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The Mouse In Biomedical Research

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The Mouse in Biomedical Research

The Mouse in Biomedical Research Book
Author : N.A
Publisher : Elsevier
Release : 2006-12-04
ISBN : 9780080469065
Language : En, Es, Fr & De

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Book Description :

History, Wild Mice, and Genetics, the first volume in the four volume set, The Mouse in Biomedical Research, provides information about the history, biology and genomics of the laboratory mouse (Mus musculus), as well as basic information on maintenance and use of mouse stocks. Mouse origins and relationships are covered in chapters on history, evolutionary taxonomy and wild mice. Genetics and genomics of the mouse are covered in chapters on genetic nomenclature, gene mapping, cytogenetics and the molecular organization of the mouse genome. Maintenance of laboratory mice is described in chapters on breeding systems for various types of strains and stocks and genetic monitoring. Use of the mouse as a model system for basic biomedical research is described in chapters on chemical mutagenesis, gene trapping, pharmacogenetics and embryo manipulation. The information in Volume 1 serves as a primer for scientists new to the field of mouse research.

The Mouse in Biomedical Research

The Mouse in Biomedical Research Book
Author : Henry L. Foster,J. David Small,James C.. Fox,James G. Fox
Publisher :
Release : 1983
ISBN : 9780122625039
Language : En, Es, Fr & De

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Book Description :

Gnotobiotics. Management and design of breeding. design and management of research facilities for mice. Nutrition. Animal health survellance and health delivery systems. Environmental and equipment monitoring. Anatomy. Embryology. Reproductive physiology. Endocrinology. Physiology. Hematology. Clinical biochemistry. Gastrointestinal microflora. Immunoglobulin genes. Lymphocyte immunogenetics. Immune response desorders normal tolal. Biomethodology and surgical techniques.

The Mouse in Biomedical Research

The Mouse in Biomedical Research Book
Author : Henry Foster
Publisher : Elsevier
Release : 1981-01-01
ISBN : 0323156061
Language : En, Es, Fr & De

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Book Description :

The Mouse in Biomedical Research, Volume I: History, Genetics, and Wild Mice focuses on the utility of the mouse as a laboratory animal in biomedical research. A historical perspective on the development and origins of the laboratory and wild mouse is given. The diversity of inbred strains of mice as well as the methods of developing and the genetic monitoring and testing of these strains are discussed. This volume consists of 14 chapters and begins with an overview of mice of the genus Mus and problems concerning evolution within the genus. The following chapters focus on taxonomy, nomenclature, and breeding systems, together with recombinant inbred and congenic resistant mouse strains. Methods of constructing, testing, and monitoring strains are described. Congenic strains, gene mapping, cytogenetics, and murine experimental studies are also considered, along with the histocompatibility-2 complex and radiation genetics. The final chapter is devoted to the pharmacogenetics of the laboratory mouse, paying particular attention to intoxication and detoxication pathways, genetically determined differences in xenobiotic metabolism, and pharmacogenetic polymorphisms. This book will be a useful reference for investigators using mice in many areas of research.

Immunology

Immunology Book
Author : N.A
Publisher :
Release : 2007
ISBN : 9780123694546
Language : En, Es, Fr & De

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Book Description :

Making Mice

Making Mice Book
Author : Karen Rader
Publisher : Princeton University Press
Release : 2018-06-05
ISBN : 0691187584
Language : En, Es, Fr & De

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Book Description :

Making Mice blends scientific biography, institutional history, and cultural history to show how genetically standardized mice came to play a central role in contemporary American biomedical research. Karen Rader introduces us to mouse "fanciers" who bred mice for different characteristics, to scientific entrepreneurs like geneticist C. C. Little, and to the emerging structures of modern biomedical research centered around the National Institutes of Health. Throughout Making Mice, Rader explains how the story of mouse research illuminates our understanding of key issues in the history of science such as the role of model organisms in furthering scientific thought. Ultimately, genetically standardized mice became icons of standardization in biomedicine by successfully negotiating the tension between the natural and the man-made in experimental practice. This book will become a landmark work for its understanding of the cultural and institutional origins of modern biomedical research. It will appeal not only to historians of science but also to biologists and medical researchers.

The Laboratory Mouse Second Edition

The Laboratory Mouse  Second Edition Book
Author : Peggy J. Danneman,Mark A. Suckow,Cory Brayton
Publisher : CRC Press
Release : 2012-09-25
ISBN : 1439854211
Language : En, Es, Fr & De

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Book Description :

Mice have long been recognized as a valuable tool for investigating the genetic and physiological bases of human diseases such as diabetes, infectious disease, cancer, heart disease, and a wide array of neurological disorders. With the advent of transgenic and other genetic engineering technologies, the versatility and usefulness of the mouse as a model in biomedical research has soared. As a result, mouse colonies everywhere are expanding, and scientists who previously focused on other models are turning their attention to the mouse. Revised to reflect advances since the first edition, The Laboratory Mouse, Second Edition continues to be the most accessible reference on the biology and care of the laboratory mouse. This guide presents basic information and common procedures in detail to provide a quick reference source for investigators, technicians, and caretakers in the humane care and use of the mouse in the laboratory setting. Expanded, updated, and now in color, this new edition includes coverage of the biological features, husbandry, management, veterinary care, experimental methodology, and resources applying specifically to the mouse.

Sourcebook of Models for Biomedical Research

Sourcebook of Models for Biomedical Research Book
Author : P. Michael Conn
Publisher : Springer Science & Business Media
Release : 2008
ISBN : 1588299333
Language : En, Es, Fr & De

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Book Description :

The collection of systems represented in this volume is a unique effort to reflect the diversity and utility of models used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. This volume is therefore a comprehensive and extensive collection of these important medical parallels.

Transgenic Mouse

Transgenic Mouse Book
Author : Marten H. Hofker,Jan van Deursen
Publisher : Springer Science & Business Media
Release : 2003
ISBN : 1592593402
Language : En, Es, Fr & De

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Book Description :

A collection of readily reproducible methods for working with mice, and particularly for generating mouse models that will enable you to better understand gene function. Described in step-by-step detail by highly experienced investigators, these proven techniques include new methods for conditional, induced knockout, and transgenic mice, as well as for working with mice in such important research areas as immunology, cancer, and atherosclerosis. Such alternative strategies as random mutagenesis and viral gene transduction for studying gene function in the mouse are also presented. Use effective methods for conditional and inducible gene expression Review mouse models for a wide range of genetic aberrations associated with human disease.

The Laboratory Mouse

The Laboratory Mouse Book
Author : Peggy J. Danneman,Mark A. Suckow,Cory Brayton
Publisher : CRC Press
Release : 2000-12-27
ISBN : 9780849376276
Language : En, Es, Fr & De

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Book Description :

Mice have been domesticated by humans for centuries, even millennia, and have been used in research since the 1600's. However, development of the laboratory mouse as a research model accelerated with genetic experiments in the early 1900's. Today, the laboratory mouse is recognized as the pre-eminent model for modern genetic research. In fact, over the last decade or so, most biomedical research facilities have experienced increases of up to three hundred percent in their mouse populations. Numerous other disciplines, including immunology, cancer biology, toxicology, developmental biology, aging research, and cardiovascular biology have recognized the mouse as a valuable research model. The Laboratory Mouse provides a single source reference for investigators, technicians, and animal caretakers charged with the care and/or use of mice in biomedical research. The book is particularly valuable to researchers at small institutions and to those who work at facilities that lack large, well-organized animal resource units.

A Guide to Methods in the Biomedical Sciences

A Guide to Methods in the Biomedical Sciences Book
Author : Ronald B. Corley
Publisher : Springer Science & Business Media
Release : 2004-12-17
ISBN : 9780387228440
Language : En, Es, Fr & De

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Book Description :

Thousands of methods have been developed in the various biomedical disciplines, and those covered in this book represent the basic, essential and most widely used methods in several different disciplines.