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The Practice Of Medicinal Chemistry

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The Practice of Medicinal Chemistry

The Practice of Medicinal Chemistry Book
Author : Camille Georges Wermuth,David Aldous,Pierre Raboisson,Didier Rognan
Publisher : Elsevier
Release : 2015-07-01
ISBN : 012417213X
Language : En, Es, Fr & De

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Book Description :

The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development. Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research An image bank is available for instructors at www.textbooks.elsevier.com

The Practice of Medicinal Chemistry

The Practice of Medicinal Chemistry Book
Author : C. G. Wermuth
Publisher : Unknown
Release : 1996
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This book collects in one single volume, the practical aspects of Medicinal Chemistry, seen from a chemical point of view, including the wealth of information which chemists accumulate over a career, but generally is never organized and presented in a coherent form in print. Emphasis is given to how medicinal chemists conduct their search for, and design of, new drug entities. In contrast to other books on the market, it focuses on the chemistry, rather than pharmacological concepts or description of the various therapeutic classes of drugs. It should become a standard reference on the tools available to medicinal chemists when designing new drugs. Key Features * These aspects are covered by: * Specific chapters devoted to the discovery of new lead compounds, including combinatorial chemistry * Clearly written chapters on modern topics such as stereochemical aspects of drug action, the use of X-ray structures of receptors and enzymes in drug discovery, and the contribution of molecular biology to drug discovery * Guidelines and operational strategems allowing identification of the portions of the molecule which are important for potency * The particular emphasis given to the three-dimensional aspects of the drug-receptor interactions, to the design of peptidomimetic drugs and to the control of the agonist-antagonist transition * Chemical solutions to solubility and to formulation problems These sections cover perhaps the most neglected areas in medicinal chemistry books * Development of new drugs: legal and economic aspects, constitutes another important area in which chemists are almost wholly self taught following their entry into industry

The Practice Of Medicinal Chemistry 3 e

The Practice Of Medicinal Chemistry  3 e Book
Author : Wermuth
Publisher : Unknown
Release : 2009-01-01
ISBN : 9788131219614
Language : En, Es, Fr & De

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Book Description :

Download The Practice Of Medicinal Chemistry 3 e book written by Wermuth, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Practice of Medicinal Chemistry

The Practice of Medicinal Chemistry Book
Author : Camille Georges Wermuth
Publisher : Academic Press
Release : 2008
ISBN : 9780123741943
Language : En, Es, Fr & De

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Book Description :

This title is directed towards organic chemists entering a career in drug research or in agrochemistry, and presents a complete guide to the drug discovery process.

Medicinal Chemistry

Medicinal Chemistry Book
Author : Frank D. King
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This is an valuable introduction to medicinal chemistry for new graduates and PhDs. It will also serve to update more experienced scientists on the newer technologies in the field.

The Practice of Medicinal Chemistry

The Practice of Medicinal Chemistry Book
Author : Camille Georges Wermuth
Publisher : Academic Press
Release : 2011-05-02
ISBN : 9780080568775
Language : En, Es, Fr & De

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Book Description :

The Practice of Medicinal Chemistry fills a gap in the list of available medicinal chemistry literature. It is a single-volume source on the practical aspects of medicinal chemistry. Considered ""the Bible"" by medicinal chemists, the book emphasizes the methods that chemists use to conduct their research and design new drug entities. It serves as a practical handbook about the drug discovery process, from conception of the molecules to drug production. The first part of the book covers the background of the subject matter, which includes the definition and history of medicinal chemistry, the measurement of biological activities, and the main phases of drug activity. The second part of the book presents the road to discovering a new lead compound and creating a working hypothesis. The main parts of the book discuss the optimization of the lead compound in terms of potency, selectivity, and safety. The Practice of Medicinal Chemistry can be considered a ""first-read"" or ""bedside book"" for readers who are embarking on a career in medicinal chemistry. NEW TO THIS EDITION: * Focus on chemoinformatics and drug discovery * Enhanced pedagogical features * New chapters including: - Drug absorption and transport - Multi-target drugs * Updates on hot new areas: NEW! Drug discovery and the latest techniques NEW! How potential drugs can move through the drug discovery/ development phases more quickly NEW! Chemoinformatics

The Handbook of Medicinal Chemistry

The Handbook of Medicinal Chemistry Book
Author : Andrew Davis,Simon E Ward
Publisher : Royal Society of Chemistry
Release : 2015-07-07
ISBN : 1782621830
Language : En, Es, Fr & De

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Book Description :

Drug discovery is a constantly developing and expanding area of research. Developed to provide a comprehensive guide, the Handbook of Medicinal Chemistry covers the past, present and future of the entire drug development process. Highlighting the recent successes and failures in drug discovery, the book helps readers to understand the factors governing modern drug discovery from the initial concept through to a marketed medicine. With chapters covering a wide range of topics from drug discovery processes and optimization, development of synthetic routes, pharmaceutical properties and computational biology, the handbook aims to enable medicinal chemists to apply their academic understanding to every aspect of drug discovery. Each chapter includes expert advice to not only provide a rigorous understanding of the principles being discussed, but to provide useful hints and tips gained from within the pharmaceutical industry. This expertise, combined with project case studies, highlighting and discussing all areas of successful projects, make this an essential handbook for all those involved in pharmaceutical development.

Experimental Organic Medicinal Chemistry

Experimental Organic   Medicinal Chemistry Book
Author : N. Swathi,T Durai Ananda Kumar
Publisher : Unknown
Release : 2016-09-27
ISBN : 9789352300792
Language : En, Es, Fr & De

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Book Description :

The modern medicinal chemistry utilizes several novel drug discovery tools to identify the drug-like molecules (lead) and to convert them into therapeutically potential molecules. The advanced and adequate practice in synthetic medicinal chemistry is essential for pharmacy graduates (B. Pharmacy and M. Pharmacy) to receive recognition in academia and industry sectors. This book titled Experimental Organic and Medicinal Chemistry-Principles & Practice consists of several topics covering both theory and practical concepts. The material spreads into synthetic and analytical approaches. The synthetic approach includes synthesis of drugs and drug intermediates and green synthetic strategy. The analytical approach deals with estimations of drugs, qualitative analysis of inorganic, organic and natural products, isolation and determination of active principles from natural sources. In addition, safety measurements, general laboratory practices, preparation of a few solutions and reagents are included as a ready reference. This book is a good companion for students of B. Pharmacy and a source book for M. Pharmacy (Pharmaceutical chemistry, Medicinal Chemistry) and other Pharmaceutical and medicinal chemistry disciplines. Salient features of this book are Systematic descriptions in simple language. Neat and self explanatory chemical reaction mechanisms. The role of reagents, alternative reagents and hazards associated are highlighted. Pharmaceutical relevance of chemical reactions are described. Limit tests, qualitative analysis of inorganic, natural and synthetic organic compounds are described in a lucid manner. Estimations of natural and organic-medicinal compounds along with isolation of active principles are discussed.

Medicinal Chemistry

Medicinal Chemistry Book
Author : Frank D. King
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Medicinal Chemistry book written by Frank D. King, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

An Introduction to Medicinal Chemistry

An Introduction to Medicinal Chemistry Book
Author : Graham L. Patrick
Publisher : Oxford University Press
Release : 2013-01-10
ISBN : 0199697396
Language : En, Es, Fr & De

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Book Description :

This volume provides an introduction to medicinal chemistry. It covers basic principles and background, and describes the general tactics and strategies involved in developing an effective drug.

Basic Concepts in Medicinal Chemistry

Basic Concepts in Medicinal Chemistry Book
Author : Marc Harrold,Robin Zavod
Publisher : ASHP
Release : 2013-01-18
ISBN : 1585283649
Language : En, Es, Fr & De

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Book Description :

Medicinal chemistry is a complex topic. Written in an easy to follow and conversational style, Basic Concepts in Medicinal Chemistry focuses on the fundamental concepts that govern the discipline of medicinal chemistry as well as how and why these concepts are essential to therapeutic decisions. The book emphasizes functional group analysis and the basics of drug structure evaluation. In a systematic fashion, learn how to identify and evaluate the functional groups that comprise the structure of a drug molecule and their influences on solubility, absorption, acid/base character, binding interactions, and stereochemical orientation. Relevant Phase I and Phase II metabolic transformations are also discussed for each functional group. Key features include: • Discussions on the roles and characteristics of organic functional groups, including the identification of acidic and basic functional groups. • How to solve problems involving pH, pKa, and ionization; salts and solubility; drug binding interactions; stereochemistry; and drug metabolism. • Numerous examples and expanded discussions for complex concepts. • Therapeutic examples that link the importance of medicinal chemistry to pharmacy and healthcare practice. • An overview of structure activity relationships (SARs) and concepts that govern drug design. • Review questions and practice problems at the end of each chapter that allow readers to test their understanding, with the answers provided in an appendix. Whether you are just starting your education toward a career in a healthcare field or need to brush up on your organic chemistry concepts, this book is here to help you navigate medicinal chemistry. About the Authors Marc W. Harrold, BS, Pharm, PhD, is Professor of Medicinal Chemistry at the Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA. Professor Harrold is the 2011 winner of the Omicron Delta Kappa "Teacher of the Year" award at Duquesne University. He is also the two-time winner of the "TOPS" (Teacher of the Pharmacy School) award at the Mylan School of Pharmacy. Robin M. Zavod, PhD, is Associate Professor for Pharmaceutical Sciences at the Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, where she was awarded the 2012 Outstanding Faculty of the Year award. Professor Zavod also serves on the adjunct faculty for Elmhurst College and the Illinois Institute of Technology. She currently serves as Editor-in-Chief of the journal Currents in Pharmacy Teaching and Learning.

Organic Chemistry Concepts and Applications for Medicinal Chemistry

Organic Chemistry Concepts and Applications for Medicinal Chemistry Book
Author : Joseph E. Rice
Publisher : Academic Press
Release : 2014-05-06
ISBN : 9780128007396
Language : En, Es, Fr & De

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Book Description :

Organic Chemistry Concepts and Applications for Medicinal Chemistry provides a valuable refresher for understanding the relationship between chemical bonding and those molecular properties that help to determine medicinal activity. This book explores the basic aspects of structural organic chemistry without going into the various classes of reactions. Two medicinal chemistry concepts are also introduced: partition coefficients and the nomenclature of cyclic and polycyclic ring systems that comprise a large number of drug molecules. Given the systematic name of a drug, the reader is guided through the process of drawing an accurate chemical structure. By emphasizing the relationship between structure and properties, this book gives readers the connections to more fully comprehend, retain, apply, and build upon their organic chemistry background in further chemistry study, practice, and exams. Focused approach to review those organic chemistry concepts that are most important for medicinal chemistry practice and understanding Accessible content to refresh the reader's knowledge of bonding, structure, functional groups, stereochemistry, and more Appropriate level of coverage for students in organic chemistry, medicinal chemistry, and related areas; individuals seeking content review for graduate and medical courses and exams; pharmaceutical patent attorneys; and chemists and scientists requiring a review of pertinent material

Foye s Principles of Medicinal Chemistry

Foye s Principles of Medicinal Chemistry Book
Author : Victoria F. Roche,S. William Zito
Publisher : LWW
Release : 2019-04
ISBN : 9781496385024
Language : En, Es, Fr & De

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Book Description :

With expert contributions from experienced educators, research scientists and clinicians, Foye's Principles of Medicinal Chemistry, Eighth Edition is an invaluable resource for professional students, graduate students and pharmacy faculty alike. This 'gold standard' text explains the chemical basis of drug action, emphasizing the structure-activity relationships, physicochemical-pharmacokinetic properties, and metabolic profiles of the most commonly used drugs. Comprehensive coverage of the most cutting edge understanding of drug chemistry, organized and written for ready comprehension Extensively referenced to allow learners to explore areas of interest in greater depth Contemporary focus on drugs viewed by practitioners as the most clinically important in today's health care environment Clinical Significance testimonials that provide a clinician's view of the relevance of medicinal chemistry to practice Science-practice interface made explicit through drug monographs that highlight therapeutic indications, adverse reactions and drug-drug interactions End-of-Chapter exercises that allow learners to test their understanding and recall of key concepts eBook available . Fast, smart, and convenient, today's eBooks can transform learning. These interactive, fully searchable tools offer 24/7 access on multiple devices, the ability to highlight and share notes, and much more

Medicinal Chemistry

Medicinal Chemistry Book
Author : Norma K Dunlap,Donna M Huryn
Publisher : Garland Science
Release : 2018-04-17
ISBN : 1351586211
Language : En, Es, Fr & De

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Book Description :

Medicinal Chemistry begins with the history of the field, starting from the serendipitous use of plant preparations to current practice of design- and target-based screening methods. Written from the perspective of practicing medicinal chemists, the text covers key drug discovery activities such as pharmacokinetics and patenting, as well as the classes and structures of drug targets (receptors, enzymes, nucleic acids, and protein-protein and lipid interactions) with numerous examples of drugs acting at each type. Selected therapeutic areas include drugs to treat cancer, infectious diseases, and central nervous system disorders. Throughout the book, historical and current examples illustrate the progress to market and case studies explore the applications of concepts discussed in the text. Each chapter features a Journal Club, as well as review and application questions to enhance and test comprehension. This textbook is ideal for upper-level undergraduates and graduate students taking a one-semester survey course on medicinal chemistry and/or drug discovery, as well as scientists entering the pharmaceutical industry.

Burger s Medicinal Chemistry and Drug Discovery Therapeutic Agents

Burger s Medicinal Chemistry and Drug Discovery  Therapeutic Agents Book
Author : Manfred E. Wolff
Publisher : Wiley-Interscience
Release : 1997-02-28
ISBN : 9780471575597
Language : En, Es, Fr & De

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Book Description :

A thoroughly revised and expanded edition of a best-selling classic reference on principles and practice of medicinal chemistry and drug discovery. Volume 1 covered principles. Volumes 2 through 5 focus on drugs that target a particular organ or system.

Heterocyclic Chemistry in Drug Discovery

Heterocyclic Chemistry in Drug Discovery Book
Author : Jie Jack Li
Publisher : John Wiley & Sons
Release : 2013-04-26
ISBN : 1118354435
Language : En, Es, Fr & De

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Book Description :

Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls. Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discovery Step-by-step descriptions of synthetic methods and practical techniques Examination of the physical properties for each heterocycle, including NMR data and quantum calculations Detailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles Heterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.

Prodrugs and Targeted Delivery

Prodrugs and Targeted Delivery Book
Author : Jarkko Rautio
Publisher : John Wiley & Sons
Release : 2011-01-11
ISBN : 3527633189
Language : En, Es, Fr & De

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Book Description :

This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs. Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development.

Comprehensive Medicinal Chemistry General principles

Comprehensive Medicinal Chemistry  General principles Book
Author : Peter D. Kennewell
Publisher : Pergamon Press
Release : 1990
ISBN : 9780080370576
Language : En, Es, Fr & De

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Book Description :

V. 1. General principles / volume editor, Peter D. Kennewell.--v. 2. Enzymes & other molecular targets / volume editor, Peter G. Sammes.--v. 3. Membranes & receptors / volume editor, John C. Emmett.--v. 4. Quantitative drug design / volume editor, Christopher A. Ramsden.--v. 5. Biopharmaceutics / volume editor, John B. Taylor.--v. 6. Cumulative subject index & drug compendium / volume editor, Colin J. Drayton.

Scaffold Hopping in Medicinal Chemistry

Scaffold Hopping in Medicinal Chemistry Book
Author : Nathan Brown
Publisher : John Wiley & Sons
Release : 2013-11-06
ISBN : 3527665161
Language : En, Es, Fr & De

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Book Description :

This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the reader's own projects. The first section serves as an introduction to the topic by describing the concept of scaffolds, their discovery, diversity and representation, and their importance for finding new chemical entities. The following part describes the most common tools and methods for scaffold hopping, whether topological, shape-based or structure-based. Methods such as CATS, Feature Trees, Feature Point Pharmacophores (FEPOPS), and SkelGen are discussed among many others. The final part contains three fully documented real-world examples of successful drug development projects by scaffold hopping that illustrate the benefits of the approach for medicinal chemistry. While most of the case studies are taken from medicinal chemistry, chemical and structural biologists will also benefit greatly from the insights presented here.

Burger s Medicinal Chemistry and Drug Discovery

Burger s Medicinal Chemistry and Drug Discovery Book
Author : Alfred Burger,Manfred E. Wolff,Donald J. Abraham
Publisher : Unknown
Release : 2021-08-01
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Burger s Medicinal Chemistry and Drug Discovery book written by Alfred Burger,Manfred E. Wolff,Donald J. Abraham, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.