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The Microbiome In Prenatal And Neonatal Life

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The Microbiome in Prenatal and Neonatal Life

The Microbiome in Prenatal and Neonatal Life Book
Author : Josef Neu
Publisher : Academic Press
Release : 2020-12-15
ISBN : 9780128205907
Language : En, Es, Fr & De

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Book Description :

The Microbiome in Prenatal and Neonatal Life clarifies that the microbiome in the maternal fetal unit and immediate changes that occur as new microbes are acquired postnatally play major roles in subsequent health and disease. Rapidly developing technologies for multi-omic analyses and systems biology are shifting paradigms in both scientific knowledge and clinical care with regard to this topic. In essence, we are changing the idea that newborns emerge from sterile environments. As such, in-utero colonization may have impacts on the development of immunity and metabolism that, with epigenetic modifications, will lead to diseases in later life. In addition, the microbial profile that develops during and after birth depends on mode of delivery, type of feeding (human milk versus formula), and various other environmental factors to which the newborn is exposed. Discusses the critical nonredundant timeframe in a newborn's life during which many factors drive immune and tissue maturation and influence the susceptibility to immune-mediated and other diseases in adult life Proves that the fetus and uterine membranes are exposed to not only microbes in close proximity but also to microbial products from metabolism of microbes in the mother Shows that since early life periods are a critical window for development, epigenetic and/or immunologic alterations may occur that can affect not only the infant during his/her lifetime but also subsequent generations Gives insight into factors that may affect the newborn microbiome and subsequent development

Fetal and Neonatal Physiology E Book

Fetal and Neonatal Physiology E Book Book
Author : Richard A. Polin,Steven H. Abman,David Rowitch,William E. Benitz
Publisher : Elsevier Health Sciences
Release : 2016-05-11
ISBN : 0323352324
Language : En, Es, Fr & De

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Book Description :

Fetal & Neonatal Physiology provides neonatologist fellows and physicians with the essential information they need to effectively diagnose, treat, and manage sick and premature infants. Fully comprehensive, this resource continues to serve as an excellent reference tool, focusing on the basic science needed for exam preparation and the key information required for full-time practice. The 5th edition is the most substantially updated and revised edition ever. In the 5 years since the last edition published, there have been thousands of publications on various aspects of development of health and disease; Fetal and Neonatal Physiology synthesizes this knowledge into definitive guidance for today's busy practitioner. Offers definitive guidance on how to effectively manage the many health problems seen in newborn and premature infants. Chapters devoted to clinical correlation help explain the implications of fetal and neonatal physiology. Allows you to apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. Features a fantastic new 4-color design with 1,000 illustrations, 170+ chapters, and over 350 contributors. 16 new chapters cover such hot topics as Epigenetics; Placental Function in Intrauterine Growth Restriction; Regulation of Pulmonary Circulation; The Developing Microbiome of the Fetus and Newborn; Hereditary Contribution to Neonatal Hyperbilirubinemia; Mechanistic Aspects of Phototherapy for Neonatal Hyperbilirubinemia; Cerebellar Development; Pathophysiology of Neonatal Sepsis; Pathophysiology of Persistent Pulmonary Hypertension of the Newborn; Pathophysiology of Meconium Aspiration Syndrome; Pathophysiology of Ventilator Dependent Infants; Pathophysiology of Hypoxic-Ischemic Brain Injury; Pathophysiology of Neonatal White Matter Injury; Pathophysiology of Meningitis; Pathophysiology of Preeclampsia; and Pathophysiology of Chorioamnionitis. New Pathophysiology of Neonatal Diseases section highlights every process associated with a disease or injury, all in one place. In-depth information, combined with end-of-chapter summaries, enables deep or quick use of the text.

Leifer s Introduction to Maternity Pediatric Nursing in Canada E Book

Leifer s Introduction to Maternity   Pediatric Nursing in Canada E Book Book
Author : Gloria Leifer,Lisa Keenan-Lindsay
Publisher : Elsevier Health Sciences
Release : 2019-09-06
ISBN : 177172207X
Language : En, Es, Fr & De

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Book Description :

Gain a solid foundation in Canadian maternity and pediatric nursing! Written in a clear, concise, friendly style, Leifer’s Intro to Maternity & Pediatric Nursing in Canada, is the first Canadian edition of the best-selling Leifer textbook. Fully revised by author, Lisa Keenan-Lindsay, RN, MN, PNC(C), it includes Canadian statistics, terminology, references, guidelines, resources, Canadian nursing best practices, assessments, and more! It’s organized by developmental stages and includes discussions of pediatric disorders by body system from simple-to-complex and health-to-illness. With a rich focus on family health, this text contains exam-style review questions, case studies, and numerous other pedagogical features to give you the tools you need to successfully care for patients within the Canadian social and institutional context. Logical organization of content by simple-to-complex and health-to-illness, makes it easy for you to locate and access information. Health Promotion Considerations boxes focus on preventive strategies for achieving prenatal wellness, health during pregnancy, postpartum health, newborn health, and pediatric illness prevention and wellness---including Canadian immunization schedules for all ages. Unfolding Case Studies with open-ended critical thinking questions assess application of content to practice as you follow one family through conception and the birth process. Nursing Care Plans provide expected outcomes, interventions, and rationales for nursing interventions. Comprehensive coverage of over 35 skills, outlined in step-by-step format cover a wide range of maternal and pediatric nursing interventions. Focus on health promotion and illness prevention, covers women’s health issues, and growth and development of child and parent. Cultural considerations applied as they relate to maternal/infant, and pediatric care in detailed tables. Safety Alerts emphasize protecting patients, family, health care providers, and the public from accidents, medication errors, and the spread of disease. Nursing Tips throughout text provide you with pertinent information applicable in the clinical setting.

The Human Microbiome in Early Life

The Human Microbiome in Early Life Book
Author : Omry Koren,Samuli Rautava
Publisher : Academic Press
Release : 2020-09-25
ISBN : 0128180986
Language : En, Es, Fr & De

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Book Description :

The Human Microbiome in Early Life: Implications to Health and Disease presents recent research advances that have highlighted the significance of early life, possibly beginning before birth, in the establishment of both the microbiome and its role in health and disease. The book reviews current knowledge on the origins of the human microbiota in early life, presents exposures which may disturb normal microbial colonization, and covers their implications to the risk of disease. Finally, emerging means to modify the early human microbiome to improve health are discussed. Examines the timeline of the human microbiome, from before conception to infancy, with an emphasis on clinical implications Evaluates the effort to understand not only the composition but also the origin of the microbiome Proves the emerging means to modify the human microbiome and particularly ‘the first 1000 days of life’ improve human health and prevent disease Generates resources to facilitate characterization of the human microbiota to further our understanding of how the microbiome impacts human health and disease

Nutrition in Infancy

Nutrition in Infancy Book
Author : Ronald Ross Watson,George Grimble,Victor R. Preedy,Sherma Zibadi
Publisher : Springer Science & Business Media
Release : 2012-12-02
ISBN : 162703224X
Language : En, Es, Fr & De

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Book Description :

Nutrition in Infancy: Volume 1 is a very useful resource for all clinicians treating and preventing nutritional problems in infants. This volume covers a wide range of topics that support wellness in infants through the prevention and treatment of infectious diseases, malnutrition, and developmental and genetic abnormalities. A variety of chapters deal with nutrients for infants with disabilities, surgery, and other special needs. Special emphasis is provided for clinicians treating the millions of children in developing countries whose death is promoted by undernutrition or malnutrition. The next sections discuss the health benefits of supplementation and breast feeding and methods to improve use of berast feeding and it’s duration. In Nutrition in Infancy: Volume 1, all of these facets of nutrition and nutritional therapy are covered in a precise and practical way. The latest developments in diagnostic procedures and nutritional support are also included. Written by a group of international experts, this volume is an indispensable new reference for clinicians with an interest in the nutrition and health of pregnant mothers and their infants.

Knobil and Neill s Physiology of Reproduction

Knobil and Neill s Physiology of Reproduction Book
Author : Tony M. Plant,Anthony J. Zeleznik
Publisher : Academic Press
Release : 2014-11-15
ISBN : 012397769X
Language : En, Es, Fr & De

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Book Description :

The Fourth Edition of Knobil & Neill continues to serve as a reference aid for research, to provide the historical context to current research, and most importantly as an aid for graduate teaching on a broad range of topics in human and comparative reproduction. In the decade since the publication of the last edition, the study of reproductive physiology has undergone monumental changes. Chief among these advances are in the areas of stem cell development, signaling pathways, the role of inflammation in the regulatory processes in the various tissues, and the integration of new animal models which have led to a greater understanding of human disease. The new edition synthesizes all of this new information at the molecular, cellular, and organismal levels of organization and present modern physiology a more understandable and comparative context. The Fourth Edition has been extensively revised, reflecting new fundamental advancements in this rapidly advancing field. Provides a common language for researchers across the fields of physiology, endocrinology, and biology to discuss their understanding of reproduction. Saves academic researchers time in quickly accessing the very latest details on reproductive physiology, as opposed to searching through thousands of journal articles.

P2 21 03 Prenatal and Postnatal Determinants in Shaping Offspring s Microbiota in the First Year of Life A Study Protocol

P2 21 03   Prenatal and Postnatal Determinants in Shaping Offspring s Microbiota in the First Year of Life  A Study Protocol Book
Author : Benedetta Raspini
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Introduction. Fetal programming during fetal life defines the set point of physiological and metabolic responses that lead into adulthood. Events happening in the first 1,000 days of life play a pivotal role in the development of chronic diseases. Also, diet and lifestyle during pregnancy are recognized to be crucial determinants in modulating offspring microbiota. After this first period, the children gut microbial composition continues to evolve until the age of 2 years; this is u201ca window of opportunityu201d for microbial modulation, impacting on child future health.The present study protocol is designed to examine the association of maternal diet and lifestyle, type of delivery and lactation with the intestinal microbiome development of infants (0-12 months) by identifying the relative abundance of the dominant organism genera; assessing the microbial diversity (u03b1-diversity); assessing inter-individual variation (u03b2-diversity).Methods. We planned to enroll 60 mothers/child couples attending the Neonatal Unit, Fondazione IRCCS Policlinico San Matteo, Pavia (Italy). The study was approved by the Human Ethics Committee (Protocol number 20180022618); children or mothers with genetic/congenital diseases, children hospitalized immediately after birth or born before 35 and after 42 weeks will be excluded. as well as non-physiological pregnancies.Data will be collected at T0 (before discharge), T1 (30 days post-partum), T2 (6 months post-partum) and T3 (12 months post-partum).u00b7Anthropometric parameters for both mothers (weight, height at T0-T3 and waist circumference at T1-T3) and children (weight, length, head circumference at T0-T3) will be assessed.u00b7Mothersu2019 dietary habits will be explored by using a previously validated questionnaire by us, while physical activity throughout the IPAQ short version (T0-T3).u00b7Information about family environment, infant feeding (breastfed/formula-fed), time/type of weaning, use of antibiotics/probiotics/supplements in both mothers and children will be obtained (T1- T3).u00b7Childrenu2019s dietary habits will be evaluated by using the INTERGROWTH-21st questionnaire at T3.u00b7Childrenu2019s stool samples will be collected (T0-T3) and analyzed using metagenomics 16s rRNA gene sequence-based methods. Shotgun sequencing will be conducted on a small subgroup.Expected results. The knowledge obtained in this study will provide the starting point for a future prospective and longer observational cohort, aimed at assessing the potential association between lifestyle and maternal factors with infant microbiome composition and their influence on adverse growth parameters. The extension of the present study aims to identify specific intervention programs targeted to first 1,000 days window besides preconception.Conflict of interest:There is no conflict of interest.

Preconception Improve Your Health and Enhance Fertility

Preconception  Improve Your Health and Enhance Fertility Book
Author : Penny Simkin,Janet Whalley,Ann Keppler,Janelle Durham,April Bolding
Publisher : Simon and Schuster
Release : 2016-03-29
ISBN : 1451671245
Language : En, Es, Fr & De

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Book Description :

Pregnancy, Childbirth, and the Newborn is one of the bestselling and most comprehensive books about pregnancy, childbirth, and newborn care on the market. Now completely updated, expanded, and redesigned, this authoritative book is the “bible” for expectant parents and childbirth educators. Here is a free sample chapter for you! In this chapter, "Preconception: Improve Your Health and Enhance Fertility", you’ll learn about: • Emotional wellness • Health • Health care • Hazards • Enhancing fertility and the odds of conception • Concerns about infertility • Planning ahead: maternity care choices If you like this sample chapter, look for Pregnancy, Childbirth, and the Newborn. The Award-Winning Resource Recommended by Experts & Loved by Parents Parents love this book because it puts them in control by explaining a wide range of options, information, and questions to ask, so parents can find what works best for their health situation, personal goals, and priorities. Experts love this book because it’s based on the latest medical research and recommendations from leading health organizations. It’s practical—rooted in the real-life experiences of new families. The five authors bring a combined total of 150 years of experience working with expectant and new families as educators, nurses, counselors, doulas, physical therapists, and lactation consultants. They have attended hundreds of births, heard thousands of birth stories, and assisted innumerable new parents in adapting to their new lives. Not only that, the authors have a combined total of 12 children and 12 grandchildren. All of this experience allows them to write with compassion, understanding, and wisdom based on what really works in the real-world of parenting. The companion website offers even more details on select subjects, including lists of all the best resources on each topic and worksheets to guide parents’ decision-making process. The website also includes a bonus chapter on pre-conception, which provides ways to improve your health and fertility before pregnancy begins.

Avery s Diseases of the Newborn E Book

Avery s Diseases of the Newborn E Book Book
Author : Christine A. Gleason,Sherin Devaskar
Publisher : Elsevier Health Sciences
Release : 2011-08-12
ISBN : 1455727148
Language : En, Es, Fr & De

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Book Description :

Avery’s Diseases of the Newborn, edited by Christine A. Gleason and Sherin U. Devaskar, is a practical, clinical reference for diagnosing and managing of all the important diseases affecting newborns. Thoroughly revised by a team of new editors, this edition provides new perspectives and updated coverage of genetics, nutrition, respiratory conditions, MRSA, neonatal pain, cardiovascular fetal interventions, care of the late preterm infant, and more. This authoritative reference is ideal as a clinical resource or subspecialty review tool. Treat newborns effectively with focused coverage of diagnosis and management, including pertinent developmental physiology and the pathogenesis of neonatal problems. Meet every challenge you face in neonatology with Avery’s authoritative, comprehensive clinical resource and subspecialty review tool. Navigate quickly and easily with extensive cross-referencing throughout the organ-related sections. Stay current with coverage of hot topics including MRSA, neonatal pain, cardiovascular fetal interventions, care of the late preterm infant, and the developing intestinal microbiome. Tap into the fresh perspectives of new editors who provide extensive updates throughout, particularly on genetic and respiratory disorders. Apply the latest nutritional findings with thorough discussions of this valuable information in the more comprehensive nutrition section. Master the fundamentals of neonatology through the greater emphasis on developmental biology and pathobiology.

Metagenomics of the Human Body

Metagenomics of the Human Body Book
Author : Karen E. Nelson
Publisher : Springer Science & Business Media
Release : 2010-11-16
ISBN : 9781441970893
Language : En, Es, Fr & De

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Book Description :

The book brings a completely different perspective than available books by combining the information gained from the human genome with that derived from parallel metagenomic studies, and new results from investigating the effects of these microbes on the host immune system. Although there are a number of books that focus on the human genome that are currently available, there are no books that bring to the forefront the mix of the human genome and the genomes and metagenomes of the microbial species that live within and on us.

The Window of Opportunity

The Window of Opportunity Book
Author : David James Purslove Barker,Renate L. Bergmann,Pearay L. Ogra
Publisher : Karger Medical and Scientific Publishers
Release : 2008-01-01
ISBN : 3805583877
Language : En, Es, Fr & De

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Book Description :

There is no longer any doubt that the inherited genetic constitution of the individual has a large influence on the entire life cycle, from human fetal development and pre- and postnatal growth to subsequent health status. However, growing evidence suggests that this predisposition is not rigid, but that early genetic imprinting, caused by exposure to a diverse spectrum of nutrients, macromolecules, microbial agents and other cellular or soluble components present in the external environment, is also of importance. According to this concept of the developmental origins of adult diseases, intrauterine and early life events play an important role in the etiology of human diseases: there seems to exist a critical 'window of opportunity' in the human infant before and during pregnancy, and up to 24 months of age. Altered exposure to different environmental agents during this critical period may determine the nature of responses in the perinatal period, and the expression of specific disease states in later life. The papers presented in this publication thus focus on the impact of perinatal growth, nutrition, environmental microflora, and host immune responses on the outcome of health and disease in later life.

The Effects of Pre and Postnatal Administration of Propionic Acid and Lipopolysaccharide on the Behaviour of Adolescent Male and Female Rats

The Effects of Pre  and Postnatal Administration of Propionic Acid and Lipopolysaccharide on the Behaviour of Adolescent Male and Female Rats Book
Author : Kelly A. Foley
Publisher : Unknown
Release : 2013
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Increasing evidence suggests the gut microbiome plays an important role in immune functioning and neurodevelopment. Metabolic products of enteric bacteria, such as short chain fatty acids and lipopolysaccharides, may alter development and subsequent behaviour. Altered microbiome composition, including elevated short chain fatty acids, and/or immune system dysfunction has been observed in children with autism spectrum disorders (ASD). This thesis describes the effects of prenatal propionic acid (PPA), a short chain fatty acid and metabolic fermentation product of antibiotic resistant enteric bacteria, and of prenatal lipopolysaccharide (LPS), a bacterial mimetic and product of enteric bacteria, on a range of behaviours in male and female neonatal, adolescent and adult rats. Long-Evans rats were administered PPA or LPS during pregnancy and rat pups were administered PPA in the second week of life. The first study evaluated the effects of prenatal PPA and LPS, and postnatal PPA, on developmental milestones in early life and on locomotor activity, repetitive behaviour, and anxiety-related behaviour in adolescent rats. Secondly, sensorimotor behaviours were examined using the acoustic startle response and prepulse inhibition. The final study investigated the effects of prenatal PPA and LPS on social and related behaviours in neonatal, adolescent, and adult rats. Overall, prenatal and postnatal treatments subtly altered behaviour in a sex-and test-specific manner. Male and female rats showed developmental delay in day of eye opening and in acquiring a nest seeking odor discrimination. Prenatal and postnatal treatments increased anxiety-related behaviour and altered acoustic startle responses in male and female adolescent rats. Male rats displayed alterations in social behaviour and locomotor activity that was not observed in female rats, supporting the male bias seen in ASD. However, female rats showed sensitivity to PPA, displaying repetitive behaviour, altered acoustic startle response, and decreased prepulse inhibition. There is evidence to suggest that these behaviours are more severe in females diagnosed with ASD. These findings demonstrate that the metabolic products of enteric bacteria, PPA and LPS, may alter development in ways resembling ASD and contribute to the growing literature on the importance of the gut microbiome and its components on influencing brain and behaviour.

Microbiota in health and disease from pregnancy to childhood

Microbiota in health and disease  from pregnancy to childhood Book
Author : Pamela D. Browne,Eric Claassen,Michael D. Cabana
Publisher : Wageningen Academic Publishers
Release : 2017-07-20
ISBN : 9086868398
Language : En, Es, Fr & De

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Book Description :

This book offers a state-of-the-art overview of the vital relationship between human microbiota and infant and child health. Renowned clinical-experimental experts in this field discuss the development of microbiota during early life and review the environmental inputs that affect the developing infant’s gut microbiota, such as early diet and (postnatal) medical interventions. They further describe the interplay between gut microbiota and functional systems of the body, from the immune system to the central nervous system. The book discusses a range of infant and childhood diseases that are associated with microbial changes or dysbiosis, such as gastrointestinal disorders, allergic diseases, autoimmune disorders and respiratory disorders. Additionally mechanisms by which microbial dysbiosis may influence behaviour in infants are discussed. Other topics include the use of current tools in molecular microbiology for microbiota-related research and clinical practice. In the management of particular paediatric disorders, the potential of microbial manipulation with pre- and probiotics during infancy and childhood is increasingly being investigated. This book presents the evidence supporting their use in practice and reviews safety aspects. Microbiota in health and disease: from pregnancy to childhood has the ambition to provide the reader with an overview of the most recent and stunning advances in the field of infant and child microbiota and their role in health, disease and prevention. As such, it is an excellent resource for health care professionals, students and researchers in the field of life sciences.

Issues in Pediatric and Adolescent Medicine Research and Practice 2011 Edition

Issues in Pediatric and Adolescent Medicine Research and Practice  2011 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-01-09
ISBN : 1464963401
Language : En, Es, Fr & De

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Book Description :

Issues in Pediatric and Adolescent Medicine Research and Practice: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Pediatric and Adolescent Medicine Research and Practice. The editors have built Issues in Pediatric and Adolescent Medicine Research and Practice: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Pediatric and Adolescent Medicine Research and Practice in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Pediatric and Adolescent Medicine Research and Practice: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Epigenetics and Human Health

Epigenetics and Human Health Book
Author : Alexander Haslberger,Sabine Greßler
Publisher : John Wiley & Sons
Release : 2011-08-24
ISBN : 352764475X
Language : En, Es, Fr & De

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Book Description :

After first introducing the concept of epigenetics, this handbook and ready reference provides an overview of the main research on epigenetics. It adopts a multidisciplinary approach, involving molecular biology, molecular epidemiology and nutritional science, with a special focus of the book is on disease prevention and treatment. Of interest to all healthcare-related professionals as well as nutritionists, and the medical community focusing on disease prevention.

Pediatric Gastrointestinal and Liver Disease E Book

Pediatric Gastrointestinal and Liver Disease E Book Book
Author : Robert Wyllie,Jeffrey S. Hyams
Publisher : Elsevier Health Sciences
Release : 2010-11-29
ISBN : 1437735665
Language : En, Es, Fr & De

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Book Description :

Pediatric Gastrointestinal and Liver Disease, by Drs. Robert Wyllie and Jeffrey S. Hyams provides the comprehensive reference you need to treat GI diseases in children. Review the latest developments in the field and get up-to-date clinical information on hot topics like polyps, capsule endoscopy, and pancreatic treatments. With expert guidance from an expanded international author base and online access to 475 board-review-style questions, this latest edition is a must-have for every practicing gastroenterologist. Confirm each diagnosis by consulting a section, organized by symptoms, that presents the full range of differential diagnoses and treatment options for each specific condition. Recognize disease processes at a glance with detailed diagrams that accurately illustrate complex concepts. Stay current with advances in the field by reviewing new chapters on Polyps and Polyposis Syndromes, Capsule Endoscopy and Small Bowel Enteroscopy, Small Bowel Transplantation, IBD, Short Gut Syndrome, Steatosis and Non-Alcoholic Fatty Liver Disease, and Pancreatic and Islet Cell Transplants. Gain fresh global perspectives from an expanded list of expert international contributors. Sharpen your visual recognition by accessing a color-plate section that displays additional endoscopy images. Prepare for certification or recertification with 475 online board review-style questions, answers, and rationales.

Williams Obstetrics 25th Edition

Williams Obstetrics  25th Edition Book
Author : Jodi S. Dashe,Steven L. Bloom,Catherine Y. Spong,Barbara L. Hoffman
Publisher : McGraw Hill Professional
Release : 2018-06-01
ISBN : 1259644332
Language : En, Es, Fr & De

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Book Description :

The world’s premier obstetrics guide–now updated with a greater focus on maternal-fetal medicine The obstetrics text that has defined the discipline for generations of obstetrician-gynecologists is now more timely—and essential—than ever. Written by authors from the nationally known University of Texas Southwestern Medical Center, Williams Obstetrics maintains its trademark comprehensive coverage and applicability at the bedside, while offering the most current perspective of the field. This landmark text begins with fundamental discussions of reproductive anatomy and physiology. These dovetail into clinical chapters covering obstetrical complications such as preterm labor, pregnancy-related infection, hemorrhage, and hypertension, among others. Representing the culmination of a century of clinical thought, the new Twenty-Fifth Edition is enhanced by more than 1,000 full-color illustrations plus an increased emphasis on the fast-growing subspecialty of maternal-fetal medicine. Features •Entire section on the diagnosis and treatment of fetal disorders, providing deeper insights into fetal complications in utero •Traditional focus on the varied medical and surgical disorders that can complicate pregnancy •1,000 eye-catching illustrations, including updated graphs, sonograms, MRIs, photographs, and photomicrographs •Solid evidence-based approach highlights the scientific underpinnings of clinical obstetrics, with special emphasis on physiological principles •Current professional and academic guidelines are incorporated into the text and appear in easy-to-read tables •Updated with 3,000 new literature citations through 2017 No other text can match the long-established scientific rigor and accessibility of Williams Obstetrics. With its state-of-the-art design and review of the newest advances and protocols, this not-be-missed clinical companion brings positive outcomes within reach.

Brain Health From Birth

Brain Health From Birth Book
Author : Rebecca Fett
Publisher : Franklin Fox Publishing LLC
Release : 2019-08-28
ISBN : 0999676156
Language : En, Es, Fr & De

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Book Description :

Raising a bright and happy child starts during pregnancy and early infancy, when small changes can have a big impact on brain development. ​ By taking advantage of this golden window of opportunity--when millions of new brain cells are formed every single day--you can help support your child's IQ, language development, memory, attention span, and emotional regulation. Importantly, the same strategies that nurture these cognitive abilities can also help reduce the odds of autism and ADHD, conditions that now impact 1 in 10 children. Brain Health from Birth is your guide to this new scientific frontier, explaining which key nutrients may be missing from your prenatal supplement, how to reduce the odds of preterm birth, what to look for in a formula, how to support your baby's microbiome, and much more. With contributions from leading obstetricians and pediatricians, science writer Rebecca Fett (author of the bestselling fertility book It Starts with the Egg) brings you practical advice you can start applying today, to help your baby thrive.

Advances in the Prevention and Treatment of Inflammation Associated Preterm Birth

Advances in the Prevention and Treatment of Inflammation Associated Preterm Birth Book
Author : Jeffrey A. Keelan,John P. Newnham
Publisher : Frontiers Media SA
Release : 2016-08-16
ISBN : 2889199681
Language : En, Es, Fr & De

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Book Description :

After decades of intensive research and over 10,000 publications, preterm birth remains a major global obstetric healthcare problem. Each year, early birth is responsible for the deaths of more than one million infants worldwide and is a major cause of life-long disability. Preterm birth places an enormous financial burden on our healthcare systems, resulting in long-term adverse health outcomes and lost productivity for many people. Preterm birth is a syndrome, associated with several different aetiologies; hence, potential treatment strategies need to be matched to pathophysiology in order to be effective. There is now unequivocal evidence that inflammation is causally involved in a majority of spontaneous preterm deliveries. However, the triggers of inflammation, and the strategies by which it can be safely and effectively prevented and treated, remain the subject of ongoing investigation and debate. While intraamniotic infection is an important cause of inflammation-associated preterm birth, particularly in very preterm deliveries, ‘sterile’ inflammation is actually a more common finding associated with preterm birth. It is likely that the nature, localisation, timing and extent of the inflammatory insult all determine the obstetric outcome and degree of risk to the fetus. These factors will also influence the success of approaches that might be employed to achieve better pregnancy outcomes. Despite our increased understanding of the causes and significance of intrauterine inflammation, we have yet to translate this knowledge into effective therapeutic strategies for preventing prematurity and mitigating its consequences for the neonate. In this Research Topic we review recent progress in treating and preventing inflammation-associated preterm birth, approaching the topic from both the causal and therapeutic perspectives. With global attention increasingly focused on the need to translate knowledge discovery into clinical translation, we hope this EBook will provide a stimulating and timely discussion that will focus research and lead to improved healthcare outcomes for women and children.