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The Neuroscience Of Depression

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Neurobiology of Depression

Neurobiology of Depression Book
Author : Francisco Lopez-Munoz,Cecilio Alamo
Publisher : CRC Press
Release : 2011-09-09
ISBN : 1439838496
Language : En, Es, Fr & De

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Book Description :

Major depressive disorders have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways hold promise as new therapeutics for depression. With the collaboration of the most prestigious international specialists in biochemistry, molecular biology, genomics, psychiatry, psychology, and pharmacology, Neurobiology of Depression discusses the nature of the central nervous system circuits responsible for the modifications of neuronal functioning that lead to depression. The book begins by discussing animal, neurophysiological, and neuropsychological models of depression as well as neural foundations. It explores genetic factors that contribute to depression and describes the effect of monoaminergic systems in the central nervous system. Next, the book profiles the rise of psychopharmacology in the treatment of depression and the research into serotonin and monoamine reuptake inhibitors. It examines the role of the glutamatergic, endocannabinoid, and opioid systems in the pathophysiology of mood disorders, as well as the effect of biological rhythms on the human body. Later chapters review the role of CRF-related ligands, CRF receptors, HPA axis activity, and glucocorticoid receptors in the regulation of the stress response and depression. They also describe cytokine modulation of molecular mechanisms. They examine the role of neuropeptide Y, nitric oxide, beta-arrestins, BDNF, and phosphodiesterases, and discuss the use of tachykinin antagonists in treatment. Finally, they analyze the neurobiological basis for the development of new antidepressant agents. Exploring myriad aspects of a disease that plagues a large percentage of the population worldwide, this volume captures the state of the science of this debilitating disorder, facilitating further research and discovery.

The Neuroscience of Depression

The Neuroscience of Depression Book
Author : Colin R. Martin,Lan-Anh Hunter,Vinood B. Patel,Victor R. Preedy,Rajkumar Rajendram
Publisher : Academic Press
Release : 2021-03-01
ISBN : 0128180102
Language : En, Es, Fr & De

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Book Description :

The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is a comprehensive reference to the aspects, features and effects of depression. This book provides readers with the behavior and psychopathological effects of depression, linking anxiety, anger and PSTD to depression. Readers are provided with a detailed outline of the genetic aspects of depression including synaptic genes and the genome-wide association studies (GWAS) of depression, followed by a thorough analysis of the neurological and imaging techniques used to study depression. This book also includes three full sections on the various effects of depression, including diet, nutrition and molecular and cellular effects. The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is the only resource for researchers and practitioners studying depression. The Neuroscience of Depression: Features, Diagnosis and Treatment Covers a pharmacological and behavioral treatment options Features sections on diagnosis and biomarkers of depression Discusses depression in children, teens and adults Contains information on comorbidity of physical and mental conditions Includes more than 250 illustrations and tables The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet Features a section on neurological and imaging, including SPECT Neuroimaging Analyzes how diet and nutrition effect depression Examines the molecular and cellular effects of depression Covers genetics of depression Includes more than 250 illustrations and tables

Systems Neuroscience in Depression

Systems Neuroscience in Depression Book
Author : Thomas Frodl
Publisher : Academic Press
Release : 2016-09-01
ISBN : 0128026286
Language : En, Es, Fr & De

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Book Description :

Systems Neuroscience in Depression provides a comprehensive overview of the normal and depressed brain processes as studied from a systems neuroscience perspective. Systems neuroscience uses a wide variety of approaches to study how networks of neurons form the bases of higher brain function. A broad overview is discussed starting with a background from neurodevelopment and neural understanding as well as novel treatment approaches for depression. This book covers basic developmental aspects and depressive psychopathology, as well as the basic scientific background from animal models and experimental research. Current advances in systems neuroscience are highlighted in studies from child and adolescent psychiatry. Integrated approaches are presented with regards to genetics, neuroimaging and neuroinflammation as well as neuroendocrinology. The field of systems and network neuroscience is evolving rapidly and this book provides a greatly needed resource for researchers and practitioners in systems neuroscience and psychiatry. Knowledge covering the whole life span from early to later life Comprehensively written chapters developing from molecules via epigenetics and neural circuits to clinical neuroscience Understanding the neurobiology of major depressive disorder Integrating stress and environmental factors with molecular underpinnings More than 25 illustrations and tables

Neurobiology of Depression

Neurobiology of Depression Book
Author : Joao Luciano de Quevedo,Andre Ferrer Carvalho,Carlos A. Zarate
Publisher : Academic Press
Release : 2019-01-03
ISBN : 0128133341
Language : En, Es, Fr & De

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Book Description :

Neurobiology of Depression: Road to Novel Therapeutics synthesizes the basic neurobiology of major depressive disorder with discussions on the most recent advances in research, including the interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and the development of novel optogenetic approaches that are changing research perspectives and revolutionizing research into depression. These basic foundational understandings on the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research are combined in this book to aid advanced students and researchers in their understanding of MDD. Depression is one of the most common mental-health disorders caused by a variety of genetic, biological, environmental and psychological factors. Major depressive disorder (MDD) is typically treated with first-line antidepressant agents that primarily target monoamine neurotransmission. However, only approximately one-third of patients with MDD achieve remission following a trial with such an antidepressant. Furthermore, MDD is a heterogeneous phenotype, and new frameworks, such as the NIMH Research Domain Criteria (RDoC) may provide a more accurate, biologically based comprehension of the symptomatic heterogeneity of this devastating illness. Aids readers in understanding major depressive disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments, to antidepressants and novel therapeutics Synthesizes discussions on the cellular and molecular mechanisms underlying symptoms with the clinical aspects of depression

Vulnerability to Depression

Vulnerability to Depression Book
Author : Rick E. Ingram,Ruth Ann Atchley,Zindel V. Segal
Publisher : Guilford Press
Release : 2011-07-07
ISBN : 160918257X
Language : En, Es, Fr & De

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Book Description :

Providing a cutting-edge examination of the mechanisms underlying depression, this volume integrates important areas of research that have largely remained separate. The authors explore both the cognitive and neurological processes that make some people more vulnerable than others to developing depression and experiencing recurrent episodes. They also probe how these processes interact—how negative life experiences, maladaptive belief systems, and patterns of thinking may actually affect neural circuitry, and vice versa. Explaining sophisticated theory and research in an accessible style, the book highlights the implications for improving clinical practices and patient outcomes.

Cognitive Affective Neuroscience of Depression and Anxiety Disorders

Cognitive Affective Neuroscience of Depression and Anxiety Disorders Book
Author : Dan J. Stein
Publisher : CRC Press
Release : 2002-11-14
ISBN : 9781841841007
Language : En, Es, Fr & De

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Book Description :

Data on depression and anxiety disorders now spans a range of fields from molecular neuroscience, through cognitive and affective science, and on to evolutionary psychology. The author here integrates this work into one volume, providing the clinician with a theoretical synthesis as well as a useful practical framework. Cognitive-Affective Neuroscience of Depression and Anxiety Disorders helps professionals in these various fields to manage patients with major depression, generalized anxiety disorder, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder and social anxiety disorder. Neuroscientists, neurologists, pharmacologists, psychiatrists and mental health practitioners will benefit from this text.

Bipolar Depression Molecular Neurobiology Clinical Diagnosis and Pharmacotherapy

Bipolar Depression  Molecular Neurobiology  Clinical Diagnosis and Pharmacotherapy Book
Author : Carlos A. Zarate Jr.,Husseini K. Manji
Publisher : Springer Science & Business Media
Release : 2009-04-16
ISBN : 3764385677
Language : En, Es, Fr & De

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Book Description :

Although our knowledge of mood disorders is expanding, comparatively little is known about bipolar depression in particular. This book offers the most up-to-date information about the diagnosis, treatment, and research surrounding bipolar depression. Early chapters provide diagnostic information and review the course, outcome and genetics of this heritable condition. The book gives a thorough and unique overview of the neurobiology of the disorder, including neuroimaging work. Several chapters delineate the treatment of bipolar depression in special populations such as children and pregnant women. Furthermore, the particular issues of suicide, focusing on the need for assessment during both acute and maintenance treatment, are addressed. Finally, acute and long-term treatment strategies for bipolar depression are discussed, including both traditional and novel therapeutics, as well as non-pharmacological treatments. This volume offers researchers and clinicians key insights into this devastating disorder.

The Upward Spiral

The Upward Spiral Book
Author : Alex Korb
Publisher : New Harbinger Publications
Release : 2015-03-01
ISBN : 1626251223
Language : En, Es, Fr & De

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Book Description :

Depression can feel like a downward spiral, pulling you into a vortex of sadness, fatigue, and apathy. In The Upward Spiral, neuroscientist Alex Korb demystifies the intricate brain processes that cause depression and offers a practical and effective approach to getting better. Based on the latest research in neuroscience, this book provides dozens of straightforward tips you can do every day to rewire your brain and create an upward spiral towards a happier, healthier life. Whether you suffer from depression or just want a better understanding of the brain, this book offers an engaging and informative look at the neuroscience behind our emotions, thoughts, and actions. The truth is that there isn’t one big solution to depression, but there are numerous simple steps you can take to alter brain activity and chemistry. Some are as easy as relaxing certain muscles to reduce anxiety, or getting more sunlight to improve your mood. Small steps in the right direction can have profound effects—giving you the power to become your best self as you literally reshape your brain, one small change at a time.

Neurobiology of Psychiatric Disorders

Neurobiology of Psychiatric Disorders Book
Author : Thomas E. Schlaepfer,Charles B. Nemeroff
Publisher : Elsevier
Release : 2012
ISBN : 0444520023
Language : En, Es, Fr & De

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Book Description :

This new volume in the Handbook of Clinical Neurology presents a comprehensive review of the fundamental science and clinical treatment of psychiatric disorders. Advances in neuroscience have allowed for dramatic advances in the understanding of psychiatric disorders and treatment. Brain disorders, such as depression and schizophrenia, are the leading cause of disability worldwide. It is estimated that over 25% of the adult population in North America are diagnosed yearly with at least one mental disorder and similar results hold for Europe. Now that neurology and psychiatry agree that all mental disorders are in fact, "brain diseases," this volume provides a foundational introduction to the science defining these disorders and details best practices for psychiatric treatment. Provides a comprehensive review of the scientific foundations of psychiatric disorders and psychiatric treatment Includes detailed results from genetics, molecular biology, brain imaging, and neuropathological, immunological, epidemiological, metabolic, therapeutic and historical aspects of the major psychiatric disorders A "must have" reference and resource for neuroscientists, neurologists, psychiatrists, and clinical psychologists as well as all research scientists investigating disorders of the brain

Inflammation and Immunity in Depression

Inflammation and Immunity in Depression Book
Author : Bernhard Baune
Publisher : Academic Press
Release : 2018-05-23
ISBN : 0128110740
Language : En, Es, Fr & De

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Book Description :

Inflammation and Immunity in Depression: Basic Science and Clinical Applications is the first book to move beyond the established theory of cytokine-induced depression and explore the broader role the immune system plays in this devastating mood disorder. The book fully explores the most recent lines of research into this rapidly advancing field, including alterations of T-cells, the neurobiological implications of neuroinflammation and immune alterations for brain development and function, and the genetic components of neuroinflammation in depression, including the relationships between stress and inflammation that are revealing gene-environment interactions in the disorder. Combining contributions from researchers worldwide, this book provides the most comprehensive discussion available today on the involvement of the innate immune and adaptive immune systems in depressive disorder. Chapters span neuroscience, psychology, clinical applications and future directions, making this book an invaluable resource for advanced students, researchers and practitioners who need to understand the complex and varied role of inflammation and immune responses in depression. Synthesizes current knowledge of inflammation and immunity in depression, ranging from basic neuroscience research, to clinical applications in psychiatry Expands on the long-established theory of cytokine-induced depression to discuss broader involvement of the immune system Explores translational potential of targeting immune dysfunction for clinical interventions

The Brain Emotion and Depression

The Brain  Emotion  and Depression Book
Author : Edmund T. Rolls
Publisher : Oxford University Press
Release : 2018-06-28
ISBN : 0192568221
Language : En, Es, Fr & De

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Book Description :

There are myriad questions that emerge when one considers emotions and decision-making: What produces emotions? Why do we have emotions? How do we have emotions? Why do emotional states feel like something? What is the relationship between emotion, reward value, and subjective feelings of pleasure? How is the value of 'good' represented in the brain? Will neuroeconomics replace classical microeconomics? How does the brain implement decision-making? Are gene-defined rewards and emotions in the interests of the genes? Does rational multistep planning enable us to go beyond selfish genes to plans in the interests of the individual? The Brain, Emotion, and Depression addresses these issues, providing a unified approach to emotion, reward value, economic value, decision-making, and their brain mechanisms. The evolutionary, adaptive value of the processes involved in emotion, the neural networks involved in emotion and decision making, and the issue of conscious emotional feelings are all considered. The book will be valuable for those in the fields of neuroscience, neurology, psychology, psychiatry, biology, animal behaviour, economics, and philosophy from the advanced undergraduate level upwards, and for all interested in emotion and decision-making.

Psychotherapy in an Age of Neuroscience

Psychotherapy in an Age of Neuroscience Book
Author : Joel Paris
Publisher : Oxford University Press
Release : 2017
ISBN : 0190601019
Language : En, Es, Fr & De

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Book Description :

Psychotherapy In an Age of Neuroscience is a critique of the neuroscience model that dominates contemporary psychiatric practice. It shows that while the neurosciences have made great advances, this line of research has thus far had little application to the care of patients. It criticizes theover-use of psychopharmacological interventions for common mental disorders such as depression, anxiety, and substance use. It examines why many, if not most, psychiatrists are seeing patients for 15-minute "med checks" oriented to current symptoms and DSM criteria, and are not taking the time tobecome familiar with the lives of their patients.The book shows that effective psychotherapeutic interventions are being under-utilized. It proposes that psychiatric practice include the use of psychotherapies that are brief and evidence-based. While most therapy will need to be carried out by psychologists and other mental health professionals,psychiatrists should take on the most complex and difficult cases that require both medication and therapy. By integrating biological and psychosocial interventions, psychiatrists can regain their reputation for breadth of vision and humanism.

Transactional Analysis for Depression

Transactional Analysis for Depression Book
Author : Mark Widdowson
Publisher : Routledge
Release : 2015-10-05
ISBN : 131759892X
Language : En, Es, Fr & De

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Book Description :

Transactional Analysis for Depression is the first research-based, transactional analysis psychotherapy manual. Developed from the author’s research into TA therapy for depression, the book also draws upon a wide range of contemporary research findings relating to depression and its treatment. Mark Widdowson provides the reader with a solid understanding about the nature of depression and clear guidance about how to provide effective psychotherapy for depressed clients. The book is a step-by-step guide to therapy, from the point of first contact through to ending, and covers: The theory and practice of TA therapy Understanding factors which maintain depression Conceptualising depression using Transactional Analysis Original material on the mechanisms of therapeutic change Optimising the psychotherapy process Key therapeutic processes in the therapy of depression Tailoring the therapy to client needs An introduction to neuroscience and the medical treatment of depression Complete with an additional resources section, including downloadable material designed to be given to clients to enhance the therapeutic process and strengthen the working alliance, Transactional Analysis for Depression provides structured, practical guidance to TA theory for therapists in practice and training.

Drugs and the Neuroscience of Behavior

Drugs and the Neuroscience of Behavior Book
Author : Adam Prus
Publisher : SAGE Publications
Release : 2017-02-06
ISBN : 1506338933
Language : En, Es, Fr & De

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Book Description :

Drugs and the Neuroscience of Behavior: An Introduction to Psychopharmacology, Second Edition by Adam Prus presents an introduction to the rapidly advancing field of psychopharmacology by examining how drug actions in the brain affect psychological processes. The book provides historical background to give readers an appreciation for the development of drug treatments and neuroscience over time, covering major topics in psychopharmacology, including new drugs and recent trends in drug use. Pedagogical features informed by the latest scholarship in teaching and learning are integrated throughout the text to ensure that readers are able to process and understand the material with ease.

Behavioral Neurobiology of Depression and Its Treatment

Behavioral Neurobiology of Depression and Its Treatment Book
Author : Philip J. Cowen,Trevor Sharp,Jennifer Y . F. Lau
Publisher : Springer Science & Business Media
Release : 2014-04-24
ISBN : 3642354254
Language : En, Es, Fr & De

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Book Description :

The book highlights important new research using current state-of-the-art approaches by prominent researchers in the field of depression. A broad range of topics is covered, beginning with a description of the phenotypic features of clinical depression, followed by chapters on the cellular and molecular basis, functional neuroimaging correlates and information-processing accounts. Finally, existing and novel treatment approaches are covered. In this way the volume brings together the key disciplines involved in the neurobiological understanding of depression to provide an update of the field and outlook to the future. Together, the volume chapters provide focused and critical reviews that span a broad range of topics suitable for both students and established investigators interested in the present state of depression research.

The Neuroscience of Mindfulness Meditation

The Neuroscience of Mindfulness Meditation Book
Author : Yi-Yuan Tang
Publisher : Springer
Release : 2017-08-09
ISBN : 3319463225
Language : En, Es, Fr & De

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Book Description :

This book presents the latest neuroscience research on mindfulness meditation and provides guidance on how to apply these findings to our work, relationships, health, education and daily lives. Presenting cutting-edge research on the neurological and cognitive changes associated with its practice Tang aims to explain how it reaps positive effects and subsequently, how best to undertake and implement mindfulness practice. Mindfulness neuroscience research integrates theory and methods from eastern contemplative traditions, western psychology and neuroscience, and is based on neuroimaging techniques, physiological measures and behavioural tests. The Neuroscience of Mindfulness Meditation begins by explaining these foundations and then moves on to themes such as the impact of personality and how mindfulness can shape behaviour change, attention and self-control. Finally, the book discusses common misconceptions about mindfulness and challenges in future research endeavours. Written by an expert in the neuroscience of mindfulness this book will be valuable for scholars, researchers and practitioners in psychotherapy and the health sciences working with mindfulness, as well as those studying and working in the fields of neuroscience and neuropsychology.

Charney Nestler s Neurobiology of Mental Illness

Charney   Nestler s Neurobiology of Mental Illness Book
Author : Dennis S. Charney,Pamela B. Sklar
Publisher : Oxford University Press
Release : 2018-01-12
ISBN : 019068142X
Language : En, Es, Fr & De

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Book Description :

Preceded by Neurobiology of mental illness / edited by Dennis S. Charney ... [et al.]. 4th ed. 2013.

The Neuroscience of Clinical Psychiatry

The Neuroscience of Clinical Psychiatry Book
Author : Edmund S. Higgins,Mark S. George
Publisher : Lippincott Williams & Wilkins
Release : 2012-11-05
ISBN : 1469802007
Language : En, Es, Fr & De

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Book Description :

Bringing the latest breakthroughs in neuroscience to the clinician, this text provides resident and practicing psychiatrists with a comprehensive, clinically relevant overview of the brain mechanisms underlying behavior and mental illness. The book presents an integrated perspective on the structures and workings of the brain, the mechanisms governing behaviors such as pleasure, aggression, and intelligence, and the pathophysiology of mental disorders. More than 200 two-color illustrations clarify key concepts. Questions and answers at the end of each chapter facilitate review and board preparation. Readers will also have online access to the complete, fully searchable text and a quiz bank of over 150 questions at www.neuroscienceofclinicalpsychiatry.com.

Lifting Depression

Lifting Depression Book
Author : Kelly Lambert
Publisher : Hachette UK
Release : 2010-01-05
ISBN : 0786732164
Language : En, Es, Fr & De

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Book Description :

In this fascinating exploration of depression, neuroscientist Kelly Lambert highlights her groundbreaking research suggesting that important clues to the mysteries of this disease have been in our hands all along. She identifies a circuit in the human brain—connecting movement, feeling, and cognition—that is responsible for symptoms of depression, and shows that when we knit a sweater, prepare a meal, or simply repair a lamp, we're actually bathing our brain in “feel-good” chemicals. Highlighting inspiring accounts of change and growth, Lifting Depression offers a compassionate and commonsense way of preventing and treating one of the modern era's most debilitating diseases.

Cognitive Dimensions of Major Depressive Disorder

Cognitive Dimensions of Major Depressive Disorder Book
Author : Bernhard T. Baune,Catherine Harmer
Publisher : Oxford University Press, USA
Release : 2019-08
ISBN : 0198810946
Language : En, Es, Fr & De

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Book Description :

Major depressive disorder (MDD) is one of the most prevalent mental disorders worldwide, and is estimated to affect 300 million people. Most research defines MDD as a categorical disorder and investigations on clinical, functional, and biological correlates are assessed by established diagnostic instruments. However, given the phenotypic and biological heterogeneity of depression, a re-focus on the clinical phenotype of MDD is required. Bridging psychiatric and psychological traditions Cognitive Dimensions of Major Depressive Disorder, discusses the characteristics of the dimensional approach of MDD. Focusing on the cognitive and emotional processes of depression, this guide offers extended and novel diagnostic and treatment approaches ranging from pharmacological to psychological interventions targeting dimensions of depression. Edited by pioneers in this field, this resource discusses hot topics such as how to define the dimensional approach to depression, the neurobiological underpinnings of cognitive dysfunction in depression, and the impairment of emotional processing deficits in depression. Cognitive Dimensions of Major Depressive Disorder is suitable for students, trainees, clinicians and scientists in the fields of psychology, neuropsychology, psychiatry, cognitive neuroscience, neurology, general practice and also for various other health care professionals.