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The Protective Arm Of The Renin Angiotensin System Ras

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The Protective Arm of the Renin Angiotensin System RAS

The Protective Arm of the Renin Angiotensin System  RAS  Book
Author : Thomas Unger,U. Muscha Steckelings,Robson Augusto Souza dos Santos
Publisher : Academic Press
Release : 2015-04-18
ISBN : 0128014857
Language : En, Es, Fr & De

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Book Description :

The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin–angiotensin system (RAS), providing readers with early insight into a complex system which will become of major medical importance in the near future. Focusing on recent research, The Protective Arm of the Renin Angiotensin System presents a host of new experimental studies on specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1–7) peptide with its receptor Mas, and the enzyme ACE 2, which exert significant beneficial, health-promoting actions by counterbalancing the well-known harmful arm of the RAS with its classical angiotensin AT1 receptor. This innovative concept of the protective arm of the RAS, examined in this reference, represents an indispensable background and will be a strong support for biomedical students, researchers, cardiologists, surgeons, nephrologists, diabetologists, and endocrinologists, as well as any other physician or researcher concerned with RAS physiology, pathophysiology and clinical implications. Provides a complete understanding of the protective side of the Renin Angiotensin System (RAS) involving angiotensin AT2 receptor, ACE2, and Ang(1-7)/Mas receptor Combines the knowledge of editors who pioneered research on the protective renin angiotensin system including; Dr. Thomas Unger, one of the founders of AT2 receptor research; Dr. Ulrike M. Steckelings, who contributed significantly to first preclinical studies with a novel specific AT2-agonist, and Dr. Robson Santos who pioneered research on angiotensin-(1-7) and its receptor Mas. Shows that the protective RAS axes are able to ameliorate the course of several cardiovascular, renal, metabolic and neurological diseases Provides the basis for the understanding of a novel therapeutic approach to stimulate components of the protective arm of the RAS.

The Protective Arm of the Renin Angiotensin System Ras

The Protective Arm of the Renin Angiotensin System  Ras  Book
Author : Thomas Unger,U. Muscha Steckelings,Robson Augusto Souza Dos Santos
Publisher : Academic Press
Release : 2015-04-20
ISBN : 9780128013649
Language : En, Es, Fr & De

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Book Description :

The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin-angiotensin system (RAS), providing readers with early insight into a complex system which will become of major medical importance in the near future. Focusing on recent research, The Protective Arm of the Renin Angiotensin System presents a host of new experimental studies on specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1-7) peptide with its receptor Mas, and the enzyme ACE 2, which exert significant beneficial, health-promoting actions by counterbalancing the well-known harmful arm of the RAS with its classical angiotensin AT1 receptor. This innovative concept of the protective arm of the RAS, examined in this reference, represents an indispensable background and will be a strong support for biomedical students, researchers, cardiologists, surgeons, nephrologists, diabetologists, and endocrinologists, as well as any other physician or researcher concerned with RAS physiology, pathophysiology and clinical implications. Provides a complete understanding of the protective side of the Renin Angiotensin System (RAS) involving angiotensin AT2 receptor, ACE2, and Ang(1-7)/Mas receptor Combines the knowledge of editors who pioneered research on the protective renin angiotensin system including; Dr. Thomas Unger, one of the founders of AT2 receptor research; Dr. Ulrike M. Steckelings, who contributed significantly to first preclinical studies with a novel specific AT2-agonist, and Dr. Robson Santos who pioneered research on angiotensin-(1-7) and its receptor Mas. Shows that the protective RAS axes are able to ameliorate the course of several cardiovascular, renal, metabolic and neurological diseases Provides the basis for the understanding of a novel therapeutic approach to stimulate components of the protective arm of the RAS.

Selected Chapters from the Renin Angiotensin System

Selected Chapters from the Renin Angiotensin System Book
Author : Aleksandar Kibel
Publisher : BoD – Books on Demand
Release : 2020-08-19
ISBN : 1789854210
Language : En, Es, Fr & De

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Book Description :

Selected Chapters from the Renin-Angiotensin System aims to provide a comprehensive overview of the most important physiological and pathophysiological roles of the renin-angiotensin system (RAS). The complex and convoluted RAS has been investigated for many years and, through rigorous scientific research, many important and previously unknown components and functions of the RAS have come to light. These discoveries have been crucial in the understanding of this system and provide a basis for effective modulation of the system as part of therapeutic strategies for a number of widespread disorders. New studies are continuing to elucidate the RAS and the mechanisms associated with its functions. This book discusses relevant scientific knowledge about the RAS and intends to introduce the reader to cutting-edge research with an accentuation on the mechanisms at the functional/physiological and molecular/cellular levels.

Angiotensin 1 7

Angiotensin  1 7  Book
Author : Robson Augusto Souza Santos
Publisher : Springer Nature
Release : 2019-08-21
ISBN : 3030226964
Language : En, Es, Fr & De

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Book Description :

This is the first book addressing in full the most important aspects of the angiotensin-(1-7), the key peptide of the protective axis and the main component in the new modulatory concept of the renin-angiotensin system. It features a detailed review of angiotensin-(1-7) and its receptor Mas, comprising the historical background, enzymatic pathways for generation, functions, integrative aspects of its protective profile, and its therapeutic potential. It also encompasses a comprehensive presentation of current knowledge about its widespread biological actions on several tissues, as well as the most recent scientific achievements, emerging from preclinical and clinical trials. Dr. Santos is a renowned researcher on the Renin-Angiontensin system, with remarkable achievements regarding the role of peptides such as alamandine and angiontensin-(1-7). He has also worked on the potential clinical applicability of angiotensin-(1-7)-related drugs for cardiovascular diseases. He has an extensive publication record in the field, including the publication of the book The Protective Arm of the Renin Angiotensin System (Academic Press, 2015). Angiotensin-(1-7) will make a unique contribution to the literature and will be an important resource for biomedical students and researchers, medical practitioners and any other professional interested in this peptide and its role in the renin-angiotensin system.

The Renin Angiotensin System

The Renin Angiotensin System Book
Author : 堀内正嗣,伊藤裕
Publisher : Unknown
Release : 2003-08-01
ISBN : 9784896005844
Language : En, Es, Fr & De

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Book Description :

Download The Renin Angiotensin System book written by 堀内正嗣,伊藤裕, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Renin Angiotensin System in Cardiovascular Disease

The Renin Angiotensin System in Cardiovascular Disease Book
Author : Naranjan S. Dhalla,Sukhwinder K. Bhullar,Anureet K. Shah
Publisher : Springer Nature
Release : 2023-02-02
ISBN : 3031149521
Language : En, Es, Fr & De

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Book Description :

This book on “Renin-Angiotensin System in Cardiovascular Disease” includes 25 chapters, which are organized in three sections, namely (i) modulatory aspects, (ii) pathophysiological aspects, and (iii) pharmacotherapeutic aspects. It includes an updated as well as comprehensive knowledge about molecular and cellular aspects for the role of the renin-angiotensin system (RAS) in the pathophysiology and therapy of cardiovascular diseases such as hypertension, atherosclerosis, ischemic heart disease, and heart failure. This book emphasizes the molecular and cellular mechanisms, signaling transduction pathways involved in the development of different cardiovascular diseases due to the prolonged activation of RAS. Furthermore, biochemical mechanisms are outlined for the inhibition of this system by the blockade of angiotensin converting enzyme as well as angiotensin II type 1 receptors in patients suffering from cardiovascular abnormalities. Since cardiovascular disease is the number one cause of death worldwide, leading to approximately 17.9 million deaths each year, there is a keen interest in understanding the pathogenesis and improving its therapy. In this regard, we can attest that this book provides ample information about essential components of RAS and their role in the development of cardiovascular disease. From the selection of recognized global experts in their area of investigation, this book can be seen to cover diverse cardiovascular aspects and molecular and cellular mechanisms of angiotensin II action for the development of different cardiovascular abnormalities. It is our contention that this book will be most suitable for promoting knowledge in the field of RAS biology and will be of great interest to health professionals involved in both experimental and clinical cardiology as well as academic investigators and cardiovascular scientists, graduate students, and fellows worldwide.

The Epigenome and Developmental Origins of Health and Disease

The Epigenome and Developmental Origins of Health and Disease Book
Author : Cheryl S Rosenfeld
Publisher : Academic Press
Release : 2015-10-10
ISBN : 0128016728
Language : En, Es, Fr & De

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Book Description :

The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or to conversely promote the health of the offspring. The book mines the existing literature from a variety of disciplines from toxicology to nutrition to epigenetics to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and the resulting deleterious phenotypic and physiological effects in our offspring. It is increasingly becoming apparent that even subtle changes in the mother’s diet, stress, and exposure to low concentrations of toxic chemicals at levels deemed safe by the EPA and FDA, such as endocrine disrupting compounds (EDC), can dramatically impact the health of our children, possibly leading to metabolic, cardiovascular, immunological, neurobehavioral disorders, and increased risk for cancer to list but a few examples. Informs how everyday choices pregnant women make can impact child development Ties together how in utero environmental changes may be inducing epigenetic changes in the offspring leading to overlapping phenotypes regardless of the initial insult (toxic, nutrition, or stress) Includes a boxed-in area in each chapter for further references and resources to keep up with the field Features video interviews with the authors and other key leaders in the field

The Role of the Renin Angiotensin System in the Central Nervous System

The Role of the Renin Angiotensin System in the Central Nervous System Book
Author : Natalia P. Rocha,Antonio Lucio Teixeira,Ana Cristina Simões E. Silva
Publisher : Frontiers Media SA
Release : 2021-10-01
ISBN : 2889713458
Language : En, Es, Fr & De

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Book Description :

Download The Role of the Renin Angiotensin System in the Central Nervous System book written by Natalia P. Rocha,Antonio Lucio Teixeira,Ana Cristina Simões E. Silva, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Aldosterone Mineralocorticoid Receptor

Aldosterone Mineralocorticoid Receptor Book
Author : Brian Harvey,Frederic Jaisser
Publisher : BoD – Books on Demand
Release : 2019-09-25
ISBN : 1839621982
Language : En, Es, Fr & De

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Book Description :

This book is an open access dissemination of the EU COST Action ADMIRE in Aldosterone/Mineralocorticoid Receptor (MR) physiology and pathophysiology. Aldosterone is the major hormone regulating blood pressure. Alterations in blood levels of aldosterone and genetic mutations in the MR receptor are major causes of hypertension and comorbidities. Many of the drugs in clinical use, and in development for treating hypertension, target aldosterone and MR actions in the kidney and cardiovascular system. The ADMIRE book assembles review chapters from 16 European ADMIRE laboratories providing the latest insights into mechanisms of aldosterone synthesis/secretion, aldosterone/MR physiology and signaling, and the pathophysiological roles of aldosterone/MR activation.

Manual of Hypertension of the European Society of Hypertension Third Edition

Manual of Hypertension of the European Society of Hypertension  Third Edition Book
Author : Giuseppe Mancia,Guido Grassi,Konstantinos Tsioufis,Anna Dominiczak,Enrico Agabiti Rosei
Publisher : CRC Press
Release : 2019-06-06
ISBN : 0429581440
Language : En, Es, Fr & De

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Book Description :

The Manual of Hypertension of the European Society of Hypertension reflects emerging concepts that have the potential to impact diagnostic and therapeutic approaches to hypertension. Updating all material, this new edition also delves into a number of areas that have received heightened interest in recent years or have become a matter of debate due to the controversial interpretation of the available data. FEATURES Reflects emerging concepts impacting diagnostic and therapeutic approaches Explores background, history, epidemiology, and risk factors Describes pharmacological, nonpharmacological, and medical treatments Examines hypertension in special populations and treatment

Textbook of Nephro Endocrinology

Textbook of Nephro Endocrinology Book
Author : Ajay K. Singh,Gordon H. Williams
Publisher : Academic Press
Release : 2009-01-12
ISBN : 9780080920467
Language : En, Es, Fr & De

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Book Description :

The Textbook of Nephro-Endocrinology is the definitive translational reference in the field of nephro-endocrinology, investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers researchers and clinicians expert, gold-standard analyses of nephro-endocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoporosis, and, hypoparathyroidism. Investigates both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems Presents a uniquely comprehensive and cross-disciplinary look at all aspects of nephro-endocrine disorders in one reference work Clear translational presentations by the top endocrinologists and nephrologists in each specific hormone or functional/systems field

Receptor Endocytosis and Signalling in Health and Disease Part A

Receptor Endocytosis and Signalling in Health and Disease   Part A Book
Author : Anonim
Publisher : Elsevier
Release : 2023-01-20
ISBN : 0443191867
Language : En, Es, Fr & De

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Book Description :

Receptor Endocytosis and Signalling in Health and Disease, Volume 194 in the Progress in Molecular Biology and Translational Science, highlights new advances in the field. Chapters in this release include An overview on receptor endocytosis and signaling, Signaling molecules: Importance in health and disease conditions, Emerging tools for studying of receptor endocytosis and signaling, Endocytosis of EGFR: Signalling in cancer, Endocytosis of AT1 and AT2 receptors: Signalling in the kidney, Regulation of transferrin receptor trafficking by optineurin and its disease-associated mutants, Endocytosis of Insulin receptor: Signalling in the regulation of glucose homeostasis, Endocytosis of VEGFR: Role in the regulation of angiogenesis, and more. Other sections in this new release include Lymphocyte and monocyte/macrophage receptors mediating immune recognition of tumors, Lymphocyte and monocyte/macrophage receptors triggering immune suppression of tumor immunity, Prion receptors and prion internalization and intra- and inter-cellular transport, Multifunctional role of the ubiquitin proteasome pathway in phagocytosis, Adrenoceptors and SCD1 in adipocytes/adipose tissues: the expression and variation in health and obesity, Frizzled receptors and SFRP5 in lipid metabolism: current findings and potential applications. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Progress in Molecular Biology and Translational Science series Includes the latest information on Receptor Endocytosis and Signaling in Health and Disease

Stress Response Signaling in Tumor Development and its Implications for Cancer Treatment

Stress Response Signaling in Tumor Development and its Implications for Cancer Treatment Book
Author : Shuyu Zhang,Feng He,Johan Bourghardt Fagman,Peng Zhao
Publisher : Frontiers Media SA
Release : 2022-10-13
ISBN : 2832502318
Language : En, Es, Fr & De

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Book Description :

Download Stress Response Signaling in Tumor Development and its Implications for Cancer Treatment book written by Shuyu Zhang,Feng He,Johan Bourghardt Fagman,Peng Zhao, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Targeting Cellular Signalling Pathways in Lung Diseases

Targeting Cellular Signalling Pathways in Lung Diseases Book
Author : Kamal Dua,Raimar Löbenberg,Ângela Cristina Malheiros Luzo,Shakti Shukla,Saurabh Satija
Publisher : Springer Nature
Release : 2021-07-02
ISBN : 9813368276
Language : En, Es, Fr & De

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Book Description :

The book comprehensively reviews and provides detailed insight into the cellular and molecular signalling mechanisms involved in pathophysiology of various respiratory diseases, towards developing effective therapeutic strategies in the management and treatment of lung disease. It also covers promising advances in the field of therapeutics that could lead to novel clinical therapies capable of preventing or reversing the disease features including novel strategies for targeting chronic lung diseases using advanced drug delivery systems. Importantly, the book examines the significance and relevance of the plant extracts and their constituents with therapeutic efficiencies against lung diseases. As such, the book offers a blend of translational, biological, chemical, and drug delivery aspects relevant to respiratory diseases, thus, offering a valuable resource for pulmonologists and translational researchers working in the field of pulmonary biology and respiratory medicine.

Oxford Handbook of Cardiology

Oxford Handbook of Cardiology Book
Author : Punit Ramrakha,Jonathan Hill
Publisher : OUP Oxford
Release : 2012-02-23
ISBN : 0191629987
Language : En, Es, Fr & De

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Book Description :

Cardiovascular disease remains the major cause of morbidity and mortality throughout developed countries and is also rapidly increasing in developing countries. Cardiovascular medicine and the specialty of cardiology continue to expand, and the remit of the cardiologist is forever broader with the development of new sub-specialties. The Oxford Handbook of Cardiology provides a comprehensive but concise guide to all modern cardiological practice with an emphasis on practical clinical management in many different contexts. This second edition addresses all the key advances made in the field since the previous edition, including interventional cardiology, electrophysiology, and pharmacology. It expands the remit to medical students and the more junior doctor while retaining the level of detail required by more senior practitioners within the field.

COVID 19 Neuroimmunology and Neural Function

COVID 19  Neuroimmunology and Neural Function Book
Author : Thomas Heinbockel,Robert Weissert
Publisher : BoD – Books on Demand
Release : 2022-09-07
ISBN : 1803550309
Language : En, Es, Fr & De

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Book Description :

The recent and ongoing COVID-19 pandemic has changed societies and research around the world. As such, this new book examines the latest developments in the field of neuroscience related to these changes. It includes six chapters in two sections: “COVID-19 Effects: Neurology, Neuroimmunology, Neurogenesis” and “Molecular and Cellular Neurochemistry.” The first section includes chapters that address such topics as COVID’s effect on adult neurogenesis, neurological manifestations of COVID-19, and COVID-19 and seizures. Chapters in the second section discuss peripheral biomarkers in multiple sclerosis, amino acids as neurotransmitters, advancements in RNA sequencing technologies, and more.

COVID 19

COVID 19 Book
Author : Moones Rahmandoust,Seyed-Omid Ranaei-Siadat
Publisher : Springer Nature
Release : 2021-08-13
ISBN : 9811631085
Language : En, Es, Fr & De

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Book Description :

This book highlights the overview of the COVID-19 pandemic from both the scientific and the social perspectives. The scientific part presents key facts of COVID-19, including the structure of the virus and the techniques for the diagnosis, treatment, and vaccine development against the disease, covering state-of-the-art findings and achievements worldwide. The social part is written by WHO professionals who worked on the frontier of the fight against the disease. It covers the global security situation during the pandemic, the WHO and governmental-level risk management measures, and the estimated impact that COVID-19 will eventually create on social life after it is globally controlled.

Drug Discovery and Evaluation

Drug Discovery and Evaluation Book
Author : Hans G. Vogel,Wolfgang H. Vogel
Publisher : Springer Science & Business Media
Release : 2013-04-17
ISBN : 366203333X
Language : En, Es, Fr & De

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Book Description :

This reference book contains a comprehensive selection of the most frequently used assays for reliably detecting pharmacological effects of potential drugs, including tests for cardiovascular, analgesic, psychotropic, metabolic, endocrine, respiratory, renal, and immunomodulatory activities. Each of the over 700 assays comprises a detailed protocol with the purpose and rationale of the method, a description of the experimental procedure, a critical assessment of the results and their pharmacological and clinical relevance, and pertinent references. Identification of specific tests is facilitated by the enclosed CD-ROM which allows for a quick and full text research. An appendix with guidelines and legal regulations for animal experiments in various countries will help to plan these experiments properly in accordance with the welfare of laboratory animals.

The Coronavirus Pandemic and the Future

The Coronavirus Pandemic and the Future Book
Author : Michael D Waters,Alok Dhawan,Tim Marrs,Diana Anderson,Stafford Warren,Claude L Hughes
Publisher : Royal Society of Chemistry
Release : 2022-04-27
ISBN : 1839163658
Language : En, Es, Fr & De

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Book Description :

This first volume chronicles the early stages of the outbreak and world-wide spread of SARS-Cov-2 (COVID-19) and delineates the role of several disciplines in therapeutic and control measures. Documenting the epidemiologic response from China, the clinical evaluation, pathology and intial therapeutics that were available during the first 6 months and onwards of the outbreak, this book records how the response to the pandemic was mounted and how various branches of science and research combined to rapidly expand our understanding of the disease.

Prehypertension and Cardiometabolic Syndrome

Prehypertension and Cardiometabolic Syndrome Book
Author : Reuven Zimlichman,Stevo Julius,Giuseppe Mancia
Publisher : Springer
Release : 2018-12-06
ISBN : 331975310X
Language : En, Es, Fr & De

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Book Description :

This book sheds new light on the management of patients with borderline cardiovascular risk factors in order to prevent their progression to end organ damage. The book stimulates discussion of this poorly understood condition and lays the groundwork for developing recommendations and guidelines. While the diagnostic and therapeutic approach to full-blown diabetes, hypertension, dyslipidemia and obesity is well defined, there is still a lack of clear understanding and guidelines as far as patients with borderline conditions – especially when multiple – are concerned. Moreover, end-organ damage depends on several factors, including genetic factors, making it difficult to predict its extent. As such, the gradual transition from a healthy subject to one with functional hemodynamic changes, and then one with structurally asymptomatic changes and lastly to overt disease needs further investigation. In order to address these knowledge gaps, the book covers a broad variety of topics, making it a valuable tool for identifying which asymptomatic subjects could profit from being appropriately screened and at what stage. Furthermore it offers insights into better treating these patients to prevent their progression to overt disease. The book appeals to cardiologists, primary care physicians and all those healthcare professional looking to optimize the management of these complex and often undiagnosed cases.