Skip to main content

The Kidney In Systemic Autoimmune Diseases

In Order to Read Online or Download The Kidney In Systemic Autoimmune Diseases Full eBooks in PDF, EPUB, Tuebl and Mobi you need to create a Free account. Get any books you like and read everywhere you want. Fast Download Speed ~ Commercial & Ad Free. We cannot guarantee that every book is in the library!

The Kidney in Systemic Autoimmune Diseases

The Kidney in Systemic Autoimmune Diseases Book
Author : Justin C Mason,Charles Pusey
Publisher : Elsevier
Release : 2007-12-14
ISBN : 9780080557045
Language : En, Es, Fr & De

GET BOOK

Book Description :

This volume brings together an international group of clinicians and clinical scientists to contribute to a state-of the-art review of the underlying pathogenic mechanisms, methods of clinical assessment, classification and diagnosis of renal disease, combined with a detailed overview of treatment strategies. An essential reference source for all those involved with the care of patients with renal involvement in systemic autoimmune disease, and for those contributing to research into the underlying pathogenic mechanisms in these disorders.

The Kidney in Systemic Autoimmune Diseases 9780444529725

The Kidney in Systemic Autoimmune Diseases  9780444529725   Book
Author : no. author
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Download The Kidney in Systemic Autoimmune Diseases 9780444529725 book written by no. author, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

A Tet regulatable Mouse Model for the Analysis of Systemic Autoimmune Disease

A Tet regulatable Mouse Model for the Analysis of Systemic Autoimmune Disease Book
Author : Karen Sunhae Lee
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Abstract: The major challenge of systemic autoimmune diseases like systemic lupus erythematosus (SLE) or systemic sclerosis (SSc), has been understanding the transition from early events of elaboration of autoantibody, to tissue fibrosis and end-organ damage. In order to determine whether the microenvironment regulates the pathologic consequences of an autoimmune response, we generated a novel mouse model that allows for the manipulation of the site and level of expression of a pseudo-autoantigen. This is a double transgenic system in which expression of a pseudo-autoantigen is controlled by a tet responsive element (TRE) and expression of the corresponding transactivator is controlled by a tissue specific promoter. Further, the timing and level of expression can be controlled by the administration of doxycycline (dox). Our pseudo-autoantigen is a fusion protein that incorporates the transferrin receptor, GFP and ovalbumin (TGO) recognized by DO11.10 CD4 + T cells. We have developed divergent mouse models of autoimmune disease by directing the expression of the pseudo-autoantigen to distinct tissue locales. In one model, expression of TGO is directed to MHC class II-positive cells. Here, the intravenous transfer of DO11.10 TH2 cells initiates an SLE-like disease, characterized by the production of anti-nuclear autoantibodies (ANA) that deposit in the kidney and cause immune complex-mediated glomerulonephritis. Intriguingly, we can limit the development of disease by removing dox from the drinking water, implicating the importance of T cell recognition of the pseudo-autoantigen in sustained autoantibody production. In the second model TGO expression is directed to the vascular endothelium. Here, the transfer of TH1 or TH17 DO11.10 T cells can trigger a disease phenotype characterized by pathogenic changes in the skin and lung. For example, TH1 DO11.10 T cells induce lung fibrosis, while TH17 cells trigger pulmonary vasculopathy, both features of SSc. Having demonstrated that these mouse models can mimic distinct systemic autoimmune disease phenotypes, they will enable us to more effectively delineate the specific conditions that promote SLE or SSc pathology.

The Kidney Diseases Dictionary

The Kidney Diseases Dictionary Book
Author : Anonim
Publisher : Unknown
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Download The Kidney Diseases Dictionary book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Skin in Systemic Autoimmune Diseases

The Skin in Systemic Autoimmune Diseases Book
Author : Piercarlo Sarzi-Puttini
Publisher : Elsevier
Release : 2006-01-26
ISBN : 9780080461922
Language : En, Es, Fr & De

GET BOOK

Book Description :

This book represents the state-of-the-art in the field of skin and autoimmune rheumatic diseases. It covers systematically a growing and multifaceted topic which is of great importance in the clinical practice. It also serves as a sharp educational tool as each chapter provides summaries and specific highlights to key references cited into the text. The pathophysiological link between skin involvement and autoimmunity has been explained in detail, as well as diagnostic and therapeutic aspects. This book yields an impressive body of well ordered information which summarizes the experience of a selected panel of distinguished physicians and scientists actively involved in the field of skin immunology and systemic autoimmunity. * Written by a respected panel of distinguished physician-scientists actively involved in the field of skin immunology and systemic autoimmunity * Box summaries at the end of each chapter highlight important topics * Up-to-date basic knowledge as well as modern approach to diagnosis and therapy

The Heart in Systemic Autoimmune Diseases

The Heart in Systemic Autoimmune Diseases Book
Author : Fabiola Atzeni,Andrea Dorea,Mike Nurmohamed,Paolo Pauletto
Publisher : Elsevier
Release : 2017-02-11
ISBN : 0444636692
Language : En, Es, Fr & De

GET BOOK

Book Description :

The Heart in Systemic Autoimmune Diseases, Second Edition, provides an overview on our current understanding of major complications relating to the heart and autoimmune diseases. It includes the latest information on the new pathogenetic mechanisms involved, along with clinical manifestations of these important comortbidities. Mortality in autoimmune diseases, in particular, rheumatoid arthritis and SLE, has increased when compared with the general population. This excess mortality is largely due to cardiovascular diseases (CVDs)-particularly those of atherosclerotic origin, such as ischemic heart disease-and is gaining recognition in all branches of medicine, from cardiology, to internal medicine, and from rheumatologists to orthopedics. Presents an impressive body of well ordered information on the topic of cardiovascular diseases and their relationship to autoimmune illness Highlights key references Summarizes the experience of a selected panel of distinguished physician-scientists who are actively involved in the field of cardiovascular disease and systemic autoimmunity

Reproductive and Hormonal Aspects of Systemic Autoimmune Diseases

Reproductive and Hormonal Aspects of Systemic Autoimmune Diseases Book
Author : Michael Lockshin,D. Ware Branch
Publisher : Gulf Professional Publishing
Release : 2006
ISBN : 0444518010
Language : En, Es, Fr & De

GET BOOK

Book Description :

This volume of the Handbook of Systemic Autoimmune Diseases series represents a medical collaboration focusing primarily on female aspects of rheumatic diseases. This collaboration recognizes the need to understand and optimally manage the care of women with autoimmune conditions that may affect their reproduction and hormonal status. This handbook will prove useful to clinicians and researchers alike. It covers practical points, ranging from which anti-rheumatic medications are safe in pregnancy to how to counsel women with scleroderma contemplating pregnancy. * Authors share an academic interest in the unique relationship between being a woman and having an autoimmune disease * Touches on controversial topics, such as the mechanism of antiphospholipid-related fetal loss and whether or not non-steroidal anti-inflammatory agents should be used in pregnancy * Includes critical and balanced reviews of the controversial association between autoimmune disease and female infertility

Diagnostic Criteria in Autoimmune Diseases

Diagnostic Criteria in Autoimmune Diseases Book
Author : Yehuda Shoenfeld,Ricard Cervera,M. Eric Gershwin
Publisher : Springer Science & Business Media
Release : 2010-06-08
ISBN : 9781603272858
Language : En, Es, Fr & De

GET BOOK

Book Description :

According to the Autoimmune Diseases Coordinating Committee (ADCC), between 14.7 and 23.5 million people in the USA – up to eight percent of the population are affected by autoimmune disease. Autoimmune diseases are a family of more than 100 chronic, and often disabling, illnesses that develop when underlying defects in the immune system lead the body to attack its own organs, tissues, and cells. In Handbook of Autoimmune Disease, the editors have gathered in a comprehensive handbook a critical review, by renowned experts, of more than 100 autoimmune diseases, divided into two main groups, namely systemic and organ-specific autoimmune diseases. A contemporary overview of these conditions with special emphasis on diagnosis is presented. Each chapter contains the essential information required by attending physicians as well as bench scientists to understand the definition of a specific autoimmune disease, the diagnostic criteria, and the treatment.

Pulmonary Involvement in Systemic Autoimmune Diseases

Pulmonary Involvement in Systemic Autoimmune Diseases Book
Author : Anonim
Publisher : Elsevier
Release : 2004-09-11
ISBN : 9780080515441
Language : En, Es, Fr & De

GET BOOK

Book Description :

In this book is found the information essential to diagnosing, managing and treating the lung complications of connective tissue diseases. This is a notoriously difficult area, which continues to puzzle clinicians, despite the fact that these disorders are increasingly frequent (as a result of longer survival in connective tissue disease). In separate chapters, the major connective tissue diseases are reviewed, with detailed discussion of a variety of lung abnormalities, including pleural disease, parenchymal lung disease and pulmonary vascular disease. There are also invaluable overviews of lung histological and CT appearances in these disorders, and a deeply insightful chapter on drug-induced lung disease in connective tissue disease. The emphasis in this book is on accuracy of evaluation and the construction of a logical management plan, based on disease severity and intrinsic progressiveness.

Vascular Manifestations of Systemic Autoimmune Diseases

Vascular Manifestations of Systemic Autoimmune Diseases Book
Author : Ronald A. Asherson,Ricard Cervera,Douglas A. Triplett,Steven B. Abramson
Publisher : CRC Press
Release : 2001-01-25
ISBN : 9781420040395
Language : En, Es, Fr & De

GET BOOK

Book Description :

Not too long ago, it was thought that inflammation of blood vessels was the sole manifestation of systemic autoimmune diseases. Today, however, we know that disorders of coagulation, injuries to both neutrophils and endothelial cells, and certain lipids and amino acids are all intricately involved in the development of vascular disease. How are all

Pediatrics in Systemic Autoimmune Diseases

Pediatrics in Systemic Autoimmune Diseases Book
Author : Rolando Cimaz,Thomas J.A. Lehman
Publisher : Elsevier
Release : 2016-06-08
ISBN : 0444635971
Language : En, Es, Fr & De

GET BOOK

Book Description :

Pediatrics in Systemic Autoimmune Diseases, Second Edition, provides a good starting point for physicians and scientists new to the field and for anyone looking for the most up-to-date summary of a particular disease. While many questions are answered, many more are raised for which we do not yet have the answers. The book provides inspiration to readers conducting their own research and helps to answer their questions. The care of children with systemic autoimmune diseases is moving forward at a rapid pace. The systemic autoimmune diseases of childhood have always represented a special problem for the physicians and scientists who care for the affected children and study their diseases. Some conditions, such as Kawasaki disease, are virtually unique to childhood, while systemic lupus erythematosus, progressive systemic sclerosis, and juvenile onset spondyloarthropathies may be thought of as the early onset of the same disease which is seen in adults. The autoinflammatory disorders appear to be of clear genetic origin, accounting for their frequent discovery in childhood. For many other conditions, such as juvenile dermatomyositis, the relationship between the conditions seen in children and that seen in adults is less certain. This book explores these phenomena, giving users a foundation on which to understand certain diseases. Includes completely updated chapters and five new chapters Explains the differences in systemic autoimmune diseases seen in children vs. those seen in adults Covers the latest advances in pathogenesis and clinical management of common conditions seen in pediatric rheumatology practices, benefiting both pediatric and adult rheumatologists, as well as physicians from other specialties Brings the reader up-to-date and allows easy access to individual topics in one place Provides the latest information available in a format that would give the clinician both a clear understanding of what has been done in the past and a scientific basis for deciding what to do for the next afflicted child in their care

The Heart in Systemic Autoimmune Diseases

The Heart in Systemic Autoimmune Diseases Book
Author : Andrea Dorea
Publisher : Elsevier
Release : 2004-01-20
ISBN : 9780080507965
Language : En, Es, Fr & De

GET BOOK

Book Description :

This first volume represents the state-of-the-art in the field of cardiovascular disease and autoimmune rheumatic diseases. Systemic autoimmune diseases comprise a family of conditions that share common pathogenetic mechanisms as well as a multi-organ involvement including the heart. This volume has been subdivided into three parts. In the first part, the immune mechanisms involved in cardiac damage have been considered. The role of proinflammatory and regulatory cytokines in driving an autoimmune response to cardiac self-tissues has been analysed. Moreover, the prevalence, the clinical meaning and the hypothetical pathogenicity of a broad spectrum of organ and non-organ specific autoantibodies have been discussed in detail. In the second part of the volume, the role of humoral and innate immunity in promoting the development of atherosclerotic plaque has been extensively reviewed, along with the newly discovered anti-inflammatory properties of statins. These two parts of the volume deal with exciting aspects of this topic, suggesting a very close connection between heart diseases and immunology. Finally, in the third part, the cardiac manifestations observed in the major systemic autoimmune conditions have been comprehensively examined. This book yields an impressive body of well ordered information, highlighting key references and summarising the experience of a selected panel of distinguished physician-scientists actively involved in the field of cardiovascular disease and systemic autoimmunity.

Antiphospholipid Syndrome in Systemic Autoimmune Diseases

Antiphospholipid Syndrome in Systemic Autoimmune Diseases Book
Author : R. Cervera,Ricard Cervera
Publisher : Elsevier
Release : 2009-04-01
ISBN : 9780080932347
Language : En, Es, Fr & De

GET BOOK

Book Description :

Antiphospholipid syndrome is an autoimmune disease that causes abnormal blood clots. It is now recognized as a major cause of common conditions, including stroke, heart attack, miscarriage, epilepsy and memory loss and as such is gaining recognition in all branches of medicine, from obstetrics to cardiology, from psychiatry to orthopedics. This book provides an overview of our current understanding of this major disease. It includes the latest information on the new pathogenetic mechanisms involved as well as clinical manifestations in both “the thrombotic and “non-thrombotic manifestations of this important disease. * Comprehensive review of this major disease * Includes information on treatment options available

Infections in Systemic Autoimmune Diseases Risk Factors and Management Volume 16

Infections in Systemic Autoimmune Diseases  Risk Factors and Management  Volume 16 Book
Author : James Galloway
Publisher : Handbook of Systemic Autoimmun
Release : 2020-03-16
ISBN : 044464217X
Language : En, Es, Fr & De

GET BOOK

Book Description :

Infections in Systemic Autoimmune Diseases: Risk Factors and Management, Volume Sixteen describes the state-of-the-art of the risk factors and management treating the most common systemic autoimmune diseases (SADS). This updated volume consists of an introductory chapter that provides a brief overview of what different types of infectious diseases exist, followed by eight chapters detailing risk factors, guidelines and recommendations per different disease and bacterial infections. International in scope, the list of more than 20 contributors from Europa and America reads like a who's who of clinical researchers in the field.

Digestive Involvement in Systemic Autoimmune Diseases

Digestive Involvement in Systemic Autoimmune Diseases Book
Author : Manuel Ramos-Casals
Publisher : Elsevier
Release : 2011-09-02
ISBN : 9780080559315
Language : En, Es, Fr & De

GET BOOK

Book Description :

The Digestive System in Systemic Autoimmune Diseases represents the state-of-the-art in the field of digestive disorders in the most common systemic autoimmune diseases. The volume consists of an introductory chapter on imaging techniques in digestive diseases, followed by eight chapters on digestive manifestations in specific systemic autoimmune diseases. The final five chapters deal with digestive diseases with an autoimmune pathogenesis and systemic manifestations. International in scope, the table of contents reads like a Who's who in clinical research on systemic autoimmune diseases. More than 20 contributors from the European Union, the United States, Mexico and South Africa share their knowledge in this detailed volume. *One book of leading international clinical and scientific experts on autoimmune and digestive diseases *A practical guide to the identification, diagnosis and treatment of digestive involvement in patients with autoimmune diseases that will be useful for all medical specialties *Several diseases and conditions not included in other text books are included, some of which are of recent emergence *Each chapter is designed to serve as a “Guide to Clinical Practice for each disease

Antiphospholipid Syndrome in Systemic Autoimmune Diseases

Antiphospholipid Syndrome in Systemic Autoimmune Diseases Book
Author : Ricard Cervera,Gerard Espinosa,Munther Khamashta
Publisher : Elsevier
Release : 2016-06-18
ISBN : 0444636560
Language : En, Es, Fr & De

GET BOOK

Book Description :

Antiphospholipid Syndrome in Systemic Autoimmune Diseases, Second Edition provides an overview of our current understanding of this major disease. It includes the latest information on the new pathogenetic mechanisms involved, along with clinical manifestations in both the thrombotic and non-thrombotic manifestations of this important disease. Antiphospholipid syndrome is an autoimmune disease that causes abnormal blood clots. It is now recognized as a major cause of common conditions, including stroke, heart attack, miscarriage, epilepsy, and memory loss, and as such is gaining recognition in all branches of medicine, from obstetrics to cardiology, and from psychiatry to orthopedics. Brings the reader up-to-date and allows easy access to individual topics in one place Written by a respected panel of distinguished physicians/scientists actively involved in the field of Antiphospholipid Syndrome Includes box summaries at the end of each chapter that highlight important topics Gives up-to-date, basic knowledge and a modern approach to diagnosis and therapy Provides a comprehensive review of this major disease Includes information on treatment options available

30 Day Journal and Tracker Reversing Systemic Autoimmune Disease

30 Day Journal and Tracker  Reversing Systemic Autoimmune Disease Book
Author : Health Formation
Publisher : Unknown
Release : 2020-02-10
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

After relentlessly studying the teachings of legendary healers, such as Dr Arnold Ehret and Dr Robert Morse, we set out on a journey of healing ourselves and reversing our very own conditions. Within our group, we were suffering from a range of diverse diseases and conditions, including Heart Disease, Kidney Disease, Diabetes, a variety of Autoimmune Diseases and Leaky Gut. During our healing journeys, we formed a journal that we would use on a daily basis, and this helped us to incorporate all of the lessons and tips that we had learnt and refined along the way - in short, it acted as a check list. It was important to us to not miss out on any knowledge and practices that had served us well. This journal is designed to guide and support you through your own journey with the core healing protocols included within its theme. One of the key conclusions that we reached through our individual journeys was that whether you are a sufferer of Systemic Autoimmune Disease, or any other condition, the same protocol that we used applies. However, dependant on the severity of your Systemic Autoimmune Disease, you may need to follow the protocols for longer, using specific herbs in order to achieve positive results, but you can make your own adjustments as you learn more. The great news is that all information and resources are readily available for personal study and application. Dr Arnold Ehret's books can be downloaded freely if you search for "arnold ehret books pdf". Visit rawfigs.com for Dr Robert Morse videos which can be searched through by keywords via the search bar. With this journal and your newly acquired knowledge, we trust that you will also soon start to experience the positive results that we did, along with the many others that send us regular positive feedback. We wish you all the best. The Health Formation Team

The Digestive Involvement in Systemic Autoimmune Diseases

The Digestive Involvement in Systemic Autoimmune Diseases Book
Author : Manuel Ramos-Casals,Munther Khamashta,Pilar Brito-Zeron,Fabiola Atzeni,Joan Rodes
Publisher : Elsevier
Release : 2017-01-18
ISBN : 0444637176
Language : En, Es, Fr & De

GET BOOK

Book Description :

The Digestive System in Systemic Autoimmune Diseases, Second Edition, represents the state-of-the-art in the field of digestive disorders in the most common systemic autoimmune diseases. This volume consists of an introductory chapter on imaging techniques in digestive diseases, followed by eight chapters on digestive manifestations in specific systemic autoimmune diseases. The final five chapters deal with digestive diseases with an autoimmune pathogenesis and systemic manifestations. International in scope, the table of contents reads like a Who's who in clinical research on systemic autoimmune diseases. More than 20 contributors from the European Union, the United States, Mexico, and South Africa share their knowledge in this detailed volume. The book provides an overview of our current understanding of digestive disorders in the most common systemic autoimmune diseases. Completely updated, including five new chapters Presents up-to-date information, giving the reader easy access to individual topics in one place Written by leading international clinical and scientific experts on autoimmune and digestive diseases Provides a practical guide to the identification, diagnosis, and treatment of digestive involvement in patients with autoimmune diseases that will be useful for all medical specialties Includes several diseases and conditions not included in other texts, some of which have only recently emerged Designed to serve as a guide to clinical practice

Systemic Lupus Erythematosus

Systemic Lupus Erythematosus Book
Author : Robert G. Lahita,George Tsokos,Jill P. Buyon,Takao Koike
Publisher : Academic Press
Release : 2010-10-29
ISBN : 0080961711
Language : En, Es, Fr & De

GET BOOK

Book Description :

Systemic lupus erythematosus (S.L.E.), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness, or remission. Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness. To date, lupus has no known cause or cure. Early detection and treatment is the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, anti-malarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, similar to those used in the treatment of cancer, are also used to suppress the immune system in lupus patients. A new edition of this established and well regarded reference which combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries. Highly illustrated and in full color throughout Basic science section expanded to allow the reader to focus on the newest techniques in molecular medicine and its effects on disease expression and treatment Clinical aspects and new drugs will be covered in great detail providing a useful reference to both experienced clinicians and physicians with an interest in lupus in their clinical practice

Identification of candidate genes involved in Mercury Toxicokinetics and Mercury Induced Autoimmunity

Identification of candidate genes involved in Mercury Toxicokinetics and Mercury Induced Autoimmunity Book
Author : Hammoudi Alkaissi
Publisher : Linköping University Electronic Press
Release : 2018-10-24
ISBN : 9176851923
Language : En, Es, Fr & De

GET BOOK

Book Description :

BACKGROUND: Autoimmune diseases require the involvement and activation of immune cells and occur when the body builds up an immune response against its own tissues. This process takes place due to the inability to distinguish self-antigen from foreign antigen. Systemic autoimmunity represents an important cause of morbidity and mortality in humans. The mechanisms triggering autoimmune responses are complex and involve a network of genetic factors. Genome wide association study (GWAS) is a powerful method, used to identify genetic risk factors in numerous diseases, such as systemic autoimmune diseases. The goal of GWAS is to identify these genetic risk factors in order to make predictions about who is at risk and investigate the biological process of disease susceptibility. There are several valuable mouse models to investigate the underlying mechanisms causing systemic autoimmune diseases in which mercury induced autoimmunity (HgIA) is a well- established and relevant model. HgIA in mice includes development of autoantibodies, immune complex glomerulonephritis, lymphocyte proliferation, hypergammaglobulinemia and polyclonal B cell activation. In humans, mercury exposure accumulates with considerable concentrations in kidney, liver, and brain. Toxicokinetics of Hg has been studied extensively but the key for inter-individual variation in humans are largely unclear. Differences in accumulation of renal Hg between inbred mouse strains suggest a genetic inter-strain variation regulating retention or/and excretion of Hg. OBJECTIVES: To find loci and candidate genes associated with phenotypes involved in the development of autoimmunity and find candidate genes involved in the regulation of renal Hg excretion. METHODS: MHC II (H-2s) mice were paired (A.SW x B10.S) to obtain F2 offspring exposed to 2.0 or 4.0 mg Hg in drinking water for 6 weeks. Mercury induced autoimmune phenotypes were studied with immunofluorescence (anti-nucleolar antibodies (ANoA)), ELISA anti-DNP/anti-ssDNA (polyclonal B cell activation), anti-chromatin antibodies (ACA) (4.0 mg Hg), and serum IgG1 concentrations. Mercury accumulation in kidney was performed previously and data was included as phenotype. F2 mice exposed to 2.0 mg Hg were genotyped with microsatellites for genome-wide scan with Ion Pair Reverse Phase High Performance Liquid Chromatography (IP RP HPLC). F2 mice exposed to 4.0 mg Hg were genotyped with single nucleotide polymorphisms for genomewide scan with SNP&SEQ technology platform. Quantitative trait loci (QTL) was established with R/QTL. Denaturing HPLC, next generation sequencing, conserved region analysis and genetic mouse strain comparison were used for haplotyping and fine mapping on QTLs associated with Hg concentration in kidney, development of ANoA and serum IgG1 hypergammaglobulinemia. Candidate genes (Pprc1, Bank1 and Nfkb1) verified by additional QTL were further investigated by real time polymerase chain reaction. Genes involved in the intracellular signaling together with candidate genes were included for gene expression analysis. RESULTS: F2 mice exposed to 2.0 mg Hg had low or no development of autoantibodies and showed no significant difference in polyclonal B cell activation in the B10.S and F2 strains. F2 mice exposed to 4.0 mg Hg developed autoantibodies and significantly increased IgG1 concentration and polyclonal B cell activation (anti-DNP). QTL analysis showed a logarithm of odds ratio (LOD) score between 2.9 – 4.36 on all serological phenotypes exposed to 4.0 mg Hg, and a LOD score of 5.78 on renal Hg concentration. Haplotyping and fine mapping associated the development of ANoA with Bank1 (B-cell scaffold protein with ankyrin repeats 1) and Nfkb1 (nuclear factor kappa B subunit 1). The serum IgG1 concentration was associated with a locus on chromosome 3, in which Rxfp4 (Relaxin Family Peptide/INSL5 Receptor 4) is a potential candidate gene. The renal Hg concentration was associated with Pprc1 (Peroxisome Proliferator-Activated Receptor Gamma, Co-activator-Related). Gene expression analysis revealed that the more susceptible A.SW strain expresses significantly higher levels of Nfkb1, Il6 and Tnf than the less susceptible B10.S strain. The A.SW strain expresses significantly lower levels of Pprc1 and cascade proteins than the B10.S strain. Development of ACA was associated with chromosomes 3, 6, 7 and 16 (LOD 3.1, 3.2, 3.4 and 6.8 respectively). Polyclonal B cell activation was associated with chromosome 2 with a LOD score of 2.9. CONCLUSIONS: By implementing a GWAS on HgIA in mice, several QTLs were discovered to be associated with the development of autoantibodies, polyclonal B cell activation and hypergammaglobulinemia. This thesis plausibly supports Bank1 and Nfkb1 as key regulators for ANoA development and HgIA seems to be initiated by B cells rather than T cells. GWAS on renal mercury excretion plausibly supports Pprc1 as key regulator and it seems that this gene has a protective role against Hg.