cell operations. Topics include the development of molecular biosensors, mechanical diagnosis, cellular-level wound healing, and a look into the advances that have been made in our understanding of the significance of mechanical rigidity/flexibility of protein/DNA structure for the manifestation of biological activities. The book begins with a summary of the results of basic mechanics to help readers who are unfamiliar with engineering mechanics. Then, representative results obtained on biological macromolecules and structures, such as proteins, DNA, RNA, polysaccharides, lipid membranes, sub-cellular organelles, and live cells are discussed. New to this second edition are recent developments in two important applications, i.e., high-resolution mechanical biosensors and the use of cell mechanics for medical diagnosis. Fully revised and expanded new edition based on the latest research and developments in the fieldExplains the basic physical concepts and mathematics of elementary mechanics needed to understand and perform experimental work Presents recent developments of force-based biosensorsIncludes novel applications of nano-biomechanics to the medical field

The World of Nano Biomechanics

The World of Nano Biomechanics Book
Author : Atsushi Ikai
Publisher : Elsevier
Release : 2007-11-02
ISBN : 9780080556048
Language : En, Es, Fr & De

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Book Description :

By using nanotechnological methods, we can now poke around protein molecules, genes, membranes, cells and more. Observation of such entities through optical and electron microscopes tempt us to touch and manipulate them. It is now possible to do so, and scientists around the world have started pulling, pushing and cutting small structures at the base of life processes to understand the effect of our hand work. The book describes the physical properties of such life supporting structures from the molecular level with a special emphasis on their designs based on the mechanical strength and flexibility, membrane and other biological nanostructures. - Describes the basic mechanical features of proteins, DNA, cell membrane and other biological nanostructures - Explains the basic concepts and mathematics of elementary mechanics needed to understand and perform experimental work

Integrated Nano Biomechanics

Integrated Nano Biomechanics Book
Author : Takami Yamaguchi,Takuji Ishikawa,Yohsuke Imai
Publisher : William Andrew
Release : 2018-06-27
ISBN : 0323389597
Language : En, Es, Fr & De

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Book Description :

Integrated Nano-Biomechanics provides an integrated look into the rapidly evolving field of nanobiomechanics. The book demystifies the processes in living organisms at the micro- and nano-scale through mechanics, using theoretical, computational and experimental means. The book develops the concept of integrating different technologies along the hierarchical structure of biological systems and clarifies biomechanical interactions among different levels for the analysis of multi-scale pathophysiological phenomena. With a focus on nano-scale processes and biomedical applications, it is shown how knowledge obtained can be utilized in a range of areas, including diagnosis and treatment of various human diseases and alternative energy production. This book is based on collaboration of researchers from a unique combination of fields, including biomechanics, computational mechanics, GPU application, electron microscopy, biology of motile micro-organisms, entomological mechanics and clinical medicine. The book will be of great interest to scientists and researchers involved in disciplines, such as micro- and nano-engineering, bionanotechnology, biomedical engineering, micro- and nano-scale fluid-mechanics (such as in MEMS devices), nanomedicine and microbiology, as well as industries such as optical devices, computer simulation, plant based energy sources and clinical diagnosis of the gastric diseases. Provides knowledge of integrated biomechanics, focusing on nano-scale, in this rapidly growing research field Explains how the different technologies can be integrated and applied in a variety of biomedical application fields, as well as for alternative energy sources Uses a collaborative, multidisciplinary approach to provide a comprehensive coverage of nano-biomechanics

Nano Biomedical Engineering 2012

Nano Biomedical Engineering 2012 Book
Author : Takami Yamaguchi
Publisher : World Scientific
Release : 2012-02-14
ISBN : 1848169280
Language : En, Es, Fr & De

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Book Description :

This book focuses on nano-biomedical engineering, the most important key technology in the world in the 21st century. It covers virtually everything within current and future research and the development of biomedical engineering. It follows four groups within the field, namely nano-biomechanics, nano-bioimaging, nano-biodevices, and nano-biointervention. Contents: Nano-BiomechanicsNano-BioimagingNano-BiodevicesNano-Biointervention Readership: Biomedical engineers of various disciplines; medical doctors (cardiovascular medicine and surgery, cerebral medicine and surgery, ONF, oncology). Keywords:Biomedical Engineering;Nanotechnology;Biomechanics;Cellular Physiology;Computational Simulation;Nano-Imaging;Molecular Imaging;Image Based Medicine;Medical RoboticsKey Features:Comprehensive introduction of the Tohoku University Global COE ProgrammeIntegrated research and education collaboration between engineering and medicineJapan's top level research promotion in the field of nano-biomedical engineering

Nano biomedical Engineering 2009

Nano biomedical Engineering 2009 Book
Author : Takami Yamaguchi
Publisher : World Scientific
Release : 2009
ISBN : 1848163525
Language : En, Es, Fr & De

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Book Description :

This proceedings volume details both current and future research and development initiatives in nano-biomedical engineering, arguably the most important technology of the world in the 21st century. It deals with the following four groups of nano-biomedical engineering: nano-biomechanics, nano-bioimaging, nano-biodevices, and nano-biointervention. Consisting of a compilation of studies conducted by group members of the Tohoku University Global Center of Excellence Program, with specially coordinated funding from the Japanese Government, the papers emphasize the integration of research and education collaboration between engineering and medicine, and showcase Japan's top-level research in the field of nano-biomedical engineering.

Emerging ICT for Bridging the Future Proceedings of the 49th Annual Convention of the Computer Society of India CSI

Emerging ICT for Bridging the Future   Proceedings of the 49th Annual Convention of the Computer Society of India  CSI  Book
Author : Suresh Chandra Satapathy,A. Govardhan,K. Srujan Raju,J. K. Mandal
Publisher : Springer
Release : 2014-11-30
ISBN : 331913728X
Language : En, Es, Fr & De

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Book Description :

This volume contains 73 papers presented at CSI 2014: Emerging ICT for Bridging the Future: Proceedings of the 49th Annual Convention of Computer Society of India. The convention was held during 12-14, December, 2014 at Hyderabad, Telangana, India. This volume contains papers mainly focused on Fuzzy Systems, Image Processing, Software Engineering, Cyber Security and Digital Forensic, E-Commerce, Big Data, Cloud Computing and ICT applications.

Atomic Force Microscopy in Liquid

Atomic Force Microscopy in Liquid Book
Author : Arturo M. Baró,Ronald G. Reifenberger
Publisher : John Wiley & Sons
Release : 2012-08-01
ISBN : 3527649824
Language : En, Es, Fr & De

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Book Description :

About 40 % of current atomic force microscopy (AFM) research is performed in liquids, making liquid-based AFM a rapidly growing and important tool for the study of biological materials. This book focuses on the underlying principles and experimental aspects of AFM under liquid, with an easy-to-follow organization intended for new AFM scientists. The book also serves as an up-to-date review of new AFM techniques developed especially for biological samples. Aimed at physicists, materials scientists, biologists, analytical chemists, and medicinal chemists. An ideal reference book for libraries. From the contents: Part I: General Atomic Force Microscopy * AFM: Basic Concepts * Carbon Nanotube Tips in Atomic Force Microscopy with * Applications to Imaging in Liquid * Force Spectroscopy * Atomic Force Microscopy in Liquid * Fundamentals of AFM Cantilever Dynamics in Liquid * Environments * Single-Molecule Force Spectroscopy * High-Speed AFM for Observing Dynamic Processes in Liquid * Integration of AFM with Optical Microscopy Techniques Part II: Biological Applications * DNA and Protein-DNA Complexes * Single-Molecule Force Microscopy of Cellular Sensors * AFM-Based Single-Cell Force Spectroscopy * Nano-Surgical Manipulation of Living Cells with the AFM

Advanced Mechanical Models of DNA Elasticity

Advanced Mechanical Models of DNA Elasticity Book
Author : Yakov M Tseytlin
Publisher : Academic Press
Release : 2016-07-29
ISBN : 0128020369
Language : En, Es, Fr & De

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Book Description :

Advanced Mechanical Models of DNA Elasticity includes coverage on 17 different DNA models and the role of elasticity in biological functions with extensive references. The novel advanced helicoidal model described reflects the direct connection between the molecule helix structure and its specific properties, including nonlinear features and transitions. It provides an introduction to the state of the field of DNA mechanics, known and widely used models with their short analysis, as well as coverage on experimental methods and data, the influence of electrical, magnetic, ionic conditions on the persistence length, and dynamics with viscosity influence. It then addresses the need to understand the nature of the non-linear overstretching transition of DNA under force and why DNA has a negative twist-stretch coupling. Includes coverage of 17 contemporary models of DNA mechanics with analysis Provides comparison of DNA and RNA mechanical features Covers advances in experimental techniques including AFM, X-ray, and optical tweezers Contains extensive references for further reading

Human Musculoskeletal Biomechanics

Human Musculoskeletal Biomechanics Book
Author : Tarun Goswami
Publisher : BoD – Books on Demand
Release : 2012-01-05
ISBN : 9533076380
Language : En, Es, Fr & De

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Book Description :

This book covers many aspects of human musculoskeletal biomechanics. As the title represents, aspects of forces, motion, kinetics, kinematics, deformation, stress, and strain are examined for a range of topics such as human muscles, skeleton, and vascular biomechanics independently or in the presence of devices. Topics range from image processing to interpret range of motion and/or diseases, to subject specific temporomandibular joint, spinal units, braces to control scoliosis, hand functions, spine anthropometric analyses along with finite element analyses. Therefore, this book will be valuable to students at introductory level to researchers at MS and PhD level searching for science of specific muscle/vascular to skeletal biomechanics. This book will be an ideal text to keep for graduate students in biomedical engineering since it is available for free, students may want to make use of this opportunity. Those that are interested to participate in the future edition of this book, on the same topic, as a contributor please feel free to contact the author.

Advances in Biomechanics and Tissue Regeneration

Advances in Biomechanics and Tissue Regeneration Book
Author : Mohamed Hamdy Doweidar
Publisher : Academic Press
Release : 2019-08-13
ISBN : 012816610X
Language : En, Es, Fr & De

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Book Description :

Advances in Biomechanics and Tissue Regeneration covers a wide range of recent development and advances in the fields of biomechanics and tissue regeneration. It includes computational simulation, soft tissues, microfluidics, the cardiovascular system, experimental methods in biomechanics, mechanobiology and tissue regeneration. The state-of-the-art, theories and application are presented, making this book ideal for anyone who is deciding which direction to take their future research in this field. In addition, it is ideal for everyone who is exploring new fields or currently working on an interdisciplinary project in tissue biomechanics. Combines new trends in biomechanical modelling and tissue regeneration Offers a broad scope, covering the entire field of tissue biomechanics Contains perspectives from engineering, medicine and biology, thus giving a holistic view of the field

Elasticity in Engineering Mechanics

Elasticity in Engineering Mechanics Book
Author : Arthur P. Boresi,Ken Chong,James D. Lee
Publisher : John Wiley & Sons
Release : 2010-12-01
ISBN : 9780470880388
Language : En, Es, Fr & De

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Book Description :

Elasticity in Engineering Mechanics has been prized by many aspiring and practicing engineers as an easy-to-navigate guide to an area of engineering science that is fundamental to aeronautical, civil, and mechanical engineering, and to other branches of engineering. With its focus not only on elasticity theory, including nano- and biomechanics, but also on concrete applications in real engineering situations, this acclaimed work is a core text in a spectrum of courses at both the undergraduate and graduate levels, and a superior reference for engineering professionals.

Computer Models in Biomechanics

Computer Models in Biomechanics Book
Author : Gerhard A. Holzapfel,Ellen Kuhl
Publisher : Springer Science & Business Media
Release : 2012-10-16
ISBN : 9400754647
Language : En, Es, Fr & De

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Book Description :

This book contains a collection of papers that were presented at the IUTAM Symposium on “Computer Models in Biomechanics: From Nano to Macro” held at Stanford University, California, USA, from August 29 to September 2, 2011. It contains state-of-the-art papers on: - Protein and Cell Mechanics: coarse-grained model for unfolded proteins, collagen-proteoglycan structural interactions in the cornea, simulations of cell behavior on substrates - Muscle Mechanics: modeling approaches for Ca2+–regulated smooth muscle contraction, smooth muscle modeling using continuum thermodynamical frameworks, cross-bridge model describing the mechanoenergetics of actomyosin interaction, multiscale skeletal muscle modeling - Cardiovascular Mechanics: multiscale modeling of arterial adaptations by incorporating molecular mechanisms, cardiovascular tissue damage, dissection properties of aortic aneurysms, intracranial aneurysms, electromechanics of the heart, hemodynamic alterations associated with arterial remodeling following aortic coarctation, patient-specific surgery planning for the Fontan procedure - Multiphasic Models: solutes in hydrated biological tissues, reformulation of mixture theory-based poroelasticity for interstitial tissue growth, tumor therapies of brain tissue, remodeling of microcirculation in liver lobes, reactions, mass transport and mechanics of tumor growth, water transport modeling in the brain, crack modeling of swelling porous media - Morphogenesis, Biological Tissues and Organs: mechanisms of brain morphogenesis, micromechanical modeling of anterior cruciate ligaments, mechanical characterization of the human liver, in vivo validation of predictive models for bone remodeling and mechanobiology, bridging scales in respiratory mechanics

Fundamentals and Applications of Nano Silicon in Plasmonics and Fullerines

Fundamentals and Applications of Nano Silicon in Plasmonics and Fullerines Book
Author : Munir H. Nayfeh
Publisher : Elsevier
Release : 2018-06-29
ISBN : 0323480586
Language : En, Es, Fr & De

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Book Description :

Fundamentals and Applications of Nano Silicon in Plasmonics and Fullerines: Current and Future Trends addresses current and future trends in the application and commercialization of nanosilicon. The book presents current, innovative and prospective applications and products based on nanosilicon and their binary system in the fields of energy harvesting and storage, lighting (solar cells and nano-capacitor and fuel cell devices and nanoLEDs), electronics (nanotransistors and nanomemory, quantum computing, photodetectors for space applications; biomedicine (substance detection, plasmonic treatment of disease, skin and hair care, implantable glucose sensor, capsules for drug delivery and underground water and oil exploration), and art (glass and pottery). Moreover, the book includes material on the use of advanced laser and proximal probes for imaging and manipulation of nanoparticles and atoms. In addition, coverage is given to carbon and how it contrasts and integrates with silicon with additional related applications. This is a valuable resource to all those seeking to learn more about the commercialization of nanosilicon, and to researchers wanting to learn more about emerging nanosilicon applications. Features a variety of designs and operation of nano-devices, helping engineers to make the best use of nanosilicon Contains underlying principles of how nanomaterials work and the variety of applications they provide, giving those new to nanosilicon a fundamental understanding Assesses the viability of various nanoslicon devices for mass production and commercialization, thereby providing an important source of information for engineers

Biomechanics at Micro and Nanoscale Levels

Biomechanics at Micro  and Nanoscale Levels Book
Author : Anonim
Publisher : Unknown
Release : 2021-09-21
ISBN : 9814474843
Language : En, Es, Fr & De

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Book Description :

Download Biomechanics at Micro and Nanoscale Levels book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Water in Biomechanical and Related Systems

Water in Biomechanical and Related Systems Book
Author : Adam Gadomski
Publisher : Springer Nature
Release : 2021
ISBN : 3030672271
Language : En, Es, Fr & De

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Book Description :

The contributed volume puts emphasis on a superior role of water in (bio)systems exposed to a mechanical stimulus. It is well known that water plays an extraordinary role in our life. It feeds mammalian or other organism after distributing over its whole volume to support certain physiological and locomotive (friction-adhesion) processes to mention but two of them, both of extreme relevance. Water content, not only in the mammalian organism but also in other biosystems such as whether those of soil which is equipped with microbiome or the ones pertinent to plants, having their own natural network of water vessels, is always subjected to a force field. The decisive force field applied to the biosystems makes them biomechanically agitated irrespective of whether they are subjected to external or internal force-field conditions. It ought to be noted that the decisive mechanical factor shows up in a close relation with the space-and-time scale in which it is causing certain specific phenomena to occur. The scale problem, emphasizing the range of action of gravitational force, thus the millimeter or bigger force vs. distance scale, is supposed to enter the so-called macroscale approach to water transportation through soil or plants’ roots system. It is merely related to a percolation problem, which assumes to properly inspect the random network architecture assigned to the biosystems invoked. The capillarity conditions turn out to be of prior importance, and the porous-medium effect has to be treated, and solved in a fairly approximate way. The deeper the scale is penetrated by a force-exerting and hydrated agent the more non-gravitational force fields manifest. This can be envisaged in terms of the corresponding thermodynamic (non-Newtonian) forces, and the phenomena of interest are mostly attributed to suitable changes of the osmotic pressure. In low Reynolds number conditions, thus in the (sub)micrometer distance-scale zone, they are related with the corresponding viscosity changes of the aqueous, e.g. cytoplasmatic solutions, of semi-diluted and concentrated (but also electrolytic) characteristics. For example, they can be observed in articulating systems of mammals, in their skin, and to some extent, in other living beings, such as lizards, geckos or even insects. Through their articulating devices an external mechanical stimulus is transmitted from macro- to nanoscale, wherein the corresponding osmotic-pressure conditions apply. The content of the proposed work can be distributed twofold. First, the biomechanical mammalian-type (or, similar) systems with extraordinary relevance of water for their functioning will be presented, also including a presentation of water itself as a key physicochemical system/medium. Second, the suitably chosen related systems, mainly of soil and plant addressing provenience, will be examined thoroughly. As a common denominator of all of them, it is proposed to look at their hydrophobic and/or (de)hydration effects, and how do they impact on their basic mechanical (and related, such as chemo-mechanical or piezoelectric, etc.) properties. An additional tacit assumption employed throughout the monograph concerns statistical scalability of the presented biosystems which is equivalent to take for granted a certain similarity between local and global system’s properties, mostly those of mechanical nature. The presented work’s chapters also focus on biodiversity and ecological aspects in the world of animals and plants, and the related systems. The chapters’ contents underscore the bioinspiration as the key landmark of the proposed monograph.

Introduction to Nanoscience and Nanotechnology

Introduction to Nanoscience and Nanotechnology Book
Author : Gabor L. Hornyak,H.F. Tibbals,Joydeep Dutta,John J. Moore
Publisher : CRC Press
Release : 2008-12-22
ISBN : 1420047809
Language : En, Es, Fr & De

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Book Description :

The maturation of nanotechnology has revealed it to be a unique and distinct discipline rather than a specialization within a larger field. Its textbook cannot afford to be a chemistry, physics, or engineering text focused on nano. It must be an integrated, multidisciplinary, and specifically nano textbook. The archetype of the modern nano textbook, Introduction to Nanoscience and Nanotechnology builds a solid background in characterization and fabrication methods while integrating the physics, chemistry, and biology facets. The remainder of this color text focuses on applications, examining engineering aspects as well as nanomaterials and industry-specific applications in such areas as energy, electronics, and biotechnology. Also available in two course-specific volumes: Introduction to Nanoscience elucidates the nanoscale along with the societal impacts of nanoscience, then presents an overview of characterization and fabrication methods. The authors systematically discuss the chemistry, physics, and biology aspects of nanoscience, providing a complete picture of the challenges, opportunities, and inspirations posed by each facet before giving a brief glimpse at nanoscience in action: nanotechnology. Fundamentals of Nanotechnology surveys the field’s broad landscape, exploring the physical basics such as nanorheology, nanofluidics, and nanomechanics as well as industrial concerns such as manufacturing, reliability, and safety. The authors then explore the vast range of nanomaterials and systematically outline devices and applications in various industrial sectors. Qualifying instructors who purchase either of these volumes (or the combined set) are given online access to a wealth of instructional materials. These include detailed lecture notes, review summaries, slides, exercises, and more. The authors provide enough material for both one- and two-semester courses.

6th World Congress of Biomechanics WCB 2010 1 6 August 2010 Singapore

6th World Congress of Biomechanics  WCB 2010   1   6 August 2010  Singapore Book
Author : Chwee Teck Lim,James Goh Cho Hong
Publisher : Springer Science & Business Media
Release : 2010-08-09
ISBN : 9783642145155
Language : En, Es, Fr & De

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Book Description :

Biomechanics covers a wide field such as organ mechanics, tissue mechanics, cell mechanics to molecular mechanics. At the 6th World Congress of Biomechanics WCB 2010 in Singapore, authors presented the largest experimental studies, technologies and equipment. Special emphasis was placed on state-of-the-art technology and medical applications. This volume presents the Proceedings of the 6th WCB 2010 which was hold in conjunction with 14th International Conference on Biomedical Engineering (ICBME) & 5th Asia Pacific Conference on Biomechanics (APBiomech). The peer reviewed scientific papers are arranged in the six themes Organ Mechanics, Tissue Mechanics, Cell Mechanics, Molecular Mechanics, Materials, Tools, Devices & Techniques, Special Topics.

Nano Biomedical Engineering 2009

Nano Biomedical Engineering 2009 Book
Author : Takami Yamaguchi
Publisher : World Scientific
Release : 2009-02-25
ISBN : 190897852X
Language : En, Es, Fr & De

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Book Description :

This proceedings volume details both current and future research and development initiatives in nano-biomedical engineering, arguably the most important technology of the world in the 21st century. It deals with the following four groups of nano-biomedical engineering: nano-biomechanics, nano-bioimaging, nano-biodevices, and nano-biointervention. Consisting of a compilation of studies conducted by group members of the Tohoku University Global Center of Excellence Program, with specially coordinated funding from the Japanese Government, the papers emphasize the integration of research and education collaboration between engineering and medicine, and showcase Japan's top-level research in the field of nano-biomedical engineering. Contents: Inner Ear Biomechanics (H Wada et al.)Development of an in vitro Tracking System for Catheter Motion (M Ohta et al.)Elasticity-Based Tissue Characterization of Arterial Wall (H Hasegawa et al.)Development of a New Positron Emission Mammography (PEM)Passive Intelligent Walker Controlled by Servo Breaks (Y Hirata et al.)Miniaturized Microfluidic Biofuel Cells (M Nishizawa)Development of a Tactile Sensor for Evaluation of Detergents (D Tsuchimi & M Tanaka)On-Chip Cell Manipulation with Magnetically Driven Microtools (F Arai & Y Yamanishi)Pulse Diagnosis Machine and Autogenic Training (T Yambe)and other papers Readership: Postgraduate students and researchers in biomedical engineering. Keywords:Biomedical Engineering;Nanotechnology;Biomechanics;Cellular Physiology;Computational Simulation;Nano-imaging;Molecular Imaging;Image-based Medicine;Medical RoboticsKey Features:Edited by Professor Takami Yamaguchi, a well-known computational biomechanist who is a member of the World Council of Biomechanics

Selected Topics in Nanoscience and Nanotechnology

Selected Topics in Nanoscience and Nanotechnology Book
Author : Andrew T. S. Wee
Publisher : World Scientific
Release : 2009
ISBN : 9812839569
Language : En, Es, Fr & De

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Book Description :

Selected Topics in Nanoscience and Nanotechnology contains a collection of papers in the subfields of scanning probe microscopy, nanofabrication, functional nanoparticles and nanomaterials, molecular engineering and bionanotechnology. Written by experts in their respective fields, it is intended for a general scientific readership who may be non-specialists in these subjects, but who want a reasonably comprehensive introduction to them. This volume is also suitable as resource material for a senior undergraduate or introductory graduate course in nanoscience and nanotechnology.

Physico Chemical Control of Cell Function

Physico Chemical Control of Cell Function Book
Author : Cesare Gargioli,Giancarlo Forte,Alberto Rainer
Publisher : Frontiers Media SA
Release : 2019-10-17
ISBN : 2889459985
Language : En, Es, Fr & De

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Book Description :

Extracellular Matrix (ECM) has been considered for a long time merely a scaffold sustaining cell and tissue function. Despite this simplistic view shared by many, nowadays ECM and their mechanic-physical and chemical characteristic acquired a progressive larger role actively regulating cell life: survival, proliferation, gene expression and differentiation. The interplay between cells and the ECM is continuously controlled at the cell level in a dynamic way. While cells synthesize the raw components of the ECM, this in turn impacts on cell function by providing chemical, topographical and mechanical hints. Such stimuli have been proven to control several aspects of cell function, including survival, proliferation, differentiation and migration. The molecular pathways activated by cells in response to the physical cues arising from the ECM are being disclosed and thus the possibility to control cell function through materials design is becoming more realistic. Current in vitro protocols, relying in 2D cell culture system, entail reductionist approaches to the complexity of cell-ECM interaction and result in cells rapidly losing their distinctive functions in culture. Understanding and replicating the 3D microenvironmental cues affecting cell function appears as a mandatory requirement for the development of next-generation biomaterials, as well as for the establishment of more physiologically relevant and predictive in vitro models of diseases. Such an effort will require a multidisciplinary approach at the convergence of biophysics, biology, nanotechnology, and bioengineering.