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The Protective Arm Of The Renin Angiotensin System Ras

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The Protective Arm of the Renin Angiotensin System RAS

The Protective Arm of the Renin Angiotensin System  RAS  Book
Author : Thomas Unger,U. Muscha Steckelings,Robson Augusto Souza dos Santos
Publisher : Academic Press
Release : 2015-04-18
ISBN : 0128014857
Language : En, Es, Fr & De

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Book Description :

The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin–angiotensin system (RAS), providing readers with early insight into a complex system which will become of major medical importance in the near future. Focusing on recent research, The Protective Arm of the Renin Angiotensin System presents a host of new experimental studies on specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1–7) peptide with its receptor Mas, and the enzyme ACE 2, which exert significant beneficial, health-promoting actions by counterbalancing the well-known harmful arm of the RAS with its classical angiotensin AT1 receptor. This innovative concept of the protective arm of the RAS, examined in this reference, represents an indispensable background and will be a strong support for biomedical students, researchers, cardiologists, surgeons, nephrologists, diabetologists, and endocrinologists, as well as any other physician or researcher concerned with RAS physiology, pathophysiology and clinical implications. Provides a complete understanding of the protective side of the Renin Angiotensin System (RAS) involving angiotensin AT2 receptor, ACE2, and Ang(1-7)/Mas receptor Combines the knowledge of editors who pioneered research on the protective renin angiotensin system including; Dr. Thomas Unger, one of the founders of AT2 receptor research; Dr. Ulrike M. Steckelings, who contributed significantly to first preclinical studies with a novel specific AT2-agonist, and Dr. Robson Santos who pioneered research on angiotensin-(1-7) and its receptor Mas. Shows that the protective RAS axes are able to ameliorate the course of several cardiovascular, renal, metabolic and neurological diseases Provides the basis for the understanding of a novel therapeutic approach to stimulate components of the protective arm of the RAS.

Loss of the Protective Arm of Renin angiotensin system Results in Hematopoietic Stem

Loss of the Protective Arm of Renin angiotensin system Results in Hematopoietic Stem Book
Author : Yaqian Duan
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Angiotensin-converting enzyme 2 (ACE2) is the primary enzyme of the vasoprotective axis of the renin-angiotensin system (RAS). We tested the hypothesis that the protective arm of the RAS axis can i) act to maintain homeostasis in the diabetic bone marrow stem cell compartment, ii) regulate the reparative function of the hematopoietic stem/progenitor cells (HSPCs) and iii) modulate the gut microbiota composition. All processes could influence the development of diabetic retinopathy. Diabetic ACE2 knockout (KO)/C57BL/6-Ins2WT/C96Y (Akita) mice were examined at 3 and 9 months after the onset of diabetes and compared to age-matched controls. Both ACE2KO-Akita and Akita cohorts showed reduced retinal thickness by optical coherence tomography at 9 months of diabetes. The absence of ACE2 in 9-month diabetic mice led to an accelerated increase in acellular capillaries, a hallmark feature of diabetic retinopathy. The absence of ACE2 also caused a reduction of both long-term and short-term repopulating HSPCs in the diabetic bone marrow at 9 months of diabetes. Reparative function studies showed that ACE2KO exacerbated diabetes-induced impairment of lineage-c-kit+ HSPC migration and proliferation as early as 3-month of diabetes. HSPCs from both early and late stage diabetic mice, pretreated with Ang-(1-7) or alamandine (two downstream peptides of ACE2) showed restored migration and proliferation. The gut microbiota has been implicated in the pathogenesis of diabetes. Analysis of the gut microbiome also revealed a distinct bacterial profile in ACE2KO-Akita group, with a great diversity of bacterial types that were previously reported to contribute to diabetic pathogenesis, including Tenericutes at the phylum level and Mollicutes at the class level, and with an activation of peptidoglycan biosynthesis pathways. Flow cytometry analysis showed that loss of ACE2 led to less infiltration of circulating angiogenic cells in the gut which may lead to an increased endothelial cell permeability in the intestinal endothelium. This leakage into the blood may promote systemic inflammation known to contribute to the pathogenesis of diabetic retinopathy. These data suggested a loss of the protective arm of RAS contributes to the impairment of HSPCs and alteration of gut microbiota, both of which may contribute to the development of diabetic retinopathy.

Manual of Hypertension of the European Society of Hypertension Third Edition

Manual of Hypertension of the European Society of Hypertension  Third Edition Book
Author : Giuseppe Mancia,Guido Grassi,Konstantinos Tsioufis,Anna Dominiczak,Enrico Agabiti Rosei
Publisher : CRC Press
Release : 2019-06-06
ISBN : 0429581440
Language : En, Es, Fr & De

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Book Description :

The Manual of Hypertension of the European Society of Hypertension reflects emerging concepts that have the potential to impact diagnostic and therapeutic approaches to hypertension. Updating all material, this new edition also delves into a number of areas that have received heightened interest in recent years or have become a matter of debate due to the controversial interpretation of the available data. FEATURES Reflects emerging concepts impacting diagnostic and therapeutic approaches Explores background, history, epidemiology, and risk factors Describes pharmacological, nonpharmacological, and medical treatments Examines hypertension in special populations and treatment

Hypertension

Hypertension Book
Author : Suzanne Oparil,Michael A. Weber
Publisher : Saunders
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The revised and updated 2nd Edition provides a logical, practical framework for managing patients with hypertension. Today's leading experts discuss all aspects of the field-from pathophysiology, pharmacological treatments, and lifestyle modifications to secondary hypertension and cardiovascular complications. Assesses the risks of specific pharmacological treatments * offers expert analysis of recent clinical trials * and provides Delivers strategies for managing patients with comorbid conditions such as diabetes, renal disease, and ischemic heart disease. Explains the role of vascular biology in the pathogenesis of hypertension. Includes 11 new chapters: The National High Blood Pressure Education Program * Angiotensin 1-7 * Aldosterone and Minealocorticoids * Vasodilator Peptides * Clinical Outcome Trials of Hypertension with Angiotensin Receptor Blockers * ACE Inhibitor Trials: Effects in Hypertension * Obesity and Hypertension: Role of Diet Drugs * Exercise and Hypertension * Pharmacokinetics of Antihypertensive Drugs * Hypertension in Children * and Dietary Approaches to Hypertension Management: The DASH Studies. Provides complete revisions of all other existing chapters. Features new clinical pearls * evidence-based therapeutic ladders that summarize key therapy regimens * and preferred treatment boxes that highlight important information.

Men s Health Third Edition

Men s Health  Third Edition Book
Author : Roger S. Kirby,Michael G. Kirby,Culley C. Carson,Alan White
Publisher : CRC Press
Release : 2009-01-29
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"This Third Edition of Men's Health provide a comprehensive and authoritative reference source to urologists, andrologists, general practitioners, and all professionals dealing with the male patient who diagnose and treat males with a variety of health problems, such as prostate cancer, male osteoporosis, and testicular cancer. This comprehensive text also examines new issues regarding some of the less frequently explored areas of men's health, such as Tourette's Syndrome, depression, and cosmetic surgery." --Book Jacket.

The Canadian Journal of Cardiology

The Canadian Journal of Cardiology Book
Author : Anonim
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Canadian Journal of Cardiology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Acronyms Initialisms Abbreviations Dictionary

Acronyms  Initialisms   Abbreviations Dictionary Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Acronyms Initialisms Abbreviations Dictionary book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Journal of the National Medical Association

Journal of the National Medical Association Book
Author : Anonim
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Journal of the National Medical Association book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Pharmacotherapy

Pharmacotherapy Book
Author : Anonim
Publisher : Unknown
Release : 1989
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Aerospace Medicine and Biology

Aerospace Medicine and Biology Book
Author : Anonim
Publisher : Unknown
Release : 1983
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A selection of annotated references to unclassified reports and journal articles that were introduced into the NASA scientific and technical information system and announced in Scientific and technical aerospace reports (STAR) and International aerospace abstracts (IAA).

Textbook of Interventional Cardiology

Textbook of Interventional Cardiology Book
Author : Eric J. Topol
Publisher : Saunders
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Completely refocused and reorganized, the new Edition of this respected resource offers you comprehensive, detailed, up-to-date, and clinically oriented coverage on all aspects of interventional cardiology. Edited by the world's most prominent specialist and researcher and contributed by more than 75 leaders in the field, this 5th edition brings you practical, evidence-based guidance on treating a full range of coronary lesions. They discuss the very latest techniques, devices, and adjunctive therapies and provide critical appraisals of emerging therapeutic approaches. The new edition is now in full-color and features a DVD of video clips demonstrating coronary intervention procedures, three new sections, and a plethora of new chapters that address the hottest topics today. Includes new sections on Patient Selection, Big Artery Vascular Interventions, and Evaluation of Interventional Techniques to help you make better informed decisions. Features new chapters on Transradial Intervention, Late Thrombosis, Biodegradable Stents, Support Devices for High-Risk PCI: IABP, CPS, LVAD, Imaging with Intracardiac Intervention (TEE and ICE), Patient Foramen Ovale and Atrial Septal Defect, Left Atrial Appendage Closure, and Regulatory Issues to keep you up to date. Presents an expanded international authorship and 50% new contributors, bringing you fresh, new perspectives. Increases the clinical focus and incorporates numerous treatment algorithms for better patient care. Uses full-color throughout for the first time, providing you with exceptional visual guidance. Includes a companion DVD of video clips demonstrating challenging techniques and procedures so know exactly how to proceed.

Dissertation Abstracts International

Dissertation Abstracts International Book
Author : Anonim
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Dissertation Abstracts International book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Annual Report

Annual Report Book
Author : India. Department of Science and Technology
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Annual Report book written by India. Department of Science and Technology, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Medical and Health Annual

Medical and Health Annual Book
Author : Anonim
Publisher : Unknown
Release : 1993
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Medical and Health Annual book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Science Citation Index

Science Citation Index Book
Author : Anonim
Publisher : Unknown
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Vols. for 1964- have guides and journal lists.

Bibliography of Reproduction

Bibliography of Reproduction Book
Author : Anonim
Publisher : Unknown
Release : 1991
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Bibliography of Reproduction book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Congressional Record

Congressional Record Book
Author : United States. Congress
Publisher : Unknown
Release : 1979
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Congressional Record book written by United States. Congress, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Federation Proceedings

Federation Proceedings Book
Author : Federation of American Societies for Experimental Biology
Publisher : Unknown
Release : 1983
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Federation Proceedings book written by Federation of American Societies for Experimental Biology, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The FASEB Journal

The FASEB Journal Book
Author : Anonim
Publisher : Unknown
Release : 1989
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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