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The Human Genome

The Human Genome Book
Author : Paul F. Kisak
Publisher : Createspace Independent Publishing Platform
Release : 2016-04-27
ISBN : 9781532979767
Language : En, Es, Fr & De

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Book Description :

The human genome is the complete set of nucleic acid sequence for humans (Homo sapiens), encoded as DNA within the 23chromosome pairs in cell nuclei and in a small DNA molecule found within individual mitochondria. Human genomes include both protein-coding DNA genes and noncoding DNA. Haploid human genomes, which are contained in germ cells (the egg and spermgamete cells created in the meiosis phase of sexual reproduction before fertilization creates a zygote) consist of three billion DNAbase pairs, while diploid genomes (found in somatic cells) have twice the DNA content. While there are significant differences among the genomes of human individuals (on the order of 0.1%), these are considerably smaller than the differences between humans and their closest living relatives, the chimpanzees (approximately 4%) and bonobos. The Human Genome Project produced the first complete sequences of individual human genomes, with the first draft sequence and initial analysis being published on February 12, 2001. The human genome was the first of all vertebrates to be completely sequenced. As of 2012, thousands of human genomes have been completely sequenced, and many more have been mapped at lower levels of resolution. The resulting data are used worldwide in biomedical science, anthropology, forensics and other branches of science. There is a widely held expectation that genomic studies will lead to advances in the diagnosis and treatment of diseases, and to new insights in many fields of biology, including human evolution. There are an estimated 20,000-25,000 human protein-coding genes. The estimate of the number of human genes has been repeatedly revised down from initial predictions of 100,000 or more as genome sequence quality and gene finding methods have improved, and could continue to drop further. Protein-coding sequences account for only a very small fraction of the genome (approximately 1.5%), and the rest is associated with non-coding RNA molecules, regulatory DNA sequences, LINEs, SINEs, introns, and sequences for which as yet no function has been determined. The total length of the human genome is over 3 billion base pairs. The genome is organized into 22 paired chromosomes, plus the X chromosome (one in males, two in females) and, in males only, one Y chromosome. These are all large linear DNA molecules contained within the cell nucleus. The genome also includes the mitochondrial DNA, a comparatively small circular molecule present in each mitochondrion. Basic information about these molecules and their gene content, based on a reference genome that does not represent the sequence of any specific individual, are provided in the following table. This book is an excellent overview of the human genome, the genetics involved and DNA.

The Human Genome

The Human Genome Book
Author : Julia E. Richards,R. Scott Hawley
Publisher : Academic Press
Release : 2010-12-12
ISBN : 9780080918655
Language : En, Es, Fr & De

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Book Description :

Significant advances in our knowledge of genetics were made during the twentieth century but in the most recent decades, genetic research has dramatically increased its impact throughout society. Genetic issues are now playing a large role in health and public policy, and new knowledge in this field will continue to have significant implications for individuals and society. Written for the non-majors human genetics course, Human Genetics, 3E will increase the genetics knowledge of students who are learning about human genetics for the first time. This thorough revision of the best-selling Human Genome,2E includes entirely new chapters on forensics, stem cell biology, bioinformatics, and societal/ethical issues associated with the field. New special features boxes make connections between human genetics and human health and disease. Carefully crafted pedagogy includes chapter-opening case studies that set the stage for each chapter; concept statements interspersed throughout the chapter that keep first-time students focused on key concepts; and end-of-chapter questions and critical thinking activities. This new edition will contribute to creating a genetically literate student population that understands basic biological research, understands elements of the personal and health implications of genetics, and participates effectively in public policy issues involving genetic information . Includes topical material on forensics, disease studies, and the human genome project to engage non-specialist students Full, 4-color illustration program enhances and reinforces key concepts and themes Uniform organization of chapters includes interest boxes that focus on human health and disease, chapter-opening case studies, and concept statements to engage non-specialist readers

Curiosity Guides The Human Genome

Curiosity Guides  The Human Genome Book
Author : John Quackenbush
Publisher : Charlesbridge
Release : 2011-02-01
ISBN : 1607343568
Language : En, Es, Fr & De

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Book Description :

The DNA sequence that comprises the human genome--the genetic blueprint found in each of our cells--is undoubtedly the greatest code ever to be broken. Completed at the dawn of a new millennium, the feat electrified both the scientific community and the general public with its tantalizing promise of new and better treatments for countless diseases, including Alzheimer's, cancer, diabetes, and Parkinson's. Yet what is arguably the most important discovery of our time has also opened a Pandora's box of questions about who we are as humans and how the unique information stored in our genomes can and might be used, making it all the more important for everyone to understand the new science of genomics. In the CURIOSITY GUIDE TO THE HUMAN GENOME, Dr. John Quackenbush, a renowned scientist and professor, conducts a fascinating tour of the history and science behind the Human Genome Project and the technologies that are revolutionizing the practice of medicine today. With a clear and engaging narrative style, he demystifies the fundamental principles of genetics and molecular biology, including the astounding ways in which genes function, alone or together with other genes and the environment, to either sustain life or trigger disease. In addition, Dr. Quackenbush goes beyond medicine to examine how DNA-sequencing technology is changing how we think of ourselves as a species by providing new insights about our earliest ancestors and reconfirming our inextricable link to all life on earth. Finally, he explores the legal and ethical questions surrounding such controversial topics as stem cell research, prenatal testing, forensics, and cloning, making this volume of the Curiosity Guides series an indispensable resource for navigating our brave new genomic world.

The Human Genome

The Human Genome Book
Author : Julia E. Richards,R. Scott Hawley
Publisher : Academic Press
Release : 2011-01
ISBN : 9780123334459
Language : En, Es, Fr & De

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Book Description :

First ed. by R. Scott Hawley and Catherine A. Mori.

Evolution of the Human Genome II Human Evolution Viewed from Genomes

Evolution of the Human Genome II  Human Evolution Viewed from Genomes Book
Author : Naruya Saitou
Publisher : Evolutionary Studies
Release : 2022-05-13
ISBN : 9784431569053
Language : En, Es, Fr & De

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Book Description :

This two-volume set provides a general overview of the evolution of the human genome; The first volume overviews the human genome with descriptions of important gene groups. This second volume provides up-to-date, concise yet ample knowledge on the genome evolution of modern humans. It comprises twelve chapters divided into two parts discussing "Non-neutral Evolution on Human Genes" (Part I) and "Evolution of Modern Human Populations" (Part II.) The most significant feature of this book is the continent-wise discussion of modern human dispersal using human genomic data in Part II. Recent results such as introgression of paleogenomes to modern humans, new methods such as computer simulation of global human dispersals, and new information on genes for humanness will be of particular interest to the readers. Since the euchromatin regions of the human genome was sequenced in 2003, a huge number of research papers were published on modern human evolution for a variety of populations. It is now time to summarize these achievements. This book stands out as the most comprehensive book on the modern human evolution, focusing on genomic points of view with a broad scope. Primary target audiences are researchers and graduate students in evolutionary biology.

The Human Genome in Health and Disease

The Human Genome in Health and Disease Book
Author : Tore Samuelsson
Publisher : Garland Science
Release : 2019-02-07
ISBN : 042966429X
Language : En, Es, Fr & De

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Book Description :

The human genome is a linear sequence of roughly 3 billion bases and information regarding this genome is accumulating at an astonishing rate. Inspired by these advances, The Human Genome in Health and Disease: A Story of Four Letters explores the intimate link between sequence information and biological function. A range of sequence-based functional units of the genome are discussed and illustrated with inherited disorders and cancer. In addition, the book considers valuable medical applications related to human genome sequencing, such as gene therapy methods and the identification of causative mutations in rare genetic disorders. The primary audiences of the book are students of genetics, biology, medicine, molecular biology and bioinformatics. Richly illustrated with review questions provided for each chapter, the book helps students without previous studies of genetics and molecular biology. It may also be of benefit for advanced non-academics, which in the era of personal genomics, want to learn more about their genome. Key selling features: Molecular sequence perspective, explaining the relationship between DNA sequence motifs and biological function Aids in understanding the functional impact of mutations and genetic variants Material presented at basic level, making it accessible to students without previous studies of genetics and molecular biology Richly illustrated with questions provided to each chapter

Life Script

Life Script Book
Author : Nicholas Wade
Publisher : Simon and Schuster
Release : 2002-03-02
ISBN : 074321739X
Language : En, Es, Fr & De

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Book Description :

With the decoding of the human genome, researchers can now read the script in which evolution has written the program for the design and operation of the human body. A new generation of medical treatments is at hand. Researchers are developing therapies so powerful that there is now no evident obstacle to the ancient goal of conquering most major diseases. Nicholas Wade has covered the sequencing of the genome, as well as other health and science stories, for The New York Times, in the course of which he has interviewed many of the principal researchers in the field. In this book he describes what the genome means for the health of present and future generations. Someday soon physicians will have access to DNA chips that, from a drop of blood, will screen a person's genes for all the diseases to which he or she may be genetically vulnerable. From full knowledge of the instruction manual of the human body, provided by the genome, pharmaceutical companies hope to develop a new generation of sophisticated drugs; one of the first genome-derived drugs is already undergoing clinical trials. Another vital tool will be regenerative medicine, a new kind of therapy in which new organs and tissues will be grown from a patient's own cells to replace those that are old or diseased. With the help of DNA chips, medical researchers will soon be able to diagnose diseases such as cancer much more precisely and to tailor specific treatments for each patient. Individualized medicine will also become an important part of the pharmaceutical world. Many drugs will be prescribed based on information from DNA chips that identify which of a range of drugs is best for each patient, as well as which drugs are likely to cause side effects. The medicine of the post-genomic era will be customized for a patient's genetic make-up, providing treatments based on a precise understanding of the mechanism of disease. Life Script describes a future in which good health, even perfect health, may become the standard for everyone -- at every age.

Understanding the Human Genome Project

Understanding the Human Genome Project Book
Author : Michael Angelo Palladino
Publisher : Benjamin-Cummings Publishing Company
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A brief booklet that explains in accessible language what readers need to understand about The Human Genome Project (HGP). This reference tool presents the background, findings, scientific and medical applications, social and ethical implications, and helps readers understand timely issues concerning The Human Genome Project. This brief 32 page booklet is a useful supplement to core books in Intro Biology (non-majors/majors), General Biology (majors), Genetics, Human Genetics (non-majors), Human Biology, Intro Biochemistry, and Intro Cell and Molecular Biology. It also includes relevant web resources and exercises for readers. For college instructors and students.

Chemistry and the Human Genome

Chemistry and the Human Genome Book
Author : Ted Lister
Publisher : Royal Society of Chemistry
Release : 2002
ISBN : 9780854043965
Language : En, Es, Fr & De

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Book Description :

This resource aims to show the chemical science behind the discovery for post-16 students of chemistry and biology, and places it in the context of science in the 21st century.

The Deeper Genome

The Deeper Genome Book
Author : John Parrington
Publisher : Oxford University Press
Release : 2017-08-24
ISBN : 0198813090
Language : En, Es, Fr & De

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Book Description :

Over a decade ago, as the Human Genome Project completed its mapping of the entire human genome, hopes ran high that we would rapidly be able to use our knowledge of human genes to tackle many inherited diseases, and understand what makes us unique among animals. But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought -- just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportion of DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'? Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact of its 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes of Neanderthals as well as that of chimps about the development of our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.

Justice and the Human Genome Project

Justice and the Human Genome Project Book
Author : Timothy F. Murphy,Marc A. Lappé
Publisher : University of California Press
Release : 2018-07-10
ISBN : 0520302788
Language : En, Es, Fr & De

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Book Description :

The Human Genome Project is an expensive, ambitious, and controversial attempt to locate and map every one of the approximately 100,000 genes in the human body. If it works, and we are able, for instance, to identify markers for genetic diseases long before they develop, who will have the right to obtain such information? What will be the consequences for health care, health insurance, employability, and research priorities? And, more broadly, how will attitudes toward human differences be affected, morally and socially, by the setting of a genetic “standard”? The compatibility of individual rights and genetic fairness is challenged by the technological possibilities of the future, making it difficult to create an agenda for a “just genetics.” Beginning with an account of the utopian dreams and authoritarian tendencies of historical eugenics movements, this book’s nine essays probe the potential social uses and abuses of detailed genetic information. Lucid and wide-ranging, these contributions will interest bioethicists, legal scholars, and policy makers. Essays: “The Genome Project and the Meaning of Difference,” Timothy F. Murphy “Eugenics and the Human Genome Project: Is the Past Prologue?,” Daniel J. Kevles “Handle with Care: Race, Class, and Genetics,” Arthur L. Caplan “Public Choices and Private Choices: Legal Regulation of Genetic Testing,” Lori B. Andrews “Rules for Gene Banks: Protecting Privacy in the Genetics Age,” George J. Annas “Use of Genetic Information by Private Insurers,” Robert J. Pokorski “The Genome Project, Individual Differences, and Just Health Care,” Norman Daniels “Just Genetics: A Problem Agenda,” Leonard M. Fleck “Justice and the Limitations of Genetic Knowledge,” Marc A. Lappé This title is part of UC Press's Voices Revived program, which commemorates University of California Press’s mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1994.

Genomics

Genomics Book
Author : Charles R. Cantor,Cassandra L. Smith
Publisher : John Wiley & Sons
Release : 2004-01-06
ISBN : 0471461865
Language : En, Es, Fr & De

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Book Description :

A unique exploration of the principles and methods underlying theHuman Genome Project and modern molecular genetics andbiotechnology-from two top researchers In Genomics, Charles R. Cantor, former director of the HumanGenome Project, and Cassandra L. Smith give the first integraloverview of the strategies and technologies behind the Human GenomeProject and the field of molecular genetics and biotechnology.Written with a range of readers in mind-from chemists andbiologists to computer scientists and engineers-the book beginswith a review of the basic properties of DNA and the chromosomesthat package it in cells. The authors describe the three maintechniques used in DNA analysis-hybridization, polymerase chainreaction, and electrophoresis-and present a complete exploration ofDNA mapping in its many different forms. By explaining both thetheoretical principles and practical foundations of modernmolecular genetics to a wide audience, the book brings thescientific community closer to the ultimate goal of understandingthe biological function of DNA. Genomics features: Topical organization within chapters for easy reference A discussion of the developing methods of sequencing, such assequencing by hybridization (SBH) in which data is read throughwords instead of letters Detailed explanations and critical evaluations of the manydifferent types of DNA maps that can be generated-includingcytogenic and restriction maps as well as interspecies cellhybrids Informed predictions for the future of DNA sequencing

God Ethics and the Human Genome

God  Ethics and the Human Genome Book
Author : Mark Bratton
Publisher : Church House Publishing
Release : 2009
ISBN : 9780715141397
Language : En, Es, Fr & De

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Book Description :

Advances in genetic science and medicine raise questions for us all, such as: How far should we intervene in 'natural' processes? How far should we go to alleviate suffering? What constitutes a worthwhile life? Exploring these questions and more, this book considers theological, ethical and legal aspects relating to the human genome.

The Future of Genetics

The Future of Genetics Book
Author : Russ Hodge
Publisher : Infobase Publishing
Release : 2010
ISBN : 0816066841
Language : En, Es, Fr & De

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Book Description :

Presents an overview of current innovations in genetic research and considers their impact on science and medicine, including the causes of aging and death, the brain, and quality of life.

The Human Genome Project and the Future of Health Care

The Human Genome Project and the Future of Health Care Book
Author : Thomas H. Murray,Mark A. Rothstein,Robert F. Murray, Jr.
Publisher : Indiana University Press
Release : 1996-12-22
ISBN : 9780253113252
Language : En, Es, Fr & De

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Book Description :

"The volume deserves our serious attention. The authors have provided us an invaluable primer about the HGP and its implications for the future of American health care." -- Jurimetrics "This book does make a real contribution... in explaining why the genetics revolution holds so much promise and why it is so difficult to bring that promise to fruition." -- The Journal of Legal Medicine "... marked by a forward-looking, analytically and empirically grounded thematic coherence. The editors' carefully crafted template and contributions successfully focus and organize the material." -- Annals of Internal Medicine "Excellent" -- Canadian Medical Association Journal "The editors have done a very good job integrating the contents into a very useful and readable information source." -- Choice "... this highly focused book is a well-written, thoughtful, and insightful consideration of the HGP and is valuable reading for anyone concerned with the future of our country's medical infrastructure." -- Science Books & Films (**Highly recommended) "A distinguished group of scientists, lawyers, and scholars have written a coherent, readable account of the legal, medical, ethical, and policy issues many (if not all) of us will be wrestling with on both a personal and a public level, as a result of current genetic research." -- Library Journal "Each of the contributors is a distinguished authority on the topic. Ethicists, especially, will find well-developed presentation of issues, with exposition of the differing ethical assumptions in tension in the society debate." -- Doody's Health Sciences Book Review Home Page How will the science of gene mapping and gene manipulation affect health care? Leading scholars explore the clinical, ethical, legal, and policy implications of the Human Genome Project for the forms of health care, who delivers it, who receives it, and who pays for it.

Human Genome Structure Function and Clinical Considerations

Human Genome Structure  Function and Clinical Considerations Book
Author : Luciana Amaral Haddad
Publisher : Springer Nature
Release : 2021-09-22
ISBN : 3030731510
Language : En, Es, Fr & De

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Book Description :

Download Human Genome Structure Function and Clinical Considerations book written by Luciana Amaral Haddad, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biotechnology and the Human Genome

Biotechnology and the Human Genome Book
Author : Benjamin Barnhart
Publisher : Springer
Release : 1988-10
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This book is based on the proceedings of the Science Writers Workshop on "Biotechnology and the Human Genome: Innovations and Impacts" held at the Brookhaven National Laboratory on September 14-16, 1987. The aim of this workshop which was sponsored by the Office of Health and Environmental Research of the Department of Energy (DOE) was to provide a forum in which science writers, reporters and other interested individuals could gain a firsthand knowledge about the scope and direction of the human genome initi ative and its supportive technologies. The speakers were leaders working in scientific disciplines that are either integral parts of the Department's genome project or that represent important ancillary science. The Department of Energy's human genome initiative is a logical ex tension of its long term commitment to investigating genetic damage from exposures to radiations and energy-related chemicals. It will exploit comp utational, engineering and biological capabilities within and as well as outside the DOE national laboratories to develop the technologies and re sources which will lead to a complete description of the human genome at the molecular level. Knowledge of the entire human genetic map and the genomic sequence will allow investigators to more rapidly and effectively identify genes involved in genetic diseases, individual variabilities including radi ation sensitivities, and physiological processes, as well as to make unpre cedented inroads into evolutionary relationships.

Human Genome Structure Function and Clinical Considerations

Human Genome Structure  Function and Clinical Considerations Book
Author : Luciana Amaral Haddad
Publisher : Springer
Release : 2021-07-09
ISBN : 9783030731502
Language : En, Es, Fr & De

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Book Description :

This book provides a detailed evidence-based overview of the latest developments in how the structure of the human genome is relevant to the health professional. It features comprehensive reviews of genome science including human chromosomal and mitochondrial DNA structure, protein-coding and noncoding genes, and the diverse classes of repeat elements of the human genome. These concepts are then built upon to provide context as to how they functionally relate to differences in phenotypic traits that can be observed in human populations. Guidance is also provided on how this information can be applied by the medical practitioner in day-to-day clinical practice. Human Genome Structure, Function and Clinical Considerations collates the latest developments in genome science and current methods for genome analysis that are relevant for the clinician, researcher and scientist who utilises precision medicine techniques and is an essential resource for any such practitioner.

How the Human Genome Works

How the Human Genome Works Book
Author : Edwin H. McConkey
Publisher : Jones & Bartlett Learning
Release : 2004
ISBN : 9780763723842
Language : En, Es, Fr & De

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Book Description :

This book covers the exxential principles of genetics in a readable, accessible format using real-life examples of the way genes affect human behavior, health and illness, development and evolution.

The Code of Codes

The Code of Codes Book
Author : Daniel J. Kevles,Leroy E. Hood
Publisher : Harvard University Press
Release : 1992
ISBN : 9780674136465
Language : En, Es, Fr & De

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Book Description :

Examines the Human Genome Project and its impact on the understanding of human development, and explores the scientific, social, and ethical issues it raises