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The Role Of 5 Ht Systems On Memory And Dysfunctional Memory

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The Role of 5 HT Systems on Memory and Dysfunctional Memory

The Role of 5 HT Systems on Memory and Dysfunctional Memory Book
Author : Alfredo Meneses
Publisher : Academic Press
Release : 2014-03-11
ISBN : 0128010835
Language : En, Es, Fr & De

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Book Description :

Drugs acting through 5-HT (5-hydroxytryptamine, or serotonin) systems modulate memory and its alterations, but the mechanisms by which they do so are poorly understood. Agonists and antagonists for 5-HT receptors, as well as serotonin uptake inhibitors, present promnesic (memory-promoting) and/or anti-amnesic effects under different conditions, and 5-HT receptors are also associated with neural changes. The Role of 5-HT Systems on Memory and Dysfunctional Memory: Emergent Targets for Memory Formation and Memory Alterations reviews and summarizes the most recent research related to 5-HT drugs and the mechanisms by which they effect alterations in memory. This latest evidence is reviewed in the context of memory deficits related to brain disorders, such as post-traumatic stress disorder, schizophrenia, post-stroke cognitive dysfunctions, Parkinson’s disease, and infection-induced memory impairments. Written by an expert in the field of memory, The Role of 5-HT Systems on Memory and Dysfunctional Memory provides an introduction to the latest research on 5-HT receptors and their contributions to the physiological and pharmacological basis of memory. Examines and summarizes the recent advances in drugs that act through the 5-HT systems Reviews findings in the context of brain disorders that involve memory deficits Covers emergent targets for memory formation and memory alterations

Serotonin and Memory

Serotonin and Memory Book
Author : Alfredo Meneses,Antonella Gasbarri
Publisher : Frontiers Media SA
Release : 2016-04-01
ISBN : 2889198022
Language : En, Es, Fr & De

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Book Description :

The study of 5-hydroxytryptamine (5-HT) systems has benefited from the identification, classification and cloning of multiple 5-HT receptors (5-HT1 to 5-HT7). Increasing evidence suggests that 5-HT pathways, reuptake site/transporter complex and 5-HT receptors represent a strategic distribution for learning and memory. A key question still remaining is whether 5-HT markers (e.g., receptors) are directly or indirectly contributing to the physiological and pharmacological basis of memory and its pathogenesis or, rather, if they represent protective or adaptable mechanisms. Certainly, Alzheimer´s disease (AD) is a very complex neuropsychiatric disorder, where memory becomes progressively dysfunctional resulting in amnesia and dementia, whereas forgetting is a physiological phenomenon occurring all the time as adaptive mechanism. As dysfunctional memory occurs in several neuropsychiatric disorders, including schizophrenia, stroke, post-traumatic stress disorder. Hence, the aim of this call is collect recent and important findings related to information about serotonin and memory or 5-HT and learning or 5-HT and memory or serotonin and learning.

Identification of Neural Markers Accompanying Memory

Identification of Neural Markers Accompanying Memory Book
Author : Alfredo Meneses
Publisher : Elsevier
Release : 2013-11-23
ISBN : 012416711X
Language : En, Es, Fr & De

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Book Description :

Identification of Neural Markers Accompanying Memory is a fresh and novel volume of memory study, providing up-to-date and comprehensive information for both students and researchers focused on the identification of neural markers accompanying memory. Contributions by experts in specific areas of memory study provide background on and definitions of memory, memory alterations, and the brain areas involved in memory and its related processes, such as consolidation, retrieval, forgetting, amnesia, and antiamnesiac effects. With coverage of the principal neurotransmitters related to memory, brain disorders presenting memory alterations, and available treatments—and with discussion of neural markers as new targets for the treatment of memory alterations—Identification of Neural Markers Accompanying Memory is a necessary and timely work for researchers in this growing field. Discusses the alterations of memory in diverse diseases Includes coverage from a basic introduction of memory investigation Reviews brain areas and neurotransmitters involved in memory Discusses behavioral models of memory Contains novel insights into the complexity of signaling and memory Includes the neuropharmacological and neurobiological bases of memory

The Role of Serotonin in Brain Development and 3 4 methylenedioxymethamphetamine induced Cognitive Deficits

The Role of Serotonin in Brain Development and 3 4 methylenedioxymethamphetamine induced Cognitive Deficits Book
Author : Tori Lynn Schaefer
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Serotonin (5-hydroxytryptamine, 5-HT) is thought to be important during brain development and is one of the first neurotransmitters to appear. It appears to act as a neurotrophic factor supporting the growth and maturation of both serotonergic and non-serotonergic cells during the pre and early postnatal periods prior to its role as a neurotransmitter. Disruption of 5-HT functioning during human development is thought to be associated with autism and schizophrenia. Early developmental exposure to stress or drugs of abuse disrupt 5-HT development and produces altered cognitive ability. To better understand the relationship between the developing serotonergic system and long-term cognitive function we employed the use of a genetic model in which 5-HT levels are depleted ~80% throughout life and the use of a model of 3,4-methylenedioxymethamphetamine (MDMA) exposure in which administration from postnatal day (P)11-20 is used; a period analogous to the second half of human gestation. Pet-1 is a transcription factor that is restricted in the brain to 5-HT neurons and has been shown to be important for their development and function. A loss of Pet-1 results in an 80% reduction of the number of 5-HT neurons as well as 5-HT tissue content. Pet-1 knockouts were tested as adults in both the Cincinnati and Morris water mazes that assess path integration and spatial learning, respectively. A reduction in cognitive ability was not observed in Pet-1 knockout mice, although they displayed decreased locomotor activity, increased marble burying, and increased startle reactivity. To better assess the role 5-HT plays during development for circuits involved in memory formation, we used a model of MDMA exposure that has previously been reported to produce protracted path integration and spatial learning deficits that last late into adulthood. In adults, MDMA produces an initial release of 5-HT followed by dramatic depletions, and these depletions can last for weeks. It was previously shown that neonatal MDMA administration on P11, the first day of the exposure period known to result in memory impairment (P11-20), also produced significant depletions in 5-HT. We further characterized the degree of 5-HT depletion that was experienced by rats exposed to P11 MDMA exposure and compared this to 5-HT reductions induced by other substituted amphetamines as well as determining the length and degree of depletion following P11-20 MDMA exposure. Substantial 5-HT depletions existed during all ten days of MDMA exposure, however, these depletions were not observed on P30. Citalopram (CIT), a highly selective SSRI, was used in combination with P11-20 MDMA exposure to attenuate the 5-HT depletions. Thereafter, cognitive ability was assessed in MDMA-treated animals with attenuated 5-HT depletions. The combination of CIT and MDMA did not improve learning ability; however CIT treatment alone produced deficits in path integration learning. These data suggest that 5-HT alterations during vulnerable critical periods can affect later cognitive ability, and they suggest that depletions in 5-HT alone may not account for cognitive dysfunction in neonatal rats treated with MDMA. Examination of specific 5-HT receptors is likely the next step to understand the mechanism involved in 5-HT disruption during development and later cognitive ability.

From Messengers to Molecules

From Messengers to Molecules Book
Author : Gernot Riedel,Bettina Platt
Publisher : Springer Science & Business Media
Release : 2004-11-03
ISBN : 9780306478628
Language : En, Es, Fr & De

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Book Description :

The decade of the brain has brought us a few steps closer to some of the key questions in neuroscience. The complexity of memory is seen on the systems and cellular level, and different types of memory are implemented in several cellular changes that can interact, or work independently. From Messengers to Molecules: Memories are Made of These, follows the arguments from different research teams for their particular area of expertise. All chapters are written to stand-alone and provide an up-to-date introduction to the topic for both specialists and novices alike. As a result, a comprehensive compendium covering cellular mechanisms contributing to memory formation in an unusual breadth has emerged. This books will be of interest to researchers working on the pharmacology, physiology and genetics of memory formation, clinicians memory disorders, industry and students in advanced courses in Neuroscience or Pharmacology.

Pharmacology of 5 HT6 Receptors

Pharmacology of 5 HT6 Receptors Book
Author : Franco Borsini
Publisher : Academic Press
Release : 2011
ISBN : 0123859026
Language : En, Es, Fr & De

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Book Description :

The serotonin 5-HT6 receptor represents a novel pharmacological target whose impact on physiopathology of CNS functions remains undetermined. Some receptor antagonists have been synthesized, and they show a modulatory role in learning and memory processes and food intake. The pharmacology of 5-HT6 receptor agonists is still under evaluation. However, both 5-HT6 antagonists and agonists seem to exert potential antidepressant activity. Recently, a second messenger system has been discovered. 5-HT6 receptor function is becoming more and more intriguing. Thus, the aim of the present book is to try to clarify the pharmacology of 5-HT6 receptors. Written by expert researchers Covers all published literature to date in the field of 5-HT6 receptors

Pharmacology of 5 HT6 receptors

Pharmacology of 5 HT6 receptors Book
Author : Anonim
Publisher : Academic Press
Release : 2011-04-05
ISBN : 0123859034
Language : En, Es, Fr & De

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Book Description :

The serotonin 5-HT6 receptor represents a novel pharmacological target whose impact on physiopathology of CNS functions remains undetermined. Some receptor antagonists have been synthesized, and they show a modulatory role in learning and memory processes and food intake. The pharmacology of 5-HT6 receptor agonists is still under evaluation. However, both 5-HT6 antagonists and agonists seem to exert potential antidepressant activity. Recently, a second messenger system has been discovered. 5-HT6 receptor function is becoming more and more intriguing. Thus, the aim of the present book is to try to clarify the pharmacology of 5-HT6 receptors. Written by expert researchers Covers all published literature to date in the field of 5-HT6 receptors

The Serotonin System

The Serotonin System Book
Author : Mark Tricklebank,Eileen Daly
Publisher : Academic Press
Release : 2019-06-15
ISBN : 0128133244
Language : En, Es, Fr & De

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Book Description :

The Serotonin System: History, Neuropharmacology, and Pathology provides an up-to-date accounting on the physiology and pathophysiology of serotonin and the role it plays in behavioral functions. In addition, the book explores the potential roles of 5-HT1 in neurodevelopmental disorders and summarizes the history of the discovery and development of serotonergic drugs for the treatment of neuropsychiatric disorders. This concise, yet thorough, volume is the perfect introduction to this critical neurotransmitter. It is ideal for students and researchers new to the study of behavior, neuropsychiatry or neuropharmacology, but is also a great resource for established investigators who want a greater perspective on serotonin. Examines the role of serotonin in physiological functions and neuropsychiatric disorders Provides in-depth knowledge on all aspects of the serotonin system Explores serotonergic receptors as targets for both current and new therapeutic compounds

Cognitive and Brain Plasticity Induced by Physical Exercise Cognitive Training Video Games and Combined Interventions

Cognitive and Brain Plasticity Induced by Physical Exercise  Cognitive Training  Video Games and Combined Interventions Book
Author : Soledad Ballesteros,Claudia Voelcker-Rehage,Louis Bherer
Publisher : Frontiers Media SA
Release : 2018-07-05
ISBN : 2889455076
Language : En, Es, Fr & De

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Book Description :

The premise of neuroplasticity on enhancing cognitive functioning among healthy as well as cognitively impaired individuals across the lifespan, and the potential of harnessing these processes to prevent cognitive decline attract substantial scientific and public interest. Indeed, the systematic evidence base for cognitive training, video games, physical exercise and other forms of brain stimulation such as entrain brain activity is growing rapidly. This Research Topic (RT) focused on recent research conducted in the field of cognitive and brain plasticity induced by physical activity, different types of cognitive training, including computerized interventions, learning therapy, video games, and combined intervention approaches as well as other forms of brain stimulation that target brain activity, including electroencephalography and neurofeedback. It contains 49 contributions to the topic, including Original Research articles (37), Clinical Trials (2), Reviews (5), Mini Reviews (2), Hypothesis and Theory (1), and Corrections (2).

Serotonin Receptors and Transporters Exploring New and Known Signaling Pathways to Improve the Efficacy of Antidepressant Treatment

Serotonin  Receptors and Transporters  Exploring New and Known Signaling Pathways to Improve the Efficacy of Antidepressant Treatment Book
Author : Thorsten Lau,Patrick Schloss,Nasser Haddjeri,Guillaume Lucas
Publisher : Frontiers Media SA
Release : 2020-07-28
ISBN : 2889638898
Language : En, Es, Fr & De

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Book Description :

Download Serotonin Receptors and Transporters Exploring New and Known Signaling Pathways to Improve the Efficacy of Antidepressant Treatment book written by Thorsten Lau,Patrick Schloss,Nasser Haddjeri,Guillaume Lucas, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

PET and SPECT of Neurobiological Systems

PET and SPECT of Neurobiological Systems Book
Author : Rudi A.J.O. Dierckx,Andreas Otte,Erik F.J. de Vries,Aren van Waarde,Adriaan A. Lammertsma
Publisher : Springer Nature
Release : 2020-09-29
ISBN : 3030531767
Language : En, Es, Fr & De

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Book Description :

This book, now in a fully updated second edition, is a comprehensive and up-to-date guide to the use of PET and SPECT for the imaging of neurobiological systems. Diverse aspects of neurotransmission in the brain are discussed, such as visualization and quantification of neuroreceptors, neuroinflammatory markers, transporters, and enzymes as well as neurotransmitter synthesis, β-amyloid deposition, cerebral blood flow, and the metabolic rate of glucose. The latest results in probe development are also detailed. A wide range of systems not addressed in the first edition are covered, reflecting the advances made in recent years. The book combines the expertise of authors internationally renowned for their dedication to the development of novel probes and techniques for the investigation of neurobiological systems. Most chapters are written jointly by radiochemists and nuclear medicine specialists to ensure a multidisciplinary approach. This state of the art compendium will be valuable to all with an interest in clinical and preclinical neuroscience. Companion volumes on the use of PET and SPECT in neurology and psychiatry complete a trilogy.

Handbook of the Behavioral Neurobiology of Serotonin

Handbook of the Behavioral Neurobiology of Serotonin Book
Author : Christian P. Muller,Barry Jacobs
Publisher : Academic Press
Release : 2009-12-30
ISBN : 9780080878171
Language : En, Es, Fr & De

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Book Description :

Serotonin (5-hydroxytryptamine, often cited as 5-HT) is one of the major excitatory neurotransmitter, and the serotonergic system is one of the best studied and understood transmitter systems. It is crucially involved in the organization of virtually all behaviours and in the regulation of emotion and mood. Alterations in the serotonergic system, induced by e.g. learning or pathological processes, underlie behavioural plasticity and changes in mood, which can finally results in abnormal behaviour and psychiatric conditions. Not surprisingly, the serotonergic system and its functional components appear to be targets for a multitude of pharmacological treatments - examples of very successful drugs targeting the serotoninergic system include Prozac and Zoloft. The last decades of research have not only fundamentally expanded our view on serotonin but also revealed in much more detail an astonishing complexity of this system, which comprises a multitude of receptors and signalling pathways. A detailed view on its role in basal, but also complex, behaviours emerged, and, was presented in a number of single review articles. Although much is known now, the serotonergic system is still a fast growing field of research contributing to our present understanding of the brains function during normal and disturbed behaviour. This handbook aims towards a detailed and comprehensive overview over the many facets of behavioural serotonin research. As such, it will provide the most up to date and thorough reading concerning the serotonergic systems control of behaviour and mood in animals and humans. The goal is to create a systematic overview and first hand reference that can be used by students and scholars alike in the fields of genetics, anatomy, pharmacology, physiology, behavioural neuroscience, pathology, and psychiatry. The chapters in this book will be written by leading scientists in this field. Most of them have already written excellent reviews in their field of expertise. The book is divided in 4 sections. After an historical introduction, illustrating the growth of ideas about serotonin function in behaviour of the last forty years, section A will focus on the functional anatomy of the serotonergic system. Section B provides a review of the neurophysiology of the serotonergic system and its single components. In section C the involvement of serotonin in behavioural organization will be discussed in great detail, while section D deals with the role of serotonin in behavioural pathologies and psychiatric disorders. The first handbook broadly discussing the behavioral neurobiology of the serotonorgic transmitter system Co-edited by one of the pioneers and opinion leaders of the past decades, Barry Jacobs (Princeton), with an international list (10 countries) of highly regarded contributors providing over 50 chapters, and including the leaders in the field in number of articles and citations: K. P. Lesch, T. Sharp, A. Caspi, P. Blier, G.K. Aghajanian, E. C. Azmitia, and others The only integrated and complete resource on the market containing the best information integrating international research, providing a global perspective to an international community Of great value not only for researchers and experts, but also for students and clinicians as a background reference

Human Exposure to New Emerging Electric Magnetic and Electromagnetic Fields

Human Exposure to New Emerging Electric  Magnetic and Electromagnetic Fields Book
Author : Tongning Wu,Ruiyun Peng,Lei Zhang,Kun Li
Publisher : Frontiers Media SA
Release : 2022-05-24
ISBN : 2889761940
Language : En, Es, Fr & De

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Book Description :

Download Human Exposure to New Emerging Electric Magnetic and Electromagnetic Fields book written by Tongning Wu,Ruiyun Peng,Lei Zhang,Kun Li, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Further Understanding of Serotonin 7 Receptors Neuro Psycho Pharmacology

Further Understanding of Serotonin 7 Receptors    Neuro Psycho Pharmacology Book
Author : Walter Adriani,Carla Perrone-Capano
Publisher : Frontiers Media SA
Release : 2016-04-20
ISBN : 2889197603
Language : En, Es, Fr & De

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Book Description :

Within the CNS and in the periphery, serotonin (5-HT) participates in a number of functions including cognition, mood, sleep-wake rhythms, intestinal inflammation. 5-HT receptors can be classified into at least seven classes, designated 5-HT1 to 5-HT7. Since its identification, the 5-HT7 receptor has been the subject of intense research efforts, driven by its presence in functionally-relevant brain regions and in the gut. The availability of selective agonists and antagonists, in combination with genetically-modified mice lacking 5-HT7 receptors, has allowed so far a better understanding about the patho-physiological roles of this receptor. This Topic will review the state-of-the-art from studies conducted in laboratory (alive animals, tissues, cells) on this respect: 1) Emerging preclinical evidence supports a role for the 5-HT7 receptor in depression, since its pharmacological blockade or genetic inactivation induce an antidepressant-like behavioural profile. 2) In addition, agonists and/or antagonists of 5-HT7 receptors may improve memory or reverse amnesia, having pro-mnesic and/or anti-amnesic effects, with therapy potential in disease-related and/or age-related cognitive impairment. 3) When adolescent rats are treated with a 5-HT7 agonist, analysis at adulthood shows an improved exploratory motivation / attentional skill as well as increased strength of connectivity among components of a forebrain “limbic” loop. 4) In vitro and in vivo studies indicate that 5-HT7R modulates the neuronal morphology, excitability and plasticity, hence contributing to the establishment of brain connectivity during embryonic and early postnatal life.The role of neuro-plasticity and the links to neuro-inflammatory processes will also be addressed. Therapeutic potential of the beneficial effects triggered by 5-HT7 stimulation warrant future research.

Oxford Textbook of Cognitive Neurology and Dementia

Oxford Textbook of Cognitive Neurology and Dementia Book
Author : Masud Husain,Jonathan M. Schott
Publisher : Oxford University Press
Release : 2018-10-29
ISBN : 0198831080
Language : En, Es, Fr & De

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Book Description :

Now in paperback, this text covers the dramatic developments that have occurred in basic neuroscience and clinical research in cognitive neurology and dementia. The text is based on the clinical approach to the patient, and provides essential knowledge that is fundamental to clinical practice.

5 HT Interaction with Other Neurotransmitters Experimental Evidence and Therapeutic Relevance Part B

5 HT Interaction with Other Neurotransmitters  Experimental Evidence and Therapeutic Relevance Part B Book
Author : Anonim
Publisher : Elsevier
Release : 2021-03-26
ISBN : 0444642595
Language : En, Es, Fr & De

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Book Description :

The Progress in Brain Research series highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Covers all key aspects of current research on 5-HT interaction with other neurotransmitters Provides extensively referenced chapters, thus giving readers a comprehensive list of resources on topics covered Includes comprehensive and in-depth background information written in a clear form that is accessible to both specialists and non-specialists

The Amygdala

The Amygdala Book
Author : Barbara Ferry
Publisher : BoD – Books on Demand
Release : 2017-07-05
ISBN : 9535132490
Language : En, Es, Fr & De

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Book Description :

The amygdala is a central component of the limbic system, which is known to play a critical role in emotional processing of learning and memory. Over these last 20 years, major advances in techniques for examining brain activity greatly helped the scientific community to determine the nature of the contribution of the amygdala to these fundamental aspects of cognition. Combined with new conceptual breakthroughs, research data obtained in animals and humans have also provided major insights into our understanding of the processes by which amygdala dysfunction contributes to various brain disorders, such as autism or Alzheimer's disease. Although the primary goal of this book is to inform experts and newcomers of some of the latest data in the field of brain structures involved in the mechanisms underlying emotional learning and memory, we hope it will also help stimulate discussion on the functional role of the amygdala and connected brain structures in these mechanisms.

Cognition in Parkinson s Disease

Cognition in Parkinson s Disease Book
Author : Anonim
Publisher : Elsevier
Release : 2022-03-02
ISBN : 0323901654
Language : En, Es, Fr & De

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Book Description :

Cognition in Parkinson's Disease, Volume 269 in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Cognition in Prodromal Parkinson’s disease, The epidemiology of cognitive function in Parkinson's disease, Real-life consequences of cognitive dysfunction in Parkinson’s disease, Animal models of cognition in Parkinson’s disease, Functional neuroanatomy of cognition in Parkinson’s disease, Neuroimaging approaches to cognition in Parkinson’s disease, Cognitive dysfunction and neuropsychiatric aspects of Parkinson’s disease, Neuropsychology of Parkinson’s disease, Cholinergic Systems, Attentional-Motor Integration, and Cognitive Control in Parkinson Disease, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Progress in Brain Research series Updated release includes the latest information on Cognition in Parkinson's Disease

Encyclopedia of Psychopharmacology

Encyclopedia of Psychopharmacology Book
Author : Ian Stolerman
Publisher : Springer Science & Business Media
Release : 2010-07-31
ISBN : 3540686983
Language : En, Es, Fr & De

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Book Description :

Here is a broad overview of the central topics and issues in psychopharmacology, biological psychiatry and behavioral neurosciences, with information about developments in the field, including novel drugs and technologies. The more than 2000 entries are written by leading experts in pharmacology and psychiatry and comprise in-depth essays, illustrated with full-color figures, and are presented in a lucid style.

Serotonin Receptors in Neurobiology

Serotonin Receptors in Neurobiology Book
Author : Amitabha Chattopadhyay
Publisher : CRC Press
Release : 2007-05-17
ISBN : 9781420005752
Language : En, Es, Fr & De

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Book Description :

A number of developments spanning a multitude of techniques makes this an exciting time for research in serotonin receptors. A comprehensive review of the subject from a multidisciplinary perspective, Serotonin Receptors in Neurobiology is among the first books to include information on serotonin receptor knockout studies. With contributions from leading experts in their fields, the book explores serotonin receptors from a broad-based, multidisciplinary approach. The approaches described vary from molecular biological techniques to fluorescence microscopy and imaging, to genetic manipulation in animal models, providing a wide range of tools to study serotonergic phenomena. While each of these approaches has its own advantages and limitations, the synthesis of information and knowledge achieved from studies using multiple approaches will result in a comprehensive understanding of the underlying complex phenomena involved in serotonergic signaling and its implications in health and disease. The book provides an overall understanding of these receptors based on currently used methodologies and techniques. It describes specific experimental procedures that will be of use to researchers interested in addressing similar problems involving other G-protein-coupled receptor signaling systems.