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The Complement FactsBook

The Complement FactsBook Book
Author : Scott R. Barnum,Theresa N. Schein
Publisher : Academic Press
Release : 2017-10-19
ISBN : 012810421X
Language : En, Es, Fr & De

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Book Description :

The Complement FactsBook, Second Edition, provides in-depth insights and an overview of the components of the complement system. This new edition highlights the use of newly recommended complement nomenclature, covering new pathways and proteins and adding information on mouse homologs. It is a completely revised and updated edition containing entries on all components of the complement system, and is an excellent source of one-stop shopping for complement information and references. It is the most convenient compilation of biochemical, biological and molecular biology for complementologists and those new in the field. This new edition is expanded to include relevant updates and topics that have evolved since the last edition was published, including C1q and Lectins, C3 Family, Serine Proteases, Serum Regulators of Complement Activation, Cell Surface Proteins, and Terminal Pathway Proteins. Domain Structure diagrams are incorporated to clearly illustrate the relationships between all the complement proteins, both within families and between families. Introduces complement function, simply described for each function Includes the cDNA sequences that are marked with intron/exon boundaries, facilitating genetic studies Presents detailed structural information, including cDNA and gene structure for all proteins Incorporates domain structures diagrams, which beautifully illustrate the relationship between all the complement proteins, both within, and between, families

The Complement FactsBook

The Complement FactsBook Book
Author : Scott R. Barnum,Bernard J. Morley,Mark J. Walport
Publisher : Academic Press
Release : 1999-10-28
ISBN : 0080529550
Language : En, Es, Fr & De

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Book Description :

The Complement FactsBook contains entries on all components of the Complement System, including C1q and Lectins, C3 Family, Serine Proteases, Serum Regulators of Complement Activation, Cell Surface Proteins, and Terminal Pathway Proteins. Domain Structure diagrams are incorporated to clearly illustrate the relationships between all the complement proteins, both within families and between families. The FactsBook also includes the cDNA sequences, marked with intron/exon boundaries, which will facilitate genetic studies. Key Features * Includes the cDNA sequences, marked with intron/exon boundaries, facilitating genetic studies * Presents detailed structural information including cDNA and gene structure for all proteins * Introduces complement function, simply described for each function * Data is as up-to-date as possible, including unpublished work from many contributors * Incorporates domain structures diagrams, which beautifully illustrate the relationship between all the complement proteins, both within, and between, families * Each chapter has been written by an expert in the field * Data is as up-to-date as possible, including unpublished work from many contributors Entries provide information on: * Alternative nomenclature * Physiochemical properties * Structure and function * Tissue distribution and regulation expression * Protein sequence/modules * Chromosomal location * Genomic structure * Database accession numbers * Deficiency and polymorphic variants * Key references

The Nuclear Receptor FactsBook

The Nuclear Receptor FactsBook Book
Author : Vincent Laudet,Hinrich Gronemeyer
Publisher : Elsevier
Release : 2001-10-24
ISBN : 9780080537801
Language : En, Es, Fr & De

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Book Description :

The FactsBook Series has established itself as the best source of easily accessible and accurate facts about protein groups. They use an easy-to-follow format and are researched and compiled by experts in the field. This Factsbook is devoted to nuclear receptors. The first section presents an introduction and describes the mode of action of the receptors in general. The second section of the book contains detailed entries covering each type of receptor. Entries provide information on: Nomenclature and structure, Isolation, DNA binding properties, Ligands, Expression, Target genes, Knockouts, Disease association, Gene structure, promoter and isoforms, Chromosomal location, Amino acid sequences, Key references

The Cytokine Factsbook

The Cytokine Factsbook Book
Author : Katherine A. Fitzgerald,Robin E. Callard,Luke A. J. O'Neill,Andy J. H. Gearing
Publisher : Academic Press
Release : 2001
ISBN : 9780121551421
Language : En, Es, Fr & De

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Book Description :

Completely revised and expanded, this second edition of The Cytokine FactsBook is the most up-to-date reference manual available for all current well-characterized interleukins, cytokines, and their receptors. An additional 52 cytokines are included, doubling the number of entries from the previous edition. The key properties of each cytokine are described and presented in a very accessible format with diagrams for each of the receptors. The Cytokine FactsBook includes free online access to the regularly updated Cytokine Webfacts. Cytokine Webfacts is a web-based comprehensive compendium of facts about cytokines and their receptors that includes a variety of data representations, such as text, signal pathway diagrams and 3D images. This exciting resource is integrated into other databases via hypertext links to provide a unique network, and contains a web-enabled version of RasMol for viewing structures.

The Complement System

The Complement System Book
Author : Janos Szebeni
Publisher : Springer Science & Business Media
Release : 2004-06-10
ISBN : 1402080557
Language : En, Es, Fr & De

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Book Description :

The Complement System: Novel Roles in Health and Disease surveys the advances in basic and applied research on the complement system over the past few years. Complement is a major protein network in blood that has been traditionally conceived as part of the immune system, a proinflammatory cascade engaged in nonspecific antimicrobial defence. However, it became clear recently that this system also plays an essential role in specific, adaptive immune responses, as well as in many basic physiological processes including cardiovascular regulation, pregnancy and tissue regeneration, just to mention a few. Complement proteins are widely involved in the immune evasion tactics of infectious microbes and cancer cells, and derangement of complement function contributes to numerous autoimmune, allergic and acute catastrophic diseases. Because pharmacological manipulation of the complement system provides therapeutic benefit in many of these conditions, we may be very close to widespread clinical use of a new class of drugs influencing complement activation or action. In fact, complementology may be one of the most versatile and dynamic subdisciplines in medicine today. The 25 reviews of this volume, written by prominent experts, provide state-of-art insights into the various aspects of an amazing progress in this field.

The Cytokine Factsbook

The Cytokine Factsbook Book
Author : Robin E. Callard,A. J. H. Gearing
Publisher : Unknown
Release : 1994
ISBN : 9780121551438
Language : En, Es, Fr & De

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Book Description :

How do you keep track of basic information on the proteins you work with? Where do you find details of their physicochemical properties, amino acid sequences, gene organization? Are you tired of scanning review articles, primary papers and databases to locate that elusive fact? The Academic Press FactsBook series will satisfy scientists and clinical researchers suffering from information overload. Each volume provides a catalogue of the essential properties of families of molecules. Gene organization, amino acid sequences, physicochemical properties, and biological activity are presented using a common, easy-to-follow format. Taken together they compile everything you wanted to know about proteins but were too busy to look for. More than 45 entries on human and murine cytokines and their receptors, including: * Cytokine receptor superfamilies * Interleukins 1-15 * Other cytokines * Additional information is provided on: * Alternative nomenclature * Cross reactivity * Sources * Bio assays * Physicochemical properties of the cytokines and their receptors * 3-D structure * Gene structure and chromosomal localisation * Amino acid sequences of the cytokines and their receptors * Receptors * Receptor distribution * Signal transduction * Chromosomal location of the receptors * References

The Leucocyte Antigen Factsbook

The Leucocyte Antigen Factsbook Book
Author : A. Neil Barclay,Marion H. Brown,S. K. Alex K. Alex Law,Andrew J. McKnight,Michael G. Tomlinson,P. Anton van der Merwe
Publisher : Elsevier
Release : 1997-06-22
ISBN : 0080535437
Language : En, Es, Fr & De

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Book Description :

A volume in the popular FactsBook Series, the First Edition of The Leucocyte Antigen FactsBook was hugely successful. The new Second Edition has been completely revised, updated, and expanded by 65% to include new findings and up-to-date key references. The introductory chapters have also been updated, especially in terms of nomenclature, the role of the World Wide Web, and new structural data. The Leucocyte Antigen FactsBook, Second Edition contains more than 200 entries, with approximately 70 new entries, on all the molecules specifically expressed in the surface of cells of the haematopoietic system, including all characterized CD antigens, antigen receptors, MHC antigens, adhesion molecules, and cytokine receptors. This FactsBook will be of enormous value to immunologists, cell biologists, biochemists, and endocrinologists. Key Features * Completely up-to-date * Revised and expanded to include over 70 new entries * More than 200 entries in total, plus additional introductory material * New structural data * New nomenclature for CD and related molecules covered

The Gene Knockout Factsbook Two Volume Set

The Gene Knockout Factsbook  Two Volume Set Book
Author : Anonim
Publisher : Academic Press
Release : 1998-10-26
ISBN : 9780080532363
Language : En, Es, Fr & De

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Book Description :

The FactsBooks Series has established itself as the best source of easily-accessible and accurate facts about protein groups. Described as "a growing series of excellent manuals" by Molecular Medicine Today, and "essential works of reference" by Trends in Biochemical Sciences, the FactsBooks have become the most popular comprehensive data resources available. Using an easy-to-follow format and drawing from meticulous research, the Factsbooks will keep you up-to-date with the latest advances in structure, amino acid sequences, physicochemical properties, and biological activity. The Gene Knockout FactsBook contains entries, grouped into subject disciplines, covering immunology, neurobiology, development, cancer, and other knockouts. It describes more than 600 gene knockouts described and listed in alphabetical order for easy reference. Key Features * Entries provide information on: * general description of the protein and its function * gene symbol and database accession number * knockout construct * mouse phenotype * key references

Systemic Lupus Erythematosus

Systemic Lupus Erythematosus Book
Author : George Tsokos
Publisher : Academic Press
Release : 2020-04-07
ISBN : 0128145528
Language : En, Es, Fr & De

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Book Description :

This completely updated and expanded second edition of Systemic Lupus Erythematosus; Basic, Applied and Clinical Aspects includes topics not covered previously with contributors who are at the forefront of each specific topic and with a global appeal. Each chapter will be short and will be presented critically and not in an encyclopedic manner and with selected, up to 50, references which should be valuable to a wider audience. As a seasoned (not old) editor, he worked with practically all the contributors and this enables to achieve the goals of the book. This manual to SLE combines basic science with clinical science to provide a translational treatment of the disease. Systemic Lupus Erythematosus, a Manual, is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries. This new edition includes new chapters on: Microbiota and lupus by Dr. Greg Silverman- a pioneer on this topic Innate immune cells and lupus Monogenic lupus And includes also new techniques and ideas that have been developed for the study of the SLE process and related conform all invariant systems like couplings with Gaussian fields and the related "geometries", measures on loops, and new perspectives on CFT. Distills current understanding of the cellular, molecular, genetic and environmental factors that instigate and drive the disease Includes comprehensive coverage of clinical features, including fatigue, organ system manifestations, overlap syndromes, infections, and more Conveys the very latest understanding of mechanisms of tissue damage, including immune complexes, antibodies, and other mechanisms that lead to organ damage Discusses the latest treatment options on disease modifying or disease controlling agents Provides 'one stop' coverage of all the latest scientific and clinical developments in SLE: new concepts in epidemiology, disease activity measures and outcomes; new concepts in immunoregulation, genetic and pathogenic mechanisms; new understanding and novel presentation of the processes of tissue/organ damage; comprehensive coverage of clinical features; and the very latest concepts in treatment

The Immunoglobulin FactsBook

The Immunoglobulin FactsBook Book
Author : Marie-Paule Lefranc,Gerard Lefranc
Publisher : Academic Press
Release : 2001-05-23
ISBN : 0080574475
Language : En, Es, Fr & De

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Book Description :

The FactsBook series has established itself as the best source of easily accessible and accurate facts about protein groups. Books in the series use an easy-to-follow format and are meticulously researched and compiled by experts in the field. The Immunoglobulin FactsBook is the first published reference for all 203 human functional and ORF immunoglobulin genes. It is complete and standardized and employs nomenclature approved by the HUGO Nomenclature Committee.

The Extracellular Matrix Factsbook

The Extracellular Matrix Factsbook Book
Author : Shirley Ayad,Ray Boot-Handford,Martin Humphries,Karl Kadler,Adrian Shuttleworth
Publisher : Elsevier
Release : 1998-03-27
ISBN : 0080531512
Language : En, Es, Fr & De

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Book Description :

The Second Edition of The Extracellular Matrix FactsBook has been completely revised, updated and expanded by over 50 percent. It contains over 85 entries on the diverse group of macromolecules that assemble toform the extracellular matrix. Entries provide information on molecular structure, isolation, primary structure, structural and functional sites, gene structure, database accession numbers, and key references. Key Features * Compiled by members of one of the foremost centers of matrix biochemistry in the world * Contains over 30 new entries, with all previous entries being revised and updated * Includes new entries on proteinases involved in the deposition of the extracellular matrix * Presents 3D ribbon diagrams in cases where the protein structure is now known

Rheumatology and Immunology Therapy

Rheumatology and Immunology Therapy Book
Author : Larry W. Moreland
Publisher : Springer Science & Business Media
Release : 2004-07-20
ISBN : 3540206256
Language : En, Es, Fr & De

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Book Description :

Entries in a practical A to Z Format Highly therapy-focused Uniform and clearly arranged entries for ease of reference Comprehensive information on symptoms and therapeutical possibilities of rheumatologic and musculoskeletal diseases as well as drugs Written by leading experts in the field

The Blood Group Antigen FactsBook

The Blood Group Antigen FactsBook Book
Author : Marion E. Reid,Christine Lomas-Francis,Martin L. Olsson
Publisher : Academic Press
Release : 2012-11-07
ISBN : 0240821300
Language : En, Es, Fr & De

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Book Description :

The Blood Group Antigen FactsBook — winner of a 2013 Highly Commended BMA Medical Book Award for Internal Medicine — has been an essential resource in the hematology, transfusion and immunogenetics fields since its first publication in the late 1990s.The third edition of The Blood Group Antigen FactsBook has been completely revised, updated and expanded to cover all 33 blood group systems. It blends scientific background and clinical applications and provides busy researchers and clinicians with at-a-glance information on over 330 blood group antigens, including history and information on terminology, expression, chromosomal assignment, carrier molecular description, functions, molecular bases of antigens and phenotypes, effect of enzymes/chemicals, clinical significance, disease associations and key references. Highly Commended 2013 BMA Medical Book Award for Internal Medicine Includes more than 330 entries on blood group antigens in individual factsheets Offers a logical and concise catalogue structure for each antigen in an improved interior design for quick reference Written by three international experts from the field of immunohematology and transfusion medicine

Handbook of Proteolytic Enzymes

Handbook of Proteolytic Enzymes Book
Author : Alan J. Barrett,Neil D. Rawlings,J. Fred Woessner
Publisher : Academic Press
Release : 2012-10-30
ISBN : 0123822203
Language : En, Es, Fr & De

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Book Description :

The third edition of the Handbook of Proteolytic Enzymes is a comprehensive reference work for the enzymes that cleave proteins and peptides, written by acknowledged experts in the field and containing over 850 chapters. Each chapter is organized into sections describing the name and history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features for a specific peptidase. There are also introductory chapters on peptidase classification and mechanisms and a comprehensive index. For the first time, the Handbook is also available online via Elsevier's ScienceDirect platform as well as a three-volume book. The online version has enhanced options, including online multimedia, cross-referencing capabilities, integrated online delivery and closer integration with the online MEROPS database of peptidases and their inhibitors. This reference work is a must-have for biochemists, biotechnologists, molecular biologists and students in these disciplines, and will be of great interest to pharmaceutical and biotechnology companies. Contains over 830 chapters Covers new research in therapeutics and drug trials Supplies content written by experts in the field

The T Cell Receptor FactsBook

The T Cell Receptor FactsBook Book
Author : Marie-Paule Lefranc,Gerard Lefranc
Publisher : Academic Press
Release : 2001-08-07
ISBN : 9780124413528
Language : En, Es, Fr & De

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Book Description :

The T Cell Receptor FactsBook contains entries on all the 176 functional variable, diversity, joining, and constant regions of the human T cell receptor, including alpha, beta, gamma, and delta loci. Introductory chapters summarize information of T cell receptor chain synthesis, chromosomal location, and an overview of the human T cell receptor loci.

Molecular Aspects of Innate and Adaptive Immunity

Molecular Aspects of Innate and Adaptive Immunity Book
Author : Kenneth B M Reid,Robert B Sim
Publisher : Royal Society of Chemistry
Release : 2008-09-29
ISBN : 1847558844
Language : En, Es, Fr & De

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Book Description :

The understanding, at the molecular level, of the interactions between innate and adaptive arms of the immune system is currently a hot topic, particularly to those interested in immunology - especially susceptibility to infectious diseases. This book provides a survey of topics, in the area of innate and adaptive immunity, which have been researched within the MRC Immunochemistry Unit, at Oxford University, over a period of forty years. The topics include: " antibody structure - for which the first Director of the Immunochemistry Unit, Professor RR Porter, was awarded a Nobel prize in 1972 " the characterization of membrane proteins on lymphoid cells - leading to the concept of these molecules belonging to an immunoglobulin super family " the proteins of the human serum complement system - one of the body's major defences against microbial infection " the human cell -surface integrins and the hyaluronan- binding proteins, which are involved in regulation of inflammation at cell surfaces and within the extracellular matrix " the family of collectin molecules - containing distinct globular carbohydrate -binding domains linked to collagen-like regions - which play important roles in innate immunity in the lungs and bloodstream by immediate recognition and clearance of microbial pathogens Each chapter in the book gives a brief historical background to a topic and then provides a survey of recent advances in the field and are written by internationally recognised renowned experts. The theme running through the chapters is that of protein structure-function relationships - including, amongst others, descriptions of quaternary structures of large oligomeric proteins, of Factor H and C1q binding to specific ligands, and of the chemistry of the mechanism of catalysis of covalent binding of activated C3 and C4 proteins to nucleophilic groups on microbial surfaces. In several chapters excellent descriptions are given with respect to how the immune system can be recruited to combat microbial infection - via proteins of both the innate and adaptive immune systems. The book also includes notable chapters which are excellent examples of the importance of how the isolation, characterisation, protein engineering and crystallisation has resulted in a full understanding of complex protein-protein interactions involved in the recognition and triggering events of important sections of the immune system: -Structure and Function of the C1 Complex - GÚrard J. Arlaud -Chemical Engineering of Therapeutic Antibodies - George T Stevenson -Leukocyte surface proteins - purification and characterisation - A. Neil Barclay -Cell Surface Integrins - Suet-Mien Tan and S.K. Alex Law This book is aimed primarily at established senior research scientists, postdoctoral research scientists and PhD students who have an interest in proteins of the immune system. However, the wide range of immunity system topics, while staying broadly within innate/adaptive immunity will also appeal to a wider audience.

Ion Channel Factsbook

Ion Channel Factsbook Book
Author : William J. Brammar
Publisher : Academic Press
Release : 1998-10-16
ISBN : 9780080535203
Language : En, Es, Fr & De

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Book Description :

The Academic Press FactsBooks series has established itself as the best source of easily-accessible and accurate facts about protein groups. Described as 'a growing series of excellent manuals' by Molecular Medicine Today, and 'essential works of reference' by Trends in Biochemical Sciences, the FactsBooks have become the most popular comprehensive data resources available. As they are meticulously researched and use an easy-to-follow format, the FactsBooks will keep you up-to-date with the latest advances in structure, amino acid sequences, physicochemical properties, and biological activity. In a set of four interrelated volumes, The Ion Channel FactsBook provides a comprehensive framework of facts about channel molecules central to electrical signaling phenomena in living cells. The fourth volume is devoted to Voltage-gated Channel Families, including those molecular complexes activated or modulated by calcium, potassium, and chloride. Nomenclature Expression Sequence Analyses Structure and function Electrophysiology Pharmacology Information retrieval

The Blood Group Antigen FactsBook

The Blood Group Antigen FactsBook Book
Author : Marion E. Reid,Christine Lomas-Francis
Publisher : Elsevier
Release : 2003-09-08
ISBN : 9780080476155
Language : En, Es, Fr & De

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Book Description :

The second edition of The Blood Group Antigen FactsBook provides key information relating to human red blood cell membrane components carrying blood group antigens, the molecular basis of the antigens, their serological characteristics, and the clinical significance of blood group antibodies. The data on this group of molecules has expanded greatly since the previous edition was published five years ago. Topics include: history and information on terminology, expression, chromosomal assignment, carrier molecule description, molecular basis of antigens, effect of enzymes/chemicals, clinical significance, disease association, phenotypes, glycotypes and key references. Over 250 fully updated entries on blood group antigens, formatted on single pages for easy use Inclusion of RHAG blood group system and over twenty new antigens Basic science paired with clinical applications to give context to information Full-color illustrations, gene maps and charts Both traditional and ISBT-sanctioned naming conventions included

The Adhesion Molecule FactsBook

The Adhesion Molecule FactsBook Book
Author : Anonim
Publisher : Elsevier
Release : 2000-08-24
ISBN : 9780080525976
Language : En, Es, Fr & De

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Book Description :

This updated and expanded Second Edition of The Adhesion Molecule FactsBook has nearly double the number of entries of the First Edition, and provides a compendium of the major cell surface adhesion molecules. The introductory chapters detail the organization of the data in the entries section, provide a background to the main adhesion molecule families, and inform the reader how to access information on adhesion molecules on the Internet. The entries have been designed to allow the reader to quickly establish the main structure and functional features of each molecule and where to find information. alternative nomenclature tissue distribution and regulation of expression ligands gene organization and chromosomal location protein structure and molecular weights amino acid sequence of the most commonly studied organisms PIR, SWISSPROT, and EMBL/GenBank accession numbers biological function key references

Glycobiology and Medicine

Glycobiology and Medicine Book
Author : John S. Axford
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1461500656
Language : En, Es, Fr & De

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Book Description :

This book contains the Proceedings of the Sixth Jenner Glycobiology and Medicine Symposium, held 14-17 September, 2002, in Seillac, France. This book highlights the latest developments in glycoimmunology, including glycosylation-dependent bacterial and viral infections, lectin and proteoglycan-dependent interactions in leukocyte homing processes to lymphoid tissues and inflamed tissues, congenital defects in glycosylation of glycoproteins and glycolipids, and the role of carbohydrates in tumour development and neuropathology, including Creutzfeldt-Jakob disease.