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The Organic Chemistry Of Drug Design And Drug Action

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The Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action Book
Author : Richard B. Silverman
Publisher : Elsevier
Release : 2012-12-02
ISBN : 0080513379
Language : En, Es, Fr & De

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Book Description :

Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction. New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization

The Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action Book
Author : Richard B. Silverman,Mark W. Holladay
Publisher : Academic Press
Release : 2014-03-29
ISBN : 0123820316
Language : En, Es, Fr & De

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Book Description :

The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters, including new examples and references Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry Chapter 3 (Receptors): Drug-receptor interactions, cation-π and halogen bonding; atropisomers; case history of the insomnia drug suvorexant Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates

The Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action Book
Author : Richard B. Silverman
Publisher : Academic Press
Release : 2005-01-19
ISBN : 9780126437331
Language : En, Es, Fr & De

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Book Description :

This CD-ROM edition of Silverman's Organic Chemisry of Drug Design and Drug Action, Second Edition reflects the significant changes in the drug industry in recent years, using an accessible interactive approach. This CD-ROM integrates the author's own PowerPoint slides, indexed and linked to the book pages in PDF format. The three-part structure includes an all-electronic text with full-text search capabilites and nearly 800 powerpoint slides. This is a unique and powerful combination of electronic study guide and full book pages. Users can hyperlink seamlessly from the main text to key points and figures on the outline and back again. It serves as a wonderful supplement for instructors as well as a fully integrated text and study aid for students. * Three-part package includes 1) powerpoint, 2) integrated powerpoint and pdf-based text, and 3) fully searchable PDF-based text with index * Includes new full-color illustrations, structures, schemes, and figures as well as extensive chapter problems and exercises * User-friendly buttons transition from overview (study-guide) format to corresponding book page and back with the click of a mouse * Full-text search capabality an incomparable tool for researchers seeking specific references and/or unindexed phrases

The Organic Chemistry Of Drug Design And Drug Action 2E

The Organic Chemistry Of Drug Design And Drug Action  2E Book
Author : R. B. Silverman
Publisher : Unknown
Release : 2004-01-01
ISBN : 9788181474506
Language : En, Es, Fr & De

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Book Description :

Drug discovery, design and development. Receptors. Enzymes. Enzyme inhibition and inactivation. DNA-interactive agents. Drug metabolism. Prodrugs and drug delivery systems.

The Organic Chemistry of Drug Design and Drug Action Power PDF

The Organic Chemistry of Drug Design and Drug Action  Power PDF Book
Author : Richard B. Silverman
Publisher : Elsevier
Release : 2005-02-04
ISBN : 0080575382
Language : En, Es, Fr & De

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Book Description :

This CD-ROM edition of Silverman's Organic Chemisry of Drug Design and Drug Action, Second Edition reflects the significant changes in the drug industry in recent years, using an accessible interactive approach. This CD-ROM integrates the author's own PowerPoint slides, indexed and linked to the book pages in PDF format. The three-part structure includes an all-electronic text with full-text search capabilites and nearly 800 powerpoint slides. This is a unique and powerful combination of electronic study guide and full book pages. Users can hyperlink seamlessly from the main text to key points and figures on the outline and back again. It serves as a wonderful supplement for instructors as well as a fully integrated text and study aid for students. * Three-part package includes 1) powerpoint, 2) integrated powerpoint and pdf-based text, and 3) fully searchable PDF-based text with index * Includes new full-color illustrations, structures, schemes, and figures as well as extensive chapter problems and exercises * User-friendly buttons transition from overview (study-guide) format to corresponding book page and back with the click of a mouse * Full-text search capabality an incomparable tool for researchers seeking specific references and/or unindexed phrases

The Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action Book
Author : Sam Springer
Publisher : Unknown
Release : 2018
ISBN : 9781684690671
Language : En, Es, Fr & De

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Book Description :

Download The Organic Chemistry of Drug Design and Drug Action book written by Sam Springer, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Rational Drug Design

Rational Drug Design Book
Author : Donald G. Truhlar,W. Jeffrey Howe,Anthony J. Hopfinger,Jeff Blaney,Richard E. Dammkoehler
Publisher : Springer Science & Business Media
Release : 1999-03-12
ISBN : 9780387987538
Language : En, Es, Fr & De

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Book Description :

Drug research and discovery are of critical importance in human health care. Computational approaches for drug lead discovery and optimization have proven successful in many recent research programs. These methods have grown in their effectiveness not only because of improved understanding of the basic science - the biological events and molecular interactions that define a target for therapeutic intervention - but also because of advances in algorithms, representations, and mathematical procedures for studying such processes. This volume surveys some of those advances. A broad landscape of high-profile topics in computer-assisted molecular design (CAMD) directed to drug design are included. Subject areas represented in the volume include receptor-based applications such as binding energy approximations, molecular docking, and de novo design; non-receptor-based applications such as molecular similarity; molecular dynamics simulations; solvation and partitioning of a solute between aqueous and nonpolar media; graph theory; non-linear multidimensional optimization, processing of information obtained from simulation studies, global optimization and search strategies, and performance enhancement through parallel computing.

Organic Chemistry of Enzyme Catalyzed Reactions Revised Edition

Organic Chemistry of Enzyme Catalyzed Reactions  Revised Edition Book
Author : Richard B. Silverman
Publisher : Elsevier
Release : 2002-03-07
ISBN : 0080513360
Language : En, Es, Fr & De

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Book Description :

The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed. This is a revised edition of a very successful book, which appeals to both academic and industrial markets. Illustrates the organic mechanism associated with each enzyme-catalyzed reaction Makes the connection between organic reaction mechanisms and enzyme mechanisms Compiles the latest information about molecular mechanisms of enzyme reactions Accompanied by clearly drawn structures, schemes, and figures Includes an extensive bibliography on enzyme mechanisms covering the last 30 years Explains how enzymes can accelerate the rates of chemical reactions with high specificity Provides approaches to the design of inhibitors of enzyme-catalyzed reactions Categorizes the cofactors that are appropriate for catalyzing different classes of reactions Shows how chemical enzyme models are used for mechanistic studies Describes catalytic antibody design and mechanism Includes problem sets and solutions for each chapter Written in an informal and didactic style

Drug Design and Action

Drug Design and Action Book
Author : Joaquín M. Campos Rosa,M. Encarnación Camacho Quesada
Publisher : Walter de Gruyter GmbH & Co KG
Release : 2017-08-21
ISBN : 3110528657
Language : En, Es, Fr & De

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Book Description :

This two volume book is an excellent introduction to this interdisciplinary area, lying on the interface between organic chemistry, biochemistry and medicine. The authors give a comprehensive overview of the field and outline the actual challenges in pharmaceutical science and industry. Volume 1 introduces the concepts of drug design and drug metabolic processes as well as antibacterial, antiviral and anticancer agents.

Studyguide for the Organic Chemistry of Drug Design and Drug Action by Silverman Richard B ISBN 9780123820303

Studyguide for the Organic Chemistry of Drug Design and Drug Action by Silverman  Richard B   ISBN 9780123820303 Book
Author : Cram101 Textbook Reviews
Publisher : Cram101
Release : 2014-07-11
ISBN : 9781497018761
Language : En, Es, Fr & De

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Book Description :

Never HIGHLIGHT a Book Again! Includes all testable terms, concepts, persons, places, and events. Cram101 Just the FACTS101 studyguides gives all of the outlines, highlights, and quizzes for your textbook with optional online comprehensive practice tests. Only Cram101 is Textbook Specific. Accompanies: 9780123820303. This item is printed on demand.

Strategies for Organic Drug Synthesis and Design

Strategies for Organic Drug Synthesis and Design Book
Author : Daniel Lednicer
Publisher : John Wiley & Sons
Release : 2009-03-04
ISBN : 9780470399590
Language : En, Es, Fr & De

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Book Description :

This book examines and evaluates the strategies utilized to design and synthesize pharmaceutically active agents. Significant updates over the last 10 years since the publication of the 1st edition include synthesis of enantiomerically pure isomers, novel chemical methodologies, and new pharmaceutical agents targeted at novel biological endpoints. Written by an experienced successful author, this book meets the needs of a growing community of researchers in pharmaceutical R &D, as well as medical professionals, by providing a useful guide for designing and synthesizing pharmaceutical agents. Additionally, it is a useful text for medicinal chemistry students.

Molecular Biology and Biotechnology

Molecular Biology and Biotechnology Book
Author : Robert A. Meyers
Publisher : John Wiley & Sons
Release : 1995-06-29
ISBN : 9780471186342
Language : En, Es, Fr & De

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Book Description :

This is one volume 'library' of information on molecular biology, molecular medicine, and the theory and techniques for understanding, modifying, manipulating, expressing, and synthesizing biological molecules, conformations, and aggregates. The purpose is to assist the expanding number of scientists entering molecular biology research and biotechnology applications from diverse backgrounds, including biology and medicine, as well as physics, chemistry, mathematics, and engineering.

Chemical Drug Design

Chemical Drug Design Book
Author : Girish Kumar Gupta,Vinod Kumar
Publisher : Walter de Gruyter GmbH & Co KG
Release : 2016-10-10
ISBN : 311036882X
Language : En, Es, Fr & De

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Book Description :

Chemical Drug Design provides a compact overview on recent advances in this rapidly developing field. With contributions on in silico drug design, natural product based compounds, as well as on ligand- and structure-based approaches, the authors present innovative methods and techniques for identifying and synthetically designing novel drugs.

Molecular Mechanics Across Chemistry

Molecular Mechanics Across Chemistry Book
Author : Anthony K. Rappé,Carla J. Casewit
Publisher : University Science Books
Release : 1997-05-07
ISBN : 9780935702774
Language : En, Es, Fr & De

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Book Description :

The remarkable breadth of modern molecular mechanics is covered in this textbook developed for an undergraduate or first-time course on molecular mechanics. The book uses a case-study approach designed to give readers exposure to the relevance and utility of molecular mechanics as well as the opportunity to study a particular problem and its solution in depth.

Molecular Docking for Computer Aided Drug Design

Molecular Docking for Computer Aided Drug Design Book
Author : S. Mohane Coumar
Publisher : Academic Press
Release : 2021-02-17
ISBN : 0128223138
Language : En, Es, Fr & De

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Book Description :

Molecular Docking for Computer-Aided Drug Design: Fundamentals, Techniques, Resources and Applications offers in-depth coverage on the use of molecular docking for drug design. The book is divided into three main sections that cover basic techniques, tools, web servers and applications. It is an essential reference for students and researchers involved in drug design and discovery. Covers the latest information and state-of-the-art trends in structure-based drug design methodologies Includes case studies that complement learning Consolidates fundamental concepts and current practice of molecular docking into one convenient resource

Medicinal Chemistry

Medicinal Chemistry Book
Author : Th Nogrady,Donald F. Weaver
Publisher : Oxford University Press
Release : 2005
ISBN : 0195104560
Language : En, Es, Fr & De

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Book Description :

Fully updated, the third edition of this popular textbook remains comprehensive, authoritatives and readable. Taking a receptor-based, target-centred approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and biochemical principles. The changes in this edition have been many and varied, including a new chapter on the immune system, updated discussions of molecular modelling techniques, and new clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level. This book is designed for students of pharmacy, chemistry, and pharmacology.

Managing the Drug Discovery Process

Managing the Drug Discovery Process Book
Author : Walter Moos,Susan Miller,Stephen Munk,Barbara Munk
Publisher : Woodhead Publishing
Release : 2016-11-08
ISBN : 0081006322
Language : En, Es, Fr & De

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Book Description :

Managing the Drug Discovery Process: How to Make It More Efficient and Cost-Effective thoroughly examines the current state of pharmaceutical research and development by providing chemistry-based perspectives on biomedical research, drug hunting and innovation. The book also considers the interplay of stakeholders, consumers, and the drug firm with attendant factors, including those that are technical, legal, economic, demographic, political, social, ecological, and infrastructural. Since drug research can be a high-risk, high-payoff industry, it is important to researchers to effectively and strategically manage the drug discovery process. This book takes a closer look at increasing pre-approval costs for new drugs and examines not only why these increases occur, but also how they can be overcome to ensure a robust pharmacoeconomic future. Written in an engaging manner and including memorable insights, this book is aimed at redirecting the drug discovery process to make it more efficient and cost-effective in order to achieve the goal of saving countless more lives through science. A valuable and compelling resource, this is a must-read for all students and researchers in academia and the pharmaceutical industry. Considers drug discovery in multiple R&D venues, including big pharma, large biotech, start-up ventures, academia, and nonprofit research institutes Analyzes the organization of pharmaceutical R&D, taking into account human resources considerations like recruitment and configuration, management of discovery and development processes, and the coordination of internal research within, and beyond, the organization, including outsourced work Presents a consistent, well-connected, and logical dialogue that readers will find both comprehensive and approachable

Fundamentals of Medicinal Chemistry and Drug Metabolism

Fundamentals of Medicinal Chemistry and Drug Metabolism Book
Author : M. O. Faruk Khan,Ashok Philip
Publisher : Bentham Science Publishers
Release : 2018-06-01
ISBN : 1681086875
Language : En, Es, Fr & De

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Book Description :

The primary objective of this 4-volume book series is to educate PharmD students on the subject of medicinal chemistry. The book set serves as a reference guide to pharmacists on aspects of chemical basis of drug action. This first volume of the series is comprised of 8 chapters focusing on basic background information about medicinal chemistry. It takes a succinct and conceptual approach to introducing important fundamental concepts required for a clear understanding of various facets of pharmacotherapeutic agents, drug metabolism and important biosynthetic pathways that are relevant to drug action. Notable topics covered in this first volume include the scope and importance of medicinal chemistry in pharmacy education, a comprehensive discussion of the organic functional groups present in drugs, and information about four major types of biomolecules (proteins, carbohydrates, lipids, nucleic acids) and key heterocyclic ring systems. The concepts of acid-base chemistry and salt formation, and their applications to the drug action and design follow thereafter. These include concepts of solubility and lipid-water partition coefficient (LWPC), isosterism, stereochemical properties, mechanisms of drug action, drug receptor interactions critical for pharmacological responses of drugs, and much more. Students and teachers will be able to integrate the knowledge presented in the book and apply medicinal chemistry concepts to understand the pharmacodynamics and pharmacokinetics of therapeutic agents in the body.

Molecular Modelling and Drug Design

Molecular Modelling and Drug Design Book
Author : K Anand Solomon
Publisher : MJP Publisher
Release : 2019-06-05
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Molecular modelling is the scientific art of simulating chemicalor biological systems, so that computational methods can beapplied to understand the process concerned. Models usingcomputers are generated using mathematical equations and areevolved based on experimental information that is taken intoconsideration during model building. This book is anintroduction to the field of molecular modelling and drug designin which biological molecules effective in treating diseases arediscovered using in silico methods.

Evaluation of Enzyme Inhibitors in Drug Discovery

Evaluation of Enzyme Inhibitors in Drug Discovery Book
Author : Robert A. Copeland
Publisher : John Wiley & Sons
Release : 2005-04-01
ISBN : 0471723266
Language : En, Es, Fr & De

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Book Description :

Download Evaluation of Enzyme Inhibitors in Drug Discovery book written by Robert A. Copeland, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.