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The Common Marmoset In Captivity And Biomedical Research

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The Common Marmoset in Captivity and Biomedical Research

The Common Marmoset in Captivity and Biomedical Research Book
Author : Robert P. Marini,Lynn M. Wachtman,Suzette D. Tardif,Keith Mansfield,James G. Fox
Publisher : Academic Press
Release : 2018-11-19
ISBN : 012811830X
Language : En, Es, Fr & De

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Book Description :

The Common Marmoset in Captivity and Biomedical Research is the first text dedicated exclusively to this species,filling an urgent need for an encyclopedic compilation of the existing information. Sponsored by the American College of Laboratory Animal Medicine as part of its authoritative Blue Book series, the book covers the biology,management, diseases, and clinical and research applications of this important species. The common marmoset (Callithrix jacchus) has come of age in the scientific community as a behaviorally complex, cognitively advanced,small, prolific, and easily maintained nonhuman primate with many of the advantages of larger animals, such as macaques, but without the attendant physical and zoonotic risks. Marmosets are currently being used in diverse areas of inquiry, including vision and auditory research, infectious disease, cognitive neuroscience, behavior, reproductive biology, toxicology and drug development, and aging. The marmoset genome has been sequenced and there is currently an intensive effort to apply gene editing technologies to the species. The creation of transgenic marmosets will provide researchers with a small nonhuman primate model to study a number of poorly understood disorders, like autism. Presents a complete view of the marmoset, covering their biology and management, diseases and clinical applications, and research applications Includes contributions from renowned and international authors and editors Provides the first authoritative and comprehensive treatment of marmosets in biomedical research as part of the ACLAM Series

Care Use and Welfare of Marmosets as Animal Models for Gene Editing Based Biomedical Research

Care  Use  and Welfare of Marmosets as Animal Models for Gene Editing Based Biomedical Research Book
Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use
Publisher : National Academies Press
Release : 2019-08-26
ISBN : 0309488516
Language : En, Es, Fr & De

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Book Description :

The marmoset, a type of small monkey native to South America, is a research model of increasing importance for biomedical research in the United States and globally. Marmosets offer a range of advantages as animal models in neuroscience, aging, infectious diseases, and other fields of study. They may be particularly useful for the development of new disease models using genetic engineering and assisted reproductive technologies. However, concerns have been voiced with respect to the development of new marmoset-based models of disease, ethical considerations for their use, the supply of marmosets available for research, and gaps in guidance for their care and management. To explore and address these concerns, the Roundtable on Science and Welfare in Laboratory Animal Use hosted a public workshop on October 22-23, 2018, in Washington, DC. The workshop focused on the availability of marmosets in the United States and abroad; animal welfare and ethical considerations stemming from the use of wildtype and genetically modified marmosets; and standards of housing and care, dietary needs, and feeding requirements for marmosets in captivity. This publication summarizes the presentations and discussions from the workshop.

Reproduction in New World Primates

Reproduction in New World Primates Book
Author : J.P. Hearn
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 9400973225
Language : En, Es, Fr & De

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Book Description :

The New World primates are becoming widely used in scientific and medical work in fields from anthropology to zoology, behaviour to urology. They have unique attributes for studies in cancer, infectious diseases, genetics, virology and reproduction. However, it is only now that their reproductive physiology is being clarified in any depth and this book is a first synthesis of that knowledge. The nine authors involved in this project have presented an up to date account of the major New World species used in biological and medical science. In addition to their distribution and conservation in the wild, essential biological data from laboratory studies are presented on reproductive cycles, gestation length, seasonal breeding, puberty and other factors. The major applications of these species in research are explored. Whenever possible, research workers should steer away from using endangered species in their studies. The New World monkeys used in research in any numbers are still fairly common ~n the wild, yet their greatest advantages are ~n their smalle size and high fecundity. This makes possible the establishment of self sustaining captive breeding colonies at a fraction of the time and cost necessary for the more conventional Old World laboratory primates. Consequently the drain on wild stocks need not be extensive as only breeding nuclei should be necessary.

Behavioral Biology of Laboratory Animals

Behavioral Biology of Laboratory Animals Book
Author : Kristine Coleman,Steven J. Schapiro
Publisher : CRC Press
Release : 2021-09-01
ISBN : 0429671296
Language : En, Es, Fr & De

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Book Description :

This 30-chapter volume informs students and professionals about the behavioral biology of animals commonly housed in laboratory and other captive settings. Each species evolved under specific environmental conditions, resulting in unique behavioral patterns, many of which are maintained in captivity even after generations of breeding. Understanding natural behavior is therefore a critical part of modern animal care practices. The descriptions, data, guidance, resources, and recommendations in this book will help the reader understand their animals better, refine the care and treatment that they receive, and improve the well-being, welfare, and wellness of their animals. The book is divided into three sections, all focusing on aspects of the behavioral biology of animals found in laboratories and related research settings. After five introductory chapters, 25 chapters are dedicated to specific taxonomic groups (including mice, zebrafish, zebra finches, reptiles, macaques) while a concluding section of ethograms provides a centralized resource for those interested in understanding, and potentially quantifying, animal behavior. The Behaviorial Biology of Laboratory Animals will provide anyone working in maintenance, care, and/or research programs that involve laboratory animals with information about the way the animals live in the wild, and the way that they should live in captive research settings. Many of the guidelines and recommendations will also be valuable to those managing and working with animals in other environments, including zoological parks, aquaria, and sanctuaries.

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment Book
Author : Joerg Bluemel,Sven Korte,Emanuel Schenck,Gerhard Weinbauer
Publisher : Academic Press
Release : 2015-03-13
ISBN : 012417146X
Language : En, Es, Fr & De

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Book Description :

The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more Includes practical examples on techniques and methods to guide your daily practice Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes

Comparative Biology of Aging

Comparative Biology of Aging Book
Author : Norman S. Wolf
Publisher : Springer Science & Business Media
Release : 2010-01-08
ISBN : 904813465X
Language : En, Es, Fr & De

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Book Description :

determined by an inability to move in response to touch. C. elegans develop through four larval stages following hatching and prior to adulthood. Adult C. elegans are reproductive for about the rst week of adulthood followed by approximately two weeks of post-reproductive adulthood prior to death. Life span is most commonly measured in the laboratory by maintaining the worms on the surface of a nutrie- agar medium (Nematode Growth Medium, NGM) with E. coli OP50 as the bacterial food source (REF). Alternative culture conditions have been described in liquid media; however, these are not widely used for longevity studies. Longevity of the commonly used wild type C. elegans hermaphrodite (N2) varies ? from 16 to 23 days under standard laboratory conditions (20 C, NGM agar, E. coli OP50 food source). Life span can be increased by maintaining animals at lower ambient temperatures and shortened by raising the ambient temperature. Use of a killed bacterial food source, rather than live E. coli, increases lifespan by 2–4 days, and growth of adult animals in the absence of bacteria (axenic growth or bac- rial deprivation) increases median life span to 32–38 days [3, 23, 24]. Under both standard laboratory conditions and bacterial deprivation conditions, wild-derived C. elegans hermaphrodites exhibit longevity comparable to N2 animals [25].

Management of Animal Care and Use Programs in Research Education and Testing

Management of Animal Care and Use Programs in Research  Education  and Testing Book
Author : Robert H. Weichbrod,Gail A. (Heidbrink) Thompson,John N. Norton
Publisher : CRC Press
Release : 2017-09-07
ISBN : 1498748457
Language : En, Es, Fr & De

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Book Description :

AAP Prose Award Finalist 2018/19 Management of Animal Care and Use Programs in Research, Education, and Testing, Second Edition is the extensively expanded revision of the popular Management of Laboratory Animal Care and Use Programs book published earlier this century. Following in the footsteps of the first edition, this revision serves as a first line management resource, providing for strong advocacy for advancing quality animal welfare and science worldwide, and continues as a valuable seminal reference for those engaged in all types of programs involving animal care and use. The new edition has more than doubled the number of chapters in the original volume to present a more comprehensive overview of the current breadth and depth of the field with applicability to an international audience. Readers are provided with the latest information and resource and reference material from authors who are noted experts in their field. The book: - Emphasizes the importance of developing a collaborative culture of care within an animal care and use program and provides information about how behavioral management through animal training can play an integral role in a veterinary health program - Provides a new section on Environment and Housing, containing chapters that focus on management considerations of housing and enrichment delineated by species - Expands coverage of regulatory oversight and compliance, assessment, and assurance issues and processes, including a greater discussion of globalization and harmonizing cultural and regulatory issues - Includes more in-depth treatment throughout the book of critical topics in program management, physical plant, animal health, and husbandry. Biomedical research using animals requires administrators and managers who are knowledgeable and highly skilled. They must adapt to the complexity of rapidly-changing technologies, balance research goals with a thorough understanding of regulatory requirements and guidelines, and know how to work with a multi-generational, multi-cultural workforce. This book is the ideal resource for these professionals. It also serves as an indispensable resource text for certification exams and credentialing boards for a multitude of professional societies Co-publishers on the second edition are: ACLAM (American College of Laboratory Animal Medicine); ECLAM (European College of Laboratory Animal Medicine); IACLAM (International Colleges of Laboratory Animal Medicine); JCLAM (Japanese College of Laboratory Animal Medicine); KCLAM (Korean College of Laboratory Animal Medicine); CALAS (Canadian Association of Laboratory Animal Medicine); LAMA (Laboratory Animal Management Association); and IAT (Institute of Animal Technology).

Nursery Rearing of Nonhuman Primates in the 21st Century

Nursery Rearing of Nonhuman Primates in the 21st Century Book
Author : Gene P. Sackett,Gerald Ruppenthal,Kate Elias
Publisher : Springer Science & Business Media
Release : 2010-05-10
ISBN : 0387256407
Language : En, Es, Fr & De

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Book Description :

Nursery Rearing of Nonhuman Primates in the 21st Century describes how and why nursery rearing of primates can produce adaptable juveniles and adults for research, conservation, and display-educational purposes. The volume details the history of nursery rearing since the mid-19th century, the outcomes of varied nursery rearing methods, the contemporary goals of nursery rearing as well as reference data derived from species commonly reared in nursery or hand-feeding situations. Examples of the changing goals of nursery rearing covered in this volume are the need for biological containment in disease research, the production of specific pathogen-free colonies by removal of neonates from the mother, the production of phenotypes for genetic and molecular biology studies, and the breeding of endangered species for conservation or research purposes.

Nonhuman Primates in Biomedical Research

Nonhuman Primates in Biomedical Research Book
Author : Christian R. Abee,Keith Mansfield,Suzette D. Tardif,Timothy Morris
Publisher : Academic Press
Release : 2012-06-07
ISBN : 0123978386
Language : En, Es, Fr & De

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Book Description :

The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The Diseases volume provides thorough reviews of naturally occurring diseases of nonhuman primates, with a section on biomedical models reviewing contemporary nonhuman primate models of human diseases. Each chapter contains an extensive list of bibliographic references, photographs, and graphic illustrations to provide the reader with a thorough review of the subject. Fully revised and updated, providing researchers with the most comprehensive review of the use of nonhuman primates in bioledical research Addresses commonly used nonhuman primate biomedical models, providing researchers with species-specific information Includes four color images throughout

Handbook of Primate Husbandry and Welfare

Handbook of Primate Husbandry and Welfare Book
Author : Sarah Wolfensohn,Paul Honess
Publisher : John Wiley & Sons
Release : 2008-04-15
ISBN : 1405156155
Language : En, Es, Fr & De

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Book Description :

Handbook of Primate Husbandry and Welfare covers all aspects of primate care and management both in the laboratory environment and in zoos. From the welfare and ethics of primate captivity through to housing and husbandry systems, environmental enrichment, nutritional requirements, breeding issues, primate diseases, and additional information on transportation and quarantine proceedings, this book provides a completely comprehensive guide to good husbandry and management of primates. Designed to be a practical field manual, the authors present the material using lists, tables and illustrations to clarify best practice. Representative species are covered – from marmosets through to macaques One of the first books dedicated to the care of primates in captivity Written by authors with many years of experience working with primates Suitable for those working with primates in either laboratories or zoos

The Laboratory Nonhuman Primate

The Laboratory Nonhuman Primate Book
Author : Jeffrey D. Fortman,Terry A. Hewett,Lisa C. Halliday
Publisher : CRC Press
Release : 2017-10-23
ISBN : 1351643274
Language : En, Es, Fr & De

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Book Description :

Extensively updated to include current literature, The Laboratory Nonhuman Primate, Second Edition, continues to serve as a quick reference source for technicians, caretakers, veterinarians, researchers, and students working with primates in biomedical research. It provides details on basic husbandry and covers biologic characteristics, regulatory compliance, common diseases, and anesthetic management. The text gives easy-to-follow descriptions of basic technical procedures including restraint, intubation, tuberculin skin testing, and collection of blood and urine samples. It also reviews advanced sampling procedures including collection of bone marrow, cerebrospinal fluid, bronchoalveolar lavage fluid, and rectal mucosal biopsy. The Laboratory Nonhuman Primate presents information in a clear, concise format to allow readers to incorporate concepts and techniques into the standard operating procedures of a facility.

Handbook of Primate Behavioral Management

Handbook of Primate Behavioral Management Book
Author : Steven J. Schapiro
Publisher : CRC Press
Release : 2017-07-12
ISBN : 1351646982
Language : En, Es, Fr & De

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Book Description :

Key features: Offers chapters by renowned experts which are comprised of three subunits: a theoretical discussion of the content area, a description of the methods employed to address the content area, and finally, and most importantly, a discussion of the ways that relevant aspects of the content area can be easily employed/adapted to enhance the behavioral management of NHPs Provides case studies that highlight the areas of expertise of the authors and emphasize ‘success stories’ that can be used to develop behavioral management strategies and build behavioral management programs Presents ‘Genera-specific’ chapters which focus on behavioral management strategies that, typically, are successfully employed with particular taxa of NHPs Includes a novel, pioneering ‘Product/services’ section that provides the producers of important technologies, equipment, and services with an opportunity to highlight the ways in which their products enhance the ability of their clients to manage the behavior of NHPs Illustrated with full color images and drawings throughout. The Handbook of Primate Behavioral Management (HPBM) fills a void in the scientific literature, providing those who work with nonhuman primates (NHPs) with a centralized reference for many issues related to the care and behavioral management of captive nonhuman primates. While there are numerous publications scattered throughout the literature that deal with the behavioral management of NHPs, this comprehensive handbook is the first single-source reference to summarize and synthesize this information. The HPBM is organized into six complementary parts starting with an introductory section. The book then provides in-depth coverage of content issues, applications and implementation, genera-specific chapters, technology-related questions involved in the behavioral management of NHPs, and a concluding section. Primate behavioral management is a topic that has recently generated a considerable number of primary publications in the scientific literature, mostly with an applied focus. Similarly, there are many primary publications currently available that address more basic issues related to the understanding of primate behavior. One of the principal goals of the HPBM is to highlight and synthesize basic science advances that can be adapted and applied to enhance the behavioral management of captive NHPs.

The Biology of Animal Stress

The Biology of Animal Stress Book
Author : Gary P. Moberg,Joy A. Mench
Publisher : CABI
Release : 2000
ISBN : 9780851999302
Language : En, Es, Fr & De

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Book Description :

The subjects of stress and animal welfare are currently attracting immense interest. This book brings together a range of perspectives from biomedical research (including human health and animal models of human stress) on stress and welfare, and assesses new approaches to conceptualising and alleviating stress.

Ethics Dumping

Ethics Dumping Book
Author : Doris Schroeder,Julie Cook,François Hirsch
Publisher : Unknown
Release : 2020-10-08
ISBN : 9781013269417
Language : En, Es, Fr & De

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Book Description :

This book provides original, up-to-date case studies of "ethics dumping" that were largely facilitated by loopholes in the ethics governance of low and middle-income countries. It is instructive even to experienced researchers since it provides a voice to vulnerable populations from the forementioned countries. Ensuring the ethical conduct of North-South collaborations in research is a process fraught with difficulties. The background conditions under which such collaborations take place include extreme differentials in available income and power, as well as a past history of colonialism, while differences in culture can add a new layer of complications. In this context, up-to-date case studies of unethical conduct are essential for research ethics training. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

Evolution Ecology and Conservation of Lorises and Pottos

Evolution  Ecology and Conservation of Lorises and Pottos  Book
Author : K. A. I. Nekaris,Anne M. Burrows
Publisher : Cambridge University Press
Release : 2020-03-19
ISBN : 1108429025
Language : En, Es, Fr & De

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Book Description :

The first book to present the latest discoveries on the behaviour, ecology and evolutionary biology of lorises and pottos.

Raptors in Captivity

Raptors in Captivity Book
Author : Lori R Arent
Publisher : Unknown
Release : 2018-05
ISBN : 9780888391094
Language : En, Es, Fr & De

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Book Description :

A first-of-its-kind resource, Raptors in Captivity is designed as a reader-friendly reference tool covering a wide range of topics from choosing a suitable species, to housing and transportation, diet, medical care, equipment, training. Raptors in Captivity is the recommended US Fish & Wildlife Service 'bible' for the care and keeping of raptors in captivity -- an incredible endorsement! If you're a zoo, rehab center or a falconer, here are the guidelines for safely caring for raptors -- and complying with permits. Covers a range of topics from making the decision to keep raptors and choosing suitable species, to housing and transportation, diet, medical care, equipment, training, and recovering a lost bird.

Family Relationships

Family Relationships Book
Author : Catherine A. Salmon,Todd K. Shackelford
Publisher : Oxford University Press
Release : 2007-09-14
ISBN : 9780198043263
Language : En, Es, Fr & De

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Book Description :

Kinship ties-the close relationships found within the family-have been a central focus of evolutionary biological analyses of social behavior ever since biologist William Hamilton extended the concept of Darwinian fitness to include an individual's actions benefiting not only his own offspring, but also collateral kin. Evolutionary biologists consider organisms not only reproductive strategists, but also nepotistic strategists. If a person's genes are just as likely to be reproduced in her sister as in her daughter, then we should expect the evolution of sororal investment in the same way as one expects maternal investment. This concept has revolutionized biologists' understanding of social interaction and developmental psychologists' understanding of the family. However, kinship ties have largely been ignored in other areas of psychology, particularly social psychology. Family Relationships brings together leading theorists and researchers from evolutionary psychology and related disciplines to illustrate the ways in which an evolutionary perspective can inform our study and understanding of family relationships. The contributors argue that family psychology is relationship specific: the relationship between mother and daughter is different from that between father and daughter or that between brother and sister or sister and sister. In other words, humans have evolved specialized mechanisms for processing information and motivating behavior that deal with the distinct demands of being a mate, father, mother, sibling, child, or grandparent. Such an evolutionary perspective on family dynamics provides a unique insight into human behavior. This volume will be an indispensable resource for psychologists, sociologists, and anthropologists, as well scholars of family, marriage, and animal behavior.

The Laboratory Primate

The Laboratory Primate Book
Author : Anonim
Publisher : Elsevier
Release : 2005-09-19
ISBN : 9780080454160
Language : En, Es, Fr & De

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Book Description :

A volume in the Handbook of Experimental Animals series, The Laboratory Primate details the past and present use of primates in biomedical research, and the husbandry, nutritional requirements, behaviour, and breeding of each of the commonly used species. Practical information on regulatory requirements, not available in other texts, is covered. Sections on experimental models cover the major areas of biomedical research, including AIDS, cancer, neurobiology and gene therapy. Assisted reproductive technology, tissue typing, and minimum group sizes for infectious disease/vaccine studies are also included. Two-color, user-friendly format, with copious illustrations and color plates Includes detailed, well-illustrated sections on gross & microscopic anatomy, common diseases, and special procedures, including surgical techniques

Care Use and Welfare of Marmosets as Animal Models for Gene Editing Based Biomedical Research

Care  Use  and Welfare of Marmosets as Animal Models for Gene Editing Based Biomedical Research Book
Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use
Publisher : National Academies Press
Release : 2019-07-26
ISBN : 0309488540
Language : En, Es, Fr & De

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Book Description :

The marmoset, a type of small monkey native to South America, is a research model of increasing importance for biomedical research in the United States and globally. Marmosets offer a range of advantages as animal models in neuroscience, aging, infectious diseases, and other fields of study. They may be particularly useful for the development of new disease models using genetic engineering and assisted reproductive technologies. However, concerns have been voiced with respect to the development of new marmoset-based models of disease, ethical considerations for their use, the supply of marmosets available for research, and gaps in guidance for their care and management. To explore and address these concerns, the Roundtable on Science and Welfare in Laboratory Animal Use hosted a public workshop on October 22-23, 2018, in Washington, DC. The workshop focused on the availability of marmosets in the United States and abroad; animal welfare and ethical considerations stemming from the use of wildtype and genetically modified marmosets; and standards of housing and care, dietary needs, and feeding requirements for marmosets in captivity. This publication summarizes the presentations and discussions from the workshop.

Guide to the Care and Use of Experimental Animals

Guide to the Care and Use of Experimental Animals Book
Author : Canadian Council On Animal Care
Publisher : Unknown
Release : 1980
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Responsability for the care of experimental animals. Laboratory animal facilities. The environament. Farm animal cafilities and environment. Laboratory animal care. Special practices. Health and safety responsabilities. Standards for experimental animal surgery. Anesthesia. Euthanasia.