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The Molecular And Clinical Pathology Of Neurodegenerative Disease

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The Molecular and Clinical Pathology of Neurodegenerative Disease

The Molecular and Clinical Pathology of Neurodegenerative Disease Book
Author : Patrick A. Lewis,Jennifer E. Spillane
Publisher : Academic Press
Release : 2018-11-16
ISBN : 0128110708
Language : En, Es, Fr & De

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Book Description :

The Molecular and Clinical Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. Bringing together up-to-date molecular biology data with clinical evidence, this book sheds a light on common molecular mechanisms that underlie many different neurodegenerative diseases and addresses the molecular pathologies in each. The combined research and clinical background of the authors provides a unique perspective in relating clinical experiences with the molecular understanding needed to examine these diseases and is a must-read for anyone who wants to learn more about neurodegeneration. Provides an up-to-date summary of neurodegeneration at a molecular, cellular, and tissue level for the most common human disorders Describes the clinical background and underlying molecular processes for Alzheimer’s disease, Parkinson’s, Prion, Motor Neuron, Huntington’s, and Multiple Sclerosis Highlights the state-of-the-art treatment options for each disorder Details examples of relevant cutting edge experimental systems, including genome editing and human pluripotent stem cell-derived neuronal models

The Molecular Pathology of Neurodegenerative Disease

The Molecular Pathology of Neurodegenerative Disease Book
Author : Patrick A. Lewis,Jennifer E. Spillane
Publisher : Academic Press
Release : 2018-10-15
ISBN : 9780128110690
Language : En, Es, Fr & De

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Book Description :

The Molecular Pathology of Neurodegenerative Disease brings together the current understanding of the molecular basis of neurodegeneration in humans in a form that is targeted not only for neuroscientists, but also for graduate students in neuroscience and the biomedical and biological sciences. There are a large number of existing books covering this subject that are aimed at a clinical audience (both at undergraduate and higher level), however the increasing interest in neurodegeneration for more basic science courses - neuroscientists, biologists, pharmacists and so forth - highlight the need for a book tailored for this audience. Presents an up-to-date summary on our current understanding of neurodegeneration at a molecular, cellular and tissue level Includes clinical vignettes so that basic science students can relate underlying molecular processes to clinical symptoms Provides background on the history of neurodegeneration Highlights the state-of-the-art treatment options for each disorder

Neurodegeneration

Neurodegeneration Book
Author : Dennis Dickson,Roy O. Weller
Publisher : John Wiley & Sons
Release : 2011-09-09
ISBN : 1444341235
Language : En, Es, Fr & De

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Book Description :

Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, α-synuclein and TDP-43) and in the extracellular compartments (e.g. β-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.

The Molecular and Cellular Basis of Neurodegenerative Diseases

The Molecular and Cellular Basis of Neurodegenerative Diseases Book
Author : Michael S. Wolfe
Publisher : Academic Press
Release : 2018-03-29
ISBN : 0128113057
Language : En, Es, Fr & De

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Book Description :

The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration Details features, advantages and limitations of animal models, as well as prospects for therapeutic development Authored by internationally recognized leaders in the field Includes illustrations that help clarify and consolidate complex concepts

Neurodegeneration

Neurodegeneration Book
Author : Dennis Dickson,Roy O. Weller
Publisher : John Wiley & Sons
Release : 2011-11-07
ISBN : 1405196939
Language : En, Es, Fr & De

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Book Description :

Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, α-synuclein and TDP-43) and in the extracellular compartments (e.g. β-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.

Neuropathology of Neurodegenerative Diseases Book and Online

Neuropathology of Neurodegenerative Diseases Book and Online Book
Author : Gabor G. Kovacs
Publisher : Cambridge University Press
Release : 2014-12-04
ISBN : 1107442427
Language : En, Es, Fr & De

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Book Description :

This heavily illustrated, must-have practical guide aids medical specialists and trainees in the diagnosis of neurodegenerative diseases. Includes diagnostic algorithms.

Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases

Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases Book
Author : Anil Gupta
Publisher : Academic Press
Release : 2021-12-17
ISBN : 0128204435
Language : En, Es, Fr & De

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Book Description :

Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases elucidates elaborately the role of caspase enzymes implicated in the initiation of molecular events leading to neuronal apoptosis in the neurodegenerative disease. The book starts with introduction to neuropathology, neurogenetics, and epidemiology of neurodegenerative disease and illustrates the involvement of human caspases, neuronal apoptosis, apoptotic pathways, genetic polymorphisms, and several other factors and underlying mechanisms in the pathology of Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. An important focus in all chapters is the intricate mechanisms and interplay that occur during or leading to neuron death in neurodegenerative diseases, along with disease pathobiology. Provides in-depth knowledge about neurotoxic potential of transition metals, impaired mitochondrial dynamics in the brain neurons, mutant proteins Aß peptide, tau protein, a-synuclein, huntingtin protein and formation of Lewy bodies, reactive oxygen and nitrogen species, ubiquitin proteasome dysregulation, and many others in neurodegenerative diseases Elucidates neurogenetics of gene APP, gene PSEN1, gene APOE, gene LRRK2, gene DJ1, and others in the pathology of neurodegenerative diseases. Explains caspases-mediated neuronal apoptosis in pathogenesis of Alzheimer’s disease covering amyloidogenesis, caspase-activated DNase, rho-associated coiled coil–containing protein kinase 1, mammalian sterile 20-like kinase 1, role of synaptic loss, microglial TREM2 receptor, microglial LRP1 receptor, microglial advanced glycation end-product receptor, astrocytic glial a 7 subtypes of nAChR, NLRP3 inflammasome, P2X purinoreceptors, miRNAs, and many other factors Demonstrates the role of caspases and apoptosis in Parkinson’s disease covering truncation of a-synuclein, neuroinflammation, parkin protein, activation of microglial cells, extrinsic and intrinsic pathways of apoptosis, ?tau314, and several other factors Explains etiopathogenesis of Huntington’s disease through covering clinically important topics as role of exon 1 HTT protein, ubiquitous nature of huntingtin, length of expanded polyglutamine tract, classically and alternately activated microglia, nuclear factor kappa B, kynurenine signaling pathway, tumor suppressor protein, PGC-1a gene, advanced glycation end-products, autophagy, and many other significant topics.

Neurodegenerative Diseases

Neurodegenerative Diseases Book
Author : Philip Beart,Michael Robinson,Marcus Rattray,Nicholas J. Maragakis
Publisher : Springer
Release : 2018-06-12
ISBN : 9783319860992
Language : En, Es, Fr & De

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Book Description :

Provides a timely overview of critical advances in molecular and cellular neurobiology, covers key methodologies driving progress, and highlights key future directions for research on neuronal injury and neurodegeneration relevant to neuronal brain pathologies. The editors bring together contributions from internationally recognized workers in the field to provide an up to date account of how and why molecular and cellular neurobiology is such an important area for clinical neuroscience. Understanding the molecular aspects of a number of neurodegenerative conditions such as Parkinson's or Alzheimer's disease for the purpose of improving patient management remains a major challenge of neurobiology be it from the basic or clinical perspective. A strategic evaluation of research contributions and the power of modern methods will help advance knowledge over the next years.

TDP 43 and Neurodegeneration

TDP 43 and Neurodegeneration Book
Author : Vijay Kumar,Manoj Kumar Jaiswal
Publisher : Academic Press
Release : 2021-10-23
ISBN : 0128204400
Language : En, Es, Fr & De

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Book Description :

Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), with overlapping clinical, genetic and pathological features. TDP-43 and Neurodegeneration: From Bench to Bedside summarizes new findings in TDP-43 pathobiology and proteinopathies. The book summarizes TDP-43’s structure, function, biology, misfolding, aggregation, pathogenesis and therapeutics. It includes autophagy-mediated therapy, role of stress granule, novel genetic, cell culture-based models, systems biology for precision medicine, development of stem cells and mechanism-based therapies that can target ALS and other related neurodegenerative diseases. This book is written for neuroscientists, neurologists, clinicians, advanced graduate students, drug discovery researchers, as well as cellular and molecular biologists involved in ALS, motor neuron disease (MND) and other neurodegenerative disorders. Reviews TDP-43 structure, folding, function, and pathology Identifies TDP-43 role in ALS, FTP, and other neurodegenerative diseases Presents a systems and precision biology perspective of TDP-43 Discusses therapeutics of TDP-43 proteinopathies Translates bench research to application bedside

Molecular Biology of Neurodegenerative Diseases Visions for the Future

Molecular Biology of Neurodegenerative Diseases  Visions for the Future Book
Author : Anonim
Publisher : Academic Press
Release : 2019-11-05
ISBN : 0128178752
Language : En, Es, Fr & De

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Book Description :

Molecular Biology of Neurodegenerative Diseases: Visions for the Future, Volume 168 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. The series includes in-depth knowledge on the molecular biological aspects of organismal physiology, with this release including chapters on Alzheimer's disease, Prion-like propagation of alpha-synuclein, What - if anything - can we learn about neurodegenerative diseases from yeast?, Mitochondrial rejuvenation and replacement as a novel strategy for treatment of age-related neurodegenerative diseases, Propagation and removal of cerebral amyloid angiopathy, and much more. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field

Molecular Mechanisms of Neurodegenerative Diseases

Molecular Mechanisms of Neurodegenerative Diseases Book
Author : Marie-Francoise Chesselet
Publisher : Springer Science & Business Media
Release : 2000-10-19
ISBN : 1592590063
Language : En, Es, Fr & De

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Book Description :

With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to the development of new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration; and the potential of genetics to identify the molecular mechanisms of neurodegenerative diseases. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.

Imaging in Neurodegenerative Disorders

Imaging in Neurodegenerative Disorders Book
Author : Luca Saba
Publisher : Oxford University Press, USA
Release : 2015
ISBN : 0199671613
Language : En, Es, Fr & De

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Book Description :

This text summarizes the latest developments in imaging techniques and other new diagnostic methods as applied to the neurodegenerative disorders.

Neurodegenerative Diseases

Neurodegenerative Diseases Book
Author : Daniela Galimberti,Elio Scarpini
Publisher : Springer
Release : 2018-03-15
ISBN : 3319729381
Language : En, Es, Fr & De

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Book Description :

This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, Lewy body dementia,Parkinson’s disease, amyotrophic lateral sclerosis, and additional less common neurodegenerative diseases. Both clinical and basic aspects of each disease are treated, including novel diagnostic criteria, old and new treatments, basic discoveries (genetics, epigenetics and molecular biology), and translation of basic research into biomarkers for early diagnosis, particularly to identify peripheral biomarkers. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis. Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields.

Parkinson s Disease

Parkinson s Disease Book
Author : Patrik Verstreken
Publisher : Academic Press
Release : 2016-12-19
ISBN : 0128038055
Language : En, Es, Fr & De

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Book Description :

Parkinson’s Disease: Molecular Mechanisms Underlying Pathology explores the molecular pathways at the basis of the cellular defects connected to Parkinson’s disease, the second most common neurodegenerative disease, and the most common movement disorder. This book presents the latest research on the pathways and mechanisms that have been discovered to play a role in Parkinson's pathology. This focus on mechanisms rather than individual genes allows the contributors to elaborate on overlapping and joint functions of different causative genes. Readers will find descriptions of model systems that present parallels (and differences) between discoveries in different species, demonstrating the importance of multidisciplinary research that spans a broad array of technologies and model organisms. Written from both a cross-methodology and cross-species perspective, the book provides readers with the current state of knowledge on the molecular biology of Parkinson’s. Written by experts in the field that focus on pathways and mechanisms implicated in Parkinson’s pathology Draws parallels between multidisciplinary discoveries in different model organisms using an array of technologies Provides a cross-methodology and cross-species approach to understanding the molecular biology of Parkinson’s disease Includes approximately 25 color Illustrations and diagrams to explain concepts and models Focuses on key pathways and mechanisms (as opposed to model organism or gene) to provide a multidisciplinary approach to Parkinson’s disease

Adenosine Receptors in Neurodegenerative Diseases

Adenosine Receptors in Neurodegenerative Diseases Book
Author : David Blum,Luisa V. Lopes
Publisher : Academic Press
Release : 2017-03-10
ISBN : 0128037458
Language : En, Es, Fr & De

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Book Description :

Adenosine Receptors in Neurodegenerative Diseases covers the role of adenosine receptors in brain function, also focusing on related methodologies and perspectives in therapeutics. The book provides an up-to-date overview by the best specialists in the field, helping readers consider the importance of adenosine and expand the global impact and visibility of adenosine research in the CNS field. Chapters include adenosine biology and signaling, gene regulation, control of motor function, and novel adenosine-based therapies in the CNS. It is an ideal resource for researchers, advanced graduate students, clinicians, and industry scientists working in the fields of clinical neuroscience and molecular and cellular neuroscience. Comprehensive reference that details adenosine receptors in neurodegenerative disorders, with details on brain function and possible therapeutics Gives insights on how these receptors modulate the neurodegenerative outcomes in different disorders Edited by two of the leading researchers in the field regarding adenosine role in the brain in aging and neurodegenerative conditions

Metal based Neurodegeneration

Metal based Neurodegeneration Book
Author : Robert Crichton,Roberta Ward
Publisher : John Wiley & Sons
Release : 2006-05-01
ISBN : 0470022566
Language : En, Es, Fr & De

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Book Description :

This exciting new book opens a window into the causes ofdebilitating neurological disorders such as Parkinson’sdisease, CJD and Huntington’s disease, and gives indicationsof the prospects for therapy, based on the understanding ofmolecular defects involved in these diseases. Looking at each specific neurological disorder in turn, the bookoutlines the role of metals in human biology, in particular in thebrain and explores tools for testing potential therapeuticstrategies. It concludes with an overview of the potential of bothchelation and antioxidant therapy and outlines some perspectivesfor the future.

Glutamine Repeats and Neurodegenerative Diseases

Glutamine Repeats and Neurodegenerative Diseases Book
Author : Peter S. Harper,Max F. Perutz
Publisher : Oxford University Press, USA
Release : 2001
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This book focuses on the discovery of a common genetic basis for a group of inherited neurological disorders including Huntington's Disease, spino-bulbar muscular atrophy and a series of hereditary ataxias. It now seems likely that these disorders are triggered by expanded trinucleotide repeats resulting in polyglutamine sequences in the specific proteins produced by the genes. This shared molecular background and other similarities, have led to the development of theoretical models for the pathogenesis of these diseases. It is now clear that the mechanisms involved are likely to be of more general relevance, outside of this particular group of disorders, with implications for other neurodegenerative processes such as those involved in Alzheimer's, Parkinson's and Prion diseases. The book starts with a review of the animal models of Huntington's Disease, before moving on to examine the issue of polyglutamine toxicity and the biochemistry of the Huntingtin protein. The latter part of the book describes how these discoveries have brought a new unity to the molecular pathology of neurodegenerative diseases, and describes other disease groups thought to be related to the presence of proteins with expanded glutamine repeats. This book is an edited and updated compilation evolving from a Royal Society discussion meeting.

Molecular Pathology in Clinical Practice

Molecular Pathology in Clinical Practice Book
Author : Debra G.B. Leonard
Publisher : Springer Science & Business Media
Release : 2007-11-25
ISBN : 0387332278
Language : En, Es, Fr & De

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Book Description :

This authoritative textbook embodies the current standard in molecular testing for practicing pathologists, and residents and fellows in training. The text is organized into eight sections: genetics, inherited cancers, infectious disease, neoplastic hematopathology, solid tumors, HLA typing, identity testing, and laboratory management. Discussion of each diagnostic test includes its clinical significance, available assays, quality control and lab issues, interpretation, and reasons for testing. Coverage extends to HIV, hepatitis, developmental disorders, bioterrorism, warfare organisms, lymphomas, breast cancer and melanoma, forensics, parentage, and much more. Includes 189 illustrations, 45 in full-color. This textbook is a classic in the making and a must-have reference.

Neurodegenerative Diseases

Neurodegenerative Diseases Book
Author : Nagehan Ersoy Tunalı
Publisher : BoD – Books on Demand
Release : 2021-01-20
ISBN : 1838801499
Language : En, Es, Fr & De

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Book Description :

Neurodegenerative diseases represent a very large group of heterogeneous disorders affecting specific subtypes of neurons in the brain. This book contributes insight both to the awareness of the brain and its neurodegenerative states. The chapters present current knowledge regarding genetics, molecular mechanisms, and new therapeutic strategies against neurodegenerative disorders. The book is intended to serve as a source to aid clinicians and researchers in the field, and also life science readers to increase their understanding and awareness of the clinical correlations, genetic aspects, neuropathological findings, and current therapeutic interventions in neurodegenerative diseases. I believe that this book will enlighten the curiosity for neurodegeneration and also encourage researchers to work on potentially effective molecular therapies for still mysterious neurodegenerative disorders.

The Neuropathology of Dementia

The Neuropathology of Dementia Book
Author : Margaret M. Esiri,Virginia M. -Y. Lee,John Q. Trojanowski
Publisher : Cambridge University Press
Release : 2004-07-22
ISBN : 9780521819152
Language : En, Es, Fr & De

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Book Description :

This completely rewritten, updated new edition, now illustrated in colour, is almost twice the size of its predecessor.