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The Pharmacological Potential Of Cyanobacteria

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The Pharmacological Potential of Cyanobacteria

The Pharmacological Potential of Cyanobacteria Book
Author : Graciliana Lopes,Marisa Silva,Vitor Vasconcelos
Publisher : Academic Press
Release : 2021-05-18
ISBN : 9780128214916
Language : En, Es, Fr & De

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Book Description :

The Pharmacological Potential of Cyanobacteria explores the bioactive compounds isolated from cyanobacteria and their relationship to human health and biotechnological applications. The book presents an overview of the chemistry and ecology of cyanobacteria, focusing on culture needs and techniques of biomass production. It is organized according to the different biological activities and biotechnological applications of compounds discovered in recent years. Besides biological activity, the mechanism of action of compounds is explained, along with molecular structure. Finally, compounds already used in therapeutics and biotechnology, as well as those in phases of approval or clinical trials are explored. Each chapter is written by a different research group with expertise in the field and publications in peer reviewed journals. Researchers and students in pharmaceutical academic research, pharmaceutical industrial sector personnel, health professionals, and nutritionists will find this book to be very useful. Covers all the bioactive compounds of cyanobacteria discovered thus far Includes chapters by experts in the field, covering the chemistry and mechanisms of action of cyanobacteria-bioactive compounds Provides a general overview of organisms, from biomass production to compound isolation and evaluation of bioactivities in different cell and cell-free systems

Pharmacological Potential of Selected Natural Compounds in the Control of Parasitic Diseases

Pharmacological Potential of Selected Natural Compounds in the Control of Parasitic Diseases Book
Author : Gabriela Hrckova,Samuel Velebny
Publisher : Springer Science & Business Media
Release : 2012-12-13
ISBN : 3709113253
Language : En, Es, Fr & De

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Book Description :

The natural world with a large number of terrestrial and marine plants and lower organisms is a great source of bioactive compounds historically used as remedies in various diseases. Within the last decade, such compounds became more attractive targets for pharmacologists and the pharmaceutical industry in drug development projects. This volume presents the pharmacological potential of chemically defined natural compounds obtained from plants, fungi, algae and cyanobacteria with antiparasitic activity, that have been tested against various endo-parasitic protozoan and helminth species. Additionally, the advantages of combined therapy using antiparasitic drugs and natural compounds with selected specific activity are reviewed and explained in the context of host pathology and immunosuppression induced by the parasites. The conclusions of this new book give suggestions for further non-empirical drug development and discuss perspectives of alternative approaches to therapy of parasitic diseases. ​

Extremophilic Cyanobacteria For Novel Drug Development

Extremophilic Cyanobacteria For Novel Drug Development Book
Author : Sikha Mandal,Jnanendra Rath
Publisher : Springer
Release : 2014-11-24
ISBN : 3319120093
Language : En, Es, Fr & De

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Book Description :

This volume presents recent developments in the novel drug development and potential of extremophilic cyanobacteria. It discusses how these tiny organism originated, produce oxygen that leads to evolution of life on the earth, how their survival strategies in extreme climatic conditions lead to diverse metabolic pathways, and the opportunity to use them to develop novel drugs. The book is comprised of five chapters, starting with the origin of cyanobacteria, their survival strategies under extreme conditions, and their capabilities to change metabolic activities.The second chapter explores the different metabolic pathways found in cyanobacteria and examines advances in this field and recent techniques like MALDI-TOF imaging and metagenomics tools as well as in silico techniques for rapid screening of secondary metabolites. Further chapters cover the glycomics of cyanobacteria, anticancer drug development, and some issues and challenges of using cyanobacteria to develop drugs. Extremophilic Cyanobacteria For Novel Drug Development provides insight into future perspectives in drug development and is a key resource for students, researchers and professionals in pharmacy, medicinal chemistry, pharmacognosy biotechnology, biology, and academics.

Extremophilic Cyanobacteria For Novel Drug Development

Extremophilic Cyanobacteria For Novel Drug Development Book
Author : Sikha Mandal,Jnanendra Rath
Publisher : Springer
Release : 2014-12-03
ISBN : 9783319120102
Language : En, Es, Fr & De

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Book Description :

This volume presents recent developments in the novel drug development and potential of extremophilic cyanobacteria. It discusses how these tiny organism originated, produce oxygen that leads to evolution of life on the earth, how their survival strategies in extreme climatic conditions lead to diverse metabolic pathways, and the opportunity to use them to develop novel drugs. The book is comprised of five chapters, starting with the origin of cyanobacteria, their survival strategies under extreme conditions, and their capabilities to change metabolic activities.The second chapter explores the different metabolic pathways found in cyanobacteria and examines advances in this field and recent techniques like MALDI-TOF imaging and metagenomics tools as well as in silico techniques for rapid screening of secondary metabolites. Further chapters cover the glycomics of cyanobacteria, anticancer drug development, and some issues and challenges of using cyanobacteria to develop drugs. Extremophilic Cyanobacteria For Novel Drug Development provides insight into future perspectives in drug development and is a key resource for students, researchers and professionals in pharmacy, medicinal chemistry, pharmacognosy biotechnology, biology, and academics.

Natural Bioactive Compounds

Natural Bioactive Compounds Book
Author : Rajeshwar P. Sinha,h.c. Donat-P. Häder
Publisher : Academic Press
Release : 2020-10-06
ISBN : 0128206594
Language : En, Es, Fr & De

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Book Description :

Natural Bioactive Compounds: Technological Advancements deals with the latest breakthroughs in the field of screening, characterization and novel applications of natural bioactive compounds from diverse group of organisms ranging from bacteria, viruses, cyanobacteria, algae, fungi, bryophytes, higher plants, sponges, corals and fishes. Written by some of the most reputed scientists in the field, this book introduces the reader to strategies and methods in the search for bioactive natural products. It is an essential read for researchers and students interested in bioactive natural products, their biological and pharmacological properties, their possible use as chemopreventive or chemotherapeutic agents, and other future potential applications. Explores natural sources of bioactive compounds, including cyanobacteria, bacteria, viruses, fungi and higher plants Discusses the potential applications of biological products, such as their use in medicine (antibiotics, cancer research, immunology), as food additives, supplements and technological substances Analyzes the contributions of emerging or developing technologies for the study of bioactive natural compounds (characterization and purification)

Antifungal Efficacy of Cyanobacteria

Antifungal Efficacy of Cyanobacteria Book
Author : Akshita Sharma,Archana Tiwari
Publisher : LAP Lambert Academic Publishing
Release : 2013-01
ISBN : 9783845478333
Language : En, Es, Fr & De

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Book Description :

Cyanobacterial secondary metabolites have diverse antagonistic activity that lead to disintegration of algal, bacterial and fungal growth. This work majorly focuses on the ability of cyanobacteria to be used as an antifungal agent, since a long time the antifungal drugs are chemical based, they are not only having problems of being hazardous when overused but also has led to the increase in the resistant power of many disease causing fungi. Cyanobacteria have a potential to become the leading antimicrobial drug as it has various advantages over the conventional chemical drugs. However, intensive research required to channelize the overall potential of cyanobacteria to be used as an antifungal drug to combat different diseases caused by fungi.

Bloom Forming Cyanobacteria as Antibacterial Agents

Bloom Forming Cyanobacteria as Antibacterial Agents Book
Author : Archana Tiwari,Deepika Sharma
Publisher : LAP Lambert Academic Publishing
Release : 2013
ISBN : 9783659348037
Language : En, Es, Fr & De

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Book Description :

Excessive growth of cyanobacteria leads to blooms. These blooms severely affect the aquatic ecosystem. This work describes the utilization of these bloom forming Cyanobacteria as potential sources of antibacterial agents. Antibacterial activity is the antagonistic effect exerted by the microbes on other living species. Cyanobacteria have a tendency to produce secondary metabolites which prevent the growth of bacteria.The antibacterial property of these microbes is due to their excellent acumen to produce secondary metabolites which prevent the growth of bacteria. The inhibition of the bacterial growth is by interfering with the protein synthesis, retarding the metabolism and rupturing the cell wall of bacteria. In this study, we have explored the antibacterial potential of two bloom forming cyanobacteria Anabaena variabilis and Synechococcus elongates against clinically isolated human pathogenic gram negative bacteria Escherichia coli, Enterococcus sp., Klebsiella sp. Exploring Cyanobacteria for antibacterial property can help us in their application as antimicrobial drug and thus prevent the various problems related to drug resistance and side effects of present day drugs.

Cyanobacteria

Cyanobacteria Book
Author : Purshotam Kaushik,Abhishek Chauhan
Publisher : New India Publishing
Release : 2009-03-08
ISBN : 9788190723770
Language : En, Es, Fr & De

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Book Description :

"The book begins with fossil record of cyanobacteria and gives comprehensive treatment of antibacterial activity of cyanobacteria based on extensive research done by the authoIt also highlights the other aspects of biological activity like anti-fungal, anti-HIV, proteinase inhibitor, anti-mycobacterial, anti-helmintics, anti-inflammatory, cytotoxic and anti-cancer characteristics of cyanobacteria. Based on nine cyanobacterial spp. Anabaena variabilis, Anabaena fertilissima, Nostoc muscorum, Nostoc punctiforme, Nostoc linckia, Nostoc commune, Spirulina platensis, Westiellopsis prolifica and Hapalosiphon sp., monograph provides information regarding application of cyanobacteria. All the experiments are represented in a simple language with explanatory diagrams. The volume also provides a glossary of technical terms used and about more than 200 references and index are in the end for the convenience of reade. The book would be useful for the research students and teachers of the universities and colleges who want to study microbiology, medicine and pharmaceutical sciences with respect to antibacterial effects. It will also be useful for the pharmaceutical industries for research and development (R&D) related to drug discovery."The book would be useful for the research students and teachers of the universities and colleges who want to study microbiology, medicine and pharmaceutical sciences with respect to antibacterial effects. It will also be useful for the pharmaceutical industries for research and development (R&D) related to drug discovery."

Current Topics in Public Health

Current Topics in Public Health Book
Author : Alfonso J. Rodriguez-Morales
Publisher : BoD – Books on Demand
Release : 2013-05-15
ISBN : 9535111213
Language : En, Es, Fr & De

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Book Description :

Public Health is regarded as the basis and cornerstone of health, generally and in medicine. Defined as the science and art of preventing disease, prolonging life and promoting health through the organized efforts and informed choices of society, organizations, public and private, communities and individuals, this discipline has been renewed by the incorporation of multiple actors, professions, knowledge areas and it has also been impacted and promoted by multiple technologies, particularly - the information technology. As a changing field of knowledge, Public Health requires evidence-based information and regular updates. Current Topics in Public Health presents updated information on multiple topics related to actual areas of interest in this growing and exciting medical science, with the conception and philosophy that we are working to improve the health of the population, rather than treating diseases of individual patients, taking decisions about collective health care that are based on the best available, current, valid and relevant evidence, and finally within the context of available resources. With participation of authors from multiple countries, many from developed and developing ones, this book offers a wide geographical perspective. Finally, all these characteristics make this book an excellent update on many subjects of world public health.

Cyanobacteria in Symbiosis

Cyanobacteria in Symbiosis Book
Author : A.N. Rai,B. Bergman,Ulla Rasmussen
Publisher : Springer Science & Business Media
Release : 2007-05-08
ISBN : 0306480050
Language : En, Es, Fr & De

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Book Description :

Cyanobacterial symbioses are no longer regarded as mere oddities but as important components of the biosphere, occurring both in terrestrial and aquatic habitats worldwide. It is becoming apparent that they can enter into symbiosis with a wider variety of organisms than hitherto known, and there are many more still to be discovered, particularly in marine environments. The chapters cover cyanobacterial symbioses with plants (algae, bryophytes, Azolla, cycads, Gunnera), cyanobacterial symbioses in marine environments, lichens, Nostoc-Geosiphon (a fungus closely related to arbuscular mycorrhiza fungi) symbiosis, and artificial associations of cyanobacteria with economically important plants. In addition, cyanobiont diversity, sensing-signalling, and evolutionary aspects of the symbiosis are dealt with. Renowned experts actively involved in research on cyanobacterial symbioses deal with ecological, physiological, biochemical, molecular, and applied aspects of all known cyanobacterial symbioses. This volume on cyanobacteria in symbiosis complements the two earlier volumes on cyanobacteria published by Kluwer (Molecular Biology of Cyanobacteria, edited by D.A. Bryant and Ecology of Cyanobacteria, edited by B.A. Whitton and M. Potts). Together, the three volumes provide the most comprehensive treatment of cyanobacterial literature as a whole. The book will serve as a valuable reference work and text for teaching and research in the field of plant-microbe interactions and nitrogen fixation.

Marine Niche Applications in Pharmaceutical Sciences

Marine Niche  Applications in Pharmaceutical Sciences Book
Author : Neelam M Nathani,Chandrashekar Mootapally,Indra R. Gadhvi,Bharat Maitreya,Chaitanya G. Joshi
Publisher : Springer Nature
Release : 2020-12-11
ISBN : 9811550174
Language : En, Es, Fr & De

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Book Description :

This book offers a comprehensive study of biological molecules acquired from marine organisms, which have been exploited for drug discovery with the aim to treat human diseases. Biomolecules have potential impacts on a diverse range of fields, including medical and pharmaceutical science, industrial science, biotechnology, basic research, molecular science, environmental science and climate change, etc. To understand and effectively apply medicinally important biomolecules, multidisciplinary approaches are called for. The ocean remains a rich biological resource, and the vast untapped potential of novel molecules from marine bio-resources has caught the interest of more and more researchers. These novel biological compounds have never been found in terrestrial or other ecosystems, but only in this rich niche. Advances in sampling techniques and technologies, along with increased funding for research and nature conservation, have now encouraged scientists to look deeper in the waters. Aquaculture supports both tremendous seafood production and the bulk production of marine-derived drugs. Furthermore, molecular methods are now being extensively employed to explore the untapped marine microbial diversity. With the help of molecular and biotech tools, the ability of marine organisms to produce new biosynthetic drugs can be greatly enhanced. This book provides an extensive compilation of the latest information on marine resources and their undisputedly vital role in the treatment of diverse ailments.

Advances in Cyanobacterial Biology

Advances in Cyanobacterial Biology Book
Author : Prashant Kumar Singh,Ajay Kumar,Vipin Kumar Singh,Alok Kumar Shrivistava
Publisher : Academic Press
Release : 2020-02-15
ISBN : 0128193123
Language : En, Es, Fr & De

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Book Description :

Advances in Cyanobacterial Biology presents the novel, practical, and theoretical aspects of cyanobacteria, providing a better understanding of basic and advanced biotechnological application in the field of sustainable agriculture. Chapters have been designed to deal with the different aspects of cyanobacteria including their role in the evolution of life, cyanobacterial diversity and classification, isolation, and characterization of cyanobacteria through biochemical and molecular approaches, phylogeny and biogeography of cyanobacteria, symbiosis, Cyanobacterial photosynthesis, morphological and physiological adaptation to abiotic stresses, stress-tolerant cyanobacterium, biological nitrogen fixation. Other topics include circadian rhythms, genetics and molecular biology of abiotic stress responses, application of cyanobacteria and cyanobacterial mats in wastewater treatments, use as a source of novel stress-responsive genes for development of stress tolerance and as a source of biofuels, industrial application, as biofertilizer, cyanobacterial blooms, use in Nano-technology and nanomedicines as well as potential applications. This book will be important for academics and researchers working in cyanobacteria, cyanobacterial environmental biology, cyanobacterial agriculture and cyanobacterial molecular biologists. Summarizes the various aspects of cyanobacterial research, from primary nitrogen fixation, to advanced nano-technology applications Addresses both practical and theoretical aspects of the cyanobacterial application Includes coverage of biochemical and molecular approaches for the identification, use and management of cyanobacteria

The Ecology of Cyanobacteria

The Ecology of Cyanobacteria Book
Author : B.A. Whitton,Malcolm Potts,M. Potts
Publisher : Springer Science & Business Media
Release : 2000-06-30
ISBN : 9780792347552
Language : En, Es, Fr & De

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Book Description :

... Begins with an overview of ... blue-green algae ... then looks at their diversity in the geological record and ... their ecology in present environments

Regulatory Genetic and Genomic Investigations of Natural Products Biosynthesis in Marine Cyanobacteria

Regulatory  Genetic  and Genomic Investigations of Natural Products Biosynthesis in Marine Cyanobacteria Book
Author : Adam Christopher Jones
Publisher : Unknown
Release : 2011
ISBN : 9781124656205
Language : En, Es, Fr & De

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Book Description :

Natural products from the marine environment constitute one of the richest and most reliable sources of bioactive molecules for drug discovery and biotechnology. Filamentous marine cyanobacteria are among the most prolific natural product producers, and with significant advances in genetics and genomics over the past decade are gaining increasing recognition for unusual or unprecedented biochemistry involved in natural product biosynthesis. However, the further development of several of these cyanobacterial secondary metabolites has not been accomplished because of low yields from field collections, slow growth of these organisms in laboratory cultures, and an absence of any genetic techniques for DNA manipulation. The aim of the research presented in this dissertation is to study the biosynthesis of natural products from the marine filamentous cyanobacterium majuscula to investigate how access to these compounds can be improved and the full potential of cyanobacterial strains can be realized. A variety of experiments are described herein, including : 1) A transcriptional analysis of the neurotoxin jamaicamide gene cluster from Lyngbya majuscula, which employed RT-PCR and reporter gene assays to better understand how cyanobacterial biosynthetic pathways are transcribed; 2) Investigations into jamaicamide regulation, which included a) protein pulldown assays to isolate possible light related regulatory proteins for this pathway and b) the development of a novel mass spectrometry approach to monitor natural product biosynthetic turnover, the effect of environmental parameters on this turnover, and confirm the impact of light on jamaicamide production; 3) Evaluating different methods for transferring DNA into Lyngbya filaments and taking the first steps in heterologously expressing portions of a Lyngbya gene cluster in the actinomycete Streptomyces coelicolor, and 4) Sequencing the genome of Lyngbya majuscula 3L, thereby revealing its natural product potential, a complex gene regulatory network and a surprising inability to fix atmospheric nitrogen. Collectively, these experiments provide new perspective on natural product biosynthesis in Lyngbya strains and direction on how these organisms and their natural products can be harnessed for biomedical and biotechnological applications.

Pharmacological Testing of Blue green Algae for Constituents Having Therapeutic Value

Pharmacological Testing of Blue green Algae for Constituents Having Therapeutic Value Book
Author : World Life Research Institute,Bruce W. Halstead
Publisher : Unknown
Release : 1970
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Pharmacological Testing of Blue green Algae for Constituents Having Therapeutic Value book written by World Life Research Institute,Bruce W. Halstead, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Chemical Biology of Natural Products

Chemical Biology of Natural Products Book
Author : David J. Newman,Gordon M. Cragg,Paul Grothaus
Publisher : CRC Press
Release : 2017-09-22
ISBN : 1351643282
Language : En, Es, Fr & De

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Book Description :

Chemical Biology of Natural Products This unique, long-awaited volume is designed to address contemporary aspects of natural product chemistry and its influence on biological systems, not solely on human interactions. The subjects covered include discovery, isolation and characterization, biosynthesis, biosynthetic engineering, pharmaceutical, and other applications of these compounds. Each chapter begins with a brief and simple introduction to the subject matter, and then proceeds to guide the reader towards the more contemporary, cutting-edge research in the field, with the contributing authors presenting current examples from their own work in order to exemplify key themes. Topics covered in the text include genome mining, heterologous expression, natural product synthesis, biosynthesis, glycosylation, chemical ecology, and therapeutic applications of natural products, both current and potential.

Chemicals from Microalgae

Chemicals from Microalgae Book
Author : Zvi Cohen
Publisher : CRC Press
Release : 1999-05-27
ISBN : 9780748405152
Language : En, Es, Fr & De

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Book Description :

The production of chemicals from microalgae is becoming a significant area of biological research. Chemicals from Microalgae seeks to cover the various aspects that relate to the use of microalgae as a source of chemicals. The chapters discuss the occurrence and physiological role of these chemicals and concentrates on the methods aimed at enhancing their content, as well as large-scale algal biomass production and down-stream processing. This work, written by one of the true pioneers in the field describes the major algal chemicals of interest, namely pigments and lipids.

Studies in Natural Products Chemistry

Studies in Natural Products Chemistry Book
Author : Ajai Prakash Gupta,Pankaj Pandotra,Rajni Sharma,Manoj Kushwaha,Suphla Gupta
Publisher : Elsevier Inc. Chapters
Release : 2013-06-25
ISBN : 0128084731
Language : En, Es, Fr & De

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Book Description :

Cancer is a dreadful human disease, increasing with changing lifestyle, nutrition, and global warming. Its treatments do not have potent medicine as the currently available drugs results in severe side effects. Past activities in this area focused on the natural products derived from medicinal plants. According to the WHO, 80% of the world’s population primarily those from developing countries rely on plant-derived medicines for the health care. Over the past few decades, significant efforts have been made, jointly by pharmaceutical and academic institutions, to isolate and identify new marine-derived natural products. With the advancement of technology and methodology in this area, numerous new compounds have been isolated and several novel anticancer compounds are under clinical investigations. The ocean biomass, covering two-third of the earth, with huge unexplored natural product offers enormous scope and presents an effective alternative in natural product drug discovery. The uniqueness in oceanic mega-diversity is due to spatial as well as temporal competition along with unique habitat with extreme pressure, temperature, and saline conditions. As a result of this, marine organisms have adapted and evolved themselves successfully since centuries in these conditions by producing molecules which are unique in structures, biosynthesis, and function. This “chemical adaptations” is an excellent source of novel chemical entities which is absent in land-based organisms. The past decade has seen more than 10,000 compounds isolated from marine sources which have dramatically increased the number of preclinical anticancers drug under evaluation, and over 300 patents on bioactive natural products from marine sources were granted during this tenure. Efforts, in this direction, became more serious and focused with National Cancer Institute, USA taking a lead role. By collaborative interactions between pharmaceutical companies and research organization, numerous drug-like molecules with several of them having clinical and preclinical potential were discovered. Ecteinascidin-743/ET-743 from Caribbean tunicate and Didemnin and Aplidine from Aplidium albicans are some of the successful examples. Sterols and dietary fibers from seaweeds also hold immense potential. However, investigation of the marine floras chemical entities as drug-like molecule is still in its embryonic stage. The present chapter showcases the past research and reviews the baseline data for promoting further research in this field.

Pharmacological Perspectives of Toxic Chemicals and Their Antidotes

Pharmacological Perspectives of Toxic Chemicals and Their Antidotes Book
Author : S.J.S. Flora,James A. Romano,Steven I. Baskin,K. Sekhar
Publisher : Springer Science & Business Media
Release : 2004-09-10
ISBN : 9783540223788
Language : En, Es, Fr & De

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Book Description :

This is the first book on toxic chemicals that puts a special focus on chemical weapons and bioterrorism. Leading experts provide up-to-date pharmacological and toxicological information on chemical warfare agents, industrial chemicals, environmental toxins, metalloid and an array of miscellaneous agents including their mechanism of toxicity. Also discussed are a number of antidotes, which are being used, or currently being investigated, for the treatments of the common toxicants.

CBM

CBM Book
Author : Anonim
Publisher : Unknown
Release : 2013
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download CBM book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.