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The Mechanics Of Inhaled Pharmaceutical Aerosols

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The Mechanics of Inhaled Pharmaceutical Aerosols

The Mechanics of Inhaled Pharmaceutical Aerosols Book
Author : Warren H. Finlay
Publisher : Elsevier
Release : 2001-06-19
ISBN : 0080511376
Language : En, Es, Fr & De

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Book Description :

The Mechanics of Inhaled Pharmaceutical Aerosols, An Introduction provides a unique and comprehensive treatment of the mechanics of inhaled pharmaceutical aerosols. The book covers a wide range of topics and many new perspectives are given by drawing on research from a variety of fields. Novel, in-depth expositions of the most common delivery devices are given, including nebulizers, dry powder inhalers and propellant metered dose inhalers. The behaviour of aerosols in the respiratory tract is explained in detail, with complete coverage of the fundamentals of current deposition models. The book begins by providing a comprehensive introduction to aspects of aerosol mechanics that are relevant to inhaled pharmaceutical aerosols. It then gives an exhaustive pedagogical description of the behaviour of evaporating and condensing droplets (both aqueous and propellant-based), an introductory chapter on lung geometry and inhalation patterns, and coverage of relevant aspects of fluid mechanics in the lung. Finally, the book provides invaluable, detailed coverage on the mechanics of common pharmaceutical aerosol delivery systems and deposition in the respiratory tract. Throughout the book are many detailed numerical examples that apply the salient concepts to typical inhaled pharmaceutical aerosols. This book will be of interest to scientists and engineers involved in the research and development of inhaled pharmaceutical aerosol products. Experienced practitioners will find many new perspectives that will greatly enhance their understanding of this complex and rapidly growing field. For those delivering therapeutic agents to the lung, this book is a must-have. Students and academics will find this book an invaluable tool and for newcomers it is a worthy guide to the diverse fields that must be understood to work in the area of inhaled pharmaceutical aerosols.

The Mechanics of Inhaled Pharmaceutical Aerosols

The Mechanics of Inhaled Pharmaceutical Aerosols Book
Author : Warren H. Finlay
Publisher : Academic Press
Release : 2019-06-01
ISBN : 0081027869
Language : En, Es, Fr & De

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Book Description :

The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction, Second Edition provides a concise, but thorough exposition of fundamental concepts in the field of pharmaceutical aerosols. This revised edition will allow researchers in the field to gain a thorough understanding of the field from first principles, allowing them to understand, design, develop and improve inhaled pharmaceutical aerosol devices and therapies. Chapters consider mechanics and deposition, specifically in the respiratory tract, while others discuss the mechanics associated with the three existing types of pharmaceutical inhalation devices. This text will be very useful for academics and for courses taught at both undergraduate and graduate levels. Because of the interdisciplinary nature of this book, it will also serve a wide audience that includes engineers and scientists involved with inhaled aerosol therapies. Provides a concise, but thorough exposition of fundamental concepts in the field of pharmaceutical aerosols Allows researchers in the field to gain an up-to-date, thorough understanding of the field from first principles Introduces the pharmaceutical aerosols field to the many engineers and scientists entering the area

Pharmaceutical Inhalation Aerosol Technology Third Edition

Pharmaceutical Inhalation Aerosol Technology  Third Edition Book
Author : Anthony J. Hickey,Sandro R. da Rocha
Publisher : CRC Press
Release : 2019-03-26
ISBN : 0429619561
Language : En, Es, Fr & De

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Book Description :

This fully revised and updated third edition of Pharmaceutical Inhalation Aerosol Technology encompasses the scientific and technical foundation for the rationale, design, componentry, assembly and quality performance metrics of therapeutic inhalers in their delivery of pharmaceutical aerosols to treat symptoms or the underlying causes of disease. It focuses on the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery. The expanded scope considers previously unaddressed aspects of pharmaceutical inhalation aerosol technology and the patient interface by including aerosol delivery, lung deposition and clearance that are used as measures of effective dose delivery.

Pharmaceutical Inhalation Aerosol Technology Second Edition

Pharmaceutical Inhalation Aerosol Technology  Second Edition Book
Author : Anthony J. Hickey
Publisher : CRC Press
Release : 2003-09-03
ISBN : 9780824756642
Language : En, Es, Fr & De

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Book Description :

This thoroughly revised and expanded reference provides authoritative discussions on the physiologic, pharmacologic, metabolic, molecular, cellular and physicochemical factors, influencing the efficacy and utilization of pharmaceutical aerosol. It analyzes the latest science and developments in the generation, administration and characterization of these compounds, showcasing current clinical applications, the efficiency and limitations of major aerosol products and emerging aerosol therapies impacting the field.

Controlled Pulmonary Drug Delivery

Controlled Pulmonary Drug Delivery Book
Author : Hugh D.C. Smyth,Anthony J. Hickey
Publisher : Springer Science & Business Media
Release : 2011-06-24
ISBN : 9781441997456
Language : En, Es, Fr & De

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Book Description :

The pace of new research and level of innovation repeatedly introduced into the field of drug delivery to the lung is surprising given its state of maturity since the introduction of the pressurized metered dose inhaler over a half a century ago. It is clear that our understanding of pulmonary drug delivery has now evolved to the point that inhalation aerosols can be controlled both spatially and temporally to optimize their biological effects. These abilities include controlling lung deposition, by adopting formulation strategies or device technologies, and controlling drug uptake and release through sophisticated particle technologies. The large number of contributions to the scientific literature and variety of excellent texts published in recent years is evidence for the continued interest in pulmonary drug delivery research. This reference text endeavors to bring together the fundamental theory and practice of controlled drug delivery to the airways that is unavailable elsewhere. Collating and synthesizing the material in this rapidly evolving field presented a challenge and ultimately a sense of achievement that is hopefully reflected in the content of the volume.

Handbook of Non Invasive Drug Delivery Systems

Handbook of Non Invasive Drug Delivery Systems Book
Author : Vitthal S. Kulkarni
Publisher : Elsevier
Release : 2009-12-31
ISBN : 9780815520269
Language : En, Es, Fr & De

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Book Description :

With the improvements in formulation science and certain transdermal delivery technologies, the non-invasive mode of drug delivery is now ready to compete with traditional methods of oral and injectible routes of drug delivery. The Handbook of Non-Invasive Drug Delivery Systems encompasses the broad field of non-invasive drug delivery systems that include drug delivery via topical, transdermal-passive, transdermal-active (device- aided enhanced penetration), trans-mucosal membrane, trans-ocular membrane as well as delivery via alveolar membrane from inhaled medication. Patient compliance has been found to be much higher when administrated by non-invasive routes and therefore they are considered to be a preferred mode of drug delivery. The book includes both science and technological aspects of new drug delivery systems. Its unique focus is that it is on new drug delivery systems that are considered to be "non-invasive". Other unique features include a chapter on Regulatory Aspects of non-invasive systems and one on FDA guidance for topical nano-drug delivery. Two chapters covering market trends and perspectives, as well as providing guidance to those marketing such systems are also included.

Drug Delivery

Drug Delivery Book
Author : Anya M Hillery,Kinam Park
Publisher : CRC Press
Release : 2016-09-15
ISBN : 1482217740
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive introduction to advanced drug delivery and targeting, covering their principles, current applications, and potential future developments. This edition has been updated to reflect significant trends and cutting-edge advances that have occurred since the first edition was published. All the original chapters have been retained, but the material therein has been updated. Eight new chapters have been added that deal with entirely new technologies and approaches. Features: Offers a comprehensive introduction to the fundamental concepts and underlying scientific principles of drug delivery and targeting Presents an in-depth analysis of the opportunities and obstacles afforded by the application of nanotechnologies for drug delivery and targeting Includes a revised and expanded section on the major epithelial routes of drug delivery currently under investigation Describes the most recent, emerging, and innovative technologies of drug delivery Provides real-life examples of the clinical translation of drug delivery technologies through the use of case studies Discusses the pertinent regulatory hurdles and safety issues of drug delivery and targeting systems—crucial considerations in order to achieve licensing approval for these new technologies

Good Cascade Impactor Practices AIM and EDA for Orally Inhaled Products

Good Cascade Impactor Practices  AIM and EDA for Orally Inhaled Products Book
Author : Terrence P. Tougas,Jolyon P. Mitchell,Svetlana A. Lyapustina
Publisher : Springer Science & Business Media
Release : 2013-04-10
ISBN : 1461462967
Language : En, Es, Fr & De

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Book Description :

The purpose of this publication is to introduce a new, simpler and more effective way in which to interpret pharmaceutical aerosol particle size data from orally inhaled products (OIPs). Currently, the compendial and regulatory requirements dictate the need for measurements by full resolution multi-stage cascade impactor (CI), a process that is demanding for the operator, time consuming, prone to experimental error, and challenging for method transfers from one laboratory to another. Furthermore, we shall show that the current practice of reducing information from mass-weighted aerodynamic particle size distribution (APSD) measurements through the use of CI stage groupings is not the most effective decision-making tool for OIP quality control (QC) in comparison with newly introduced, mutually-independent efficient data analysis (EDA) metrics that can be derived either from full resolution or abbreviated impactor measurements (AIM).

Handbook of Lung Targeted Drug Delivery Systems

Handbook of Lung Targeted Drug Delivery Systems Book
Author : Yashwant Pathak,Nazrul Islam
Publisher : CRC Press
Release : 2021-10-18
ISBN : 1000450805
Language : En, Es, Fr & De

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Book Description :

Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences covers every aspect of the drug delivery to lungs, the physiology and pharmacology of the lung, modelling for lung delivery, drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications. With the advent of nano sciences and significant development in the nano particulate drug delivery systems there has been a renewed interest in the lung as an absorption surface for various drugs. The emergence of the COVID-19 virus has brought lung and lung delivery systems into focus, this book covers new developments and research used to address the prevention and treatment of respiratory diseases. Written by well-known scientists with years of experience in the field this timely handbook is an excellent reference book for the scientists and industry professionals. Key Features: Focuses particularly on the chemistry, clinical pharmacology, and biological developments in this field of research. Presents comprehensive information on emerging nanotechnology applications in diagnosing and treating pulmonary diseases Explores drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications Examines specific formulations targeted to pulmonary systems

Murray Nadel s Textbook of Respiratory Medicine E Book

Murray   Nadel s Textbook of Respiratory Medicine E Book Book
Author : V.Courtney Broaddus,Joel D Ernst,Talmadge E King, Jr,Stephen C. Lazarus,Kathleen F. Sarmiento,Lynn M. Schnapp,Renee D Stapleton,Michael B. Gotway
Publisher : Elsevier Health Sciences
Release : 2021-05-28
ISBN : 0323655882
Language : En, Es, Fr & De

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Book Description :

Known for its clear readability, thorough coverage, and expert authorship, Murray & Nadel’s Textbook of Respiratory Medicine has long been the gold standard text in the fast-changing field of pulmonary medicine. The new 7th Edition brings you fully up to date with newly expanded content, numerous new chapters, a new editorial team, and extensive updates throughout. It covers the entire spectrum of pulmonology in one authoritative point-of-care reference, making it an ideal resource for pulmonary physicians, fellows, and other pulmonary practitioners. Offers definitive, full-color coverage of basic science, diagnosis, evaluation, and treatment of the full range of respiratory diseases. Provides detailed explanations of each disease entity and differential diagnoses with state-of-the-art, evidence-based content by global leaders in the field. Contains a newly expanded section on common presentations of respiratory disease, plus new chapters on COVID-19, asthma and obesity, airplane travel, lung cancer screening, noninvasive support of oxygenation, lung microbiome, thoracic surgery, inhaled substances, treatment of lung cancer, and more. Covers hot topics such as vaping; advanced ultrasound applications and procedures; interventional pulmonology; immunotherapy; lung cancer targeted therapy; outbreaks, pandemics and bioterrorism; point-of-care ultrasound; use of high-flow oxygen, and more. Includes extensively reorganized sections on basic science, pleural disease, and sleep, with new chapters and approaches to the topics. Features more than 1,450 anatomic, algorithmic, and radiologic images (400 are new!) including CT, PET, MR, and HRCT, plus extensive online-only content: 200 procedural and conceptual videos plus audio clips of lung sounds. Brings you up to date with the latest respiratory drugs, mechanisms of action, indications, precautions, adverse effects, and recommendations, with increased emphasis on algorithms to illustrate decision making.

Inhalation Aerosols

Inhalation Aerosols Book
Author : Anthony J. Hickey,Heidi M. Mansour
Publisher : CRC Press
Release : 2019-03-21
ISBN : 1351660527
Language : En, Es, Fr & De

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Book Description :

Inhalation aerosols continue to be the basis for successful lung therapy for several diseases, with therapeutic strategies and the range of technology significantly evolving in recent years. In response, this third edition takes a new approach to reflect the close integration of technology with its application. After briefly presenting the general considerations that apply to aerosol inhalation, the central section of the book uses the focus on disease and therapeutic agents to illustrate the application of specific technologies. The final integrated strategies section draws the major points from the applications for disease targets and drug products.

Simulation and Modeling Methodologies Technologies and Applications

Simulation and Modeling Methodologies  Technologies and Applications Book
Author : Mohammad S. Obaidat,Joaquim Filipe,Janusz Kacprzyk,Nuno Pina
Publisher : Springer Science & Business Media
Release : 2013-11-26
ISBN : 3319035819
Language : En, Es, Fr & De

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Book Description :

This book includes extended and revised versions of a set of selected papers from the 2012 International Conference on Simulation and Modeling Methodologies, Technologies and Applications (SIMULTECH 2012) which was sponsored by the Institute for Systems and Technologies of Information, Control and Communication (INSTICC) and held in Rome, Italy. SIMULTECH 2012 was technically co-sponsored by the Society for Modeling & Simulation International (SCS), GDR I3, Lionphant Simulation, Simulation Team and IFIP and held in cooperation with AIS Special Interest Group of Modeling and Simulation (AIS SIGMAS) and the Movimento Italiano Modellazione e Simulazione (MIMOS).

Murray Nadel s Textbook of Respiratory Medicine E Book

Murray   Nadel s Textbook of Respiratory Medicine E Book Book
Author : Robert C Mason,John F. Murray,Jay A. Nadel,Michael Gotway
Publisher : Elsevier Health Sciences
Release : 2015-03-17
ISBN : 0323261930
Language : En, Es, Fr & De

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Book Description :

Ideal for fellows and practicing pulmonologists who need an authoritative, comprehensive reference on all aspects of pulmonary medicine, Murray and Nadel’s Textbook of Respiratory Medicine offers the most definitive content on basic science, diagnosis, evaluation and treatment of the full spectrum of respiratory diseases. Full-color design enhances teaching points and highlights challenging concepts. Understand clinical applications and the scientific principles of respiratory medicine. Detailed explanations of each disease entity allow you to work through differential diagnoses. Key Points and Key Reading sections highlight the most useful references and resources for each chapter. An expanded sleep section now covers four chapters and includes control of breathing, consequences of sleep disruption, as well as obstructive and central apnea. New chapters in the Critical Care section cover Noninvasive Ventilation (NIV) and Extracorporeal Support of Gas Exchange (ECMO). New chapters focusing on diagnostic techniques now include Invasive Diagnostic Imaging and Image-Guided Interventions and Positron Emission Tomography, and a new chapter on Therapeutic Bronchoscopy highlights the interventional role of pulmonologists.

Biofluid Dynamics

Biofluid Dynamics Book
Author : Clement Kleinstreuer
Publisher : CRC Press
Release : 2006-04-26
ISBN : 0849322219
Language : En, Es, Fr & De

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Book Description :

Requiring only an introductory background in continuum mechanics, including thermodynamics, fluid mechanics, and solid mechanics, Biofluid Dynamics: Principles and Selected Applications contains review, methodology, and application chapters to build a solid understanding of medical implants and devices. For additional assistance, it includes a glossary of biological terms, many figures illustrating theoretical concepts, numerous solved sample problems, and mathematical appendices. The text is geared toward seniors and first-year graduate students in engineering and physics as well as professionals in medicine and medical implant/device industries. It can be used as a primary selection for a comprehensive course or for a two-course sequence. The book has two main parts: theory, comprising the first two chapters; and applications, constituting the remainder of the book. Specifically, the author reviews the fundamentals of physical and related biological transport phenomena, such as mass, momentum, and heat transfer in biomedical systems, and highlights complementary topics such as two-phase flow, biomechanics, and fluid-structure interaction. Two appendices summarize needed elements of engineering mathematics and CFD software applications, and these are also found in the fifth chapter. The application part, in form of project analyses, focuses on the cardiovascular system with common arterial diseases, organ systems, targeted drug delivery, and stent-graft implants. Armed with Biofluid Dynamics, students will be ready to solve basic biofluids-related problems, gain new physical insight, and analyze biofluid dynamics aspects of biomedical systems.

Toxicological Evaluation of Electronic Nicotine Delivery Products

Toxicological Evaluation of Electronic Nicotine Delivery Products Book
Author : Manuel C. Peitsch,Julia Hoeng
Publisher : Academic Press
Release : 2021-01-14
ISBN : 0128209356
Language : En, Es, Fr & De

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Book Description :

Toxicological Evaluation of Electronic Nicotine Delivery Products (ENDP) discusses the scientific basis for the toxicological assessment and evaluation of ENDPs. The book covers aerosol chemistry, in vitro and in vivo studies as well as clinical studies. It provides the basis for the evaluation of short and long term-effects, along with relative risks. It also examines the potential role of ENDPs in tobacco harm reduction and how they may reduce the risk of disease in smokers who switch to them. This book is a comprehensive resource for toxicologists, health practitioners and public health professionals who want the scientific information necessary to assess the relative risk of ENDPs when compared with cigarette smoking and cessation. Delivers a comprehensive overview of current state of science Offers an integrated analysis of e-cigarettes and heated tobacco products Provides guidance for methodologies

First Principles of Meteorology and Air Pollution

First Principles of Meteorology and Air Pollution Book
Author : Mihalis Lazaridis
Publisher : Springer Science & Business Media
Release : 2010-11-18
ISBN : 9789400701625
Language : En, Es, Fr & De

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Book Description :

This book’s main objective is to decipher for the reader the main processes in the atmosphere and the quantification of air pollution effects on humans and the environment, through first principles of meteorology and modelling/measurement approaches. The understanding of the complex sequence of events, starting from the emission of air pollutants into the atmosphere to the human health effects as the final event, is necessary for the prognosis of potential risk to humans from specific chemical compounds and mixtures of them. It fills a gap in the literature by providing a solid grounding in the first principles of meteorology and air pollution, making it particularly useful for undergraduate students. Its broad scope makes it a valuable text in many related disciplines, containing a comprehensive and integrated methodology to study the first principles of air pollution, meteorology, indoor air pollution, and human exposure. Problem-solving exercises help to reinforce concepts.

Pharmaceutical Inhalation Aerosol Technology

Pharmaceutical Inhalation Aerosol Technology Book
Author : Anthony J. Hickey,Sandro R. Da Rocha
Publisher : CRC Press
Release : 2019-03-21
ISBN : 9781138063075
Language : En, Es, Fr & De

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Book Description :

This fully revised and updated third edition of Pharmaceutical Inhalation Aerosol Technology encompasses the scientific and technical foundation for the rationale, design, componentry, assembly and quality performance metrics of therapeutic inhalers in their delivery of pharmaceutical aerosols to treat symptoms or the underlying causes of disease. It focuses on the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery. The expanded scope considers previously unaddressed aspects of pharmaceutical inhalation aerosol technology and the patient interface by including aerosol delivery, lung deposition and clearance that are used as measures of effective dose delivery.

Confocal Raman Microscopy

Confocal Raman Microscopy Book
Author : Jan Toporski,Thomas Dieing,Olaf Hollricher
Publisher : Springer
Release : 2018-03-01
ISBN : 3319753800
Language : En, Es, Fr & De

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Book Description :

This second edition provides a cutting-edge overview of physical, technical and scientific aspects related to the widely used analytical method of confocal Raman microscopy. The book includes expanded background information and adds insights into how confocal Raman microscopy, especially 3D Raman imaging, can be integrated with other methods to produce a variety of correlative microscopy combinations. The benefits are then demonstrated and supported by numerous examples from the fields of materials science, 2D materials, the life sciences, pharmaceutical research and development, as well as the geosciences.

Aerosol Measurement

Aerosol Measurement Book
Author : Pramod Kulkarni,Paul A. Baron,Klaus Willeke
Publisher : John Wiley & Sons
Release : 2011-09-09
ISBN : 9781118001677
Language : En, Es, Fr & De

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Book Description :

Aerosol Measurement: Principles, Techniques, and Applications Third Edition is the most detailed treatment available of the latest aerosol measurement methods. Drawing on the know-how of numerous expert contributors; it provides a solid grasp of measurement fundamentals and practices a wide variety of aerosol applications. This new edition is updated to address new and developing applications of aerosol measurement, including applications in environmental health, atmospheric science, climate change, air pollution, public health, nanotechnology, particle and powder technology, pharmaceutical research and development, clean room technology (integrated circuit manufacture), and nuclear waste management.