Skip to main content

The Cytokines Of The Immune System

In Order to Read Online or Download The Cytokines Of The Immune System Full eBooks in PDF, EPUB, Tuebl and Mobi you need to create a Free account. Get any books you like and read everywhere you want. Fast Download Speed ~ Commercial & Ad Free. We cannot guarantee that every book is in the library!

The Cytokines of the Immune System

The Cytokines of the Immune System Book
Author : Zlatko Dembic
Publisher : Academic Press
Release : 2015-05-23
ISBN : 0124200109
Language : En, Es, Fr & De

GET BOOK

Book Description :

The Cytokines of the Immune System catalogs cytokines and links them to physiology and pathology, providing a welcome and hugely timely tool for scientists in all related fields. In cataloguing cytokines, it lists their potential for therapeutic use, links them to disease treatments needing further research and development, and shows their utility for learning about the immune system. This book offers a new approach in the study of cytokines by combining detailed guidebook-style cytokine description, disease linking, and presentation of immunologic roles. Supplies new ideas for basic and clinical research Provides cytokine descriptions in a guidebook-style, cataloging the origins, structures, functions, receptors, disease-linkage, and therapeutic potentials Offers a textbook-style view on the immune system with the immunologic role of each cytokine

Cytokine Frontiers

Cytokine Frontiers Book
Author : Takayuki Yoshimoto,Tomohiro Yoshimoto
Publisher : Springer Science & Business Media
Release : 2013-10-28
ISBN : 4431544429
Language : En, Es, Fr & De

GET BOOK

Book Description :

This book guides the reader through the latest research on the cytokine network, covering signaling pathways, control of the immune response, and potential therapeutics. Different cytokines stimulate diverse responses in various phases of inflammation and immunity, including the innate immune response, the generation of effector T cells, and the development of antibodies by the humoral immune system. It is now clear that the pathophysiology of many infectious, autoimmune, allergic, and malignant diseases can be largely explained by which cytokines are induced and subsequently regulate the cellular responses. In clinical medicine, cytokines are involved in a wide spectrum of diseases. This book describes in three parts the properties and roles of 15 key cytokines under physiological and pathological conditions. Part I presents nine cytokines associated with inflammatory disorders, pro-inflammatory cytokines, and the recently identified new helper T (Th) subset: Th17 cells. Part II gives details of three cytokines associated with allergic disorders, including Th2 responses and recently identified types of innate cells. Part III describes three cytokines that are associated with immunological tolerance and anti-inflammation, including regulatory T (Treg) cells, IL-10-producing Treg (Tr1) cells, and inducible IL-35-producing Treg (iTr35) cells. Cytokines are considered to be important as therapeutic targets for specific agonists or antagonists in numerous immune and inflammatory diseases. The ultimate goal of this book is to facilitate the development of therapeutic treatments for such diseases which has been limited by an insufficient understanding of the biology of cytokines and the complicated network that they create.

Interleukins

Interleukins Book
Author : Payam Behzadi
Publisher : BoD – Books on Demand
Release : 2021-07-14
ISBN : 1839690984
Language : En, Es, Fr & De

GET BOOK

Book Description :

The immune system recruits a wide range of molecule groups and categories, each of which has its own function, property, and structure. Among these, interleukins play a pivotal role in supporting the immune and non-immune systems of the human body. Interleukins as effective cytokines participate in different conditions such as homeostasis, infectious diseases, autoimmune diseases, and cancers. This unique property of interleukins makes them invaluable biomarkers that can be used as important biosensors. This book is divided into three sections: “Interleukins’ Classification and Evolutionary Features”, “Autoimmune Diseases and Low Immune System”, and “Cancer and Injuries”. Chapters examine the role of various interleukins in conditions such as leukemia, rheumatoid arthritis, and allergic and autoimmune diseases.

The Effect of Laughter on Modulating Inflammatory Cytokines in the Immune System

The Effect of Laughter on Modulating Inflammatory Cytokines in the Immune System Book
Author : Andy Mohr,Kyla Shafer,Casey Stoneberger
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Download The Effect of Laughter on Modulating Inflammatory Cytokines in the Immune System book written by Andy Mohr,Kyla Shafer,Casey Stoneberger, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cytokines

Cytokines Book
Author : Robert E. Faith,Anthony J. Murgo,Robert A. Good,Nicholas P. Plotnikoff
Publisher : CRC Press
Release : 2006-10-10
ISBN : 1420003801
Language : En, Es, Fr & De

GET BOOK

Book Description :

Cytokine involvement in the immune system's response to stress is now very well documented. Cytokine activity has been implicated in a variety of mental and physical diseases, and has been shown to have a significant role in fueling the vicious circle of depression and illness. The first edition of Cytokines: Stress and Immunity pointed out

Brain Neurosecretory Cytokines

Brain Neurosecretory Cytokines Book
Author : Armen A. Galoyan
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1441988939
Language : En, Es, Fr & De

GET BOOK

Book Description :

Brain Neurosecretory Cytokines: Immune Response and Neuronal Survival summarizes the biological and chemical data of signal molecules of the brain neuroendocrine immune system, mainly proline-rich peptides, which play an important role in the regulation of immune response, neuronal survival, hematopoiesis, and adaptation. The author also describes the role of PRPs for the protection of neurons against neurodegenerative disturbances and diseases. Brain Neurosecretory Cytokines: Immune Response and Neuronal Survival will be of great aid to the researchers and students in various areas of neurobiological profile (neurochemistry, neuroendocrinology, neurophysiology, and endocrinology).

How the Immune System Works

How the Immune System Works Book
Author : Lauren M. Sompayrac
Publisher : John Wiley & Sons
Release : 2019-04-15
ISBN : 111954212X
Language : En, Es, Fr & De

GET BOOK

Book Description :

How the Immune System Works has helped thousands of students understand what's in their hefty immunology textbooks. In this book, Dr. Sompayrac cuts through the jargon and details to reveal, in simple language, the essence of this complex subject: how the immune system fits together, how it protects us from disease and, perhaps most importantly, why it works the way it does. Featuring Dr. Sompayrac's hallmark lively prose and engaging analogies, How the Immune System Works has been rigorously updated for this sixth edition, including the latest information on subjects such as vaccines, immunological memory, and cancer. A highlight of this edition is a new chapter on immunotherapies – currently one of the hottest topics in immunology. Whether you are completely new to immunology, or require a refresher, How the Immune System Works will provide you with a clear and engaging overview of this fascinating subject.

Functional Characterization of IL 39 a Novel Cytokine Produced by Macrophages and Barrier Tissues

Functional Characterization of IL 39  a Novel Cytokine Produced by Macrophages and Barrier Tissues Book
Author : Irina Ushach
Publisher : Unknown
Release : 2015
ISBN : 9781339526997
Language : En, Es, Fr & De

GET BOOK

Book Description :

Cytokines are fundamental components of the immune system and understanding their biology is a necessary step in understanding immune functions in both health and disease. Cytokines represent key mediators of the immune system which act as molecular messages that regulate both the initiation and the phenotype of the immune responses. Because of their central role in shaping immune functions, every new cytokine that has been reported has generated significant interest and has created a new field of research.Here, I describe the identification of a novel cytokine Metrnl, which we proposed to be renamed interleukin-39 (IL-39) to reflect its association with functions of the immune system. I have explored in-depth regulation of IL-39 expression in macrophages and found that its production is regulated by multiple stimuli. Specifically, IL-39 production is highly induced by several cytokines including TNFalpha, IL-17, IL-12 and IL-4 whereas TGFbeta and IFNgamma inhibit its production. Additionally, I have found that physiological levels of IL-39 significantly increase in response to sterile inflammation induced by thioglycollate injection. To elucidate function(s) of IL-39, I have generated a colony of IL-39-/- mice. Initial phenotyping of these mice did not reveal defects in immune cell populations in major immune compartments such as in the thymus, spleen, lymph nodes and bone marrow. Many cytokines such as IFNgamma, IL-4, TGFbeta and IL-10 play a role in humoral immune responses. Therefore, I compared serum IgM, total IgG and IgA levels in IL-39 deficient and wild type mice and found that IL-39-/- mice had increased levels of IgM and decreased levels of total IgG. Among four IgG isotypes, I found significant reduction in IgG3 and IgG2b in serum of IL-39 deficient mice. Furthermore, splenocytes isolated from IL-39-/- mice produced altered levels of several cytokines and chemokines under T-cell activation conditions (with anti-CD3/anti-CD28). For example, splenocytes from IL-39 deficient mice secreted increased amount of CXCL9, CXCL10 and IL-2 while the levels of CCL3, CCL4 and IFNgamma were reduced. Because these cytokines and chemokines play important roles in protection against many pathogens, we sought to determine if IL-39 plays a role in immune response to a murine model of a T. gondii infection. Indeed, we found that IL-39-/- mice were more susceptible to the infection and displayed altered levels of several immune cell populations. This includes reduced levels of CD4+ T cells and CD8+ T cells in spleens of IL-39-/- mice when compared to WT controls. Together, these results indicate that IL-39 is a cytokine that is produced by macrophages in response to inflammation and has important functions in regulating innate and/or adaptive immune responses.

Cytokines Modulators in Plants Chemical and Therapeutics Studies

Cytokines Modulators in Plants  Chemical and Therapeutics Studies Book
Author : Farid Badria,Diaaeldin M. Elimam,Fatma M. Abdel Bar,Hosam M. Zaghloul
Publisher : Unknown
Release : 2019-12-24
ISBN : 9783346098023
Language : En, Es, Fr & De

GET BOOK

Book Description :

Master's Thesis from the year 2016 in the subject Medicine - Pharmacology, language: English, abstract: The aim of the present study is (1) the screening group of plants that are traditionally used as immune-enhancers in an attempt to find the major fractions that are responsible for the activity of these plants and correlating them with already published studies. (2) The Modification of structure of the most active immunomodulatory component through semisynthetic derivatization reactions. The modifications will be made in pursuance of gaining a deeper insight of the structural requirements for immunomodulatory activity. (3) Testing the immunomodulatory activities of both natural and semisynthetic compounds. And (4) studying the mechanism of action of the active compounds as antioxidantand anti-proliferative. Immunity is the body ability to identify and resist harmful pathogen. Metaphorically, the immunity is the body's army that enables prevention as well as fighting of infectious diseasestoprotect self-tissues and organs from damage. The immune system has a multi-layered construction with multiple defense stages. The skin is considered the first barrier of immunity. Then, physiological barriers take place, which are body physical conditions for examplepH and temperature that affordunsuitableenvironments for pathogens to live. Then, if a pathogen has escaped the first barriers and entered the body, it deals with innate immunity as well as acquired and/or adaptive immunity. Both systems consist of number of molecules and cells that interact in a complex manner to detect and eliminate any threat. Detection as well as elimination relay on bonding of immune cellular surface receptors as well as chemical binding to pathogens to trigger complex interaction of signaling of immune response.

Cancer Immunotherapy

Cancer Immunotherapy Book
Author : Jenni Punt
Publisher : Elsevier Inc. Chapters
Release : 2013-06-04
ISBN : 0128059001
Language : En, Es, Fr & De

GET BOOK

Book Description :

Once alerted by the innate immune system to the presence of a pathogen or a cellular abnormality, the adaptive immune system responds by activating and expanding antigen-specific B and T lymphocytes. This chapter focuses specifically on the activation and activities of T lymphocytes, which coordinate the adaptive immune response. We open with a description of where and how naïve T cells first encounter antigen. We then examine what factors influence the differentiation of helper CD4+ T lymphocytes into one of several effector subsets, each of which secretes a distinct subset of cytokines. We follow with a discussion of the origin and function of cytotoxic CD8+ T cells, the lymphocyte with the capacity to directly kill tumor cells. We close with a brief summary of the unique challenges that face the adaptive immune system when it tried to mount a response to a tumor.

Recent Advances in Immunology to Target Cancer Inflammation and Infections

Recent Advances in Immunology to Target Cancer  Inflammation and Infections Book
Author : Jagat Kanwar
Publisher : BoD – Books on Demand
Release : 2012-05-09
ISBN : 9535105922
Language : En, Es, Fr & De

GET BOOK

Book Description :

Immunology is the branch of biomedical sciences to study of the immune system physiology both in healthy and diseased states. Some aspects of autoimmunity draws our attention to the fact that it is not always associated with pathology. For instance, autoimmune reactions are highly useful in clearing off the excess, unwanted or aged tissues from the body. Also, generation of autoimmunity occurs after the exposure to the non-self antigen that is structurally similar to the self, aided by the stimulatory molecules like the cytokines. Thus, a narrow margin differentiates immunity from auto-immunity as already discussed. Hence, finding answers for how the physiologic immunity turns to pathologic autoimmunity always remains a question of intense interest. However, this margin could be cut down only if the physiology of the immune system is better understood. The individual chapters included in this book will cover all the possible aspects of immunology and pathologies associated with it. The authors have taken strenuous effort in elaborating the concepts that are lucid and will be of reader's interest.

Cytokines and Their Therapeutic Potential

Cytokines and Their Therapeutic Potential Book
Author : Manzoor Ahmad Mir
Publisher : Unknown
Release : 2020-03-05
ISBN : 9781536170177
Language : En, Es, Fr & De

GET BOOK

Book Description :

The book "Cytokines and Their Therapeutic Potential" comprises of five chapters and describes the origin, production and scope of cytokines, which are the most important molecules of immune system around which the field of functional immunology revolves. This book describes how the immune system responds to injuries and insults by foreign antigens (bacteria, viruses etc.) and produces cytokines, which then, through various immune response mechanisms, protect the body against pathogenic invasions, how these glycoproteins are involved in the differentiation and maturation of immune cells, how lymph nodes are involved in concentrating the different forms of cytokines, how immunogenicity of a cytokine is affected and how a cytokine is related to the immune response. Various types of cytokines and the organization and expression of cytokine receptors are described separately. The properties, mechanistic function and therapeutic cytokines are also discussed in separate chapters. The characteristics, production and important roles played by different cytokines in research, diagnostics and therapeutics is described separately. Lastly the role of cytokines and chemokine's in infectious diseases and their importance in the detection of various kinds of diseases like cancer, HIV-AIDS, tuberculosis, malaria etc. are discussed in detail separately. The book contains a reasonable number of diagrams, flowcharts and tables. Besides this, various interesting and self-explanatory illustrations are incorporated to make the book useful to the students for whom it is written. The question bank, which includes long answer type, short answer type and multiple choice questions with their answers at the very end of each chapter, is developed to get a full grasp of the topic.

Cytokines

Cytokines Book
Author : Payam Behzadi
Publisher : BoD – Books on Demand
Release : 2020-08-19
ISBN : 178984858X
Language : En, Es, Fr & De

GET BOOK

Book Description :

The human immune system is a complicated biological network that employs a collection of cells, molecules, and proteins. Cytokines play an important role in regulating the innate and adaptive immune systems by different receptors and signaling pathways. As such, they are also implicated in the occurrence of different disorders and diseases. This book presents a comprehensive overview of immunology, the immune system, and cytokines. Chapters cover such topics as the role and importance of tumor necrosis factor (TNF) in the human body, the association of cytokines with different disorders and diseases, and the role of cytokines in dentistry.

T cell Cytokines in the X e n o p u s Immune System

T cell Cytokines in the X  e  n  o  p  u  s   Immune System Book
Author : Laura Haynes
Publisher : Unknown
Release : 1992
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Download T cell Cytokines in the X e n o p u s Immune System book written by Laura Haynes, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Immunology

Immunology Book
Author : Andrew E. Williams
Publisher : John Wiley & Sons
Release : 2011-10-04
ISBN : 1119979889
Language : En, Es, Fr & De

GET BOOK

Book Description :

2012 PROSE Award, Clinical Medicine: Honorable Mention The vast majority of medically important pathogens infect their host across a body surface such as the skin, or across a mucosal tissue such as the respiratory tract or intestines, as these sites are the ones exposed to the external environment. By focusing on immunity at mucosal and body surfaces this book presents a fresh, new approach to the teaching of immunology. After an introduction to the basic structure of the immune system, the book looks at two important families of signalling molecules: cytokines and chemokines, before covering the workings of the mucosal immune system. It continues by examining immunity against the four major groups of pathogens - viruses, bacteria, fungi and parasites, and concludes by looking at disorders of the immune system, mucosal tumour immunology and the process of vaccination. A fresh, new approach to the subject focusing on mucosal and body surfaces. Describes the mucosal immune systems of the gastrointestinal, respiratory and urogenital tracts, as well as the skin. Details the important roles of cytokines and chemokines in an immune response. Separate chapters devoted to immunity against viruses, bacteria, fungi and parasites. Includes chapter summaries, boxes with topics of special interest and an extensive glossary. Clearly written and well- illustrated in full colour throughout. Students across a range of disciplines, including biology, biochemistry, biomedicine, medicine and veterinary sciences, will find this book invaluable, both as an introduction to basic immunology and as a guide to mucosal immune defence mechanisms.

Immunopharmacology

Immunopharmacology Book
Author : Manzoor M. Khan
Publisher : Springer
Release : 2016-06-21
ISBN : 3319302736
Language : En, Es, Fr & De

GET BOOK

Book Description :

The concept of immunotherapy was in infancy when the first edition was written; since then, major advances have been made, not only with several prominent clinical trials, but also with the approval of cell-based therapy by the FDA for the treatment of cancer in 2010. These events resulted in a gradually narrowing gap between early scientific knowledge and the late development of immune-based therapies. Consequently, the significance and magnitude of these advances warranted a revision of this contribution; this revised edition will provide a deeper understanding of the recent advances and discoveries related to the function of the immune response and their applications in the development of novel therapies to treat human diseases. Some of the key discoveries during the past five years include: the identification of the new subsets of helper T cells; new cytokines and their networks; and novel signal transduction mechanisms. For example, the identification of TH17 subset of helper T cells, in addition to TH1 and TH2 cells, not only advanced our understanding of the function of the basic immune response, but also raised our awareness of the possible etiology and pathogenesis of diseases such as allergy, asthma, rheumatoid arthritis, and other auto-immune/immune system based diseases. The newly identified powerful cytokine networks, that regulate both innate and acquired immune responses, emerged as a result of the finding of new cell types such as innate lymphoid cells and iNKT. Identification of the novel cytokines and their networks has advanced our knowledge of the mechanisms involved in the maintenance of tissue homeostasis, including inflammation and tissue repair during stress and injury. The development of HIV vaccines has also seen dramatic changes over the last few years. There has been a shift from a sole focus on T cell vaccines to a holistic approach that pertains to the induction of both humoral and cellular elements. This entails the induction of antibodies – both binding and neutralizing – to prevent infection. The cellular vaccination produces a safety net of CD8+ T-cell responses to suppress the replication of the virus in the infected patients, and both of the effector arms are aided by helper T cells. From the perspective of clinical applications, significant advances have also been made in: oral immunotherapy for allergic disease, the possible treatment of HIV infection, the development of new monoclonal antibodies and their fragments to treat human diseases, and immune cell based therapies for cancer.

The Innate Immune System

The Innate Immune System Book
Author : Tom Monie
Publisher : Academic Press
Release : 2017-02-16
ISBN : 0081007582
Language : En, Es, Fr & De

GET BOOK

Book Description :

The Innate Immune System: A Compositional and Functional Perspective focuses on the components and functionality of the innate immune system, detailing how they work in their own right, and then progressing to cover their relevance to disease and how they interface with the adaptive response. Despite the growing appreciation of the importance of the innate immune system, many classical immunology books still focus predominantly on the adaptive immune response. Not only is this unbalanced, but it fails to reflect the growing synergy between the activation and function of the innate response and the final nature of adaptive response. This book fills the gap in knowledge that is needed to fully understand and appreciate the topic. Provides a clear, but simple picture of the main principle of innate immunity and the interlink with adaptive responses Fulfills an unmet need in the area of innate immunity Gives a constructive and progressive approach to introducing and explaining the key players in the innate immune response Introduces and explains the key players in the innate immune response with a constructive and progressive approach Presents the components of the innate response and shows how these interrelated areas connect with one another from a functional perspective Enables the reader to gradually increase their level of understanding and knowledge without the risk of becoming confused, thereby ensuring they fully comprehend the integrated signaling pathways

Pharmacology of Cytokines

Pharmacology of Cytokines Book
Author : Alberto Mantovani,Charles A. Dinarello,Petro Ghezzi
Publisher : Oxford University Press, USA
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Cytokines are polypeptide mediators which act as communication signals among cells of the immune system as well as among other cells and tissues in the body. They are a heterogeneous and complex group and include interferons, tumor necrosis factor and chemokines. They play a key role in homeostasis and inhost defense and are involved in such inflammatory and autoimmune diseases such as rheumatoid arthritis as well as infectious diseases such as HIV infection and septic shock. Modulation of the production and action of cytokines, as well as their exploitation as therapeutic agents has been the object of intense and competitive research. This book overviews the field of cytokine research and describes the various approaches that have been taken to develop the pharmacology of these novel mediators. The pharmacology of cytokines is an exploding area which is entering the clinical arena. The book in the framework of the immunobiology of cytokines, examines the interactions with the cytokine system of a variety of compounds ranging from simple synthetic chemicals to biotechnological products. In addition to examinig individual agents and approaches, the book examines the pathophysiology of individual body systems and analyzes specific contexts for the pathophysiology of these mediators as well as pharmacological approaches for their control.

The Ageing Immune System and Health

The Ageing Immune System and Health Book
Author : Valquiria Bueno,Janet M. Lord,Thomas A. Jackson
Publisher : Springer
Release : 2016-10-03
ISBN : 3319433652
Language : En, Es, Fr & De

GET BOOK

Book Description :

The present book intends to provide an update on immunosenescence and how deficiencies in the immune system contribute to a higher susceptibility to infections, decline in organ function, reduced vaccination responses, age-related disease and the ageing process itself, negatively affecting longevity. Our focus is on the main changes in immune system cells and their products occurring during the ageing process and the possible consequences for health and disease. This includes: discussion of the modulatory and/or suppressive mechanisms associated with the alterations in T regulatory cells, B regulatory cells and Myeloid Derived Suppressor cells; changes in the immune system observed in chronic neurodegenerative diseases, cancer, lung disease and frailty will also be discussed. Most importantly we provide recent literature information about possible interventions (focusing on physical activity) that could alleviate the negative effects of immunosenescence. The Ageing Immune System and Health is a comprehensive guide on the field intended to all physicians, researchers, professors and students interested on relationship between immune system, ageing and health.