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The Dementias 2

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The Dementias 2

The Dementias 2 Book
Author : John Herbert Growdon,Martin Rossor
Publisher : Elsevier Health Sciences
Release : 2007-01-01
ISBN : 075067542X
Language : En, Es, Fr & De

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Book Description :

This volume in the Blue Books of Neurology series provides you with rapid access to practical, clinical guidance on the diagnosis and treatment of all forms of dementia, including Alzheimer's disease, dementia with Lewy bodies, Parkinson's disease, and many others. Organized by the most common neurodegenerative diseases, it reflects new insights regarding commonalities among the neurodegenerative diseases, and clusters them according to their dominant molecular pathologic signatures, so you can best treat any dementia you see. Differentiate among various forms of dementia and provide the appropriate management strategy. Correlate neuroimaging with neuropsychological testing to form more accurate diagnoses. Administer the latest approved drugs to improve your patients' brain function. A new two-color design and full-color images throughout helps you access information more easily. New chapters and new authors help you incorporate the latest information and fresh perspectives into your practice.

The Dementias Hope Through Research Revised December 2017

The Dementias  Hope Through Research  Revised December 2017  Book
Author : U.S. Department of Health and Human Services
Publisher : Lulu.com
Release : 2019-04-13
ISBN : 0359588298
Language : En, Es, Fr & De

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Book Description :

Dementia is the loss of cognitive functioning?the ability to think, remember, or reason?to such an extent that it interferes with a person's daily life and activities. These functions include memory, language skills, visual perception, problem solving, self-management, and the ability to focus and pay attention. Some people with dementia cannot control their emotions, and their personalities may change. Dementia ranges in severity from the mildest stage, when it is just beginning to affect a person's functioning, to the most severe stage, when the person must depend completely on others for basic activities of daily living. Age is the primary risk factor for developing dementia. For that reason, the number of people living with dementia could double in the next 40 years as the number of Americans age 65 and older increases from 48 million today to more than 88 million in 2050. Regardless of the form of dementia, the personal, economic, and societal demands can be devastating.

Dementia 21 Vol 2

Dementia 21 Vol  2 Book
Author : Shintaro Kago
Publisher : Fantagraphics Books
Release : 2020-02-19
ISBN : 1683962818
Language : En, Es, Fr & De

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Book Description :

Devilishly funny, absurdist manga short stories about a sprightly home aide caring for a series of eccentric patients. In Vol. 2, Yukie boldly decides to join the resistance ― against a squadron of maniacal diapers hell-bent on taking over the world! A shorthanded hospital hires zombies to care for its patients, but … what exactly do they eat? When an old man creates a machine that causes out-of-body experiences, what could possibly go wrong? And why are children getting rocket launchers in their stockings? Three words: Santa has dementia!

Simple Coloring Book

Simple Coloring Book Book
Author : Dementia Activity Studio
Publisher : Unknown
Release : 2019-06-16
ISBN : 9781074259846
Language : En, Es, Fr & De

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Book Description :

Coloring book for dementia Patients After the widespread success of our first edition, and the influx of positive feedback, we have developed our second Version of the simple colouring book. Through the feedback from both patients and carers who have used the first edition, we have further developed another book of colouring activities - Keeping what worked, and leaving behind that didn't. We would like to thank all our customers for the positive feedback in our first edition, and are so happy to hear that it is helping with your loved ones and patients! Dementia coloring book: Anti-Stress and memory loss colouring pad for the elderly is an innovative colouring book developed specifically for those suffering from Dementia and Alzheimers, or other elderly citizens who may be showing signs of memory loss. Note: This book does not mention dementia, Alzheimers or anything else that may cause stress or anxiety for these patients. Unlike other elderly colouring books, these colouring pages are tailored for those at all stages of dementia. With no complex activities, and the use of only circular shapes, these colouring pages were made to stimulate brain activity in a way which will help not only calm those using it, but encourage the appropriate mental patterns required for memory stability. Each page is repeated a number of times throughout the course of the colouring book, which allows carers to clearly see process from the start of the book to the end of the book. Although pages are not ranked in order of complexity, the repetition of pages throughout the book will allow clear patterns of improvement to be observed by family, friends and carers. The dementia coloring book was developed from insights given by neurologists, psychologists, caregivers and dementia and alzheimers patients, to only contain what is proven to work. It is recommended that a schedule is developed with these activities, to provide further structure to the task. This may be one page a day, one each morning and night, or a number each day for consecutive days. Book Features: 90 Pages of coloring in Repeated activities for easy tracking of progress Circular designs to stimulate the correct parts of the brain Simple designs that are designed to reduce stress Favourite themes repeated from first editions Unfavourable designs left out For other dementia and Alzhiemers products, check Dementia Activity Studio.

Type 2 Diabetes and Dementia

Type 2 Diabetes and Dementia Book
Author : Velandai Srikanth,Zoe Arvanitakis
Publisher : Academic Press
Release : 2018-02-09
ISBN : 0128096942
Language : En, Es, Fr & De

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Book Description :

Type 2 Diabetes and Dementia details the relationship between diabetes, dementia and the future of medicine and therapeutics. Chapters range from epidemiology, clinical features, neuroimaging biomarkers, neuropathology, macrostructural and molecular mechanisms, risk assessment and prevention strategies, and the application of therapeutics. The book reflects the translational aspects of the current science in the field, with an emphasis on the display of neuroimaging and neuropathology. It contains contributions from world experts, and is ideal for clinicians and researchers in the fields of neurology, neuroscience, geriatric medicine and endocrinology. Presents a comprehensive overview that details the relationship between diabetes, dementia and the future of medicine and therapeutics Written for researchers and clinicians in neurology, neuroscience, geriatric medicine and endocrinology Includes topics ranging from epidemiology, clinical features, neuroimaging biomarkers, neuropathology, macrostructural and molecular mechanisms, risk assessment, prevention strategies and therapeutic applications

Bathing Without a Battle

Bathing Without a Battle Book
Author : Ann Louise Barrick PhD,Joanne Rader RN, MN, PMHNP,Beverly Hoeffer DNSc, RN, FAAN,Philip D. Sloane MD, MPH,Stacey Biddle COTA/L
Publisher : Springer Publishing Company
Release : 2008-03-10
ISBN : 9780826115072
Language : En, Es, Fr & De

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Book Description :

2008 AJN Book of the Year Winner! Like its popular predecessor, the new edition of Bathing Without a Battle presents an individualized, problem-solving approach to bathing and personal care of individuals with dementia. On the basis of extensive original research and clinical experience, the editors have developed strategies and techniques that work in both institution and home settings. Their approach is also appropriate for caregiving activities other than bathing, such as morning and evening care, and for frail elders not suffering from dementia. For this second edition, the authors have included historical material on bathing and substantially updated the section on special concerns, including: Pain Skin care Determining the appropriate level of assistance Transfers The environment An enhanced final section addresses ways to support caregivers by increasing their understanding of the care recipient's needs and their knowledge of interventions to improve care and comfort. It also emphasizes self-care and system-level changes to promote person-directed care. Several chapters include specific insights and wisdom from direct caregivers.

Frontiers in Clinical Drug Research Dementia Volume 2

Frontiers in Clinical Drug Research     Dementia  Volume 2 Book
Author : José Juan Antonio Ibarra Arias
Publisher : Bentham Science Publishers
Release : 2021-11-09
ISBN : 9815039482
Language : En, Es, Fr & De

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Book Description :

Among neurodegenerative diseases, those that lead to a state of dementia are the aim of several investigations. Dementia is a chronic disease the prevalence of which is increasing worldwide. The number of dementia patients in the world is approximately 50 million, and it is estimated that the number of patients will reach 131.5 million by 2050. This increase will be accompanied by a significant increase in medical expenditures and other expenses, especially for elderly patients. Therefore, the maintenance cost of dementia in the future is expected to be quite high. For this reason, several investigations aim, firstly, to describe the key mechanisms involved in the origin of dementia and, secondly, to establish preventive and therapeutic strategies in order to understand and mitigate this debilitating pathology. This volume of Frontiers in Clinical Drug Research - Dementia explores the current comorbidities that cause cognitive impairment and the current management alternatives for clinical cases of dementia. The reviews contributed in these volume will provide readers with a current perspective on the subject. The topics covered in this volume include: - Comorbidities inducing mild cognitive impairment - an evaluation of the risk caused by some pathological conditions - Tau-targeted therapy in Alzheimer's disease - history and current state - Emerging nanotherapeutic strategies in Alzheimer's disease - Implication of dehydroepiandrosterone on dementia related to oxidative stress - Polyphenol compounds as potential therapeutic agents in Alzheimer’s disease The volume is a timely update on dementia treatment for clinical physicians, neurologists, gerontologists, pharmaceutical and medicinal chemistry researchers, and physiologists.

The Dementias

The Dementias Book
Author : John Herbert Growdon,Martin Rossor
Publisher : Butterworth-Heinemann Medical
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Dementia, technically defined as cognitive impairments sufficiently pervasive and severe enough that they disrupt independent life, is one of the most devastating symptoms of neurologic disease. While Alzheimer's disease (AD) is the most common neurodegenerative disease that causes it, more than 50 medical, psychiatric, and neurological conditions are associated with dementia. Well organized and expertly planned, this text provides new concepts of patient management that have come about through recent neuroscience research. This volume, reviewing the dementias with the needs of the clinician in mind, is unique in that the section dealing with disease mechanisms reviews the exciting recent scientific advance in regard to Alzheimer disease, whereas the clinical section(section A) focuses not on Alzheimer disease but upon related disorders, the less common dementing syndromes due to other neurodegenerative disorders. The editors of this Blue Book have brought together an extraordinary group of experts to define the scientific advances primarily in Alzheimer's disease (section B) and new treatments (section C) being developed. * Written for non-expert general neurologists and residents * Provides new concepts of patient management discovered in neuroscience research * Includes unique coverage of recent scientific advances in Alzheimer's Disease

Care Giving In Dementia

Care Giving In Dementia Book
Author : Gemma Jones,Bere Miesen
Publisher : Routledge
Release : 2021-12-17
ISBN : 1317854322
Language : En, Es, Fr & De

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Book Description :

Care-giving in dementia is a new speciality with its own rapidly growing body of knowledge. This second volume of contributions from leading practitioners and researchers around the world is a handbook for all those involved in 'hands on' caring, or in planning care, for persons with dementia. Volume 2 of Care-Giving in Dementia provides a rich source of information on most recent thinking about individualized long-term care of both dementia sufferers and their families. Key themes in Volume 2 are: * the subjective experience of dementia * the provision of care for family carers * differing cultural perspectives of dementia * the crucial importance of life-history information for understanding a person's reaction to their illness. Chapters on the search for an ethical framework and the best environment within which to provide care are particularly timely.

The Neuropathology of Dementia

The Neuropathology of Dementia Book
Author : Margaret M. Esiri,Virginia M. -Y. Lee,John Q. Trojanowski
Publisher : Cambridge University Press
Release : 2004-07-22
ISBN : 9780521819152
Language : En, Es, Fr & De

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Book Description :

This completely rewritten, updated new edition, now illustrated in colour, is almost twice the size of its predecessor.

Ethnicity and the Dementias

Ethnicity and the Dementias Book
Author : Gwen Yeo,Dolores Gallagher-Thompson
Publisher : Routledge
Release : 2013-05-13
ISBN : 1136895612
Language : En, Es, Fr & De

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Book Description :

In recent years, the literature on the topic of ethnic and racial issues in Alzheimer’s disease and other dementias has increased dramatically. At the same time, the need for cultural competence in all of geriatric care, including dementia care, is increasingly being acknowledged. Researchers and providers are beginning to recognize the impending "ethnogeriatric imperative," as the number of elders from diverse ethnic and cultural backgrounds continues to rise. Ethnicity and the Dementias offers invaluable background information in this area, while also examining how those suffering from dementia and their family members respond or adapt to the challenges that follow. Thoroughly updated and revised from the first edition, the book features contributions from leading clinicians and researchers on the epidemiology of dementias by ethnic population, new information on the assessment of diverse populations, and updates and inclusions of new populations in the management of dementia and working with families. The book is ideal for practitioners, researchers, and policy makers in search of the most current ethnogeriatric findings.

Ethnicity and Dementias

Ethnicity and Dementias Book
Author : Gwen Yeo,Dolores Gallagher Thompson
Publisher : Taylor & Francis
Release : 2014-04-04
ISBN : 1317822595
Language : En, Es, Fr & De

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Book Description :

First published in 1996. Routledge is an imprint of Taylor & Francis, an informa company.

Neurodegeneration

Neurodegeneration Book
Author : Dennis Dickson,Roy O. Weller
Publisher : John Wiley & Sons
Release : 2011-09-09
ISBN : 1444341235
Language : En, Es, Fr & De

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Book Description :

Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, α-synuclein and TDP-43) and in the extracellular compartments (e.g. β-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.

Neurogenetics

Neurogenetics Book
Author : Anonim
Publisher : Elsevier
Release : 2018-01-09
ISBN : 0444640770
Language : En, Es, Fr & De

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Book Description :

Neurogenetics, Part II, Volume 148, the latest release in the Handbook of Clinical Neurology, provides the latest information on the genetic methodologies that are having a significant impact on the study of neurological and psychiatric disorders. Using genetic science, researchers have identified over 200 genes that cause or contribute to neurological disorders. Still an evolving field of study, defining the relationship between genes and neurological and psychiatric disorders is expected to dramatically grow in scope. Part II builds on the foundation of Part I, expanding the coverage to dementias, paroxysmal disorders, neuromuscular disorders, white matter and demyelination diseases, cerebrovascular diseases, adult psychiatric disorders and cancer and phacomatoses. Contains comprehensive coverage of neurogenetics Details the latest science and its impact on our understanding of neurological, psychiatric disorders Presents a focused reference for clinical practitioners and the neuroscience/neurogenetics research community

Molecular Mechanisms of Dementia

Molecular Mechanisms of Dementia Book
Author : Akhlaq A. Farooqui
Publisher : Academic Press
Release : 2019-04-15
ISBN : 0128167319
Language : En, Es, Fr & De

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Book Description :

Considerable progress has been made in neurochemical and therapeutic aspects of dementia research in recent years. Molecular and Therapeutic Aspects of Dementia presents readers with comprehensive and cutting-edge information on the neurochemical mechanisms of various types of dementias. It provides a clearly written and logically organized and comprehensive overview of molecular aspects of risk factors, symptoms, pathogenesis, biomarkers, and therapeutic strategies for various types of dementia. This book is written for the international audience of neurochemists, neuroscientists, neurologists, neuropharmacologists, and clinicians. The hope is that this discussion will not only integrate and consolidate knowledge in this field, but will jumpstart more studies on molecular mechanisms and therapeutic aspects of dementia. The comprehensive information in this monograph may not only help in early detection of various types of dementia and dementia linked neurological disorders, but also promote discovery of new drugs, which may block or delay the onset of dementia in elderly patients. Understanding the course of dementia is important not only for patients, caregivers, and health professionals, but also for health policy-makers, who have to plan for national resources needed in the management of an increasing number of dementia cases. Provides a comprehensive overview of molecular aspects of risk factors, symptoms, pathogenesis, biomarkers, and therapeutic strategies for various types of dementia Summarizes cutting edge research information on signal transduction processes associated with neurochemistry of dementia Discusses the synthesis, metabolism, and role of lipid mediators in dementia

Mayo Clinic on Alzheimer s Disease and Other Dementias

Mayo Clinic on Alzheimer s Disease and Other Dementias Book
Author : Jonathan Graff-Radford,Angela M. Lunde
Publisher : Rosetta Books
Release : 2020-10-06
ISBN : 0795352921
Language : En, Es, Fr & De

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Book Description :

A reference on preventing, treating, and coping with dementia, from “one of the most reliable, respected health resources that Americans have” (Publishers Weekly). This book from the world-renowned Mayo Clinic offers an update on what experts know about Alzheimer’s and related dementias, including the latest research into treatment and prevention, ways to live well with dementia, and recommendations for caregivers. While Alzheimer’s disease is the most common type of dementia, many related types also affect adults worldwide, causing loss of memory, reason, judgment, and other cognitive functions. Although the diseases that cause dementia have long been considered unrelenting and incurable, recent advances offer hope. This book includes information about: • What to expect of typical aging and what are the earliest signs of abnormal aging • Memory loss and other forms of cognitive impairment that may lead to dementia • Characteristic features of Alzheimer’s disease and related dementias, including frontotemporal degeneration, Lewy body dementia, and vascular cognitive impairment • The latest research on Alzheimer’s disease and related dementias • Caring for and supporting someone living with dementia Are there ways you can lower your risk? Can dementia be prevented? Can you live well with dementia? If so, how? You’ll find answers to these important questions and more in this book.

Genetics Neurology Behavior and Diet in Dementia

Genetics  Neurology  Behavior  and Diet in Dementia Book
Author : Colin R. Martin,Victor R Preedy
Publisher : Academic Press
Release : 2020-08-11
ISBN : 0128158697
Language : En, Es, Fr & De

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Book Description :

Genetics, Neurology, Behavior, and Diet in Dementia: The Neuroscience of Dementia, Volume 2 consolidates different fields of dementia research into a single book, covering a range of subjects, including Alzheimer’s disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, and molecular biology. This foundational, comprehensive book assembles the latest understanding on all dementias and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. Offers comprehensive coverage of a broad range of topics related to dementia Serves as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunction Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations Serves as a "one-stop" source for everything you need to know about dementia

Clinical Manual of Alzheimer Disease and Other Dementias

Clinical Manual of Alzheimer Disease and Other Dementias Book
Author : Myron F. Weiner,Anne M. Lipton
Publisher : American Psychiatric Pub
Release : 2012-02-24
ISBN : 1585629618
Language : En, Es, Fr & De

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Book Description :

In Clinical Manual of Alzheimer Disease and Other Dementias, practicing psychiatrists and neurologists provide essential input into neuropsychiatric assessment and the diagnosis and treatment of a wide range of neuropsychiatric conditions, including Alzheimer disease and traumatic brain injury. The manual provides invaluable information on both evaluation/diagnosis and treatment. Case studies offer real-life clinical experiences by some of the country's leading experts in the field. Clinical Manual of Alzheimer Disease and Other Dementias Includes DSM-IV-TR cognitive disorders and addresses other cognitive syndromes and psychiatric symptoms that may confound diagnosis. Provides clinical insights into the diagnostic signs and symptoms of dementing illnesses, including Alzheimer disease, frontotemporal dementias, delirium, amnesia, and other cognitive disorders. Reviews the psychiatric syndromes that are related to dementing illnesses and deals with their treatment. Discusses the detection and management of depression in the evaluation of a person with a cognitive complaint or symptoms. Emphasizes the behavioral disorders that accompany dementing illness and presents an approach to their pharmacological and nonpharmacological management. Delineates clinical workup for medical conditions that may underly cognitive or other psychiatric symptoms. Provides an overview of clinical tools and techniques for diagnosing cognitive dysfunction, including history taking, mental status evaluation, physical and neurological examination, and neuropsychological testing. Presents an illustrated review of the most current techniques of neuroimaging in differential diagnosis. Includes key clinical points in every chapter summarizing important concepts. In addition to topics covered in the textbook, the manual includes a chapter on community resources to enable clinicians to better support patients and families through local and national organizations and agencies. This text is a must-have reference for clinical psychiatrists, resident fellows, residents in training, medical students in psychiatry rotations, clinical psychologists, and psychiatric nurses.

The American Psychiatric Publishing Textbook of Alzheimer Disease and Other Dementias

The American Psychiatric Publishing Textbook of Alzheimer Disease and Other Dementias Book
Author : Myron F. Weiner,Anne M. Lipton
Publisher : American Psychiatric Pub
Release : 2009-03-02
ISBN : 1585628948
Language : En, Es, Fr & De

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Book Description :

The American Psychiatric Publishing Textbook of Alzheimer Disease and Other Dementias is an up-to-date and comprehensive overview of dementia for psychiatrists and other health care practitioners who deal with cognitively impaired adults in outpatient, inpatient, and long-term care settings. With content ranging from clinical guidance to basic research, it contains information on nearly every subject related to dementing conditions or illnesses -- not only providing extensive coverage of clinical management issues but also enabling a deeper understanding of the causes of dementia. Designed to assist the practitioner faced with everyday dilemmas, from dosages of antipsychotic drugs to legal and ethical issues, this textbook describes in detail the most common conditions and diseases leading to dementia and covers pharmacologic, behavioral, and environmental treatments. It also considers a broader range of cognitive disorders and impairment in order to help practitioners recognize and treat primary brain diseases and systemic disorders affecting the brain before they reach the stage of dementia. Building on the editors' earlier work The Dementias: Diagnosis, Treatment, and Research, this new book expands on its scope, with nearly twice the number of contributors -- all clinicians or researchers at the vanguard of the field. New to this edition are chapters on epidemiology, history of dementia, biomarkers for Alzheimer disease, care of the late-stage dementia patient, prevention of dementia, and chapters devoted to: Vascular cognitive impairment, emphasizing the importance of early detection with development of appropriate treatments and risk factor control Dementia with Lewy bodies and other synucleinopathies, describing differences in cognitive profile between synucleinopathies and Alzheimer disease Frontotemporal dementias, including behavioral and language variants Traumatic brain injury, distinguishing between proximal and distal effects and risk factors for dementia later in life An abundance of charts and illustrations, extensive references and additional readings, and chapter-end key points make this a practical volume for learning, while appendixes include easily administered instruments useful in daily practice for grading cognition, day-to-day function, neuropsychiatric symptoms, and quality of life. Whether used as a clinical guide or as a sourcebook on technical and scientific developments, The American Psychiatric Publishing Textbook of Alzheimer Disease and Other Dementias is an important reference for psychiatrists, neurologists, geriatricians, primary care physicians, and other health professionals who deal with cognitively impaired adults.

The Dementia Caregiver

The Dementia Caregiver Book
Author : Marc E. Agronin
Publisher : Rowman & Littlefield
Release : 2015-10-22
ISBN : 1442231920
Language : En, Es, Fr & De

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Book Description :

Becoming a caregiver for someone with Alzheimer’s disease or another neurocognitive disorder can be an unexpected, undesirable, underappreciated—and yet noble role. It is heartbreaking to watch someone lose the very cognitive capacities that once helped to define them as a person. But because of the nature of these disorders, the only way to become an effective caregiver and cope with the role’s many daily challenges is to become well-informed about the disease. With the right information, resources and tips on caregiving and working with professionals, you can become your own expert at both caring for your charge and taking care of yourself. In these pages, Marc Agronin guides readers through a better understanding of the changes their loved one may be going through, and helps them tap into the various resources available to them as they embark on an uncertain caregiving journey. Insisting that a caregiver also maintain his or her own health and well being, Agronin guides caregivers in their efforts to provide care, but to also look to themselves as recipients of care from themselves and others. Shedding light on the debilitating disorders themselves as well as their everyday realities, this book is a much-needed resource for anyone caring for another person suffering from Alzheimer’s disease and other neurocognitive disorders.