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The Immunology Of Neurological Disease

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The Molecular Immunology of Neurological Diseases

The Molecular Immunology of Neurological Diseases Book
Author : Sunil Kumar
Publisher : Academic Press
Release : 2021-02-16
ISBN : 0128232544
Language : En, Es, Fr & De

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Book Description :

The Molecular Immunology of Neurological Diseases provides a comprehensive review of current updates in molecular immunogenetics of different neurological diseases. Readers will learn about the role of immune cells and their modulation strategies to help in the development of therapeutic approaches for both acute and chronic neurodegenerative disorders. There is no other book available on the topic. It has long been thought that the brain is an immune-privilege organ with very limited immune response. However recent studies have made clear that both systemic 'brain' and peripheral 'blood' immune cell responses play key roles in determining brain pathology in neurodegenerative disorders. This book summarizes the role of immune cell activation in the central nervous system microenvironment in acute and chronic neurodegenerative disorders. In addition, it discusses the key role of immune cells and their modulation strategies for the development of current therapeutic approaches. Discusses the molecular immunogenetics of different neurological diseases Covers strategies for the development of therapeutic approaches Encompasses both acute and chronic neurogenerative disorders Describes the molecular pathogenesis of viral genes in various diseases Features chapters on migraine, muscular dystrophy and cancer

Autoimmune Neurological Disease

Autoimmune Neurological Disease Book
Author : Michael P. Pender,Pamela A. McCombe
Publisher : Cambridge University Press
Release : 1995-10-27
ISBN : 0521461138
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive, up-to-date and critical overview of the immunological aspects of autoimmune neurological disease. These diseases include common conditions such as multiple sclerosis, the Guillain-Barre syndrome and myasthenia gravis. The introductory chapters on antigen recognition and self-nonself recognition, and neuroimmunology, are followed by chapters on specific diseases. These are presented in a standardised format with sections on clinical features, genetics, neuropathology, pathophysiology, immunology and therapy. Each chapter has a concluding section which summarises key points and suggests directions for future research. Animal models of autoimmune neurological disease are also covered in detail because of their importance in understanding the human diseases. The book is suitable for clinicians and neurologists managing patients with these diseases, and for immunologists, neuroscientists and neurologists investigating the pathogenesis and pathophysiology of these disorders.

Inflammatory Disorders of the Nervous System

Inflammatory Disorders of the Nervous System Book
Author : Alireza Minagar,J. Steven Alezander
Publisher : Springer Science & Business Media
Release : 2005-06
ISBN : 1588294242
Language : En, Es, Fr & De

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Book Description :

A cutting-edge review of the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as "endothelial and leukocyte microparticles" and "gene microarray technology" to help explain important links between the central nervous system (CNS) and general inflammatory processes. Among the diseases examined from an inflammatory perspective are multiple sclerosis, acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, CNS vasculitis, neuropsychiatric systemic lupus erythematosis, Alzheimer's disease, and Parkinson's disease. The role of the immune system in neuroinflammation is also explored in such disorders as neurosarcoidois, HIV-Associated dementia, and HTLV-associated neurological disorders.

Autoantibodies in Neurological Diseases

Autoantibodies in Neurological Diseases Book
Author : Angela Vincent,Gianvito Martino
Publisher : Springer Science & Business Media
Release : 2001-09-01
ISBN : 9788847001190
Language : En, Es, Fr & De

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Book Description :

Immune-mediated neurological disorders present an increasing challenge to neu­ rologists. Recent advances have identified new antibodies, new effector mechanisms and new diagnostic tests; these have greatly enhanced our understanding of disease aetiology and opened up therapeutic opportunities, but a critical understanding of this fast -developing field is not easy to find. This volume was conceived following a very successful course on neuroimmu­ no logy in Bergamo in 2000, and was written mainly by clinicians who are active in the laboratory. It will help to keep practising neurologists and neuroimmuno­ logists abreast of the most recent developments, and to assess new information more critically. Angela Vincent and Gianvito Martino should be congratulated on master-min­ ding this timely and practical text. July 2001 J. Newsom-Davis Professor Emeritus University of Oxford Table of Contents Introduction -Approaches to Understanding Immune-Mediated Neurological Disorders: Measuring and Evaluating Autoantibodies to Neuronal Antigens G. MARTINO, A. VINCENT ..••.•...•...•..••...•.••..•....••.••.....

Neuroimmunology

Neuroimmunology Book
Author : Bibiana Bielekova,Robert P. Lisak
Publisher : Oxford University Press, USA
Release : 2019
ISBN : 0190050802
Language : En, Es, Fr & De

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Book Description :

Neuroimmunology, the latest volume in the Contemporary Neurology Series, provides a practical, clinical, and scientific background on a diverse group of neurological disorders in this rapidly expanding field. The book includes chapters on multiple sclerosis and related disorders in adults and children, neuromyelitis optica spectrum disorder, Guillain-Barre Syndrome, chronic inflammatory demyelinating polyradiculoneuropathy and variants, immune-mediated disorders of the neuromuscular junction, inflammatory myopathies, paraneoplastic disorders and autoimmune encephalitities, and neurologic manifestations of systemic immune-mediated diseases. Unique to the work, the authors have included an introductory chapter on the basics of immunology and another on mechanisms of action of therapies used in neuroimmunologic disorders. The clinical chapters cover epidemiology, pathology, pathogenesis, and pathophysiology of the different diseases along with clinical presentation, diagnostic testing, differential diagnosis, and treatment. All are presented in an accessible, practical format, making this volume a valuable resource for physicians and other healthcare providers that will care for persons with neuroimmunologic diseases.

Autoimmune Neurology

Autoimmune Neurology Book
Author : Anonim
Publisher : Elsevier
Release : 2016-03-11
ISBN : 0444634460
Language : En, Es, Fr & De

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Book Description :

Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. Includes comprehensive coverage of autoimmune neurology Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities

Neuroimmunology

Neuroimmunology Book
Author : Amanda L. Piquet,Enrique Alvarez
Publisher : Springer Nature
Release : 2021-03-08
ISBN : 3030618838
Language : En, Es, Fr & De

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Book Description :

This book provides a clinical focus on neuroinflammatory diseases as well as a review in pathophysiology and treatment approaches. Organized into six parts, the book begins with a basic review of the immune system and concepts for learning and treating neuroimmune conditions. The next four sections cover specific subfields of neuroimmunology and autoimmune neurology - the clinical and diagnostic features of multiple sclerosis, other autoimmune conditions of the central nervous system, autoimmune conditions of the peripheral nervous system, and systemic autoimmune conditions that affect the nervous system. To conclude, Section six discusses various clinical approaches to specific presentations in neuroimmunology, including pediatric demyelinating diseases. These sections provide practical clinical information to improve the reader’s knowledge in this complex field. The chapters are written by world renown authors with extensive knowledge to help provide up to date information. The full scope of autoimmune neurology is discussed, which is a unique feature of this book. Neuroimmunology serves as a resource for those in training including residents and fellows to provide clear clinical reasoning and background in a rapidly advancing field.

Translational Neuroimmunology in Multiple Sclerosis

Translational Neuroimmunology in Multiple Sclerosis Book
Author : Ruth Arnon,Ariel Miller
Publisher : Academic Press
Release : 2016-05-10
ISBN : 0128020075
Language : En, Es, Fr & De

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Book Description :

Multiple sclerosis (MS) is the most common disabling neurological disease of young adults. More than 2.3 million people are affected by MS worldwide. Symptoms can vary widely, depending on the localization and amount of the damage induced by combined inflammatory, demyelinating, and neurodegenerative processes. Although a cure for MS does not currently exist, therapies can help treat MS attacks, attenuate disease activity, reduce progress of the disease, and manage symptoms. Translational Neuroimmunology in Multiple Sclerosis provides an overview of recent findings and knowledge of the neuroimmunology of multiple sclerosis, from experimental models and the human disease to the translation of this research to immunotherapeutic strategies. Chapters describe genetic and environmental factors underlying the disease pathogenesis of MS as a basis for development of immunotherapies, immunological markers of disease activity, pharmacogenetics, and responses to therapy. Immunomodulatory therapies currently in practice and future therapeutic strategies on the horizon—such as neuroprotective strategies, stem cells, and repair promotion—are discussed. Contributed by renowned leaders in the field, this cross-disciplinary volume is a great resource for basic scientists and clinical practitioners in neuroscience, neurology, immunology, pharmacology, and in-drug development. Provides an overview of recent findings and knowledge of the neuroimmunology of multiple sclerosis and the translation of this research to immunotherapy treatment Edited by renowned leaders in the field of neuroimmunology and multiple sclerosis Contains the latest resource material for basic and clinical scientists and practitioners in neuroscience, neurology, immunology, and pharmacology

From Basic Immunology to Immune Mediated Demyelination

From Basic Immunology to Immune Mediated Demyelination Book
Author : Gianvito Martino,Luciano Adorini
Publisher : Springer Science & Business Media
Release : 1999-03-01
ISBN : 9788847000544
Language : En, Es, Fr & De

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Book Description :

Morphological, physiological and pathological evidence demonstrates that ner­ vous and immune systems interact not only in maintaining brain homeostasis, but also in causing neurological diseases. The studyofthese interactions repre­ sents the basis on which neuroimmunologyhas grown during the years. At pre­ sent, several neurological diseases are recognized to be caused by a derange­ ment of the immune system in either its regulatory or effector functions. The main scope ofthis book, to discuss how an unbalanced immune system maylead to immune-mediated neurological diseases, is achieved in three parts. The first part provides an overview on how the immune system works. This is propaedeutical to understanding interactions between the immune and ner­ vous systems, which are discussed in the second part. The third part of the book focuses on one particular area of neuroimmunology, the immune disor­ ders leading to the damage of central and peripheral myelin. Given the opportunity to review first the immune system in itself and then how it operates during immune-mediated demyelinating disorders, we have tried to provide the reader with a basis for clearly understanding how interac­ tions between the immune and nervous systems can be protective or pathoge­ nic. This knowledge is a prerequisite for a rationale immune intervention tar­ geting these disorders.

Humoral Immunity in Neurological Diseases

Humoral Immunity in Neurological Diseases Book
Author : D. Karcher
Publisher : Springer Science & Business Media
Release : 2013-03-08
ISBN : 1468410032
Language : En, Es, Fr & De

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Book Description :

Download Humoral Immunity in Neurological Diseases book written by D. Karcher, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Neuro Immuno Gastroenterology

Neuro Immuno Gastroenterology Book
Author : Cris S. Constantinescu,Rāzvan I. Arsenescu,Violeta Arsenescu
Publisher : Springer
Release : 2016-05-24
ISBN : 3319286099
Language : En, Es, Fr & De

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Book Description :

This book addresses important issues regarding the interaction between the nervous system, the immune system, and the digestive system. Gut flora has a profound influence on the shaping of the immune response, not only in the gastrointestinal system but also in the nervous system. Fascinatingly, manipulation of intestinal immune responses can be used to modulate neurological disease. Conversely, the nervous system and the psyche have significant effects on the functioning of the gut and liver. After introductory chapters on the neurology, the immunology and microbiology of the gut, the effects of the gut immune system and gut flora and its manipulation on neurological disease are discussed, followed by molecular mimicry and immune tolerance in neuroimmune diseases. Additionally, several chapters deal with gastrointestinal manifestations of neurological diseases. Neuro-Immuno-Gastroenterology is aimed at neurologists, gastroenterologists, and immunologists.

Neuroimmune Diseases

Neuroimmune Diseases Book
Author : Hiroshi Mitoma,Mario Manto
Publisher : Springer
Release : 2019-08-13
ISBN : 3030195155
Language : En, Es, Fr & De

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Book Description :

A translational overview of neuroimmune diseases for neuroscientists and clinicians that clarifies the pathological mechanisms underlying neuroimmune diseases and builds a comprehensive bridge between the latest research findings and their clinical implications in daily practice. The material is presented in two steps. The first section comprises a review of the pathogenic actions of immune cells in brain diseases. Here the authors discuss the mechanisms through which immune cells disrupt the functions of nerve cells. The second section explores the ways in which the brain becomes dysfunctional due to impaired nerve cell function. Based on pathogenesis, diagnostic and therapeutic strategies are discussed for each clinical category. The book will be invaluable for use in clinical practice of neuroimmune diseases

Medical Information Systems

Medical Information Systems Book
Author : Ralph R. Grams
Publisher : Springer Science & Business Media
Release : 2013-11-11
ISBN : 147571422X
Language : En, Es, Fr & De

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Book Description :

A cutting-edge review of the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as "endothelial and leukocyte microparticles" and "gene microarray technology" to help explain important links between the central nervous system (CNS) and general inflammatory processes. Among the diseases examined from an inflammatory perspective are multiple sclerosis, acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, CNS vasculitis, neuropsychiatric systemic lupus erythematosis, Alzheimer's disease, and Parkinson's disease. The role of the immune system in neuroinflammation is also explored in such disorders as neurosarcoidois, HIV-Associated dementia, and HTLV-associated neurological disorders.

Immunological Aspects of the Vascular Endothelium

Immunological Aspects of the Vascular Endothelium Book
Author : Caroline O. S. Savage,Jeremy D. Pearson
Publisher : Cambridge University Press
Release : 1995-09-07
ISBN : 9780521452496
Language : En, Es, Fr & De

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Book Description :

Originally published in 1995, this volume looks at the functioning of the vascular endothelium, and the diseases and tissue injury that arise as a result of inflammation and immunological responses. The vascular endothelium is a metabolically highly active layer of cells lining all blood vessel walls. Through its interactions with leucocytes and other mediators, it is central to the development of inflammatory foci and to lymphocyte trafficking around the body. Tissue injury may arise here as a result of abnormal inflammatory or immune responses. The potential for such injury to contribute to autoimmune disease is discussed in this book, particularly in relation to autoimmune vascular disease of the renal, rheumatological and neurological systems, as well as in organ transplantation.

Autoimmune Neurology

Autoimmune Neurology Book
Author : Sean J. Pittock,Angela Vincent
Publisher : Elsevier
Release : 2016-03-15
ISBN : 9780444634320
Language : En, Es, Fr & De

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Book Description :

"Autoimmune Neurology" presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. Includes comprehensive coverage of autoimmune neurologyDetails the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disordersPresents a focused reference for clinical practitioners and the clinical neurology and neurology research communities

Viruses Immunity and Mental Disorders

Viruses  Immunity  and Mental Disorders Book
Author : Edouard Kurstak,Z.J. Lipowski,P.V. Morozov
Publisher : Springer
Release : 2013-06-29
ISBN : 9781461290070
Language : En, Es, Fr & De

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Book Description :

In spite of progress in biomedical research, we know little about the causes, prevention, and treatment of the numerous mental and neurological disorders that afflict up to 15% of all individuals. In the last decade, great advances have been made in the physiopathology of mental and neurological disorders, leading to at least a partial control of Parkinson's disease, epilepsy, certain psychoses, and anxiety syndromes. Despite the fact that an underlying specific neurotransmitter deficiency has been demonstrated in Alzheimer's and Parkinson's diseases, the immune dysfunction and viral hypotheses continue to be attractive for investigators dealing with these degenerative diseases of the aging brain, which afflict 10% of senior citizens. A retrospective epidemiologic study suggests that the encephalitis lethargica and parkinsonism were almost certainly caused by the 1918 influenza virus pandemics. It must be stressed that the etiopathogenesis of many mental disorders is not known, and this ignorance has led to several untenable neurophysiological and biochemical hypotheses. Epidemiologic investigations show a high prevalence of functional psychoses and organic mental disorders. Although many of them are conceptualized as biopsychosocial disorders, recent data indicate that the biological component appears more and more as a major etiologic factor. Among the various biological hypotheses, the viral and im munologic concept has become a significant one. In view of recent discoveries in virology and immunity, it becomes clear that viral and immunologic hypotheses should be inves tigated more systematically concerning the mechanisms of numerous mental and neu rological disorders.

Neuro Immune Interactions in Inflammation and Autoimmunity

Neuro Immune Interactions in Inflammation and Autoimmunity Book
Author : Valentin A. Pavlov,Niccolo Terrando
Publisher : Frontiers Media SA
Release : 2018-07-24
ISBN : 2889455335
Language : En, Es, Fr & De

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Book Description :

The nervous system plays an important role in the regulation of immunity and inflammation. On the other hand unbalanced immune responses in inflammatory and autoimmune conditions may have a deleterious impact on neuronal integrity and brain function. Recent studies have characterized neural pathways communicating peripheral inflammatory signals to the CNS, and brain- and spinal cord-derived circuitries controlling various innate and adaptive immune responses and inflammation. A prototypical neural reflex circuit that regulates immunity and inflammation is the vagus nerve-based “inflammatory reflex”. Ongoing research has revealed cellular and molecular mechanisms underlying these neural circuits and indicated new therapeutic approaches in inflammatory and autoimmune disorders. Pharmacological and bioelectronic modulation of neural circuitry has been successfully explored in preclinical settings of sepsis, arthritis, inflammatory bowel disease, obesity-driven disorders, diabetes and other diseases. These studies paved the way to successful clinical trials with bioelectronic neuronal modulation in rheumatoid arthritis and inflammatory bowel disease. Dysregulated release of cytokines and other inflammatory molecules may have a severe impact on brain function. Brain inflammation (neuroinflammation), imbalances in brain neuronal integrity and neurotransmitter systems, and cognitive impairment are characteristic features of post-operative conditions, sepsis, liver diseases, diabetes and other disorders characterized by immune and metabolic dysregulation. Derangements in cytokine release also play a pivotal role in depression. Characteristic brain reactive antibodies in autoimmune conditions, including systemic lupus erythematosus and neuromyelitis optica, significantly contribute to brain pathology and cognitive impairment. These studies, and the simultaneous characterization of neuro-protective cytokines, identified new therapeutic approaches for treating neurological complications in inflammatory and autoimmune disorders. This Frontiers Research Topic is a forum for publishing research findings and methodological and conceptual advances at the intersection of immunology and neuroscience. We hope that presenting new insight into bi-directional neuro-immune communication in inflammation and autoimmunity will foster further collaborations and facilitate the development of new efficient therapeutic strategies.

Translational Neuroimmunology of Multiple Sclerosis

Translational Neuroimmunology of Multiple Sclerosis Book
Author : Ruth Arnon,Ariel Miller
Publisher : Unknown
Release : 2016-01-04
ISBN : 9780128019146
Language : En, Es, Fr & De

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Book Description :

Multiple Sclerosis (MS) is the most common disabling neurological disease of young adults, although it can also affect children and adults. More than 2.3 million people are affected by MS worldwide. Symptoms can vary widely, depending on the amount of damage and the nerves that are affected. People with severe cases of MS may lose the ability to walk or speak clearly. Although there is not currently a cure for MS, therapies can help treat MS attacks, manage symptoms and reduce progress of the disease. This book will provide an overview of recent findings and knowledge of the Neuroimmunology of Multiple Sclerosis and the translation of this research to immunotherapy treatment. Chapters will include the disease pathogenesis of MS as a basis for development of immunotherapies, immunological markers, pharmacogenetics and responses to therapy. Immunomodulatory therapies currently in practice and future therapeutic strategies on the horizon will also be discussed. Edited by renowned leaders in the field, this book will be a great resource for basic and clinical scientists and practitioners in neuroscience, neurology, immunology, and pharmacology. Provides an overview of recent findings and knowledge of the neuroimmunology of Multiple Sclerosis and the translation of this research to immunotherapy treatment Edited by renowned leaders in the field of neuroimmunology and Multiple Sclerosis A great resource for basic and clinical scientists and practitioners in neuroscience, neurology, immunology, and pharmacology

Inflammation and Stroke

Inflammation and Stroke Book
Author : Giora Z. Feuerstein
Publisher : Springer
Release : 2012-12-06
ISBN : 3034882971
Language : En, Es, Fr & De

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Book Description :

Stroke is a leading cause of death in developed countries. However, current therapeutic strategies for stroke have been largely unsuccessful. One possible explanation is that research and pharmacological management have focused on very early events in brain ischemia. New research has shown that brain ischemia and trauma elicit strong inflammatory reactions driven by both external and brain cells. The recognition of inflammation as a fundamental response to brain ischemia provides novel opportunities for new anti-inflammatory therapies. For the first time, an international body of researchers presents the latest findings about the cellular and humoral aspects of immune and inflammatory reactions in the brain. The work may have an impact on the treatment of neuroinjuries and ancillary brain diseases, and increase the understanding of the roles infections and immune reactions play in the brain milieu.

Neuroinflammation and Neurodegeneration

Neuroinflammation and Neurodegeneration Book
Author : Phillip K. Peterson,Michal Toborek
Publisher : Springer
Release : 2014-07-08
ISBN : 149391071X
Language : En, Es, Fr & De

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Book Description :

State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer’s disease, Parkinson’s disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters.