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The Guide To Investigation Of Mouse Pregnancy

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The Guide to Investigation of Mouse Pregnancy

The Guide to Investigation of Mouse Pregnancy Book
Author : B. Anne Croy,Aureo T. Yamada,Francesco J. Demayo,S. Lee Adamson
Publisher : Academic Press
Release : 2017-11-13
ISBN : 9780128100943
Language : En, Es, Fr & De

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Book Description :

The Guide to Investigation of Mouse Pregnancy is the first publication to cover the mouse placenta or the angiogenic tree the mother develops to support the placenta. This much-needed resource covers monitoring of the cardiovascular system, gestational programming of chronic adult disease, epigenetic regulation, gene imprinting, and stem cells. Offering detailed and integrated information on how drugs, biologics, stress, and manipulations impact pregnancy in the mouse model, this reference highlights techniques used to analyze mouse pregnancy. Joining the ranks of much referenced mouse resources, The Guide to Investigation of Mouse Pregnancy is the only manual providing needed content on pregnancy in animal models for translational medicine and research. Provides instruction on how to collect pre-clinical data on pregnancy in mouse models for eventual use in human applications Describes the angiogenic tree the mother s uterus develops to support pregnancy and the monitoring of pregnancy-induced cardiovascular changes Educates readers on placental cell lineages, decidual development including immune cells, epigenetic regulation, gene imprinting, stem cells, birth and lactation Discusses how stress, environmental toxicants and other manipulations impact upon placental function and pregnancy success "

The Guide to Investigation of Mouse Pregnancy

The Guide to Investigation of Mouse Pregnancy Book
Author : B. Anne Croy,Aureo T. Yamada,Francesco J. DeMayo,S. Lee Adamson
Publisher : Academic Press
Release : 2013-12-09
ISBN : 0123947944
Language : En, Es, Fr & De

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Book Description :

The Guide to Investigation of Mouse Pregnancy is the first publication to cover the mouse placenta or the angiogenic tree the mother develops to support the placenta. This much-needed resource covers monitoring of the cardiovascular system, gestational programming of chronic adult disease, epigenetic regulation, gene imprinting, and stem cells. Offering detailed and integrated information on how drugs, biologics, stress, and manipulations impact pregnancy in the mouse model, this reference highlights techniques used to analyze mouse pregnancy. Joining the ranks of much referenced mouse resources, The Guide to Investigation of Mouse Pregnancy is the only manual providing needed content on pregnancy in animal models for translational medicine and research. Provides instruction on how to collect pre-clinical data on pregnancy in mouse models for eventual use in human applications Describes the angiogenic tree the mother’s uterus develops to support pregnancy and the monitoring of pregnancy-induced cardiovascular changes Educates readers on placental cell lineages, decidual development including immune cells, epigenetic regulation, gene imprinting, stem cells, birth and lactation Discusses how stress, environmental toxicants and other manipulations impact upon placental function and pregnancy success

Pathology of the Developing Mouse

Pathology of the Developing Mouse Book
Author : Brad Bolon
Publisher : CRC Press
Release : 2015-04-24
ISBN : 1420070096
Language : En, Es, Fr & De

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Book Description :

Pathology of the Developing Mouse provides, in so far as feasible, one complete reference on the design, analysis, and interpretation of abnormal findings that may be detected in developing mice before and shortly after birth. In particular, this book is designed specifically to be not only a "how to do" manual for developmental pathology experimentation in mice but, more importantly, a "how to interpret" resource for pathologists and other biomedical scientists faced for the first or hundredth time with defining the significance of distorted features in some fantastic murine developmental monstrosity. The topics covered in this volume include a full range of subjects encountered when building and wielding a developmental pathology tool kit: baseline anatomic and physiologic traits of developing mice principles of good experimental design and statistical analysis for mouse developmental pathology studies procedures for anatomic pathology examinations, to evaluate structural changes at the macroscopic (gross), microscopic (cells and tissues), and ultrastructural (subcellular) levels, suing conventional autopsy-based or novel non-invasive imaging techniques; methods for clinical pathology testing, to assess the biochemical and cellular composition of tissues and fluids; options and protocols for in situ molecular pathology analysis, to undertake site-specific explorations of the various mechanisms responsible for producing adverse findings (i.e., "lesions") during development; and well-referenced and illustrated guides to the interpretation of anatomic pathology and clinical pathology changes in the animal (embryos, fetuses, neonates, and juveniles) and its support system (placenta).

Hormones and Pregnancy

Hormones and Pregnancy Book
Author : Felice Petraglia,Mariarosaria Di Tommaso,Federico Mecacci
Publisher : Cambridge University Press
Release : 2022-10-13
ISBN : 1316516660
Language : En, Es, Fr & De

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Book Description :

Summarizes the role of hormones in pregnancy and how to manage gestational disorders in patients.

Kaufman s Atlas of Mouse Development Supplement

Kaufman   s Atlas of Mouse Development Supplement Book
Author : Richard Baldock,Jonathan Bard,Duncan Davidson,Gillian Morriss-Kay
Publisher : Academic Press
Release : 2015-09-23
ISBN : 0128009136
Language : En, Es, Fr & De

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Book Description :

Kaufman's Atlas of Mouse Development: With Coronal Sections continues the stellar reputation of the original Atlas by providing updated, in-depth anatomical content and morphological views of organ systems.The publication offers written descriptions of the developmental origins of the organ systems alongside high-resolution images for needed visualization of developmental processes. Matt Kaufman himself has annotated the coronal images in the same clear, meticulous style of the original Atlas. Kaufman's Atlas of Mouse Development: With Coronal Sections follows the original Atlas as a continuation of the standard in the field for developmental biologists and researchers across biological and biomedical sciences studying mouse development. Provides high-resolution images for best visualization of key developmental processes and structures Offers in-depth anatomy and morphological views of organ systems Written descriptions convey developmental origins of the organ systems

Pathology of Genetically Engineered and Other Mutant Mice

Pathology of Genetically Engineered and Other Mutant Mice Book
Author : John P. Sundberg,Peter Vogel,Jerrold M. Ward
Publisher : John Wiley & Sons
Release : 2022-01-26
ISBN : 1119624576
Language : En, Es, Fr & De

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Book Description :

An updated and comprehensive reference to pathology in every organ system in genetically modified mice The newly revised and thoroughly updated Second Edition of Pathology of Genetically Engineered and Other Mutant Mice delivers a comprehensive resource for pathologists and biomedical scientists tasked with identifying and understanding pathologic changes in genetically modified mice. The book is organized by body system, includes descriptions and explanations of a wide range of findings, as well as hundreds of color photographs illustrating both common and rare lesions that may be found in genetically engineered and wild type mice. The book is written by experienced veterinary and medical pathologists working in veterinary medical colleges, medical colleges, and research institutes. Covering the latest discoveries in mouse pathology resulting from advancements in biotechnology research over the last 30 years, this singular and accessible resource is a must-read for veterinary and medical pathologists and researchers working with genetically engineered and other mice. Readers will also benefit from: A thorough introduction to mouse pathology and mouse genetic nomenclature, as well as databases useful for analysis of mutant mice An exploration of concepts related to validating animal models, including the Cinderella Effect Practical discussions of basic necropsy methods and grading lesions for computational analyses Concise diagnostic approaches to the respiratory tract, the oral cavity and GI tract, the cardiovascular system, the liver and pancreas, the skeletal system, and other tissues As a one-stop and up to date reference on mouse pathology, Pathology of Genetically Engineered and Other Mutant Mice is an essential book for veterinary and medical pathologists, as well as for scientists, researchers, and toxicologists whose work brings them into contact with genetically modified mice.

Understanding the Materno Fetal Interface During Microbial Infections

Understanding the Materno Fetal Interface During Microbial Infections Book
Author : Demba Sarr,Ricardo E. Fretes,Ulrike Kemmerling,Sodiomon B. Sirima
Publisher : Frontiers Media SA
Release : 2020-12-11
ISBN : 2889662403
Language : En, Es, Fr & De

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Book Description :

Pregnancy is a physiologically and immunologically challenging health state. Immunological and physiological changes throughout the course of pregnancy make pregnant women usually susceptible to infection with microbial agents. Infections with pathogens during pregnancy can have devastating consequences to both the fetus and his/her mother. These infections are linked with adverse pregnancy outcomes. Infections with parasites, viruses, or bacteria can be associated with maternal anemia, abortion, intrauterine growth retardation, preterm delivery, fetal morbidity and high risk of mortality during the first years of life. Despite these significant consequences and complications associated with infections by microbial pathogens during the course of gestation, very little is known about the underlying mechanisms of the pathogenesis and immunopathology of infections during pregnancy. The Research Topic proposed here in, will focus on microbial infections during pregnancy. Studies and review papers addressing the pregnant host/fetus/pathogen interactions, the host/fetus immunological response against infections during gestation, trans-placental transfer of infections during pregnancy are welcome. Topics related to model systems used to mirror the biology in human, the pathogenesis and molecular pathways as well as the mechanisms of the disease at the maternofetal interface including the placenta, the amniotic fluid, and the fetal membranes will be considered making the scope and interest of the topic relatively broad. There is a growing number of pathogens associated with pregnancy. In most cases, women are more susceptible to infections with these pathogens when they become pregnant in comparison to their non-pregnant counterparts. Unfortunately, vertical transmission occurs in most cases but the underlying mechanisms are still unknown. The placenta has always been considered as a barrier against congenital infections but studies have indicated that microbial pathogens breach this barrier. The amniotic fluid, and the fetal membranes are also important components of vertical transmission because of their non-sterile state even in most healthy pregnancies. During pregnancy, infections by malaria or toxoplasmosis as well as other viral or bacterial pathogens lead to an uncontrolled inflammatory response recognized as a significant cause for preterm delivery and intra uterine growth retardation leading to low birth weight, a risk factor to infant morbidity and mortality. To successfully prevent, treat, eradicate or educate about microbial infections during pregnancy, we must understand the molecular mechanisms by which they cause poor birth outcomes including how vertical transmission occurs at the maternofetal interface.

Paul s Fundamental Immunology

Paul s Fundamental Immunology Book
Author : Martin Flajnik
Publisher : Lippincott Williams & Wilkins
Release : 2022-07-19
ISBN : 1975142527
Language : En, Es, Fr & De

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Book Description :

Selected as a Doody's Core Title for 2022! Defining the field of immunology for 40 years, Paul’s Fundamental Immunology continues to provide detailed, authoritative, up-to-date information that uniquely bridges the gap between basic immunology and the disease process. The fully revised 8th edition maintains the excellence established by Dr. William E. Paul, who passed away in 2015, and is now under new editorial leadership of Drs. Martin F. Flajnik, Nevil J. Singh, and Steven M. Holland. It’s an ideal reference and gold standard text for graduate students, post-doctoral fellows, basic and clinical immunologists, microbiologists and infectious disease physicians, and any physician treating diseases in which immunologic mechanisms play a role.

Point Particles to Capture Polarized Embryonic Cells Cold Pools in the Atmosphere

Point Particles to Capture Polarized Embryonic Cells   Cold Pools in the Atmosphere Book
Author : Silas Boye Nissen
Publisher : Niels Bohr Institute, Faculty of Science, University of Copenhagen
Release : 2020-08-31
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Part 1: How are the incredible diversity and robustness compatible with animal morphologies? Based on apical-basal and planar cell polarities’ ubiquity, I suggest a 3D mathematical model: Point particles represent cells having zero, one, or two unit-arrows representing polarities. I test the model abilities on preimplantation development, sea urchin gastrulation, mammalian neurulation, organoid folding, and tubulogenesis. I find that a minimal, versatile toolbox, including cellular polarities, captures the emergence of diverse and robust animal morphologies. Part 2: How are deep convective events spatially organized in the tropical atmosphere? Here, I test the importance of atmospheric cold pools for organizing convection. I suggest a 2D mathematical model: Points expand into circles representing cold pools. When circles meet, a convective event occurs, and a new circle forms. I find this model captures convective scale increase and initial stages of convective self-aggregation. The latter is crucial due to its link to tropical cyclogenesis.

Reproduction in Mammals

Reproduction in Mammals Book
Author : Virginia Hayssen,Teri J. Orr
Publisher : JHU Press
Release : 2017-10-27
ISBN : 1421423162
Language : En, Es, Fr & De

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Book Description :

A fascinating look at the diverse reproductive strategies of numerous female mammals, from hyenas to goats, kangaroos to whales. Newborn mammals can weigh as little as a dime or as much as a motorcycle. Some receive milk for only a few days, whereas others nurse for years. Humans typically have only one baby at a time following nine months of pregnancy, but other mammals have twenty or more young after only a few weeks in utero. What causes this incredible reproductive diversity? In Reproduction in Mammals, Virginia Hayssen and Teri J. Orr present readers with a fascinating examination of the varied reproductive strategies of a broad spectrum of mammals, from marsupials to whales. This unique book's comprehensive coverage gathers stories from many taxa into a single, cohesive perspective that centers on the reproductive lives of females. The authors shed light on a number of intriguing questions, including • do bigger moms have bigger babies? • do primates have longer pregnancies than other groups? • does habitat influence animals' reproductive patterns? • do carnivores typically produce larger litters than prey species? The book opens with the authors' definition of what constitutes a female perspective and an examination of the evolution of reproduction in mammals. It then outlines the typical individual mammalian female: her genetics, anatomy, and physiology. Taking a nuanced approach, Hayssen and Orr describe the female reproductive cycle and explore female mammals' interactions with males and offspring. Readers will come away from this thought-provoking book with an understanding of not only how reproduction fits into the lives of female mammals but also how biology has affected the enormously diverse reproductive patterns of the phenotypes we observe today.

The Vertebrate Blood Gas Barrier in Health and Disease

The Vertebrate Blood Gas Barrier in Health and Disease Book
Author : Andrew N. Makanya
Publisher : Springer
Release : 2015-08-27
ISBN : 3319183923
Language : En, Es, Fr & De

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Book Description :

This comprehensive volume on the blood-gas barrier (BGB) among vertebrates covers its structure and composition along with aspects of evolution, bioengineering, and morphometry. The book also discusses the embryological development of the BGB, including chronology of events and molecular control in vertebrates; modulation of the barrier function, including cyclic stretch-induced increases in alveolar epithelial permeability; mechanisms of lung vascular/epithelial permeability; transport mechanisms of the BGB, including sodium transport channels; factors affecting trans-barrier traffic of fluids, such as chronic elevation of pulmonary microvascular pressure; stress failure; regulation and repair in acute lung injury; chronic lung disease; and lung transportation. Ten authoritative chapters approach the blood-gas barrier holistically, from basic structure and development to pathology and treatment. Properties of the BGB are discussed in the earlier chapters, followed by prenatal and post-natal development and mechanisms of the healthy BGB. The latter half of the book delves into the pathology of the BGB, analyzing common afflictions and exploring options for treatment, including its alterations during lung transplantation. Intuitively structured and comprehensive, The Vertebrate Blood-Gas Barrier in Health and Disease is ideal for researchers and clinicians interested in pneumology and angiology.

Pericyte Biology in Different Organs

Pericyte Biology in Different Organs Book
Author : Alexander Birbrair
Publisher : Springer
Release : 2019-04-01
ISBN : 3030110931
Language : En, Es, Fr & De

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Book Description :

The present book is an attempt to describe the most recent developments in the area of pericyte biology which is one of the emergent hot topics in the field of molecular and cellular biology today. Here, we present a selected collection of thirteen detailed chapters on what we know so far about pericytes in distinct organs in physiological and pathological conditions. Further, it provides an update on the most novel functions attributed to these cells and will introduce a newer generation of researchers and scientists to the importance of these cells, ranging from their discovery in different organs through current state-of-the-science. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cells and vascular research. This volume explores pericytes' physiologic roles in different tissues, ranging from the pancreas, lungs and liver through skeletal muscle, gut, retina and more. Together with its companion volumes Pericyte Biology in Disease and Pericyte Biology – Novel Concepts, Pericyte Biology in Different Organs presents a comprehensive update on the latest information and most novel functions attributed to pericytes. To those researchers newer to this area, it will be useful to have the background information on these cells' unique history. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cells and researchers or clinicians involved with specific organs.

Advances in Biomechanics and Tissue Regeneration

Advances in Biomechanics and Tissue Regeneration Book
Author : Mohamed Hamdy Doweidar
Publisher : Academic Press
Release : 2019-08-13
ISBN : 012816610X
Language : En, Es, Fr & De

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Book Description :

Advances in Biomechanics and Tissue Regeneration covers a wide range of recent development and advances in the fields of biomechanics and tissue regeneration. It includes computational simulation, soft tissues, microfluidics, the cardiovascular system, experimental methods in biomechanics, mechanobiology and tissue regeneration. The state-of-the-art, theories and application are presented, making this book ideal for anyone who is deciding which direction to take their future research in this field. In addition, it is ideal for everyone who is exploring new fields or currently working on an interdisciplinary project in tissue biomechanics. Combines new trends in biomechanical modelling and tissue regeneration Offers a broad scope, covering the entire field of tissue biomechanics Contains perspectives from engineering, medicine and biology, thus giving a holistic view of the field

Causes and Consequences of Intrauterine Growth Restriction

Causes and Consequences of Intrauterine Growth Restriction Book
Author : Elke Winterhager,Ivo Bendix,Suzanne Lee Miller
Publisher : Frontiers Media SA
Release : 2020-06-04
ISBN : 2889637689
Language : En, Es, Fr & De

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Book Description :

Download Causes and Consequences of Intrauterine Growth Restriction book written by Elke Winterhager,Ivo Bendix,Suzanne Lee Miller, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Hype or Hope New Frontiers in Endometrial Research

Hype or Hope  New Frontiers in Endometrial Research Book
Author : Madhuri S. Salker,Dorothy K. Sojka,Biserka Mulac Jericevic,Christos Stournaras
Publisher : Frontiers Media SA
Release : 2022-02-25
ISBN : 2889745228
Language : En, Es, Fr & De

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Book Description :

Download Hype or Hope New Frontiers in Endometrial Research book written by Madhuri S. Salker,Dorothy K. Sojka,Biserka Mulac Jericevic,Christos Stournaras, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Dietary Reference Intakes for Vitamin A Vitamin K Arsenic Boron Chromium Copper Iodine Iron Manganese Molybdenum Nickel Silicon Vanadium and Zinc

Dietary Reference Intakes for Vitamin A  Vitamin K  Arsenic  Boron  Chromium  Copper  Iodine  Iron  Manganese  Molybdenum  Nickel  Silicon  Vanadium  and Zinc Book
Author : Institute of Medicine,Food and Nutrition Board,Standing Committee on the Scientific Evaluation of Dietary Reference Intakes,Subcommittee of Interpretation and Uses of Dietary Reference Intakes,Subcommittee on Upper Reference Levels of Nutrients,Panel on Micronutrients
Publisher : National Academies Press
Release : 2002-07-19
ISBN : 9780309072793
Language : En, Es, Fr & De

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Book Description :

This volume is the newest release in the authoritative series issued by the National Academy of Sciences on dietary reference intakes (DRIs). This series provides recommended intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for individuals based on age and gender. In addition, a new reference intake, the Tolerable Upper Intake Level (UL), has also been established to assist an individual in knowing how much is "too much" of a nutrient. Based on the Institute of Medicine's review of the scientific literature regarding dietary micronutrients, recommendations have been formulated regarding vitamins A and K, iron, iodine, chromium, copper, manganese, molybdenum, zinc, and other potentially beneficial trace elements such as boron to determine the roles, if any, they play in health. The book also: Reviews selected components of food that may influence the bioavailability of these compounds. Develops estimates of dietary intake of these compounds that are compatible with good nutrition throughout the life span and that may decrease risk of chronic disease where data indicate they play a role. Determines Tolerable Upper Intake levels for each nutrient reviewed where adequate scientific data are available in specific population subgroups. Identifies research needed to improve knowledge of the role of these micronutrients in human health. This book will be important to professionals in nutrition research and education.

Nutrition During Pregnancy and Lactation

Nutrition During Pregnancy and Lactation Book
Author : Leanne M. Redman
Publisher : MDPI
Release : 2020-01-03
ISBN : 3039280546
Language : En, Es, Fr & De

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Book Description :

Pregnancy is a viewed as a window to future health. With the birth of the developmental origins of human adult disease hypothesis, research and clinical practice has turned its attention to the influence of maternal factors such as health and lifestyle surrounding pregnancy as a means to understand and prevent the inter-generational inheritance of chronic disease susceptibility. Outcomes during pregnancy have long-lasting impacts on both women on children. Moreover, nutrition early in life can influence growth and the establishment of lifelong eating habits and behaviors. This Special Issue on “Nutrition during Pregnancy and Lactation: Implications for Maternal and Infant Health” is intended to highlight new epidemiological, mechanistic and interventional studies that investigate maternal nutrition around the pregnancy period on maternal and infant outcomes. Submissions may include original research, narrative reviews, and systematic reviews and meta-analyses.

Morphological Mouse Phenotyping

Morphological Mouse Phenotyping Book
Author : Jesus Ruberte,Ana Carretero,Marc Navarro
Publisher : Elsevier
Release : 2017
ISBN : 0128128771
Language : En, Es, Fr & De

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Book Description :

Annotation Morphological Mouse Phenotyping: Anatomy, Histology and Imaging is an atlas of explanatory diagrams and text that guides the reader through normal mouse anatomy, histology, and imaging. The book is targeted for mouse researchers and veterinarian and human pathologists, and presents a complete, integrative description of normal mouse morphology. Disease animal models are fundamental in research to improve human health. The success of using genetically engineered mice to evaluate molecular disease hypotheses has encouraged the development of massive global projects, making the mouse the most used animal disease model. Laboratory mouse populations are straining the housing capacity of pharmaceutical and biotechnology companies, as well as public research institutions. However, the scientific community lacks sufficient expertise in morphological phenotyping to effectively characterize and validate these animal models. The mouse displays fundamental morphological similarities to humans; however, a mouse is not a man. Features more than 2,200 original images showing the anatomy, histology, and cellular structure of mouse organsIncludes images specifically produced for this book in the Mouse Imaging Platform (Center for Animal Biotechnology and Gene Therapy, Universitat Autònoma de Barcelona)Offers an integrative vision of mouse morphology using correlative X-ray, computed tomography, magnetic resonance, and ultrasound images Employs classical anatomical techniques such as conventional dissection, skeletal preparations, vascular injections, and histological, immunohistochemical, and electron microscopy techniques to characterize mouse morphology.

Guide for the Care and Use of Laboratory Animals

Guide for the Care and Use of Laboratory Animals Book
Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee for the Update of the Guide for the Care and Use of Laboratory Animals
Publisher : National Academies Press
Release : 2011-01-27
ISBN : 0309154006
Language : En, Es, Fr & De

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Book Description :

A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.