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The Role Of 5 Ht Systems On Memory And Dysfunctional Memory

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The Role of 5 HT Systems on Memory and Dysfunctional Memory

The Role of 5 HT Systems on Memory and Dysfunctional Memory Book
Author : Alfredo Meneses
Publisher : Academic Press
Release : 2014-03-14
ISBN : 9780128008362
Language : En, Es, Fr & De

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Book Description :

Drugs acting through 5-HT (5-hydroxytryptamine, or serotonin) systems modulate memory and its alterations, but the mechanisms by which they do so are poorly understood. Agonists and antagonists for 5-HT receptors, as well as serotonin uptake inhibitors, present promnesic (memory-promoting) and/or anti-amnesic effects under different conditions, and 5-HT receptors are also associated with neural changes. The Role of 5-HT Systems on Memory and Dysfunctional Memory: Emergent Targets for Memory Formation and Memory Alterations reviews and summarizes the most recent research related to 5-HT drugs and the mechanisms by which they effect alterations in memory. This latest evidence is reviewed in the context of memory deficits related to brain disorders, such as post-traumatic stress disorder, schizophrenia, post-stroke cognitive dysfunctions, Parkinson's disease, and infection-induced memory impairments. Written by an expert in the field of memory, The Role of 5-HT Systems on Memory and Dysfunctional Memory provides an introduction to the latest research on 5-HT receptors and their contributions to the physiological and pharmacological basis of memory. Examines and summarizes the recent advances in drugs that act through the 5-HT systems Reviews findings in the context of brain disorders that involve memory deficits Covers emergent targets for memory formation and memory alterations

The Role of 5 HT Systems on Memory and Dysfunctional Memory

The Role of 5 HT Systems on Memory and Dysfunctional Memory Book
Author : Alfredo Meneses
Publisher : Academic Press
Release : 2014-03-11
ISBN : 0128010835
Language : En, Es, Fr & De

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Book Description :

Drugs acting through 5-HT (5-hydroxytryptamine, or serotonin) systems modulate memory and its alterations, but the mechanisms by which they do so are poorly understood. Agonists and antagonists for 5-HT receptors, as well as serotonin uptake inhibitors, present promnesic (memory-promoting) and/or anti-amnesic effects under different conditions, and 5-HT receptors are also associated with neural changes. The Role of 5-HT Systems on Memory and Dysfunctional Memory: Emergent Targets for Memory Formation and Memory Alterations reviews and summarizes the most recent research related to 5-HT drugs and the mechanisms by which they effect alterations in memory. This latest evidence is reviewed in the context of memory deficits related to brain disorders, such as post-traumatic stress disorder, schizophrenia, post-stroke cognitive dysfunctions, Parkinson’s disease, and infection-induced memory impairments. Written by an expert in the field of memory, The Role of 5-HT Systems on Memory and Dysfunctional Memory provides an introduction to the latest research on 5-HT receptors and their contributions to the physiological and pharmacological basis of memory. Examines and summarizes the recent advances in drugs that act through the 5-HT systems Reviews findings in the context of brain disorders that involve memory deficits Covers emergent targets for memory formation and memory alterations

Serotonin and Memory

Serotonin and Memory Book
Author : Alfredo Meneses,Antonella Gasbarri
Publisher : Frontiers Media SA
Release : 2016-04-01
ISBN : 2889198022
Language : En, Es, Fr & De

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Book Description :

The study of 5-hydroxytryptamine (5-HT) systems has benefited from the identification, classification and cloning of multiple 5-HT receptors (5-HT1 to 5-HT7). Increasing evidence suggests that 5-HT pathways, reuptake site/transporter complex and 5-HT receptors represent a strategic distribution for learning and memory. A key question still remaining is whether 5-HT markers (e.g., receptors) are directly or indirectly contributing to the physiological and pharmacological basis of memory and its pathogenesis or, rather, if they represent protective or adaptable mechanisms. Certainly, Alzheimer´s disease (AD) is a very complex neuropsychiatric disorder, where memory becomes progressively dysfunctional resulting in amnesia and dementia, whereas forgetting is a physiological phenomenon occurring all the time as adaptive mechanism. As dysfunctional memory occurs in several neuropsychiatric disorders, including schizophrenia, stroke, post-traumatic stress disorder. Hence, the aim of this call is collect recent and important findings related to information about serotonin and memory or 5-HT and learning or 5-HT and memory or serotonin and learning.

The Role of Serotonin in Brain Development and 3 4 methylenedioxymethamphetamine induced Cognitive Deficits

The Role of Serotonin in Brain Development and 3 4 methylenedioxymethamphetamine induced Cognitive Deficits Book
Author : Tori Lynn Schaefer
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Serotonin (5-hydroxytryptamine, 5-HT) is thought to be important during brain development and is one of the first neurotransmitters to appear. It appears to act as a neurotrophic factor supporting the growth and maturation of both serotonergic and non-serotonergic cells during the pre and early postnatal periods prior to its role as a neurotransmitter. Disruption of 5-HT functioning during human development is thought to be associated with autism and schizophrenia. Early developmental exposure to stress or drugs of abuse disrupt 5-HT development and produces altered cognitive ability. To better understand the relationship between the developing serotonergic system and long-term cognitive function we employed the use of a genetic model in which 5-HT levels are depleted ~80% throughout life and the use of a model of 3,4-methylenedioxymethamphetamine (MDMA) exposure in which administration from postnatal day (P)11-20 is used; a period analogous to the second half of human gestation. Pet-1 is a transcription factor that is restricted in the brain to 5-HT neurons and has been shown to be important for their development and function. A loss of Pet-1 results in an 80% reduction of the number of 5-HT neurons as well as 5-HT tissue content. Pet-1 knockouts were tested as adults in both the Cincinnati and Morris water mazes that assess path integration and spatial learning, respectively. A reduction in cognitive ability was not observed in Pet-1 knockout mice, although they displayed decreased locomotor activity, increased marble burying, and increased startle reactivity. To better assess the role 5-HT plays during development for circuits involved in memory formation, we used a model of MDMA exposure that has previously been reported to produce protracted path integration and spatial learning deficits that last late into adulthood. In adults, MDMA produces an initial release of 5-HT followed by dramatic depletions, and these depletions can last for weeks. It was previously shown that neonatal MDMA administration on P11, the first day of the exposure period known to result in memory impairment (P11-20), also produced significant depletions in 5-HT. We further characterized the degree of 5-HT depletion that was experienced by rats exposed to P11 MDMA exposure and compared this to 5-HT reductions induced by other substituted amphetamines as well as determining the length and degree of depletion following P11-20 MDMA exposure. Substantial 5-HT depletions existed during all ten days of MDMA exposure, however, these depletions were not observed on P30. Citalopram (CIT), a highly selective SSRI, was used in combination with P11-20 MDMA exposure to attenuate the 5-HT depletions. Thereafter, cognitive ability was assessed in MDMA-treated animals with attenuated 5-HT depletions. The combination of CIT and MDMA did not improve learning ability; however CIT treatment alone produced deficits in path integration learning. These data suggest that 5-HT alterations during vulnerable critical periods can affect later cognitive ability, and they suggest that depletions in 5-HT alone may not account for cognitive dysfunction in neonatal rats treated with MDMA. Examination of specific 5-HT receptors is likely the next step to understand the mechanism involved in 5-HT disruption during development and later cognitive ability.

Canadian Journal of Physiology and Pharmacology

Canadian Journal of Physiology and Pharmacology Book
Author : Anonim
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Canadian Journal of Physiology and Pharmacology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Identification of Neural Markers Accompanying Memory

Identification of Neural Markers Accompanying Memory Book
Author : Alfredo Meneses
Publisher : Elsevier
Release : 2013-11-23
ISBN : 012416711X
Language : En, Es, Fr & De

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Book Description :

Identification of Neural Markers Accompanying Memory is a fresh and novel volume of memory study, providing up-to-date and comprehensive information for both students and researchers focused on the identification of neural markers accompanying memory. Contributions by experts in specific areas of memory study provide background on and definitions of memory, memory alterations, and the brain areas involved in memory and its related processes, such as consolidation, retrieval, forgetting, amnesia, and antiamnesiac effects. With coverage of the principal neurotransmitters related to memory, brain disorders presenting memory alterations, and available treatments—and with discussion of neural markers as new targets for the treatment of memory alterations—Identification of Neural Markers Accompanying Memory is a necessary and timely work for researchers in this growing field. Discusses the alterations of memory in diverse diseases Includes coverage from a basic introduction of memory investigation Reviews brain areas and neurotransmitters involved in memory Discusses behavioral models of memory Contains novel insights into the complexity of signaling and memory Includes the neuropharmacological and neurobiological bases of memory

Memory Dysfunctions

Memory Dysfunctions Book
Author : New York Academy of Sciences
Publisher : Unknown
Release : 1985
ISBN : 9780897662826
Language : En, Es, Fr & De

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Book Description :

Download Memory Dysfunctions book written by New York Academy of Sciences, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Pharmacology of 5 HT6 receptors

Pharmacology of 5 HT6 receptors Book
Author : Anonim
Publisher : Academic Press
Release : 2011-04-05
ISBN : 0123859034
Language : En, Es, Fr & De

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Book Description :

The serotonin 5-HT6 receptor represents a novel pharmacological target whose impact on physiopathology of CNS functions remains undetermined. Some receptor antagonists have been synthesized, and they show a modulatory role in learning and memory processes and food intake. The pharmacology of 5-HT6 receptor agonists is still under evaluation. However, both 5-HT6 antagonists and agonists seem to exert potential antidepressant activity. Recently, a second messenger system has been discovered. 5-HT6 receptor function is becoming more and more intriguing. Thus, the aim of the present book is to try to clarify the pharmacology of 5-HT6 receptors. Written by expert researchers Covers all published literature to date in the field of 5-HT6 receptors

Clinical and Pharmacological Studies in Psychiatric Disorders

Clinical and Pharmacological Studies in Psychiatric Disorders Book
Author : Graham D. Burrows,Trevor R. Norman,Collegium Internationale Neuro-psychopharmacologicum. Congress,Lorraine Dennerstein
Publisher : Unknown
Release : 1985
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Clinical and Pharmacological Studies in Psychiatric Disorders book written by Graham D. Burrows,Trevor R. Norman,Collegium Internationale Neuro-psychopharmacologicum. Congress,Lorraine Dennerstein, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cognitive and Brain Plasticity Induced by Physical Exercise Cognitive Training Video Games and Combined Interventions

Cognitive and Brain Plasticity Induced by Physical Exercise  Cognitive Training  Video Games and Combined Interventions Book
Author : Soledad Ballesteros,Claudia Voelcker-Rehage,Louis Bherer
Publisher : Frontiers Media SA
Release : 2018-07-05
ISBN : 2889455076
Language : En, Es, Fr & De

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Book Description :

The premise of neuroplasticity on enhancing cognitive functioning among healthy as well as cognitively impaired individuals across the lifespan, and the potential of harnessing these processes to prevent cognitive decline attract substantial scientific and public interest. Indeed, the systematic evidence base for cognitive training, video games, physical exercise and other forms of brain stimulation such as entrain brain activity is growing rapidly. This Research Topic (RT) focused on recent research conducted in the field of cognitive and brain plasticity induced by physical activity, different types of cognitive training, including computerized interventions, learning therapy, video games, and combined intervention approaches as well as other forms of brain stimulation that target brain activity, including electroencephalography and neurofeedback. It contains 49 contributions to the topic, including Original Research articles (37), Clinical Trials (2), Reviews (5), Mini Reviews (2), Hypothesis and Theory (1), and Corrections (2).

5 HT Interaction with Other Neurotransmitters Experimental Evidence and Therapeutic Relevance Part B

5 HT Interaction with Other Neurotransmitters  Experimental Evidence and Therapeutic Relevance Part B Book
Author : Anonim
Publisher : Elsevier
Release : 2021-03-26
ISBN : 0444642595
Language : En, Es, Fr & De

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Book Description :

The Progress in Brain Research series highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Covers all key aspects of current research on 5-HT interaction with other neurotransmitters Provides extensively referenced chapters, thus giving readers a comprehensive list of resources on topics covered Includes comprehensive and in-depth background information written in a clear form that is accessible to both specialists and non-specialists

Serotonin Receptors and Transporters Exploring New and Known Signaling Pathways to Improve the Efficacy of Antidepressant Treatment

Serotonin  Receptors and Transporters  Exploring New and Known Signaling Pathways to Improve the Efficacy of Antidepressant Treatment Book
Author : Thorsten Lau,Patrick Schloss,Nasser Haddjeri,Guillaume Lucas
Publisher : Frontiers Media SA
Release : 2020-07-28
ISBN : 2889638898
Language : En, Es, Fr & De

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Book Description :

Download Serotonin Receptors and Transporters Exploring New and Known Signaling Pathways to Improve the Efficacy of Antidepressant Treatment book written by Thorsten Lau,Patrick Schloss,Nasser Haddjeri,Guillaume Lucas, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Serotonin in the Central Nervous System and Periphery

Serotonin in the Central Nervous System and Periphery Book
Author : Akikazu Takada,Gerald Curzon
Publisher : Elsevier Science Limited
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This work contains contributions on the progress of serotonin research. On the central nervous system, papers deal with topics such as 5-HT receptors and animal models of anxiety; in the periphery, the roles of 5-HT and effects of antagonists of 5-HT receptors in the circulation are presented.

Memory Disorders in Psychiatric Practice

Memory Disorders in Psychiatric Practice Book
Author : German E. Berrios,John R. Hodges
Publisher : Cambridge University Press
Release : 2000-03-16
ISBN : 9780521576710
Language : En, Es, Fr & De

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Book Description :

Memory complaints are a frequent feature of psychiatric disorder, even in the absence of organic disease. In this practical reference for the clinician, first published in 2000, German Berrios and John Hodges lead an international team of eminent psychiatrists, behavioural neurologists and clinical psychologists to focus on the psychiatric and organic aspects of memory disorders from the perspective of the multidisciplinary memory clinic. These disorders include organic syndromes such as the dementias, the amnesic syndrome and transient amnestic states, and also psychiatric aspects of memory disorders in the functional psychoses. Among the specific topics reviewed are the paramnesias, conditions such as déjà vu, flashbulb and flashback memories, and the problems of recovered, false and feigned memories. Throwing light on established conditions, and also introducing two new syndromes, this book makes a major contribution to the understanding and clinical management of memory disorders in psychiatry, neuropsychology and other disciplines.

PET and SPECT of Neurobiological Systems

PET and SPECT of Neurobiological Systems Book
Author : Rudi A.J.O. Dierckx,Andreas Otte,Erik F.J. de Vries,Aren van Waarde,Adriaan A. Lammertsma
Publisher : Springer Nature
Release : 2020-09-29
ISBN : 3030531767
Language : En, Es, Fr & De

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Book Description :

This book, now in a fully updated second edition, is a comprehensive and up-to-date guide to the use of PET and SPECT for the imaging of neurobiological systems. Diverse aspects of neurotransmission in the brain are discussed, such as visualization and quantification of neuroreceptors, neuroinflammatory markers, transporters, and enzymes as well as neurotransmitter synthesis, β-amyloid deposition, cerebral blood flow, and the metabolic rate of glucose. The latest results in probe development are also detailed. A wide range of systems not addressed in the first edition are covered, reflecting the advances made in recent years. The book combines the expertise of authors internationally renowned for their dedication to the development of novel probes and techniques for the investigation of neurobiological systems. Most chapters are written jointly by radiochemists and nuclear medicine specialists to ensure a multidisciplinary approach. This state of the art compendium will be valuable to all with an interest in clinical and preclinical neuroscience. Companion volumes on the use of PET and SPECT in neurology and psychiatry complete a trilogy.

Animal Behaviour Abstracts

Animal Behaviour Abstracts Book
Author : Anonim
Publisher : Unknown
Release : 2001
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Animal Behaviour Abstracts book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Dissertation Abstracts International

Dissertation Abstracts International Book
Author : Anonim
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Dissertation Abstracts International book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Preservation of Memory

The Preservation of Memory Book
Author : Davide Bruno
Publisher : Psychology Press
Release : 2015-12-22
ISBN : 1317556437
Language : En, Es, Fr & De

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Book Description :

An increase in average life expectancy has given rise to a number of pressing health challenges for the 21st century. Age-related memory loss, whether due to a neurodegenerative condition such as Alzheimer’s disease, or as a product of the normal process of aging, is perhaps the most significant of the health problems of old age presently confronting our society. The Preservation of Memory explores non-invasive, empirically sound strategies that can be implemented to ensure long-lasting and effective retention of information. The chapters in this volume describe and evaluate both well-established and novel methods for improving and strengthening memory, for people with and without dementia. They also look at ways in which effective detection and care can be implemented, and describe empirical findings that can be translated into everyday practice. The contributors take a multidisciplinary approach, motivated by the desire to look beyond and across boundaries to find new areas of knowledge and new opportunities. The Preservation of Memory will be useful reading for students and researchers focusing upon memory, aging and dementia, and also for mental health practitioners, social workers, and carers of persons living with dementia or other memory impairments.

Cognition and Mood Interactions

Cognition and Mood Interactions Book
Author : Miao-Kun Sun
Publisher : Nova Science Pub Incorporated
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Interaction between cognition and mood regulation is a common neural and behavioural phenomenon. This book brings together an international group of neuroscientists who are investigating neural and molecular mechanisms underlying cognition, mood, and interactions between cognition and mood. Exciting advances are occurring in the understanding of the neural and molecular link between dementia and depression. This unique book provides a comprehensive overview of cognitive and mood neurosciences, with a strong emphasis on interactions between dementia and depression. It begins with an introduction to the fundamental concepts of dementia and depression and core issues facing clinical and neurological investigators. Then, several chapters cover the neurochemical substrates underlying the manifestation of cognition and mood regulation, including monoamines, excitatory amino acids, and angiotensins. Separate chapters are devoted to animal models of human dementia and behavioural changes in Alzheimer's dementia, the most common cause of progressive decline of cognition in aged humans. Subsequent chapters cover common molecular and neural abnormalities of cognitive impairments and mood deregulation, including topics such as neural atrophy, cholesterol, stress, and ageing. The book ends with current knowledge of convergence of antidementic and antidepressive pharmacology. The book is intended for scientists involved in the field, who may want a broader knowledge of all the aspects related to cognition and mood regulation, and for PhD or MD students, residents and neurologists who may wish to learn more about the interactions between cognition and mood. Neuropharmacologists will also benefit from the knowledge presented in the book in developing drugs that are more efficient to modify cognition and mood and more effective to restore normal cognitive and mood regulation.

Attention Deficit Hyperactivity Disorders New Insights for the Healthcare Professional 2013 Edition

Attention Deficit Hyperactivity Disorders  New Insights for the Healthcare Professional  2013 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2013-07-22
ISBN : 1481657100
Language : En, Es, Fr & De

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Book Description :

Attention Deficit Hyperactivity Disorders: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Attention Deficit Hyperactivity Disorders: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Attention Deficit Hyperactivity Disorders: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.