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The Epigenetics Of Autoimmunity

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The Epigenetics of Autoimmunity

The Epigenetics of Autoimmunity Book
Author : Rongxin Zhang
Publisher : Academic Press
Release : 2018-04-25
ISBN : 0128099283
Language : En, Es, Fr & De

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Book Description :

The Epigenetics of Autoimmunity covers a topic directly related to translational epigenetics. Via epigenetic mechanisms, a number of internal and external environmental risk factors, including smoking, nutrition, viral infection and the exposure to chemicals, could exert their influence on the pathogenesis of autoimmune diseases. Such factors could impact the epigenetic mechanisms, which, in turn, build relationship with the regulation of gene expression, and eventually triggering immunologic events that result in instability of immune system. Since epigenetic aberrations are known to play a key role in a long list of human diseases, the translational significance of autoimmunity epigenetics is very high. To bridge the gap between environmental and genetic factors, over the past few years, great progress has been made in identifying detailed epigenetic mechanisms for autoimmune diseases. Furthermore, with rapid advances in technological development, high-throughput screening approaches and other novel technologies support the systematic investigations and facilitate the epigenetic identification. This book covers autoimmunity epigenetics from a disease-oriented perspective and several chapters are presented that provide advances in wide-spread disorders or diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes (T1DM), systemic sclerosis (SSc), primary Sjögren's syndrome (pSS) and autoimmune thyroid diseases (AITDs). These emerging epigenetic studies provide new insights into autoimmune diseases, raising great expectations among researchers and clinicians. This seminal book on this topic comprehensively covers the most recent advances in this exciting and rapidly developing new science. They might reveal not only new clinical biomarkers for diagnosis and disease progression, but also novel targets for potential epigenetic therapeutic treatment. Provides the accurate and cutting-edge information on autoimmunity epigenetics Wide coverage appeals to those interested in fundamental epigenetics and inheritance to those with more clinical interests Critical reviews of the mean of deriving and analysing autoimmunity epigenetics information as well as its translational potential Up-to-date coverage of emerging topics in autoimmunity epigenetics

The Epigenetics of Autoimmune Diseases

The Epigenetics of Autoimmune Diseases Book
Author : Moncef Zouali
Publisher : John Wiley & Sons
Release : 2009-04-01
ISBN : 9780470743560
Language : En, Es, Fr & De

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Book Description :

The role of epigenetic mechanisms in autoimmune disease is only now starting to become clear. Understanding these mechanisms, their effect on cellular function and the role of environmental factors is vital to determining how to manage these often debilitating and fatal diseases. Drawing on the research of leading experts, this book provides a valuable insight into this important new area of autoimmunity research and a clear, up-to-date view on the major advances in the field. Specific coverage includes: How highly developed epigenetic mechanisms are involved in several aspects of normal immune regulation, in addition to maintaining immune tolerance to self-determinants. Specific epigenetic aspects of human autoimmune diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, autoimmune diabetes, thyroid autoimmunity, inflammatory bowel disease and autoimmune hepatitis. How understanding epigenetic mechanisms can lead to therapeutic strategies based on manipulation of this previously unexploited facet of immune regulation. Discussion of the novel approaches that are being investigated to prevent or treat autoimmune diseases. This book is an essential resource for those actively involved in the field. It is also of interest to basic researchers interested in understanding the origin of autoimmunity and clinical specialists interested in gaining in-depth understanding of the pathogenesis of autoimmune diseases and their treatment.

Exam Prep for The Epigenetics of Autoimmunity

Exam Prep for  The Epigenetics of Autoimmunity Book
Author : Anonim
Publisher : Unknown
Release : 2021-04-16
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Exam Prep for The Epigenetics of Autoimmunity book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Epigenetic Contributions in Autoimmune Disease

Epigenetic Contributions in Autoimmune Disease Book
Author : Esteban Ballestar
Publisher : Springer Science & Business Media
Release : 2011-02-16
ISBN : 1441982167
Language : En, Es, Fr & De

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Book Description :

This volume focuses on the relevance of epigenetic mechanisms in autoimmune disease. It provides new directions for future research in autoimmune disease.

Epigenetics in Allergy and Autoimmunity

Epigenetics in Allergy and Autoimmunity Book
Author : Christopher Chang,Qianjin Lu
Publisher : Springer Nature
Release : 2020-05-22
ISBN : 9811534497
Language : En, Es, Fr & De

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Book Description :

This book will address the growing roles of epigenetics in disease pathogenesis, and review the contribution of epigenetic modifications to disease onset and progression. The roles that epigenetics plays in facilitating effects of the environment on allergy and immunologic diseases will be reviewed. The book is divided into three parts – the first is an introduction to epigenetics and the methods that have been developed to study epigenetics, the second addresses epigenetics in allergic diseases and the third part will cover epigenetics in autoimmune diseases. With the rapid expansion of knowledge of how genes are regulated and how this regulation affects disease phenotypes, this book will be attractive to experienced researchers as well as those just launching an epigenetics research program. It will also be of interest to allergist, immunologists, rheumatologists and dermatologist who are engaged in clinical practice as a resource for understanding the basis for personalized and precision medicine. For example, the role that epigenetics plays in the pathogenesis in various allergic and autoimmune disorders and how this determines disease phenotypes will be covered extensively in this book. This book will thus help fill the gap in available resources on epigenetics in allergy and autoimmune diseases.

Epigenetics in Human Disease

Epigenetics in Human Disease Book
Author : Trygve Tollefsbol
Publisher : Academic Press
Release : 2012-07-26
ISBN : 0123884160
Language : En, Es, Fr & De

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Book Description :

Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs

Autoimmunity Part B

Autoimmunity  Part B Book
Author : M. Eric Gershwin,Yehuda Shoenfeld
Publisher : Wiley-Blackwell
Release : 2007-10-08
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The incidence of autoimmune diseases is increasing worldwide, and the search for better management of these diseases and even for a cure is being pursued by scientists from many disciplines. Tools from the areas of genetics, neuroscience, cell biology, virology, and infectious disease are being applied to the problem and are yielding useful results. This is the second volume of a series of four on autoimmunity, and findings related to particular organs, organ systems, and diseases are presented. The focus in Part B is on genetics and advances in treatment. Part A presents new principles in autoimmunity and new diagnostic tools. See Parts C and D for clinical venues in autoimmunity. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

Departments of Labor Health and Human Services Education and Related Agencies Appropriations for 2012

Departments of Labor  Health and Human Services  Education  and Related Agencies Appropriations for 2012 Book
Author : United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Departments of Labor Health and Human Services Education and Related Agencies Appropriations for 2012 book written by United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Pathogenesis of Autoimmunity in New Zealand Black Mice

The Pathogenesis of Autoimmunity in New Zealand Black Mice Book
Author : Steven Hideo Yoshida
Publisher : Unknown
Release : 1989
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Pathogenesis of Autoimmunity in New Zealand Black Mice book written by Steven Hideo Yoshida, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Computational Epigenetics and Diseases

Computational Epigenetics and Diseases Book
Author : Anonim
Publisher : Academic Press
Release : 2019-02-06
ISBN : 0128145145
Language : En, Es, Fr & De

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Book Description :

Computational Epigenetics and Diseases, written by leading scientists in this evolving field, provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases. In particular, the major computational tools, databases, and strategies for computational epigenetics analysis, for example, DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA, are summarized, in the context of human diseases. This book discusses bioinformatics methods for epigenetic analysis specifically applied to human conditions such as aging, atherosclerosis, diabetes mellitus, schizophrenia, bipolar disorder, Alzheimer disease, Parkinson disease, liver and autoimmune disorders, and reproductive and respiratory diseases. Additionally, different organ cancers, such as breast, lung, and colon, are discussed. This book is a valuable source for graduate students and researchers in genetics and bioinformatics, and several biomedical field members interested in applying computational epigenetics in their research. Provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases Summarizes the major computational tools, databases, and strategies for computational epigenetics analysis, such as DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA Covers the major milestones and future directions of computational epigenetics in various kinds of human diseases such as aging, atherosclerosis, diabetes, heart disease, neurological disorders, cancers, blood disorders, liver diseases, reproductive diseases, respiratory diseases, autoimmune diseases, human imprinting disorders, and infectious diseases

Epigenetics and Dermatology

Epigenetics and Dermatology Book
Author : Qianjin Lu,Christopher C. Chang,Bruce C. Richardson
Publisher : Academic Press
Release : 2015-02-16
ISBN : 0128012722
Language : En, Es, Fr & De

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Book Description :

Epigenetics and Dermatology explores the role of epigenetics in the pathogenesis of autoimmune-related skin diseases and skin cancer. Leading contributors cover common and uncommon skin conditions in which extensive epigenetic research has been done. They explain how environmental exposures (chemicals, drugs, sunlight, diet, stress, smoking, infection, etc.) in all stages of life (from a fetus in-utero to an elderly person) may result in epigenetic changes that lead to development of some skin diseases in life. They also discuss the possibilities of new and emergent epigenetic treatments which are gradually being adopted in management of various skin diseases. Chapters follow a conventional structure, covering fundamental biology of the disease condition, etiology and pathogenesis, diagnosis, commonly available treatments, and epigenetic therapy where applicable. Discusses the basic biology of skin diseases and skin cancers induced or aggravated by aberrant epigenetic changes Evaluates how to approach autoimmune-related skin diseases from a therapeutic perspective using the wealth of emergent epigenetic clinical trials Offers a coherent and structured table of contents with basic epigenetic biology followed by discussion of the spectrum of rheumatologic through neoplastic skin diseases, finally ending with a discourse on epigenetic therapy

The Year in Immunology

The Year in Immunology Book
Author : Noel R. Rose
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Year in Immunology book written by Noel R. Rose, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Autoimmunity

Autoimmunity Book
Author : M. Eric Gershwin,Yehuda Shoenfeld
Publisher : Unknown
Release : 2005
ISBN : 9781573315166
Language : En, Es, Fr & De

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Book Description :

Both novel scientific (basic immunology) and clinical aspects of autoimmunity and autoimmune diseases are presented in this volume in papers written by the world's leading autoimmunologists.

The Lancet

The Lancet Book
Author : Anonim
Publisher : Unknown
Release : 1963-05
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Lancet book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Epigenetic Aspects of Chronic Diseases

Epigenetic Aspects of Chronic Diseases Book
Author : Helmtrud I. Roach,Felix Bronner,Richard O.C. Oreffo
Publisher : Springer Science & Business Media
Release : 2011-04-01
ISBN : 9781848826441
Language : En, Es, Fr & De

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Book Description :

Epigenetic Aspects of Chronic Diseases assembles in comprehensive form what is known about the role of epigenetics in chronic disease development. This book provides new insights into treatment, including modulation of epigenetic regulation. Each chapter gives an outline of a respective disease, explains why epigenetics may be involved in the disease process and then presents the evidence of how changes in epigenetic status contribute to initiation and progress of the disease. The final chapters look towards future therapeutic treatment, based on manipulation of epigenetic aspects. Written by widely published experts, Epigenetic Aspects of Chronic Diseases is a valuable reference tool for clinicians and researchers who investigate and treat chronic diseases, as well as health care personnel, post-doctoral fellows and medical or dental students.

Frontiers in Multiple Sclerosis

Frontiers in Multiple Sclerosis Book
Author : Anonim
Publisher : Unknown
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Organ specific Autoimmunity

Organ specific Autoimmunity Book
Author : Pierluigi E. Bigazzi,Georg Wick,Konrad Wicher
Publisher : Marcel Dekker Incorporated
Release : 1990
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

An international group of scientists contribute 19 perspectives on the current state of organ-specific and tissue-specific autoimmunity, describing experimentally induced and spontaneously occurring animal models for autoimmune diseases as examples for the development and assessment of new therapeutic strategies, and detailing clinical studies on the autoimmune processes and responses in such disorders as rheumatoid arthritis, syphilis, schizophrenia, multiple sclerosis, thyroid disease and autoimmune thyroiditis, autoimmune myocarditis, diabetes mellitus and polyendocrine syndromes, and human male infertility. Annotation(c) 2003 Book News, Inc., Portland, OR (booknews.com)

The Journal of Immunology

The Journal of Immunology Book
Author : Anonim
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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The Thyroid Gland Environment and Autoimmunity

The Thyroid Gland  Environment  and Autoimmunity Book
Author : H. A. Drexhage,J. J. M. de Vijlder,Willem Maarten Wiersinga
Publisher : Unknown
Release : 1990
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Thyroid Gland Environment and Autoimmunity book written by H. A. Drexhage,J. J. M. de Vijlder,Willem Maarten Wiersinga, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Genetic Predisposition to Disease

Genetic Predisposition to Disease Book
Author : Sara L. Torres,Marta S. Marin
Publisher : Nova Science Pub Incorporated
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A genetic predisposition is a genetic effect which influences the phenotype of an organism but which can be modified by the environmental conditions. Genetic testing is able to identify individuals who are genetically predisposed to certain health problems such as cancer or other life altering diseases. This book discusses the determination of the genetic basis of health problems that will help the precise mechanisms of health problem such as a disease or physical disorder.