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The Neuroscience Of Autism

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The Neuroscience of Autism

The Neuroscience of Autism Book
Author : Rajesh K. Kana
Publisher : Academic Press
Release : 2022-05-27
ISBN : 012816736X
Language : En, Es, Fr & De

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Book Description :

The Neuroscience of Autism provides a comprehensive accounting of autism spectrum disorders by integrating scientific findings from behavioral, cognitive and neurobiological research. The book begins by defining autism, identifying characteristics and prevalence, exploring its history, and then moving on to the cognitive and social bases of behavioral symptoms, the brain bases of behavioral and cognitive symptoms, and finally, intervention practices. It examines theoretical models such as weak central coherence, enhanced perceptual functioning, and the extreme male brain hypothesis. Finally, the book addresses the increased attention on the brain connectivity model of autism, looking at the synchronization of brain activity across different brain areas, the causal influence of a brain region on another, and white matter cable connections in the brain. Delves into the increasing prevalence of autism in the United States Focuses on screening tools for early identification Discusses the neuroanatomical differences seen in individuals with autism Examines the inferences gained from functional MRI studies of autism

The Neuroscience of Autism Spectrum Disorders

The Neuroscience of Autism Spectrum Disorders Book
Author : Joseph D. Buxbaum,Patrick R. Hof
Publisher : Academic Press
Release : 2012-12-31
ISBN : 0123919304
Language : En, Es, Fr & De

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Book Description :

Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder. New research is leading to greater understanding of and ability to treat the disorder at an earlier age. It is hoped that further genetic and imaging studies will lead to biologically based diagnostic techniques that could help speed detection and allow early, more effective intervention. Edited by two leaders in the field, this volume offers a current survey and synthesis of the most important findings of the neuroscience behind autism of the past 20 years. With chapters authored by experts in each topic, the volume explores etiology, neuropathology, imaging, and pathways/models. Offering a broad background of ASDs with a unique focus on neurobiology, the volume offers more than the others on the market with a strictly clinical focus or a single authored perspective that fails to offer expert, comprehensive coverage. Researchers and graduate students alike with an interest in developmental disorders and autism will benefit, as will autism specialists across psychology and medicine looking to expand their expertise. Uniquely explores ASDs from a neurobiological angle, looking to uncover the molecular/cellular basis rather than to merely catalog the commonly used behavioral interventions Comprehensive coverage synthesizes widely dispersed research, serving as one-stop shopping for neurodevelopmental disorder researchers and autism specialists Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available

Understanding Autism

Understanding Autism Book
Author : Steven O. Moldin,John L R Rubenstein
Publisher : CRC Press
Release : 2006-04-25
ISBN : 1420004204
Language : En, Es, Fr & De

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Book Description :

Taking an all-inclusive look at the subject, Understanding Autism: From Basic Neuroscience to Treatment reviews state-of-the-art research on the diagnosis, treatment, and prevention of autism. The book addresses potential mechanisms that may underlie the development of autism and the neural systems that are likely to be affected by these molecular, genetic, and infectious etiologies. It reviews key findings that inform diagnosis, epidemiology, clinical neuroscience, and treatment. The book concludes with a discussion of the economic cost of autism and provides a biomedical and public health perspective of the impact of this devastating disease. With chapters authored by clinical and basic researchers at the forefront of molecular and systems neuroscience, clinical neuroscience, and health economics, the book presents a powerful and comprehensive synthesis of current research on autism and its underlying neural substrates. The book's two editors are considered elite pioneers in this area of research. Dr. Rubenstein was recently elected to the highly prestigious Institute of the Medicine, an honor reserved for those most committed to professional achievement and public service.

The Neuroscience of Autism Spectrum Disorders

The Neuroscience of Autism Spectrum Disorders Book
Author : Joseph D. Buxbaum,Patrick R. Hof
Publisher : Academic Press
Release : 2013
ISBN : 012391924X
Language : En, Es, Fr & De

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Book Description :

Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder. New research is leading to greater understanding of and ability to treat the disorder at an earlier age. It is hoped that further genetic and imaging studies will lead to biologically based diagnostic techniques that could help speed detection and allow early, more effective intervention. Edited by two leaders in the field, this volume offers a current survey and synthesis of the most important findings of the neuroscience behind autism of the past 20 years. With chapters authored by experts in each topic, the volume explores etiology, neuropathology, imaging, and pathways/models. Offering a broad background of ASDs with a unique focus on neurobiology, the volume offers more than the others on the market with a strictly clinical focus or a single authored perspective that fails to offer expert, comprehensive coverage. Researchers and graduate students alike with an interest in developmental disorders and autism will benefit, as will autism specialists across psychology and medicine looking to expand their expertise. Uniquely explores ASDs from a neurobiological angle, looking to uncover the molecular/cellular basis rather than to merely catalog the commonly used behavioral interventions Comprehensive coverage synthesizes widely dispersed research, serving as one-stop shopping for neurodevelopmental disorder researchers and autism specialists Edited work with chapters authored by leaders in the field around the globe - the broadest, most expert coverage available

Special Issue The Emerging Neuroscience of Autism Spectrum Disorders

Special Issue  The Emerging Neuroscience of Autism Spectrum Disorders Book
Author : Society for Neuroscience
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Special Issue The Emerging Neuroscience of Autism Spectrum Disorders book written by Society for Neuroscience, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Handbook of Developmental Cognitive Neuroscience

Handbook of Developmental Cognitive Neuroscience Book
Author : Professor of Pediatrics and Neuroscience Charles A Nelson
Publisher : MIT Press
Release : 2001
ISBN : 9780262140737
Language : En, Es, Fr & De

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Book Description :

Winner of the 2001 Professional/Scholarly Publishing Annual Awards Competition presented by the Association of American Publishers, Inc. in the category of Single Volume Reference: Science. The publication of this handbook testifies to the rapid growth of developmental cognitive neuroscience as a distinct field. Brain imaging and recording technologies, along with well-defined behavioral tasks—the essential methodological tools of cognitive neuroscience—are now being used to study development. Whereas earlier methodologies allowed scientists to study only adult brains, recent technological advances have yielded methods that can be safely used to study structure-function relations and their development in children's brains. These new techniques combined with more refined cognitive models account for the progress and heightened activity in developmental cognitive neuroscience research. The handbook contains forty-one original contributions exploring basic aspects of neural development, sensory and sensorimotor systems, language, cognition, and emotion. Aided by recent results in neurobiology establishing that the human brain remains malleable and plastic throughout much of the lifespan, the contributors also explore the implications of lifelong neural plasticity for brain and behavioral development. This book is also available online as part of MIT CogNet, The Cognitive and Brain Sciences Community online.

The Neurobiology of Autism

The Neurobiology of Autism Book
Author : Margaret L. Bauman,Thomas L. Kemper
Publisher : JHU Press
Release : 2005
ISBN : 9780801880469
Language : En, Es, Fr & De

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Book Description :

In the decade since the first edition of The Neurobiology of Autism was published, research has revealed valuable new information about the nature and origins of autism, including genetics and abnormalities in such neurotransmitters as acetylcholine and serotonin. For this long-anticipated new edition, neurologists Margaret L. Bauman and Thomas L. Kemper bring together leading researchers and clinicians to present the most current scientific knowledge and theories about autism. The contributors cover genetics, imaging studies, physiology, neuroanatomy and neurochemistry, immunology, brain function, the epidemiology of the disease, and related disorders. Thoroughly updated, The Neurobiology of Autism remains the best single-volume work on the wide array of research being conducted into the causes, characteristics, and treatment of autism. Contributors: George M. Anderson, Yale Child Study Center; Tara L. Arndt, University of Rochester Medical Center (URMC); Trang Au, University of Massachusetts Medical School (UMMC); Jocelyne Bachevalier, University of Texas Health Science Center; Irina N. Bespalova, Seaver Autism Research Center, Mt. Sinai School of Medicine (SARC); Gene J. Blatt, Boston University School of Medicine (BUSM); Susan E. Bryson, IWK Health Centre–Dalhousie University; Timothy M. Buie, Massachusetts General Hospital (MGH); Joseph D. Buxbaum, SARC; Kathryn M. Carbone, The Johns Hopkins University School of Medicine (JHUSM); Diane C. Chugani, Wayne State University; Daniel F. Connor, UMMC; Edwin H. Cook, Jr., University of Chicago; S. Hossein Fatemi, University of Minnesota Medical School; Susan E. Folstein, Tufts University School of Medicine; Eric Fombonne, McGill University; Randi Jenssen Hagerman, UC Davis Medical Center; Elizabeth Petri Henske, Fox Chase Cancer Center, Philadelphia; Jeannette J. A. Holden, Queen's University; Ronald J. Killiany, BUSM; Omanand Koul, UMMC; Mandy Lee, Newcastle General Hospital, U.K.; Xudong Liu, Queen's University; Tara L. Moore, BUSM; Mark B. Moss, BUSM; Karin B. Nelson, National Institute of Neurological Disorders and Stroke; Phillip G. Nelson, National Institute of Child Health and Human Development; Elaine Perry, Newcastle General Hospital; Jonathan Pevsner, JHUSM; Mikhail V. Pletnikov, JHUSM; Stephen W. Porges, University of Illinois at Chicago; Lucio Rehbein, Universidad de la Frontera, Chile; Jennifer Reichert, SARC; Patricia M. Rodier, URMC; Beth Rosen-Sheidley, MGH; Susan L. Smalley, UCLA Neuropsychiatric Research Institute; Ronald J. Steingard, UMMC; Helen Tager-Flusberg, BUSM; Gary L. Wenk, University of Arizona; Andrew W. Zimmerman, JHUSM

Asperger Syndrome or High Functioning Autism

Asperger Syndrome or High Functioning Autism  Book
Author : Eric Schopler,Gary B. Mesibov,Linda J. Kunce
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1461553695
Language : En, Es, Fr & De

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Book Description :

The precise relationship between high-functioning autism and Asperger Syndrome is still a subject of debate. This volume provides a general overview of the disorder and present diverse opinions on diagnosis and assessment, neuropsychological issues, treatment, and related conditions. A special section features personal essays by individuals diagnosed with autism or Asperger Syndrome. The result is a comprehensive and useful survey of the current state of the field that will be of great interest to clinicians, teachers, researchers, and parents.

Tracing Autism

Tracing Autism Book
Author : Des Fitzgerald
Publisher : University of Washington Press
Release : 2017-07-10
ISBN : 0295741929
Language : En, Es, Fr & De

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Book Description :

In Tracing Autism, Des Fitzgerald offers an up-close account of the search for a neurological explanation of autism. As autism has gained cultural prominence with more diagnoses and more controversy, its biological causes remain elusive. Through in-depth interviews with neuroscientists, psychologists, and psychiatrists, Fitzgerald examines what it means to do scientific research in the ambiguous terrain of autism research, a field marked by shifting horizons of uncertainty and ambivalence. He draws out how autism scientists talk and feel their way through their research, demonstrating its profoundly affective character, and expanding our understanding of what is at stake in the new brain sciences.

The Neurology of Autism

The Neurology of Autism Book
Author : Mary Coleman
Publisher : Oxford University Press
Release : 2009-04-23
ISBN : 0199728399
Language : En, Es, Fr & De

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Book Description :

In Neurology of Autism, Mary Coleman, Catalina Betancur, G. Robert DeLong, Christopher Gillberg, Yoshiko Nomura, Lorenzo Pavone, Martin Ruggieri, and Michele Zappella use the tools of neurological analysis to address a number of the major questions that have arisen in the study of autism. The answers they present have important implications for the direction of future autism research, diagnosis, and treatment. What are the neurological signs and symptoms of autism? The latest information is presented here in an in-depth discussion of epilepsy, cranial circumference, changes in muscle tone, stereotypies, and mutism found in children with autism. In addition, a template is provided for practitioners to follow when conducting neurological examinations of a child with autism. What are the best options for the treatment of autism? The current medical, educational, and alternative therapies are thoroughly reviewed and evaluated. Is autism reversible? The question is explored for syndromic autism, where diseases may have a transient autistic phase, and reviewed in detail for nonsyndromic autism. Is autism primarily a single disease, as originally described by Leo Kanner? Research presented here suggests that autism is, instead, a syndrome involving many disease entities. Has the incidence of autism been increasing in recent years? A sophisticated, historical review of autisms prevalence rates suggests that it has never been rare. What is the relationship between autism and Asperger syndrome? The latest evidence presented here sheds light on the degree to which both syndromes share more than clinical characteristics; they also have some similar findings in imaging, neuropathological, and genetic studies. Which components of the brains neural networks need to be impaired to cause the appearance of autistic symptoms? Although there are many candidate regions, dysfunction of the cerebellum and its circuits is noted to be of great interest. Student and professional researchers, practitioners, and parents will find this book to be a valuable resource for both the latest information from basic-science research and its application to the diagnosis and treatment of autism. "[This book] includes up-to-date genetic evidence, underlining the complexities of genetic/environmental influences...I recommend this easy and informative read." -European Journal of Pediatric Neurology "...authoritative." -The Lancet Neurology "Coleman's new book is an absolute must-read for anyone interested in the progress made in understanding the causes of autism. The field owes her a tribute worthy of someone who has transformed an area of neuroscience." -Simon Baron-Cohen in Nature Neuroscience "[I]nformative and comprehensive in its treatment of the neurologic basis of autism...well written and easy to understand...the contributing authors have done an excellent job of making complex medical concepts understandable to all. The glossary at the end of the book is extremely helpful in this regard. The book is well referenced, provides helpful tables throughout, and includes a summary of relevant points at the end of each chapter.The authors are to be commended for presenting a very balanced view of current knowledge; they also indicate what we do not yet understand about brain functioning in autism and provide an important road map for ongoing exploration." -Marshalyn Yeargin-Allsopp in The New England Journal of Medicine "At last it is recognised that developmental neurology is the appropriate context in which to explain autism. The authors of this volume, all pioneers in the field, consider new ideas on autism in this context. They succeed in making surprising and illuminating comparisons between autism and neurological disorders whose origin is already known. This work is a significant step towards understanding the causes of autistic disorders."-Uta Frith, Institute of Cognitive Neuroscience and Department of Psychology, University College London "When and if the secret of autism is teased from the myriad disease states that exhibit the syndrome, it will be through efforts such as are represented in this volume. Dr. Coleman has 'picked the brains' of recognized experts from neurology and related sciences, and has assembled a wealth of up-to-date and meticulously referenced information regarding both those diseases and the core symptoms of autism." -Peter B. Rosenberger, Massachusetts General Hospital

Homeostatic Control of Brain Function

Homeostatic Control of Brain Function Book
Author : Detlev Boison,Susan A. Masino
Publisher : Oxford University Press
Release : 2015-12
ISBN : 0199322295
Language : En, Es, Fr & De

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Book Description :

Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders. Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies to restore and maintain homeostatic functions can help improve brain health, no matter the diagnosis. Employing homeostatic therapies may lead to future cures or treatments that address multiple comorbidities. In an age where brain diseases such as Alzheimer's or Parkinson's are ever present, the incorporation of homeostatic techniques could successfully promote better overall brain health. Key Features include - A focus on the homeostatic controls that significantly depend on the way one lives, eats, and drinks. - Highlights from emerging research in non-pharmaceutical therapies including botanical medications, meditation, diet, and exercise. - Incorporation of homeostatic therapies into existing basic and clinical research paradigms. - Extensive scientific basic and clinical research ranging from molecules to disorders. - Emerging practical information for improving homeostasis. - Examples of homeostatic therapies in preventing and delaying dysfunction. Both editors, Detlev Boison and Susan Masino, bring their unique expertise in homeostatic research to the overall scope of this work. This book is accessible to all with an interest in brain health; scientist, clinician, student, and lay reader alike.

Autism and Pervasive Developmental Disorders

Autism and Pervasive Developmental Disorders Book
Author : Fred R. Volkmar
Publisher : Cambridge University Press
Release : 2019-01-24
ISBN : 1108693628
Language : En, Es, Fr & De

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Book Description :

Interest in autism and related disorders has exploded. Established as an essential book on this complex syndrome, the new edition has been extensively revised to reflect significant advances in research. Featuring contributions from leading international authorities in the clinical and social sciences, the book covers recent progress in our understanding of the field and offers a perspective on the present state of the discipline. With new material on topics such as evidence-based treatment and practice, the book covers changes in diagnosis resulting from the publication of DSM-V, and developments in how autism is understood, including the removal of language delay as a necessary diagnostic criterion. Far-reaching, the book considers aspects from epidemiology, genetics, and neurobiology, to core symptoms, early interventions, and pharmacology. One section critically surveys the history of autism as a diagnostic concept, and issues such as an ageing population and the impact of research on national policy are considered.

The Neuroscience of Normal and Pathological Development

The Neuroscience of Normal and Pathological Development Book
Author : Colin R. Martin,Victor R. Preedy,Rajkumar Rajendram
Publisher : Academic Press
Release : 2021-10-12
ISBN : 0128183721
Language : En, Es, Fr & De

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Book Description :

Diagnosis, Management and Modeling of Neurodevelopmental Disorders: The Neuroscience of Development is a comprehensive reference on the diagnosis and management of neurodevelopment and associated disorders. This book discusses the mechanisms underlying neurological development and provides readers with a detailed introduction to the neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. It also examines pharmacological and non-pharmacological interventions of development-related conditions. Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with proper and abnormal development. This book discusses the mechanisms underlying neurological development and provides readers with a detailed introduction to the neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurodevelopment. It also examines in vitro and in vivo modelling of development with stem cells and model systems. Diagnosis, Management and Modeling of Neurodevelopmental Disorders: The Neuroscience Of Development: Provides the most comprehensive coverage of the broad range of topics related to the neuroscience of development Features sections on diagnosis and biomarkers Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Focuses on neurodevelopmental disorders and environmental factors that influence neural development Includes more than 500 illustrations and tables Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior, and Diet: Provides the most comprehensive coverage of the broad range of topics related to the neuroscience of development Features sections on the genetics of developmental conditions and accompanying behavior Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Focuses on neurodevelopmental disorders and environmental factors that influence neural development Includes more than 500 illustrations and tables

Handbook of the Neuroscience of Language

Handbook of the Neuroscience of Language Book
Author : Brigitte Stemmer,Harry A. Whitaker
Publisher : Academic Press
Release : 2008-04-29
ISBN : 0080564917
Language : En, Es, Fr & De

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Book Description :

In the last ten years the neuroscience of language has matured as a field. Ten years ago, neuroimaging was just being explored for neurolinguistic questions, whereas today it constitutes a routine component. At the same time there have been significant developments in linguistic and psychological theory that speak to the neuroscience of language. This book consolidates those advances into a single reference. The Handbook of the Neuroscience of Language provides a comprehensive overview of this field. Divided into five sections, section one discusses methods and techniques including clinical assessment approaches, methods of mapping the human brain, and a theoretical framework for interpreting the multiple levels of neural organization that contribute to language comprehension. Section two discusses the impact imaging techniques (PET, fMRI, ERPs, electrical stimulation of language cortex, TMS) have made to language research. Section three discusses experimental approaches to the field, including disorders at different language levels in reading as well as writing and number processing. Additionally, chapters here present computational models, discuss the role of mirror systems for language, and cover brain lateralization with respect to language. Part four focuses on language in special populations, in various disease processes, and in developmental disorders. The book ends with a listing of resources in the neuroscience of language and a glossary of items and concepts to help the novice become acquainted with the field. Editors Stemmer & Whitaker prepared this book to reflect recent developments in neurolinguistics, moving the book squarely into the cognitive neuroscience of language and capturing the developments in the field over the past 7 years. History section focuses on topics that play a current role in neurolinguistics research, aphasia syndromes, and lesion analysis Includes section on neuroimaging to reflect the dramatic changes in methodology over the past decade Experimental and clinical section reflects recent developments in the field

Social Cognition

Social Cognition Book
Author : Tricia Striano,Vincent Reid
Publisher : Wiley-Blackwell
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

How we perceive and interpret the actions of others is crucial if we are to develop into healthy adults. It has even been argued that a lack of social cognitive skills lays a strong foundation for a variety of atypical developmental disorders, including autism. Fortunately, our understanding of how humans process and interpret each other's actions has increased by leaps and bounds in the past decade. At the vanguard of these encouraging developments has been groundbreaking research in the fields of cognitive neuroscience, developmental psychology, and autism. Social Cognition: Development, Neuroscience and Autism is the first volume to fully integrate these areas of cutting-edge research on social cognition through contributions from some of the world's foremost experts in all three disciplines. The text is edited by distinguished development specialists who preface each section with chapter by chapter summaries that seamlessly link each of the contributing essays. Sections include related chapters on perspectives on social cognition, social cognition during infancy, social cognition and the adult brain, and social cognition: the challenge of autism. The text's final section serves as a commentary highlighting the fundamental issues that have been addressed in the text. Social Cognition: Development, Neuroscience and Autism is an indispensable addition to the rapidly expanding field of social cognition—and will provide valuable new insights on how we think and learn.

Autism Spectrum Disorder

Autism Spectrum Disorder Book
Author : Susan P. Sherkow,Alexandra M. Harrison , M.D.
Publisher : Rowman & Littlefield
Release : 2013-11-14
ISBN : 0765708639
Language : En, Es, Fr & De

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Book Description :

Autism Spectrum Disorder: Perspectives from Psychoanalysis and Neuroscience, offers a guide to understanding and treating the ASD toddler from the dual perspectives of psychoanalysis and neurofunction through describing in great detail intensive treatments of four children who began therapy as toddlers. The authors hypothesize that dyadic therapy and Reflective Network Therapy can impact a child by modifying the biochemistry of the brain, resulting in alteration of emotion and cognition. Their chapter on neurobiological mechanisms of change describes these hypotheses in depth.

The Neuropsychology of Autism

The Neuropsychology of Autism Book
Author : Deborah Fein
Publisher : Oxford University Press
Release : 2011-06-09
ISBN : 0195378318
Language : En, Es, Fr & De

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Book Description :

The Neuropsychology of Autism provides an up-to-date summary on the neuropsychology of autism spectrum disorders (ASD), written by leaders in the field. It summarizes current knowledge about neurochemistry, neuroanatomy, genetics, and clinical presentations and provides helpful discussions on key functions such as language, memory, attention, executive functions, social cognition, motor and sensory functioning.

Advances in the Cognitive Neuroscience of Autism

Advances in the Cognitive Neuroscience of Autism Book
Author : Sally Ozonoff
Publisher : Unknown
Release : 2022-06-29
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Advances in the Cognitive Neuroscience of Autism book written by Sally Ozonoff, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Autism Spectrum Disorders From Genotypes to Phenotypes

Autism Spectrum Disorders  From Genotypes to Phenotypes Book
Author : Valsamma Eapen,Andrew J. Whitehouse,Charles Claudianos,Rudi Crncec
Publisher : Frontiers Media SA
Release : 2015-12-10
ISBN : 2889196801
Language : En, Es, Fr & De

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Book Description :

This Research Topic covers the pathogenetic processes in Autism Spectrum Disorder (ASD) that underpin the translation of genetic vulnerability to clinically significant symptoms. Available research data in ASD suggests that it is a neural connectivity disorder and that the social communication and related neurobehavioural symptoms result from reduced synchronization between key "social brain" regions. These interconnected neural systems can be understood through the relationship between functionally relevant anatomic areas and neurochemical pathways, the programming of which are genetically modulated during neurodevelopment and mediated through a range of epigenetic and environmental modulators. Elucidating the underlying molecular mechanisms can provide an invaluable window for understanding the neural wiring that regulates higher brain functions and consequent clinical phenotypes. In keeping with the multi modal and diverse origins of ASD, this Research Topic explores the genetic underpinnings and environmental modulation in the aetiology; neural substrates, biomarkers and endophenotypes that underlie clinical characteristics; as well as neurochemical pathways and pathophysiological mechanisms that pave the way for therapeutic interventions. Furthermore, since genetically mediated deficits and consequent functional impairments involve activity-dependent synapse development that depends on postnatal learning and experience, the trajectory towards the final clinical expression could be modulated by early interventions that exploit the neuronal maturation and brain plasticity. However, identifying these diverse pathogenetic processes and tailoring interventions would require subtyping ASD into homogeneous subgroups. In this regard, this topic covers the current state of evidence in the literature through topic reviews as well as ongoing original work that provides tangible hypotheses and directions for future research.

The Neuroscience of Human Relationships Attachment and the Developing Social Brain Second Edition

The Neuroscience of Human Relationships  Attachment and the Developing Social Brain  Second Edition  Book
Author : Louis Cozolino
Publisher : W. W. Norton & Company
Release : 2014-03-24
ISBN : 0393707911
Language : En, Es, Fr & De

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Book Description :

A revised edition of the best-selling text on how relationships build our brains. As human beings, we cherish our individuality yet we know that we live in constant relationship to others, and that other people play a significant part in regulating our emotional and social behavior. Although this interdependence is a reality of our existence, we are just beginning to understand that we have evolved as social creatures with interwoven brains and biologies. The human brain itself is a social organ and to truly understand being human, we must understand not only how we as whole people exist with others, but how our brains, themselves, exist in relationship to other brains. The first edition of this book tackled these important questions of interpersonal neurobiology—that the brain is a social organ built through experience—using poignant case examples from the author’s years of clinical experience. Brain drawings and elegant explanations of social neuroscience wove together emerging findings from the research literature to bring neuroscience to the stories of our lives. Since the publication of the first edition in 2006, the field of social neuroscience has grown at a mind-numbing pace. Technical advances now provide more windows into our inner neural universe and terms like attachment, empathy, compassion, and mindfulness have begun to appear in the scientific literature. Overall, there has been a deepening appreciation for the essential interdependence of brain and mind. More and more parents, teachers, and therapists are asking how brains develop, grow, connect, learn, and heal. The new edition of this book organizes this cutting-edge, abundant research and presents its compelling insights, reflecting a host of significant developments in social neuroscience. Our understanding of mirror neurons and their significance to human relationships has continued to expand and deepen and is discussed here. Additionally, this edition reflects the gradual shift in focus from individual brain structures to functional neural systems—an important and necessary step forward. A great deal of neural overlap has been discovered in brain activation when we are thinking about others and ourselves. This raises many questions including how we come to know others and whether the notion of an “individual self” is anything more than an evolutionary strategy to support our interconnection. In short, we are just beginning to see the larger implications of all neurological processes—how the architecture of the brain can help us to better understand individuals and our relationships. This book gives readers a deeper appreciation of how and why relationships have the power to reshape our brains throughout our life.